CBFB

gene product
PEBP2B
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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289 antibodies from 34 providers.

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AntibodyRefsTypeAVIWBELICCIPIHCFC
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Biorbyt
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OriGene
9 antibodies
Invitrogen Antibodies
3 antibodies
Abgent
5 antibodies
Aviva Systems Biology
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Arigo
1 antibody
Novus Biologicals
5 antibodies
ProSci
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1 antibody
LifeSpan BioSciences, Inc.
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GeneTex
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Abbexa
4 antibodies
Boster Biological Technology
1 antibody
R&D Systems
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Bethyl Laboratories
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RabMAbs
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Cell Signaling Technology, Inc
2 antibodies
Abbkine
1 antibody
MyBioSource
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NSJ Bioreagents
1 antibody
Abnova Corporation
3 antibodies
Creative Diagnostics
6 antibodies
St John's Laboratory
1 antibody
United States Biological
37 antibodies
RayBiotech, Inc.
1 antibody
Everest Biotech
1 antibody
Rockland Immunochemicals, Inc.
1 antibody
GenWay
1 antibody
Sino Biological Inc.
1 antibody
Sigma-Aldrich
3 antibodies