Antibody data
- Antibody Data
- Antigen structure
- References [6]
- Comments [0]
- Validations
- Western blot [1]
- Flow cytometry [1]
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Validation data
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- Product number
- ABIN954577 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Ring Finger Protein 8 (RNF8) antibody
- Antibody type
- Polyclonal
- Description
- Affinity chromatography on Protein A
- Reactivity
- Human
- Host
- Rabbit
- Vial size
- 0.4 mL
- Storage
- Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
- Handling
- Avoid repeated freezing and thawing.
Submitted references The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination.
53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair.
Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response.
Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage.
PCNA is ubiquitinated by RNF8.
PCNA is ubiquitinated by RNF8.
Ramachandran S, Chahwan R, Nepal RM, Frieder D, Panier S, Roa S, Zaheen A, Durocher D, Scharff MD, Martin A
Proceedings of the National Academy of Sciences of the United States of America 2010 Jan 12;107(2):809-14
Proceedings of the National Academy of Sciences of the United States of America 2010 Jan 12;107(2):809-14
53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair.
Noon AT, Shibata A, Rief N, Löbrich M, Stewart GS, Jeggo PA, Goodarzi AA
Nature cell biology 2010 Feb;12(2):177-84
Nature cell biology 2010 Feb;12(2):177-84
Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response.
Marteijn JA, Bekker-Jensen S, Mailand N, Lans H, Schwertman P, Gourdin AM, Dantuma NP, Lukas J, Vermeulen W
The Journal of cell biology 2009 Sep 21;186(6):835-47
The Journal of cell biology 2009 Sep 21;186(6):835-47
Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage.
Gong Z, Cho YW, Kim JE, Ge K, Chen J
The Journal of biological chemistry 2009 Mar 13;284(11):7284-93
The Journal of biological chemistry 2009 Mar 13;284(11):7284-93
PCNA is ubiquitinated by RNF8.
Zhang S, Chea J, Meng X, Zhou Y, Lee EY, Lee MY
Cell cycle (Georgetown, Tex.) 2008 Nov 1;7(21):3399-404
Cell cycle (Georgetown, Tex.) 2008 Nov 1;7(21):3399-404
PCNA is ubiquitinated by RNF8.
Zhang S, Chea J, Meng X, Zhou Y, Lee EY, Lee MY
Cell cycle (Georgetown, Tex.) 2008 Nov 1;7(21):3399-404
Cell cycle (Georgetown, Tex.) 2008 Nov 1;7(21):3399-404
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- FACS