18470-1-AP

antibody from Proteintech Group

Targeting: PROM1 AC133, CD133, CORD12, MCDR2, PROML1, RP41, STGD4

Provider product page for 18470-1-AP

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References [224]
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Product number: 18470-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#18470-1-AP, RRID:AB_2172859
Product name: CD133 antibody
Antibody type: Polyclonal
Description: KD/KO validated CD133 antibody (Cat. #18470-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PROM1 protein structure - 18470-1-AP shown in red.

Submitted references Melatonin inhibits the stemness of head and neck squamous cell carcinoma by modulating HA synthesis via the FOSL1/HAS3 axis.

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Combining microfluidic chip and low-attachment culture devices to isolate oral cancer stem cells.

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Journal of dental sciences 2024 Jan;19(1):560-567

Sulforaphane Suppresses MCF-7 Breast Cancer Cells Growth via miR-19/PTEN Axis to Antagonize the Effect of Butyl Benzyl Phthalate.

Cao W, Lu X, Zhong C, Wu J
Nutrition and cancer 2023;75(3):980-991

FAK downregulation suppresses stem-like properties and migration of human colorectal cancer cells.

Xu C, Zhang W, Liu C
PloS one 2023;18(4):e0284871

NPM1 promotes nasopharyngeal carcinoma metastasis and stemness by recruiting Mdm2 to induce the ubiquitination-mediated degradation of p53.

Hu L, Gong P, Zhou N, Wang S, He C, Zhou Y, Li Q, Zhao X, Peng H
American journal of cancer research 2023;13(5):1766-1785

Tibial cortex transverse transport potentiates diabetic wound healing via activation of SDF-1/CXCR4 signaling.

Ou S, Wu X, Yang Y, Xia C, Zhang W, Qu Y, Li J, Chen B, Zhu L, Xu C, Qi Y
PeerJ 2023;11:e15894

YAP1 affects the prognosis through the regulation of stemness in endometrial cancer.

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PeerJ 2023;11:e15891

Radiated tumor cell-derived microparticles effectively kill stem-like tumor cells by increasing reactive oxygen species.

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A novel TOX3-WDR5-ABCG2 signaling axis regulates the progression of colorectal cancer by accelerating stem-like traits and chemoresistance.

Hao J, Huang J, Hua C, Zuo Y, Yu W, Wu X, Li L, Xue G, Wan X, Ru L, Guo Z, Han S, Deng W, Lin F, Guo W
PLoS biology 2023 Sep;21(9):e3002256

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Cancer science 2023 Jun;114(6):2277-2292

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Zhou P, Peng X, Tang S, Zhang K, Tan Z, Li D, Shen L, Peng J, Yang L
Oncogene 2023 Apr;42(16):1308-1320

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BioMed research international 2022;2022:6441179

Celecoxib-Induced Modulation of Colon Cancer CD133 Expression Occurs through AKT Inhibition and Is Monitored by (89)Zr Immuno-PET.

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PLHPP2 inhibits the stemness of colorectal cancer by inactivating the Nrf2 signaling pathway.

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Cell death discovery 2022 Oct 15;8(1):418

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Chen J, Liu G, Wang X, Hong H, Li T, Li L, Wang H, Xie J, Li B, Li T, Lu D, Zhang Y, Zhao H, Yao C, Wen K, Li T, Chen J, Wu S, He K, Zhang WN, Zhao J, Wang N, Han Q, Xia Q, Qi J, Chen J, Zhou T, Man J, Zhang XM, Li AL, Pan X
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Pharmacological research 2022 May;179:106222

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Xue F, Bai Y, Jiang Y, Liu J, Jian K
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Selection of CD133-targeted DNA aptamers for the efficient and specific therapy of colorectal cancer.

Li W, Wang Z, Gao T, Sun S, Xu M, Pei R
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Claudin1 decrease induced by 1,25-dihydroxy-vitamin D3 potentiates gefitinib resistance therapy through inhibiting AKT activation-mediated cancer stem-like properties in NSCLC cells.

Jia Z, Wang K, Duan Y, Hu K, Zhang Y, Wang M, Xiao K, Liu S, Pan Z, Ding X
Cell death discovery 2022 Mar 18;8(1):122

Expression of HIF-1α, ANXA3, CD133 and their associations with clinicopathological parameters in human colon carcinoma.

Chai X, Wu X, Ren J, Du K, Wu X, Feng F, Zheng J
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Stress-induced epinephrine promotes epithelial-to-mesenchymal transition and stemness of CRC through the CEBPB/TRIM2/P53 axis.

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Journal of translational medicine 2022 Jun 7;20(1):262

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World journal of stem cells 2022 Jul 26;14(7):539-555

UPF1/circRPPH1/ATF3 feedback loop promotes the malignant phenotype and stemness of GSCs.

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REC8 enhances stemness and promotes metastasis of colorectal cancer through BTK/Akt/β-catenin signaling pathway.

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Frontiers in cell and developmental biology 2021;9:679806

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Journal of Cancer 2021;12(15):4686-4697

RGC-32 Acts as a Hub to Regulate the Transcriptomic Changes Associated With Astrocyte Development and Reactive Astrocytosis.

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Frontiers in oncology 2021;11:635233

MiR-552-3p promotes malignant progression of gallbladder carcinoma by reactivating the Akt/β-catenin signaling pathway due to inhibition of the tumor suppressor gene RGMA.

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Annals of translational medicine 2021 Sep;9(17):1374

Regulatory T cells promote glioma cell stemness through TGF-β-NF-κB-IL6-STAT3 signaling.

Liu S, Zhang C, Wang B, Zhang H, Qin G, Li C, Cao L, Gao Q, Ping Y, Zhang K, Lian J, Zhao Q, Wang D, Zhang Z, Zhao X, Yang L, Huang L, Yang B, Zhang Y
Cancer immunology, immunotherapy : CII 2021 Sep;70(9):2601-2616

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Liu HT, Xia T, You YW, Zhang QC, Ni HS, Liu YF, Liu YR, Xu YQ, You B, Zhang ZX
Laryngoscope investigative otolaryngology 2021 Oct;6(5):1228-1234

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Wang R, Liu J, Li K, Yang G, Chen S, Wu J, Xie X, Ren H, Pang Y
Journal of experimental & clinical cancer research : CR 2021 Oct 13;40(1):318

DOC-2/DAB2 interactive protein destabilizes c-Myc to impair the growth and self-renewal of colon tumor-repopulating cells.

Li H, Zhou Y, Wang M, Wang H, Zhang Y, Peng R, Zhang R, Zhang M, Zhang M, Qiu P, Liu L, Zhao Q, Liu J
Cancer science 2021 Nov;112(11):4593-4603

Curcumol inhibits malignant biological behaviors and TMZ-resistance in glioma cells by inhibiting long noncoding RNA FOXD2-As1-promoted EZH2 activation.

Lv X, Sun J, Hu L, Qian Y, Fan C, Tian N
Aging 2021 Nov 5;13(21):24101-24116

Apatinib suppresses lung cancer stem-like cells by complex interplay between β-catenin signaling and mitochondrial ROS accumulation.

Zhu J, Li X, Liang C, Zhou X, Ge M, Chen Y, Jin J, Yin J, Xu H, Xie C, Zhong C
Cell death discovery 2021 May 12;7(1):102

PIM447 inhibits oncogenesis and potentiates cisplatin effects in hepatoblastoma.

Wadhwani N, Markert HR, Marayati R, Bownes LV, Quinn CH, Aye JM, Stewart JE, Yoon KJ, Beierle EA
Journal of pediatric surgery 2021 Jun;56(6):1157-1164

Diallyl trisulphide, a H(2) S donor, compromises the stem cell phenotype and restores thyroid-specific gene expression in anaplastic thyroid carcinoma cells by targeting AKT-SOX2 axis.

Zhang L, Xu S, Cheng X, Zheng J, Wang Y, Wu J, Wang X, Wu L, Yu H, Bao J
Phytotherapy research : PTR 2021 Jun;35(6):3428-3443

Expression of CD44 and CD133 stem cell markers in squamous cell carcinoma of esophagus.

Gupta P, Rizvi SZ, Lal N, Gupta V, Srivastav AN, Musa O
Indian journal of pathology & microbiology 2021 Jul-Sep;64(3):472-478

HOXB7 acts as an oncogenic biomarker in head and neck squamous cell carcinoma.

Wu X, Li J, Yan T, Ke X, Li X, Zhu Y, Yang J, Li Z
Cancer cell international 2021 Jul 24;21(1):393

Deletion of the phosphatase INPP5E in the murine retina impairs photoreceptor axoneme formation and prevents disc morphogenesis.

Sharif AS, Gerstner CD, Cady MA, Arshavsky VY, Mitchell C, Ying G, Frederick JM, Baehr W
The Journal of biological chemistry 2021 Jan-Jun;296:100529

RAB27A-dependent release of exosomes by liver cancer stem cells induces Nanog expression in their differentiated progenies and confers regorafenib resistance.

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Journal of gastroenterology and hepatology 2021 Dec;36(12):3429-3437

miR-378d suppresses malignant phenotype of ESCC cells through AKT signaling.

Peng J, Shi S, Yu J, Liu J, Wei H, Song H, Wang S, Li Z, He S, Li L, Zhang H, Yan Z, Zhao R, Liu Y, Liu Y, Li J, Zhang R, Wang W
Cancer cell international 2021 Dec 22;21(1):702

Arl4c promotes the growth and drug resistance of pancreatic cancer by regulating tumor-stromal interactions.

Chen X, Zhang Y, Qian W, Han L, Li W, Duan W, Wu Z, Wang Z, Ma Q
iScience 2021 Dec 17;24(12):103400

CRSP8 promotes thyroid cancer progression by antagonizing IKKα-induced cell differentiation.

Liao Y, Hua Y, Li Y, Zhang C, Yu W, Guo P, Zou K, Li W, Sun Y, Wang R, Zuo Y, Sui S, Tian C, Hao J, Chen M, Hu S, Chen M, Long Q, Wang X, Zou L, Xie F, Guo W, Deng W
Cell death and differentiation 2021 Apr;28(4):1347-1363

SPT6 recruits SND1 to co-activate human telomerase reverse transcriptase to promote colon cancer progression.

Diao C, Guo P, Yang W, Sun Y, Liao Y, Yan Y, Zhao A, Cai X, Hao J, Hu S, Yu W, Chen M, Wang R, Li W, Zuo Y, Pan J, Hua C, Lu X, Fan W, Zheng Z, Deng W, Luo G, Guo W
Molecular oncology 2021 Apr;15(4):1180-1202

Cigarette smoke supports stemness and epithelial-mesenchymal transition in bladder cancer stem cells through SHH signaling.

Sun X, Song J, Li E, Geng H, Li Y, Yu D, Zhong C
International journal of clinical and experimental pathology 2020;13(6):1333-1348

β-Elemene Enhances the Chemotherapeutic Effect of 5-Fluorouracil in Triple-Negative Breast Cancer via PI3K/AKT, RAF-MEK-ErK, and NF-κB Signaling Pathways.

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OncoTargets and therapy 2020;13:5207-5222

Alpha-1 Antitrypsin Induces Epithelial-to-Mesenchymal Transition, Endothelial-to-Mesenchymal Transition, and Drug Resistance in Lung Cancer Cells.

Wu DM, Liu T, Deng SH, Han R, Zhang T, Li J, Xu Y
OncoTargets and therapy 2020;13:3751-3763

Inhibiting EMT, stemness and cell cycle involved in baicalin-induced growth inhibition and apoptosis in colorectal cancer cells.

Yang B, Bai H, Sa Y, Zhu P, Liu P
Journal of Cancer 2020;11(8):2303-2317

CCL21/CCR7 interaction promotes EMT and enhances the stemness of OSCC via a JAK2/STAT3 signaling pathway.

Chen Y, Shao Z, Jiang E, Zhou X, Wang L, Wang H, Luo X, Chen Q, Liu K, Shang Z
Journal of cellular physiology 2020 Sep;235(9):5995-6009

TAp63α targeting of Lgr5 mediates colorectal cancer stem cell properties and sulforaphane inhibition.

Chen Y, Wang MH, Zhu JY, Xie CF, Li XT, Wu JS, Geng SS, Han HY, Zhong CY
Oncogenesis 2020 Oct 10;9(10):89

Nanog mediates tobacco smoke-induced enhancement of renal cancer stem cell properties.

Zhang T, Sun H, Liu R, Cao W, Zhang T, Li E, Sun X, Wu W, Yu D, Zhong C
Environmental toxicology 2020 Nov;35(11):1274-1283

Deficiency of pseudogene UPAT leads to hepatocellular carcinoma progression and forms a positive feedback loop with ZEB1.

Xiang L, Huang X, Wang S, Ou H, Chen Z, Hu Z, Huang Y, Li X, Yuan Y, Yang D
Cancer science 2020 Nov;111(11):4102-4117

Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis.

Park DE, Cheng J, McGrath JP, Lim MY, Cushman C, Swanson SK, Tillgren ML, Paulo JA, Gokhale PC, Florens L, Washburn MP, Trojer P, DeCaprio JA
Nature cell biology 2020 May;22(5):603-615

microRNA-454 promotes liver tumor-initiating cell expansion by regulating SOCS6.

Lei Z, Tang X, Si A, Yang P, Wang L, Luo T, Guo G, Zhang Q, Cheng Z
Experimental cell research 2020 May 1;390(1):111955

Mesenchymal stem cells maintain the stemness of colon cancer stem cells via interleukin-8/mitogen-activated protein kinase signaling pathway.

Ma X, Liu J, Yang X, Fang K, Zheng P, Liang X, Liu J
Experimental biology and medicine (Maywood, N.J.) 2020 Mar;245(6):562-575

Leptin and Notch Signaling Cooperate in Sustaining Glioblastoma Multiforme Progression.

Panza S, Russo U, Giordano F, Leggio A, Barone I, Bonofiglio D, Gelsomino L, Malivindi R, Conforti FL, Naimo GD, Giordano C, Catalano S, Andò S
Biomolecules 2020 Jun 9;10(6)

Targeting Ephrin Receptor Tyrosine Kinase A2 with a Selective Aptamer for Glioblastoma Stem Cells.

Affinito A, Quintavalle C, Esposito CL, Roscigno G, Giordano C, Nuzzo S, Ricci-Vitiani L, Scognamiglio I, Minic Z, Pallini R, Berezovski MV, de Francisis V, Condorelli G
Molecular therapy. Nucleic acids 2020 Jun 5;20:176-185

HOTAIR expands the population of prostatic cancer stem-like cells and causes Docetaxel resistance via activating STAT3 signaling.

Wang N, Jiang Y, Lv S, Wen H, Wu D, Wei Q, Dang Q
Aging 2020 Jul 13;12(13):12771-12782

Aerobic and resistance training enhances endothelial progenitor cell function via upregulation of caveolin-1 in mice with type 2 diabetes.

Zhai L, Liu Y, Zhao W, Chen Q, Guo T, Wei W, Luo Z, Huang Y, Ma C, Huang F, Dai X
Stem cell research & therapy 2020 Jan 3;11(1):10

Role of LLT1 and PCNA as Natural Killer Cell Immune Evasion Strategies of HCT 116 Cells.

Malaer JD, Mathew PA
Anticancer research 2020 Dec;40(12):6613-6621

β-Elemene enhances radiosensitivity in non-small-cell lung cancer by inhibiting epithelial-mesenchymal transition and cancer stem cell traits via Prx-1/NF-kB/iNOS signaling pathway.

Zou K, Li Z, Zhang Y, Mu L, Chen M, Wang R, Deng W, Zou L, Liu J
Aging 2020 Dec 9;13(2):2575-2592

TRIM24 promotes stemness and invasiveness of glioblastoma cells via activating Sox2 expression.

Zhang LH, Yin YH, Chen HZ, Feng SY, Liu JL, Chen L, Fu WL, Sun GC, Yu XG, Xu DG
Neuro-oncology 2020 Dec 18;22(12):1797-1808

Effect of Aerobic and Resistance Training on Endothelial Progenitor Cells in Mice with Type 2 Diabetes.

Dai X, Zhai L, Su Q, Luo B, Wei C, Liu Y, Huang Y, Ma C, Ying Y
Cellular reprogramming 2020 Aug;22(4):189-197

Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells.

Shi C, Yang J, Hu L, Liao B, Qiao L, Shen W, Xie F, Zhu G
Aging 2020 Aug 3;12(15):15546-15555

Identification of a subpopulation of long-term tumor-initiating cells in colon cancer.

Peng L, Xiong Y, Wang R, Xiang L, Zhou H, Gu H
Bioscience reports 2020 Aug 28;40(8)

Adenovirus infection promotes the formation of glioma stem cells from glioblastoma cells through the TLR9/NEAT1/STAT3 pathway.

Zang J, Zheng MH, Cao XL, Zhang YZ, Zhang YF, Gao XY, Cao Y, Shi M, Han H, Liang L
Cell communication and signaling : CCS 2020 Aug 26;18(1):135

1,25-dihydroxyvitamin D3 signaling-induced decreases in IRX4 inhibits NANOG-mediated cancer stem-like properties and gefitinib resistance in NSCLC cells.

Jia Z, Zhang Y, Yan A, Wang M, Han Q, Wang K, Wang J, Qiao C, Pan Z, Chen C, Hu D, Ding X
Cell death & disease 2020 Aug 20;11(8):670

CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling.

Huang R, Wang S, Wang N, Zheng Y, Zhou J, Yang B, Wang X, Zhang J, Guo L, Wang S, Chen Z, Wang Z, Xiang S
Cell death & disease 2020 Apr 16;11(4):234

Oncogenic MSH6-CXCR4-TGFB1 Feedback Loop: A Novel Therapeutic Target of Photothermal Therapy in Glioblastoma Multiforme.

Chen Y, Liu P, Sun P, Jiang J, Zhu Y, Dong T, Cui Y, Tian Y, An T, Zhang J, Li Z, Yang X
Theranostics 2019;9(5):1453-1473

Sulforaphane Inhibits the Acquisition of Tobacco Smoke-Induced Lung Cancer Stem Cell-Like Properties via the IL-6/ΔNp63α/Notch Axis.

Xie C, Zhu J, Jiang Y, Chen J, Wang X, Geng S, Wu J, Zhong C, Li X, Meng Z
Theranostics 2019;9(16):4827-4840

Therapeutic Effects of Human Urine-Derived Stem Cells in a Rat Model of Cisplatin-Induced Acute Kidney Injury In Vivo and In Vitro.

Sun B, Luo X, Yang C, Liu P, Yang Y, Dong X, Yang Z, Xu J, Zhang Y, Li L
Stem cells international 2019;2019:8035076

Inhibition of Autophagy with Chloroquine Enhanced Sinoporphyrin Sodium Mediated Photodynamic Therapy-induced Apoptosis in Human Colorectal Cancer Cells.

Zhu B, Li S, Yu L, Hu W, Sheng D, Hou J, Zhao N, Hou X, Wu Y, Han Z, Wei L, Zhang L
International journal of biological sciences 2019;15(1):12-23

Cinobufagin Suppresses The Characteristics Of Osteosarcoma Cancer Cells By Inhibiting The IL-6-OPN-STAT3 Pathway.

Zhang C, Ma K, Li WY
Drug design, development and therapy 2019;13:4075-4090

Sonic hedgehog pathway mediates genistein inhibition of renal cancer stem cells.

Li E, Zhang T, Sun X, Li Y, Geng H, Yu D, Zhong C
Oncology letters 2019 Sep;18(3):3081-3091

Long non-coding RNA linc00645 promotes TGF-β-induced epithelial-mesenchymal transition by regulating miR-205-3p-ZEB1 axis in glioma.

Li C, Zheng H, Hou W, Bao H, Xiong J, Che W, Gu Y, Sun H, Liang P
Cell death & disease 2019 Sep 26;10(10):717

circPTN sponges miR-145-5p/miR-330-5p to promote proliferation and stemness in glioma.

Chen J, Chen T, Zhu Y, Li Y, Zhang Y, Wang Y, Li X, Xie X, Wang J, Huang M, Sun X, Ke Y
Journal of experimental & clinical cancer research : CR 2019 Sep 11;38(1):398

Macrophage migration inhibitory factor promotes the invasion and metastasis of oral squamous cell carcinoma through matrix metalloprotein-2/9.

Wang SS, Zheng M, Pang X, Zhang M, Yu XH, Wu JB, Gao XL, Wu JS, Yang X, Tang YJ, Tang YL, Liang XH
Molecular carcinogenesis 2019 Oct;58(10):1809-1821

CtBP-a targetable dependency for tumor-initiating cell activity and metastasis in pancreatic adenocarcinoma.

Chawla AT, Chougoni KK, Joshi PJ, Cororaton AD, Memari P, Stansfield JC, Park H, Seth R, Szomju B, Sima AP, Idowu MO, Ellis KC, Grossman SR
Oncogenesis 2019 Oct 4;8(10):55

Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets.

Chien CH, Chuang JY, Yang ST, Yang WB, Chen PY, Hsu TI, Huang CY, Lo WL, Yang KY, Liu MS, Chu JM, Chung PH, Liu JJ, Chou SW, Chen SH, Chang KY
Journal of biomedical science 2019 Oct 19;26(1):77

Pre-metastatic niche triggers SDF-1/CXCR4 axis and promotes organ colonisation by hepatocellular circulating tumour cells via downregulation of Prrx1.

Tang Y, Lu Y, Chen Y, Luo L, Cai L, Peng B, Huang W, Liao H, Zhao L, Pan M
Journal of experimental & clinical cancer research : CR 2019 Nov 21;38(1):473

ANGPTL4 Induces TMZ Resistance of Glioblastoma by Promoting Cancer Stemness Enrichment via the EGFR/AKT/4E-BP1 Cascade.

Tsai YT, Wu AC, Yang WB, Kao TJ, Chuang JY, Chang WC, Hsu TI
International journal of molecular sciences 2019 Nov 11;20(22)

Enhancing responsiveness of pancreatic cancer cells to gemcitabine treatment under hypoxia by heme oxygenase-1 inhibition.

Abdalla MY, Ahmad IM, Rachagani S, Banerjee K, Thompson CM, Maurer HC, Olive KP, Bailey KL, Britigan BE, Kumar S
Translational research : the journal of laboratory and clinical medicine 2019 May;207:56-69

miR-194 inhibits liver cancer stem cell expansion by regulating RAC1 pathway.

Ran RZ, Chen J, Cui LJ, Lin XL, Fan MM, Cong ZZ, Zhang H, Tan WF, Zhang GQ, Zhang YJ
Experimental cell research 2019 May 1;378(1):66-75

Nr5a2 promotes cancer stem cell properties and tumorigenesis in nonsmall cell lung cancer by regulating Nanog.

Ye T, Li J, Sun Z, Liu Y, Kong L, Zhou S, Tang J, Wang J, Xing HR
Cancer medicine 2019 Mar;8(3):1232-1245

Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway.

Li Z, Chen Y, An T, Liu P, Zhu J, Yang H, Zhang W, Dong T, Jiang J, Zhang Y, Jiang M, Yang X
Journal of experimental & clinical cancer research : CR 2019 Mar 29;38(1):139

lncARSR promotes liver cancer stem cells expansion via STAT3 pathway.

Yang C, Cai WC, Dong ZT, Guo JW, Zhao YJ, Sui CJ, Yang JM
Gene 2019 Mar 1;687:73-81

MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer.

He W, Liang B, Wang C, Li S, Zhao Y, Huang Q, Liu Z, Yao Z, Wu Q, Liao W, Zhang S, Liu Y, Xiang Y, Liu J, Shi M
Oncogene 2019 Jun;38(23):4637-4654

CSC-3436 inhibits TWIST-induced epithelial-mesenchymal transition via the suppression of Twist/Bmi1/Akt pathway in head and neck squamous cell carcinoma.

Lai YJ, Yu WN, Kuo SC, Ho CT, Hung CM, Way TD, Chen CT
Journal of cellular physiology 2019 Jun;234(6):9118-9129

Delivery of Anti-miRNA for Triple-Negative Breast Cancer Therapy Using RNA Nanoparticles Targeting Stem Cell Marker CD133.

Yin H, Xiong G, Guo S, Xu C, Xu R, Guo P, Shu D
Molecular therapy : the journal of the American Society of Gene Therapy 2019 Jul 3;27(7):1252-1261

Low-Dose IFNγ Induces Tumor Cell Stemness in Tumor Microenvironment of Non-Small Cell Lung Cancer.

Song M, Ping Y, Zhang K, Yang L, Li F, Zhang C, Cheng S, Yue D, Maimela NR, Qu J, Liu S, Sun T, Li Z, Xia J, Zhang B, Wang L, Zhang Y
Cancer research 2019 Jul 15;79(14):3737-3748

CCAAT/enhancer-binding protein delta regulates the stemness of glioma stem-like cells through activating PDGFA expression upon inflammatory stimulation.

Wang SM, Lin HY, Chen YL, Hsu TI, Chuang JY, Kao TJ, Ko CY
Journal of neuroinflammation 2019 Jul 12;16(1):146

Missense Mutations in the Human Nanophthalmos Gene TMEM98 Cause Retinal Defects in the Mouse.

Cross SH, Mckie L, Keighren M, West K, Thaung C, Davey T, Soares DC, Sanchez-Pulido L, Jackson IJ
Investigative ophthalmology & visual science 2019 Jul 1;60(8):2875-2887

Downregulation of DAPK1 promotes the stemness of cancer stem cells and EMT process by activating ZEB1 in colorectal cancer.

Yuan W, Ji J, Shu Y, Chen J, Liu S, Wu L, Zhou Z, Liu Z, Tang Q, Zhang X, Shu X
Journal of molecular medicine (Berlin, Germany) 2019 Jan;97(1):89-102

miR-365 regulates liver cancer stem cells via RAC1 pathway.

Jiang ZB, Ma BQ, Liu SG, Li J, Yang GM, Hou YB, Si RH, Gao P, Yan HT
Molecular carcinogenesis 2019 Jan;58(1):55-65

BPTF promotes hepatocellular carcinoma growth by modulating hTERT signaling and cancer stem cell traits.

Zhao X, Zheng F, Li Y, Hao J, Tang Z, Tian C, Yang Q, Zhu T, Diao C, Zhang C, Chen M, Hu S, Guo P, Zhang L, Liao Y, Yu W, Chen M, Zou L, Guo W, Deng W
Redox biology 2019 Jan;20:427-441

FOXO1 associated with sensitivity to chemotherapy drugs and glial-mesenchymal transition in glioma.

Chen C, Han G, Li Y, Yue Z, Wang L, Liu J
Journal of cellular biochemistry 2019 Jan;120(1):882-893

Tobacco smoke induced hepatic cancer stem cell-like properties through IL-33/p38 pathway.

Xie C, Zhu J, Wang X, Chen J, Geng S, Wu J, Zhong C, Li X
Journal of experimental & clinical cancer research : CR 2019 Jan 28;38(1):39

Matrix stiffness mediates stemness characteristics via activating the Yes-associated protein in colorectal cancer cells.

Tan F, Huang Y, Pei Q, Liu H, Pei H, Zhu H
Journal of cellular biochemistry 2019 Feb;120(2):2213-2225

Long non-coding RNA THOR promotes liver cancer stem cells expansion via β-catenin pathway.

Cheng Z, Lei Z, Yang P, Si A, Xiang D, Zhou J, Hüser N
Gene 2019 Feb 5;684:95-103

miR-219 regulates liver cancer stem cell expansion via E-cadherin pathway.

Si A, Wang L, Miao K, Zhang R, Ji H, Lei Z, Cheng Z, Fang X, Hao B
Cell cycle (Georgetown, Tex.) 2019 Dec;18(24):3550-3561

An Effective Multi-Stage Liposomal DNA Origami Nanosystem for In Vivo Cancer Therapy.

Palazzolo S, Hadla M, Russo Spena C, Caligiuri I, Rotondo R, Adeel M, Kumar V, Corona G, Canzonieri V, Toffoli G, Rizzolio F
Cancers 2019 Dec 12;11(12)

Sulforaphane inhibits gastric cancer stem cells via suppressing sonic hedgehog pathway.

Ge M, Zhang L, Cao L, Xie C, Li X, Li Y, Meng Y, Chen Y, Wang X, Chen J, Zhang Q, Shao J, Zhong C
International journal of food sciences and nutrition 2019 Aug;70(5):570-578

CD146 is highly expressed in glioma stem cells and acts as a cell cycle regulator.

Yawata T, Higashi Y, Kawanishi Y, Nakajo T, Fukui N, Fukuda H, Ueba T
Journal of neuro-oncology 2019 Aug;144(1):21-32

Ambient fine particulate matter inhibits 15-lipoxygenases to promote lung carcinogenesis.

Li MY, Liu LZ, Li W, Ng CSH, Liu Y, Kong AWY, Zhao Z, Wang S, Qi H, Jia H, Yang S, Du J, Long X, Ho RLK, Chak ECW, Wan IYP, Mok TSK, Underwood MJ, Gali NK, Ning Z, Chen GG
Journal of experimental & clinical cancer research : CR 2019 Aug 16;38(1):359

miR-504 suppresses mesenchymal phenotype of glioblastoma by directly targeting the FZD7-mediated Wnt-β-catenin pathway.

Liu Q, Guan Y, Li Z, Wang Y, Liu Y, Cui R, Wang Y
Journal of experimental & clinical cancer research : CR 2019 Aug 16;38(1):358

Depletion of the lncRNA RP11-567G11.1 inhibits pancreatic cancer progression.

Huang R, Nie W, Yao K, Chou J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108685

Long non-coding RNA DILC promotes the progression of gallbladder carcinoma.

Liang C, Yang P, Han T, Wang RY, Xing XL, Si AF, Ma QY, Chen Z, Li HY, Zhang B
Gene 2019 Apr 30;694:102-110

The PAX6-ZEB2 axis promotes metastasis and cisplatin resistance in non-small cell lung cancer through PI3K/AKT signaling.

Wu DM, Zhang T, Liu YB, Deng SH, Han R, Liu T, Li J, Xu Y
Cell death & disease 2019 Apr 25;10(5):349

Isolation and Characterization of Cerebellum-Derived Stem Cells in Poststroke Human Brain.

Beppu M, Nakagomi T, Takagi T, Nakano-Doi A, Sakuma R, Kuramoto Y, Tatebayashi K, Matsuyama T, Yoshimura S
Stem cells and development 2019 Apr 15;28(8):528-542

Induction of cells with prostate cancer stem-like properties from mouse induced pluripotent stem cells via conditioned medium.

Xu N, Li X, Watanabe M, Ueki H, Hu H, Li N, Araki M, Wada K, Xu A, Liu C, Nasu Y, Huang P
American journal of cancer research 2018;8(8):1624-1632

Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19.

Ren J, Ding L, Zhang D, Shi G, Xu Q, Shen S, Wang Y, Wang T, Hou Y
Theranostics 2018;8(14):3932-3948

The neurofilament derived-peptide NFL-TBS.40-63 enters in-vitro in human neural stem cells and increases their differentiation.

Barreau K, Montero-Menei C, Eyer J
PloS one 2018;13(8):e0201578

Nuclear CD133 expression predicts poor prognosis for hepatocellular carcinoma.

Yu GF, Lin X, Luo RC, Fang WY
International journal of clinical and experimental pathology 2018;11(4):2092-2099

Tumor suppressor LKB1 inhibits the progression of gallbladder carcinoma and predicts the prognosis of patients with this malignancy.

Hu MT, Wang JH, Yu Y, Liu C, Li B, Cheng QB, Jiang XQ
International journal of oncology 2018 Sep;53(3):1215-1226

KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells.

Zhu ZC, Liu JW, Li K, Zheng J, Xiong ZQ
Oncogene 2018 May;37(22):2936-2952

SUV39H2 promotes colorectal cancer proliferation and metastasis via tri-methylation of the SLIT1 promoter.

Shuai W, Wu J, Chen S, Liu R, Ye Z, Kuang C, Fu X, Wang G, Li Y, Peng Q, Shi W, Li Y, Zhou Q, Huang W
Cancer letters 2018 May 28;422:56-69

Cigarette smoke stimulates the stemness of renal cancer stem cells via Sonic Hedgehog pathway.

Qian W, Kong X, Zhang T, Wang D, Song J, Li Y, Li X, Geng H, Min J, Kong Q, Liu J, Liu Z, Wang D, Zhang Z, Yu D, Zhong C
Oncogenesis 2018 Mar 13;7(3):24

Wnt/β-catenin signaling mediates the suppressive effects of diallyl trisulfide on colorectal cancer stem cells.

Zhang Q, Li XT, Chen Y, Chen JQ, Zhu JY, Meng Y, Wang XQ, Li Y, Geng SS, Xie CF, Wu JS, Zhong CY, Han HY
Cancer chemotherapy and pharmacology 2018 Jun;81(6):969-977

Effects of three-dimensional collagen scaffolds on the expression profiles and biological functions of glioma cells.

Jia W, Jiang X, Liu W, Wang L, Zhu B, Zhu H, Liu X, Zhong M, Xie D, Huang W, Jia W, Li S, Liu X, Zuo X, Cheng D, Dai J, Ren C
International journal of oncology 2018 Jun;52(6):1787-1800

Effects of baicalein on pancreatic cancer stem cells via modulation of sonic Hedgehog pathway.

Song L, Chen X, Wang P, Gao S, Qu C, Liu L
Acta biochimica et biophysica Sinica 2018 Jun 1;50(6):586-596

Stat3/Oct-4/c-Myc signal circuit for regulating stemness-mediated doxorubicin resistance of triple-negative breast cancer cells and inhibitory effects of WP1066.

Cheng CC, Shi LH, Wang XJ, Wang SX, Wan XQ, Liu SR, Wang YF, Lu Z, Wang LH, Ding Y
International journal of oncology 2018 Jul;53(1):339-348

Wnt/β-catenin modulates chronic tobacco smoke exposure-induced acquisition of pulmonary cancer stem cell properties and diallyl trisulfide intervention.

Wang J, Chen J, Jiang Y, Shi Y, Zhu J, Xie C, Geng S, Wu J, Zhang Q, Wang X, Meng Y, Li Y, Chen Y, Cao W, Wang X, Zhong C, Li X
Toxicology letters 2018 Jul;291:70-76

Targeting USP22 Suppresses Tumorigenicity and Enhances Cisplatin Sensitivity Through ALDH1A3 Downregulation in Cancer-Initiating Cells from Lung Adenocarcinoma.

Yun X, Zhang K, Wang J, Pangeni RP, Yang L, Bonner M, Wu J, Wang J, Nardi IK, Gao M, Raz DJ
Molecular cancer research : MCR 2018 Jul;16(7):1161-1171

Balance between fibroblast growth factor 10 and secreted frizzled-relate protein-1 controls the development of hair follicle by competitively regulating β-catenin signaling.

Zhang H, Nan W, Wang S, Si H, Li G
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:1531-1537

Correlation of CD133 and Oct-4 expression with clinicopathological and demographic parameters in oral squamous cell carcinoma patients.

Singh A, Srivastava AN, Akhtar S, Siddiqui MH, Singh P, Kumar V
National journal of maxillofacial surgery 2018 Jan-Jun;9(1):8-13

Intermittent calorie restriction enhances epithelial-mesenchymal transition through the alteration of energy metabolism in a mouse tumor model.

Kusuoka O, Fujiwara-Tani R, Nakashima C, Fujii K, Ohmori H, Mori T, Kishi S, Miyagawa Y, Goto K, Kawahara I, Kuniyasu H
International journal of oncology 2018 Feb;52(2):413-423

Phenethyl isothiocyanate inhibits colorectal cancer stem cells by suppressing Wnt/β-catenin pathway.

Chen Y, Li Y, Wang XQ, Meng Y, Zhang Q, Zhu JY, Chen JQ, Cao WS, Wang XQ, Xie CF, Li XT, Geng SS, Wu JS, Zhong CY, Han HY
Phytotherapy research : PTR 2018 Dec;32(12):2447-2455

Honokiol Eliminates Glioma/Glioblastoma Stem Cell-Like Cells Via JAK-STAT3 Signaling and Inhibits Tumor Progression by Targeting Epidermal Growth Factor Receptor.

Fan Y, Xue W, Schachner M, Zhao W
Cancers 2018 Dec 26;11(1)

ZEB1-mediated vasculogenic mimicry formation associates with epithelial-mesenchymal transition and cancer stem cell phenotypes in prostate cancer.

Wang H, Huang B, Li BM, Cao KY, Mo CQ, Jiang SJ, Pan JC, Wang ZR, Lin HY, Wang DH, Qiu SP
Journal of cellular and molecular medicine 2018 Aug;22(8):3768-3781

An intestinal stem cell niche in Apc mutated neoplasia targetable by CtBP inhibition.

Chawla AT, Cororaton AD, Idowu MO, Damle PK, Szomju B, Ellis KC, Patel BB, Grossman SR
Oncotarget 2018 Aug 21;9(65):32408-32418

MDM2 Degrades Deacetylated Nucleolin Through Ubiquitination to Promote Glioma Stem-Like Cell Enrichment for Chemotherapeutic Resistance.

Ko CY, Lin CH, Chuang JY, Chang WC, Hsu TI
Molecular neurobiology 2018 Apr;55(4):3211-3223

Generation of an anti-angiogenic endothelial progenitor cell line via endostatin gene transfer.

Ai J, Sun JH, Wan T, Ma J, Feng L, Yao K
Molecular medicine reports 2018 Apr;17(4):5814-5820

MicroRNA-326 sensitizes human glioblastoma cells to curcumin via the SHH/GLI1 signaling pathway.

Yin S, Du W, Wang F, Han B, Cui Y, Yang D, Chen H, Liu D, Liu X, Zhai X, Jiang C
Cancer biology & therapy 2018 Apr 3;19(4):260-270

Multivoxel magnetic resonance spectroscopy identifies enriched foci of cancer stem-like cells in high-grade gliomas.

He T, Qiu T, Wang X, Gui H, Wang X, Hu Q, Xia H, Qi G, Wu J, Ma H
OncoTargets and therapy 2017;10:195-203

Bufalin reverses acquired drug resistance by inhibiting stemness in colorectal cancer cells.

Sun J, Xu K, Qiu Y, Gao H, Xu J, Tang Q, Yin P
Oncology reports 2017 Sep;38(3):1420-1430

STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway.

Jin L, Vu T, Yuan G, Datta PK
Cancer research 2017 Oct 15;77(20):5464-5478

Effects of lentivirus-mediated endostatin on endothelial progenitor cells.

Ai J, Sun JH, Ma J, Yao K
Oncotarget 2017 Nov 7;8(55):94431-94439

Stress stimuli induce cancer-stemness gene expression via Sp1 activation leading to therapeutic resistance in glioblastoma.

Chang KY, Huang CT, Hsu TI, Hsu CC, Liu JJ, Chuang CK, Hung JJ, Chang WC, Tsai KK, Chuang JY
Biochemical and biophysical research communications 2017 Nov 4;493(1):14-19

Association of ATF4 Expression With Tissue Hypoxia and M2 Macrophage Infiltration in Infantile Hemangioma.

Xia HF, Zhu JY, Wang JN, Ren JG, Cai Y, Wang FQ, Zhang W, Chen G, Zhao YF, Zhao JH
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2017 May;65(5):285-294

Silencing of Btbd7 Inhibited Epithelial-Mesenchymal Transition and Chemoresistance in CD133(+) Lung Carcinoma A549 Cells.

Fang LZ, Zhang JQ, Liu L, Fu WP, Shu JK, Feng JG, Liang X
Oncology research 2017 May 24;25(5):819-829

Overexpression of PER3 Inhibits Self-Renewal Capability and Chemoresistance of Colorectal Cancer Stem-Like Cells via Inhibition of Notch and β-Catenin Signaling.

Zhang F, Sun H, Zhang S, Yang X, Zhang G, Su T
Oncology research 2017 May 24;25(5):709-719

Small G protein Rac GTPases regulate the maintenance of glioblastoma stem-like cells in vitro and in vivo.

Lai YJ, Tsai JC, Tseng YT, Wu MS, Liu WS, Lam HI, Yu JH, Nozell SE, Benveniste EN
Oncotarget 2017 Mar 14;8(11):18031-18049

miR-19 targeting of GSK3β mediates sulforaphane suppression of lung cancer stem cells.

Zhu J, Wang S, Chen Y, Li X, Jiang Y, Yang X, Li Y, Wang X, Meng Y, Zhu M, Ma X, Huang C, Wu R, Xie C, Geng S, Wu J, Zhong C, Han H
The Journal of nutritional biochemistry 2017 Jun;44:80-91

(-)-Epigallocatechin-3-Gallate Inhibits Colorectal Cancer Stem Cells by Suppressing Wnt/β-Catenin Pathway.

Chen Y, Wang XQ, Zhang Q, Zhu JY, Li Y, Xie CF, Li XT, Wu JS, Geng SS, Zhong CY, Han HY
Nutrients 2017 Jun 3;9(6)

Oncogenic Role of SND1 in Development and Progression of Hepatocellular Carcinoma.

Jariwala N, Rajasekaran D, Mendoza RG, Shen XN, Siddiq A, Akiel MA, Robertson CL, Subler MA, Windle JJ, Fisher PB, Sanyal AJ, Sarkar D
Cancer research 2017 Jun 15;77(12):3306-3316

CUEDC2 suppresses glioma tumorigenicity by inhibiting the activation of STAT3 and NF-κB signaling pathway.

Li F, Tang C, Jin D, Guan L, Wu Y, Liu X, Wu X, Wu QY, Gao D
International journal of oncology 2017 Jul;51(1):115-127

Fatty acids inhibit anticancer effects of 5-fluorouracil in mouse cancer cell lines.

Tanabe E, Kitayoshi M, Fujii K, Ohmori H, Luo Y, Kadochi Y, Mori S, Fujiwara R, Nishiguchi Y, Sasaki T, Kuniyasu H
Oncology letters 2017 Jul;14(1):681-686

Znf179 induces differentiation and growth arrest of human primary glioblastoma multiforme in a p53-dependent cell cycle pathway.

Lee KH, Chen CL, Lee YC, Kao TJ, Chen KY, Fang CY, Chang WC, Chiang YH, Huang CC
Scientific reports 2017 Jul 6;7(1):4787

Wnt/β-catenin pathway mediates (-)-Epigallocatechin-3-gallate (EGCG) inhibition of lung cancer stem cells.

Zhu J, Jiang Y, Yang X, Wang S, Xie C, Li X, Li Y, Chen Y, Wang X, Meng Y, Zhu M, Wu R, Huang C, Ma X, Geng S, Wu J, Zhong C
Biochemical and biophysical research communications 2017 Jan 1;482(1):15-21

CXCR4 is involved in CD133-induced EMT in non-small cell lung cancer.

Tu Z, Xie S, Xiong M, Liu Y, Yang X, Tembo KM, Huang J, Hu W, Huang X, Pan S, Liu P, Altaf E, Kang G, Xiong J, Zhang Q
International journal of oncology 2017 Feb;50(2):505-514

RYK promotes the stemness of glioblastoma cells via the WNT/ β-catenin pathway.

Adamo A, Fiore D, De Martino F, Roscigno G, Affinito A, Donnarumma E, Puoti I, Ricci Vitiani L, Pallini R, Quintavalle C, Condorelli G
Oncotarget 2017 Feb 21;8(8):13476-13487

MACC1 facilitates chemoresistance and cancer stem cell‑like properties of colon cancer cells through the PI3K/AKT signaling pathway.

Wang J, Wang W, Cai H, Du B, Zhang L, Ma W, Hu Y, Feng S, Miao G
Molecular medicine reports 2017 Dec;16(6):8747-8754

Ascl2 activation by YAP1/KLF5 ensures the self-renewability of colon cancer progenitor cells.

Wei X, Ye J, Shang Y, Chen H, Liu S, Liu L, Wang R
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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The CD133 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CD133. This antibody recognizes human,mouse,rat antigen. The CD133 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 18470-1-AP.pdf

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