66666-1-Ig

antibody from Proteintech Group

Targeting: PROM1 AC133, CD133, CORD12, MCDR2, PROML1, RP41, STGD4

Provider product page for 66666-1-Ig

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Antibody data

Antibody Data
Antigen structure
References [51]
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Product number: 66666-1-Ig - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#66666-1-Ig, RRID:AB_2801586
Product name: CD133 antibody
Antibody type: Monoclonal
Description: CD133 antibody (Cat. #66666-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: FC, IHC, WB,ELISA.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 2B8A2
Vial size: 20ul, 150ul

PROM1 protein structure - 66666-1-Ig shown in red.

Submitted references YTHDF1 promotes the viability and self‑renewal of glioma stem cells by enhancing LINC00900 stability.

Zhang Y, Zhu Y, Zhang Y, Liu Z, Zhao X
International journal of oncology 2024 May;64(5)

Novel lncRNA Gm33149 modulates metastatic heterogeneity in melanoma by regulating the miR-5623-3p/Wnt axis via exosomal transfer.

Chen Y, Zhang YH, Li J, Shi L, Xie JC, Han X, Chen YT, Xiang M, Li BW, Xing HR, Wang JY
Cancer gene therapy 2024 Mar;31(3):364-375

RANKL/RANK signaling recruits Tregs via the CCL20-CCR6 pathway and promotes stemness and metastasis in colorectal cancer.

Ouyang J, Hu S, Zhu Q, Li C, Kang T, Xie W, Wang Y, Li Y, Lu Y, Qi J, Xia M, Chen J, Yang Y, Sun Y, Gao T, Ye L, Liang Q, Pan Y, Zhu C
Cell death & disease 2024 Jun 20;15(6):437

Identification and Validation of a Prognostic Signature Derived from the Cancer Stem Cells for Oral Squamous Cell Carcinoma.

Shi M, Huang K, Wei J, Wang S, Yang W, Wang H, Li Y
International journal of molecular sciences 2024 Jan 14;25(2)

Epigenetic inhibition of CTCF by HN1 promotes dedifferentiation and stemness of anaplastic thyroid cancer.

Pan Z, Lu X, Xu T, Chen J, Bao L, Li Y, Gong Y, Che Y, Zou X, Tan Z, Huang P, Ge M
Cancer letters 2024 Jan 1;580:216496

Cell-Surface GRP78-Targeted Chimeric Antigen Receptor T Cells Eliminate Lung Cancer Tumor Xenografts.

Wang S, Wei W, Yuan Y, Guo J, Liang D, Zhao X
International journal of molecular sciences 2024 Jan 1;25(1)

YAP/TAZ-TEAD activity promotes the malignant transformation of cervical intraepithelial neoplasia through enhancing the characteristics and Warburg effect of cancer stem cells.

Li S, Li X, Yang YB, Wu SF
Apoptosis : an international journal on programmed cell death 2024 Aug;29(7-8):1198-1210

A novel SLC25A1 inhibitor, parthenolide, suppresses the growth and stemness of liver cancer stem cells with metabolic vulnerability.

Zhang Z, Qiao Y, Sun Q, Peng L, Sun L
Cell death discovery 2023 Sep 23;9(1):350

Adipose‑derived stem cell‑mediated alphastatin targeting delivery system inhibits angiogenesis and tumor growth in glioma.

Liang C, Wei T, Zhang T, Niu C
Molecular medicine reports 2023 Nov;28(5)

Cdk4 Regulates Glioblastoma Cell Invasion and Stemness and Is Target of a Notch Inhibitor Plus Resveratrol Combined Treatment.

Giordano F, D'Amico M, Montalto FI, Malivindi R, Chimento A, Conforti FL, Pezzi V, Panno ML, Andò S, De Amicis F
International journal of molecular sciences 2023 Jun 13;24(12)

ISG15 and ISGylation modulates cancer stem cell-like characteristics in promoting tumor growth of anaplastic thyroid carcinoma.

Xu T, Zhu C, Chen J, Song F, Ren X, Wang S, Yi X, Zhang Y, Zhang W, Hu Q, Qin H, Liu Y, Zhang S, Tan Z, Pan Z, Huang P, Ge M
Journal of experimental & clinical cancer research : CR 2023 Jul 27;42(1):182

Targeting CD44 Variant 5 with an Antibody-Drug Conjugate Is an Effective Therapeutic Strategy for Intrahepatic Cholangiocarcinoma.

Bei Y, He J, Dong X, Wang Y, Wang S, Guo W, Cai C, Xu Z, Wei J, Liu B, Zhang N, Shen P
Cancer research 2023 Jul 14;83(14):2405-2420

CDKAL1 Drives the Maintenance of Cancer Stem-Like Cells by Assembling the eIF4F Translation Initiation Complex.

Huang R, Yamamoto T, Nakata E, Ozaki T, Kurozumi K, Wei F, Tomizawa K, Fujimura A
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Apr;10(12):e2206542

HIGD2A silencing impairs hepatocellular carcinoma growth via inhibiting mitochondrial function and the MAPK/ERK pathway.

Huang K, Liu Z, Xie Z, Li X, Zhang H, Chen Y, Wang Y, Lin Z, Li C, Liu H, Zhang X
Journal of translational medicine 2023 Apr 12;21(1):253

LASS2 impairs proliferation of glioma stem cells and migration and invasion of glioma cells mainly via inhibition of EMT and apoptosis promotion.

Zhao WJ, Fan YP, Ou GY, Qiao XY
Journal of Cancer 2022;13(7):2281-2292

CAFs-secreted exosomal cricN4BP2L2 promoted colorectal cancer stemness and chemoresistance by interacting with EIF4A3.

Qu Z, Yang KD, Luo BH, Zhang F
Experimental cell research 2022 Sep 15;418(2):113266

MARCH1 promotes the growth and maintaining of stem cell-like characteristics of gastric cancer cells by activating the Wnt/β-catenin signaling pathway.

Liang W, Zhang T, Huo J, Yang J
Tissue & cell 2022 Oct;78:101895

Insights into an NEk2 inhibitory profile of nitidine chloride by molecular docking and biological evaluation.

Li D, Lu J, Zhang Q, Zhou Y, Li L, Zhu H, Li T
BMC chemistry 2022 Oct 9;16(1):75

Promoter Methylation of Cancer Stem Cell Surface Markers as an Epigenetic Biomarker for Prognosis of Oral Squamous Cell Carcinoma.

Han YK, Park HY, Park SG, Hwang JJ, Park HR, Yi JM
International journal of molecular sciences 2022 Nov 23;23(23)

Urinary extracellular vesicles signature for diagnosis of kidney disease.

Takizawa K, Ueda K, Sekiguchi M, Nakano E, Nishimura T, Kajiho Y, Kanda S, Miura K, Hattori M, Hashimoto J, Hamasaki Y, Hisano M, Omori T, Okamoto T, Kitayama H, Fujita N, Kuramochi H, Ichiki T, Oka A, Harita Y
iScience 2022 Nov 18;25(11):105416

Bufalin Inhibits Tumorigenesis, Stemness, and Epithelial-Mesenchymal Transition in Colorectal Cancer through a C-Kit/Slug Signaling Axis.

Ding L, Yang Y, Lu Q, Qu D, Chandrakesan P, Feng H, Chen H, Chen X, Liao Z, Du J, Cao Z, Weygant N
International journal of molecular sciences 2022 Nov 1;23(21)

Sinomenine hydrochloride suppresses the stemness of breast cancer stem cells by inhibiting Wnt signaling pathway through down-regulation of WNT10B.

Li X, Chen W, Huang L, Zhu M, Zhang H, Si Y, Li H, Luo Q, Yu B
Pharmacological research 2022 May;179:106222

Oxidative stress-induced endothelial cells-derived exosomes accelerate skin flap survival through Lnc NEAT1-mediated promotion of endothelial progenitor cell function.

Guo L, Chen Y, Feng X, Sun D, Sun J, Mou S, Zhao K, An R
Stem cell research & therapy 2022 Jul 18;13(1):325

Endothelial cell-derived S1P promotes migration and stemness by binding with GPR63 in colorectal cancer.

Zeng S, Liang Y, Hu H, Wang F, Liang L
Pathology, research and practice 2022 Dec;240:154197

CRIP1 suppresses BBOX1-mediated carnitine metabolism to promote stemness in hepatocellular carcinoma.

Wang J, Zhou Y, Zhang D, Zhao W, Lu Y, Liu C, Lin W, Zhang Y, Chen K, Wang H, Zhao L
The EMBO journal 2022 Aug 1;41(15):e110218

m6A Modification-Mediated DUXAP8 Regulation of Malignant Phenotype and Chemotherapy Resistance of Hepatocellular Carcinoma Through miR-584-5p/MAPK1/ERK Pathway Axis.

Liu Z, Lu J, Fang H, Sheng J, Cui M, Yang Y, Tang B, Zhang X
Frontiers in cell and developmental biology 2021;9:783385

ENC1 Facilitates Colorectal Carcinoma Tumorigenesis and Metastasis via JAK2/STAT5/AKT Axis-Mediated Epithelial Mesenchymal Transition and Stemness.

Cui Y, Yang J, Bai Y, Li Q, Yao Y, Liu C, Wu F, Zhang J, Zhang Y
Frontiers in cell and developmental biology 2021;9:616887

Pediatric Giant Cell Glioblastoma Presenting with Intracranial Dissemination at Diagnosis: A Case Report.

Kinoshita T, Yano H, Nakayama N, Suzui N, Iida T, Endo S, Yasue S, Ozeki M, Kobayashi K, Miyazaki T, Iwama T
NMC case report journal 2021;8(1):151-157

The Role of KDM2B and EZH2 in Regulating the Stemness in Colorectal Cancer Through the PI3K/AKT Pathway.

Sanches JGP, Song B, Zhang Q, Cui X, Yabasin IB, Ntim M, Li X, He J, Zhang Y, Mao J, Lu Y, Li L
Frontiers in oncology 2021;11:637298

Pharmacological targeting PTK6 inhibits the JAK2/STAT3 sustained stemness and reverses chemoresistance of colorectal cancer.

Liu C, Pan Z, Chen Q, Chen Z, Liu W, Wu L, Jiang M, Lin W, Zhang Y, Lin W, Zhou R, Zhao L
Journal of experimental & clinical cancer research : CR 2021 Sep 22;40(1):297

Reduced DAPK1 Expression Promotes Stem Cell-Like Characteristics of Prostate Cancer Cells by Activating ZEB1 via Hippo/YAP Signaling Pathway.

Nong S, Wei Z, Wang Z, Ma L, Guan Y, Ni J
Stem cells and development 2021 Sep 15;30(18):934-945

Long noncoding RNA DUXAP10 promotes the stemness of glioma cells by recruiting HuR to enhance Sox12 mRNA stability.

Wu B, Yang C, Fang Y, Ding W, Zhang Y
Environmental toxicology 2021 May;36(5):840-849

The critical role of peroxiredoxin-2 in colon cancer stem cells.

Peng L, Xiong Y, Wang R, Xiang L, Zhou H, Fu Z
Aging 2021 Mar 26;13(8):11170-11187

EIF5A2 enhances stemness of epithelial ovarian cancer cells via a E2F1/KLF4 axis.

Wang K, Wang Y, Wang Y, Liu S, Wang C, Zhang S, Zhang T, Yang X
Stem cell research & therapy 2021 Mar 16;12(1):186

Prrx1 promotes stemness and angiogenesis via activating TGF-β/smad pathway and upregulating proangiogenic factors in glioma.

Chen Z, Chen Y, Li Y, Lian W, Zheng K, Zhang Y, Zhang Y, Lin C, Liu C, Sun F, Sun X, Wang J, Zhao L, Ke Y
Cell death & disease 2021 Jun 15;12(6):615

The LncRNA RP11-279C4.1 Enhances the Malignant Behaviour of Glioma Cells and Glioma Stem-Like Cells by Regulating the miR-1273g-3p/CBX3 Axis.

Wang F, Zhang L, Luo Y, Zhang Q, Zhang Y, Shao Y, Yuan L
Molecular neurobiology 2021 Jul;58(7):3362-3373

Gankyrin activates the hedgehog signalling to drive metastasis in osteosarcoma.

Wang C, Jing J, Hu X, Yu S, Yao F, Li Z, Cheng L
Journal of cellular and molecular medicine 2021 Jul;25(13):6232-6241

Parthenolide inhibits the tumor characteristics of renal cell carcinoma.

Liu D, Han Y, Liu L, Ren X, Zhang H, Fan S, Qin T, Li L
International journal of oncology 2021 Jan;58(1):100-110

Fangchinoline exerts antitumour activity by suppressing the EGFR‑PI3K/AKT signalling pathway in colon adenocarcinoma.

Jiang F, Ren S, Chen Y, Zhang A, Zhu Y, Zhang Z, Li Z, Piao D
Oncology reports 2021 Jan;45(1):139-150

Benzidine promotes the stemness of bladder cancer stem cells via activation of the Sonic hedgehog pathway.

Wang D, Xie D, Bi L, Wang Y, Zou C, Chen L, Geng H, Qian W, Li Y, Sun H, Wang X, Lu Y, Yu D, Zhong C
Oncology letters 2021 Feb;21(2):146

Cyclic Stretch Induces Vascular Smooth Muscle Cells to Secrete Connective Tissue Growth Factor and Promote Endothelial Progenitor Cell Differentiation and Angiogenesis.

Yan J, Wang WB, Fan YJ, Bao H, Li N, Yao QP, Huo YL, Jiang ZL, Qi YX, Han Y
Frontiers in cell and developmental biology 2020;8:606989

MiR-153 reduces stem cell-like phenotype and tumor growth of lung adenocarcinoma by targeting Jagged1.

Zhao G, Zhang Y, Zhao Z, Cai H, Zhao X, Yang T, Chen W, Yao C, Wang Z, Wang Z, Han C, Wang H
Stem cell research & therapy 2020 May 6;11(1):170

Ginsenoside Rg3 attenuates the osimertinib resistance by reducing the stemness of non-small cell lung cancer cells.

Tan Q, Lin S, Zeng Y, Yao M, Liu K, Yuan H, Liu C, Jiang G
Environmental toxicology 2020 Jun;35(6):643-651

Cyclovirobuxine D inhibits colorectal cancer tumorigenesis via the CTHRC1‑AKT/ERK‑Snail signaling pathway.

Jiang F, Chen Y, Ren S, Li Z, Sun K, Xing Y, Zhu Y, Piao D
International journal of oncology 2020 Jul;57(1):183-196

Comprehensive profiling identifies a novel signature with robust predictive value and reveals the potential drug resistance mechanism in glioma.

Zeng F, Wang K, Liu X, Zhao Z
Cell communication and signaling : CCS 2020 Jan 6;18(1):2

RNA Binding Protein RNPC1 Suppresses the Stemness of Human Endometrial Cancer Cells via Stabilizing MST1/2 mRNA.

Wu X, Wang Y, Zhong W, Cheng H, Tian Z
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 23;26:e921389

lncRNA TPTEP1 inhibits stemness and radioresistance of glioma through miR‑106a‑5p‑mediated P38 MAPK signaling.

Tang T, Wang LX, Yang ML, Zhang RM
Molecular medicine reports 2020 Dec;22(6):4857-4867

ROS/KRAS/AMPK Signaling Contributes to Gemcitabine-Induced Stem-like Cell Properties in Pancreatic Cancer.

Zhao H, Wu S, Li H, Duan Q, Zhang Z, Shen Q, Wang C, Yin T
Molecular therapy oncolytics 2019 Sep 27;14:299-312

Sphere‑forming assay vs. organoid culture: Determining long‑term stemness and the chemoresistant capacity of primary colorectal cancer cells.

Zhao H, Yan C, Hu Y, Mu L, Huang K, Li Q, Li X, Tao D, Qin J
International journal of oncology 2019 Mar;54(3):893-904

Gab2 Ablation Reverses the Stemness of HER2-Overexpressing Breast Cancer Cells.

Zhang P, Chen Y, Gong M, Zhuang Z, Wang Y, Mu L, Wang T, Pan J, Liu Y, Xu J, Liang R, Yuan Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(1):52-65

Liver-enriched activator protein 1 as an isoform of CCAAT/enhancer-binding protein beta suppresses stem cell features of hepatocellular carcinoma.

Yang LH, Wang Y, Qiao S, Wang MJ, Chen F, Zi XY, Li JX, Zhang HB, Yu B, Hu YP
Cancer management and research 2018;10:873-885

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