Antibody data
- Antibody Data
- Antigen structure
- References [23]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
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Validation data
Reference
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- Product number
- 12175-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12175-1-AP, RRID:AB_2157444
- Product name
- OXCT1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated OXCT1 antibody (Cat. #12175-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Pan-Cancer Analysis of Glycolytic and Ketone Bodies Metabolic Genes: Implications for Response to Ketogenic Dietary Therapy.
Barth syndrome-related cardiomyopathy is associated with a reduction in myocardial glucose oxidation.
WHSC1 Promotes Cell Proliferation, Migration, and Invasion in Hepatocellular Carcinoma by Activating mTORC1 Signaling.
Trimetazidine Ameliorates Myocardial Metabolic Remodeling in Isoproterenol-Induced Rats Through Regulating Ketone Body Metabolism via Activating AMPK and PPAR α.
Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation.
β-Hydroxybutyrate Increases Exercise Capacity Associated with Changes in Mitochondrial Function in Skeletal Muscle.
Effects of a Ketogenic Diet Containing Medium-Chain Triglycerides and Endurance Training on Metabolic Enzyme Adaptations in Rat Skeletal Muscle.
Ketogenic diet activates protective γδ T cell responses against influenza virus infection.
Role of OXCT1 in ovine adipose and preadipocyte differentiation.
Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus-Merzbacher disease.
Role and therapeutic potential of dietary ketone bodies in lymph vessel growth.
Hepatocyte-Macrophage Acetoacetate Shuttle Protects against Tissue Fibrosis.
Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2.
Low ketolytic enzyme levels in tumors predict ketogenic diet responses in cancer cell lines in vitro and in vivo.
E2F6 Impairs Glycolysis and Activates BDH1 Expression Prior to Dilated Cardiomyopathy.
CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.
Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress.
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.
Impact of peripheral ketolytic deficiency on hepatic ketogenesis and gluconeogenesis during the transition to birth.
Successful adaptation to ketosis by mice with tissue-specific deficiency of ketone body oxidation.
Obligate role for ketone body oxidation in neonatal metabolic homeostasis.
Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy.
Adaptation of myocardial substrate metabolism to a ketogenic nutrient environment.
Qian L, Li Y, Cao Y, Meng G, Peng J, Li H, Wang Y, Xu T, Zhang L, Sun B, Li B, Yu D
Frontiers in oncology 2021;11:689068
Frontiers in oncology 2021;11:689068
Barth syndrome-related cardiomyopathy is associated with a reduction in myocardial glucose oxidation.
Greenwell AA, Gopal K, Altamimi TR, Saed CT, Wang F, Tabatabaei Dakhili SA, Ho KL, Zhang L, Eaton F, Kruger J, Al Batran R, Lopaschuk GD, Oudit GY, Ussher JR
American journal of physiology. Heart and circulatory physiology 2021 Jun 1;320(6):H2255-H2269
American journal of physiology. Heart and circulatory physiology 2021 Jun 1;320(6):H2255-H2269
WHSC1 Promotes Cell Proliferation, Migration, and Invasion in Hepatocellular Carcinoma by Activating mTORC1 Signaling.
Dai J, Jiang L, Qiu L, Shao Y, Shi P, Li J
OncoTargets and therapy 2020;13:7033-7044
OncoTargets and therapy 2020;13:7033-7044
Trimetazidine Ameliorates Myocardial Metabolic Remodeling in Isoproterenol-Induced Rats Through Regulating Ketone Body Metabolism via Activating AMPK and PPAR α.
Li H, Ma Z, Zhai Y, Lv C, Yuan P, Zhu F, Wei L, Li Q, Qi X
Frontiers in pharmacology 2020;11:1255
Frontiers in pharmacology 2020;11:1255
Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation.
Al Batran R, Gopal K, Capozzi ME, Chahade JJ, Saleme B, Tabatabaei-Dakhili SA, Greenwell AA, Niu J, Almutairi M, Byrne NJ, Masson G, Kim R, Eaton F, Mulvihill EE, Garneau L, Masters AR, Desta Z, Velázquez-Martínez CA, Aguer C, Crawford PA, Sutendra G, Campbell JE, Dyck JRB, Ussher JR
Cell metabolism 2020 May 5;31(5):909-919.e8
Cell metabolism 2020 May 5;31(5):909-919.e8
β-Hydroxybutyrate Increases Exercise Capacity Associated with Changes in Mitochondrial Function in Skeletal Muscle.
Monsalves-Alvarez M, Morales PE, Castro-Sepulveda M, Sepulveda C, Rodriguez JM, Chiong M, Eisner V, Lavandero S, Troncoso R
Nutrients 2020 Jun 29;12(7)
Nutrients 2020 Jun 29;12(7)
Effects of a Ketogenic Diet Containing Medium-Chain Triglycerides and Endurance Training on Metabolic Enzyme Adaptations in Rat Skeletal Muscle.
Fukazawa A, Koike A, Karasawa T, Tsutsui M, Kondo S, Terada S
Nutrients 2020 Apr 30;12(5)
Nutrients 2020 Apr 30;12(5)
Ketogenic diet activates protective γδ T cell responses against influenza virus infection.
Goldberg EL, Molony RD, Kudo E, Sidorov S, Kong Y, Dixit VD, Iwasaki A
Science immunology 2019 Nov 15;4(41)
Science immunology 2019 Nov 15;4(41)
Role of OXCT1 in ovine adipose and preadipocyte differentiation.
Zeng J, Zhou SW, Zhao J, Jin MH, Kang DJ, Yang YX, Wang XL, Chen YL
Biochemical and biophysical research communications 2019 May 14;512(4):779-785
Biochemical and biophysical research communications 2019 May 14;512(4):779-785
Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus-Merzbacher disease.
Stumpf SK, Berghoff SA, Trevisiol A, Spieth L, Düking T, Schneider LV, Schlaphoff L, Dreha-Kulaczewski S, Bley A, Burfeind D, Kusch K, Mitkovski M, Ruhwedel T, Guder P, Röhse H, Denecke J, Gärtner J, Möbius W, Nave KA, Saher G
Acta neuropathologica 2019 Jul;138(1):147-161
Acta neuropathologica 2019 Jul;138(1):147-161
Role and therapeutic potential of dietary ketone bodies in lymph vessel growth.
García-Caballero M, Zecchin A, Souffreau J, Truong AK, Teuwen LA, Vermaelen W, Martín-Pérez R, de Zeeuw P, Bouché A, Vinckier S, Cornelissen I, Eelen G, Ghesquière B, Mazzone M, Dewerchin M, Carmeliet P
Nature metabolism 2019 Jul;1(7):666-675
Nature metabolism 2019 Jul;1(7):666-675
Hepatocyte-Macrophage Acetoacetate Shuttle Protects against Tissue Fibrosis.
Puchalska P, Martin SE, Huang X, Lengfeld JE, Daniel B, Graham MJ, Han X, Nagy L, Patti GJ, Crawford PA
Cell metabolism 2019 Feb 5;29(2):383-398.e7
Cell metabolism 2019 Feb 5;29(2):383-398.e7
Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2.
Nishimura T, Nakata A, Chen X, Nishi K, Meguro-Horike M, Sasaki S, Kita K, Horike SI, Saitoh K, Kato K, Igarashi K, Murayama T, Kohno S, Takahashi C, Mukaida N, Yano S, Soga T, Tojo A, Gotoh N
Oncogene 2019 Apr;38(14):2464-2481
Oncogene 2019 Apr;38(14):2464-2481
Low ketolytic enzyme levels in tumors predict ketogenic diet responses in cancer cell lines in vitro and in vivo.
Zhang J, Jia PP, Liu QL, Cong MH, Gao Y, Shi HP, Yu WN, Miao MY
Journal of lipid research 2018 Apr;59(4):625-634
Journal of lipid research 2018 Apr;59(4):625-634
E2F6 Impairs Glycolysis and Activates BDH1 Expression Prior to Dilated Cardiomyopathy.
Major JL, Dewan A, Salih M, Leddy JJ, Tuana BS
PloS one 2017;12(1):e0170066
PloS one 2017;12(1):e0170066
CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.
Schatton D, Pla-Martin D, Marx MC, Hansen H, Mourier A, Nemazanyy I, Pessia A, Zentis P, Corona T, Kondylis V, Barth E, Schauss AC, Velagapudi V, Rugarli EI
The Journal of cell biology 2017 Mar 6;216(3):675-693
The Journal of cell biology 2017 Mar 6;216(3):675-693
Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress.
Huang, Li T, Wang L, Zhang L, Yan R, Li K, Xing S, Wu G, Hu L, Jia W, Lin SC, Dang CV, Song L, Gao P, Zhang H
Cell research 2016 Oct;26(10):1112-1130
Cell research 2016 Oct;26(10):1112-1130
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.
Youm YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D'Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD
Nature medicine 2015 Mar;21(3):263-9
Nature medicine 2015 Mar;21(3):263-9
Impact of peripheral ketolytic deficiency on hepatic ketogenesis and gluconeogenesis during the transition to birth.
Cotter DG, Ercal B, d'Avignon DA, Dietzen DJ, Crawford PA
The Journal of biological chemistry 2013 Jul 5;288(27):19739-49
The Journal of biological chemistry 2013 Jul 5;288(27):19739-49
Successful adaptation to ketosis by mice with tissue-specific deficiency of ketone body oxidation.
Cotter DG, Schugar RC, Wentz AE, d'Avignon DA, Crawford PA
American journal of physiology. Endocrinology and metabolism 2013 Feb 15;304(4):E363-74
American journal of physiology. Endocrinology and metabolism 2013 Feb 15;304(4):E363-74
Obligate role for ketone body oxidation in neonatal metabolic homeostasis.
Cotter DG, d'Avignon DA, Wentz AE, Weber ML, Crawford PA
The Journal of biological chemistry 2011 Mar 4;286(9):6902-10
The Journal of biological chemistry 2011 Mar 4;286(9):6902-10
Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy.
Maurer GD, Brucker DP, Bähr O, Harter PN, Hattingen E, Walenta S, Mueller-Klieser W, Steinbach JP, Rieger J
BMC cancer 2011 Jul 26;11:315
BMC cancer 2011 Jul 26;11:315
Adaptation of myocardial substrate metabolism to a ketogenic nutrient environment.
Wentz AE, d'Avignon DA, Weber ML, Cotter DG, Doherty JM, Kerns R, Nagarajan R, Reddy N, Sambandam N, Crawford PA
The Journal of biological chemistry 2010 Aug 6;285(32):24447-56
The Journal of biological chemistry 2010 Aug 6;285(32):24447-56
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 12175-1-AP(SCOT antibody) at dilution of 1:400
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of MCF-7 cells, using OXCT1 antibody 12175-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line