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- References [14]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 19687-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19687-1-AP, RRID:AB_10666440
- Product name
- BLOC1S1-Specific antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated BLOC1S1-Specific antibody (Cat. #19687-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references BLOC1S1 depletion via splice-switching oligonucleotides improves mitochondrial respiration and rescues ALS phenotypes.
Interaction Proteomics of Polycystins 1 and 2 Reveal a Novel Role for the BLOC-1/BORC Lysosomal Positioning Complex.
DL-3-n-Butylphthalide Protects Mitochondria Against Ischemia/Hypoxia Damage via Suppressing GCN5L1-Mediated Drp1 Acetylation in Neurons and Mouse Brains.
Drp1 acetylation mediated by CDK5-AMPK-GCN5L1 axis promotes cerebral ischemic injury via facilitating mitochondrial fission.
Validation of GCN5L1/BLOC1S1/BLOS1 antibodies using knockout cells and tissue.
Core biomarkers analysis benefit for diagnosis on human intrahepatic cholestasis of pregnancy.
Validation of GCN5L1/BLOC1S1/BLOS1 Antibodies Using Knockout Cells and Tissue.
General Control of Amino Acid Synthesis 5-Like 1-Mediated Acetylation of Manganese Superoxide Dismutase Regulates Oxidative Stress in Diabetic Kidney Disease.
NAD(+) Repletion Reverses Heart Failure With Preserved Ejection Fraction.
HIV-1 Vpr protein impairs lysosome clearance causing SNCA/alpha-synuclein accumulation in neurons.
Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α.
A guide to assessing endoplasmic reticulum homeostasis and stress in mammalian systems.
GCN5L1 controls renal lipotoxicity through regulating acetylation of fatty acid oxidation enzymes.
Snapin promotes HIV-1 transmission from dendritic cells by dampening TLR8 signaling.
Hor JH, Ow JR, Ng W, Ramasamy B, Tabaglio T, Lim KNH, Bin Muzakar MI, Lim VJW, Gurrampati RR, Rajarethinam R, Ngo ST, Ramadass V, Ling SC, Lakshmanan M, Wee KB, Ng SY
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Mar 4;34(3):1672-1683
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Mar 4;34(3):1672-1683
Interaction Proteomics of Polycystins 1 and 2 Reveal a Novel Role for the BLOC-1/BORC Lysosomal Positioning Complex.
Lukmani F, Shillingford JM, Brauer M, Pancholi D, Germain JS, Shayman JA, Raught B, Gupta GD
Molecular & cellular proteomics : MCP 2025 Nov;24(11):101091
Molecular & cellular proteomics : MCP 2025 Nov;24(11):101091
DL-3-n-Butylphthalide Protects Mitochondria Against Ischemia/Hypoxia Damage via Suppressing GCN5L1-Mediated Drp1 Acetylation in Neurons and Mouse Brains.
Zhang H, Zhang N, Yang X, Zhang J, Ge X, Wang L, Wang S, Wen Y
CNS neuroscience & therapeutics 2025 Dec;31(12):e70682
CNS neuroscience & therapeutics 2025 Dec;31(12):e70682
Drp1 acetylation mediated by CDK5-AMPK-GCN5L1 axis promotes cerebral ischemic injury via facilitating mitochondrial fission.
Zhang J, Wang S, Zhang H, Yang X, Ren X, Wang L, Yang Y, Yang Y, Wen Y
Molecular medicine (Cambridge, Mass.) 2024 Oct 10;30(1):173
Molecular medicine (Cambridge, Mass.) 2024 Oct 10;30(1):173
Validation of GCN5L1/BLOC1S1/BLOS1 antibodies using knockout cells and tissue.
Bugga P, Stoner MW, Manning JR, Mushala BAS, Bhattarai N, Sharifi-Sanjani M, Webster BR, Thapa D, Scott I
The Biochemical journal 2024 May 22;481(10):643-651
The Biochemical journal 2024 May 22;481(10):643-651
Core biomarkers analysis benefit for diagnosis on human intrahepatic cholestasis of pregnancy.
Fang Y, Kang Z, Zhang W, Xiang Y, Cheng X, Gui M, Fang D
BMC pregnancy and childbirth 2024 Aug 10;24(1):525
BMC pregnancy and childbirth 2024 Aug 10;24(1):525
Validation of GCN5L1/BLOC1S1/BLOS1 Antibodies Using Knockout Cells and Tissue.
Bugga P, Stoner MW, Manning JR, Mushala BAS, Thapa D, Scott I
bioRxiv : the preprint server for biology 2023 Jul 21;
bioRxiv : the preprint server for biology 2023 Jul 21;
General Control of Amino Acid Synthesis 5-Like 1-Mediated Acetylation of Manganese Superoxide Dismutase Regulates Oxidative Stress in Diabetic Kidney Disease.
Lv T, Lu Y, Liu Y, Feng H, Li C, Sheng W, Cui Z, Zhu S, Gu X, Yang Z, Wan Q
Oxidative medicine and cellular longevity 2021;2021:6691226
Oxidative medicine and cellular longevity 2021;2021:6691226
NAD(+) Repletion Reverses Heart Failure With Preserved Ejection Fraction.
Tong D, Schiattarella GG, Jiang N, Altamirano F, Szweda PA, Elnwasany A, Lee DI, Yoo H, Kass DA, Szweda LI, Lavandero S, Verdin E, Gillette TG, Hill JA
Circulation research 2021 May 28;128(11):1629-1641
Circulation research 2021 May 28;128(11):1629-1641
HIV-1 Vpr protein impairs lysosome clearance causing SNCA/alpha-synuclein accumulation in neurons.
Santerre M, Arjona SP, Allen CN, Callen S, Buch S, Sawaya BE
Autophagy 2021 Jul;17(7):1768-1782
Autophagy 2021 Jul;17(7):1768-1782
Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α.
Le Thomas A, Ferri E, Marsters S, Harnoss JM, Lawrence DA, Zuazo-Gaztelu I, Modrusan Z, Chan S, Solon M, Chalouni C, Li W, Koeppen H, Rudolph J, Wang W, Wu TD, Walter P, Ashkenazi A
Nature communications 2021 Dec 15;12(1):7310
Nature communications 2021 Dec 15;12(1):7310
A guide to assessing endoplasmic reticulum homeostasis and stress in mammalian systems.
Sicari D, Delaunay-Moisan A, Combettes L, Chevet E, Igbaria A
The FEBS journal 2020 Jan;287(1):27-42
The FEBS journal 2020 Jan;287(1):27-42
GCN5L1 controls renal lipotoxicity through regulating acetylation of fatty acid oxidation enzymes.
Lv T, Hu Y, Ma Y, Zhen J, Xin W, Wan Q
Journal of physiology and biochemistry 2019 Nov;75(4):597-606
Journal of physiology and biochemistry 2019 Nov;75(4):597-606
Snapin promotes HIV-1 transmission from dendritic cells by dampening TLR8 signaling.
Khatamzas E, Hipp MM, Gaughan D, Pichulik T, Leslie A, Fernandes RA, Muraro D, Booth S, Zausmer K, Sun MY, Kessler B, Rowland-Jones S, Cerundolo V, Simmons A
The EMBO journal 2017 Oct 16;36(20):2998-3011
The EMBO journal 2017 Oct 16;36(20):2998-3011
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 19687-1-AP(BLOC1S1-Specific antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The BLOC1S1-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human BLOC1S1-Specific. This antibody recognizes human,mouse,rat antigen. The BLOC1S1-Specific antibody has been validated for the following applications: ELISA, WB, IHC analysis.
