- 36-1100 - Invitrogen Antibodies FLT1 antibody

Submitted references Histological changes of cervical tumours following Zanthoxylum acanthopodium DC treatment, and its impact on cytokine expression.

Simanullang RH, Situmorang PC, Herlina M, Noradina, Silalahi B, Manurung SS
Saudi journal of biological sciences 2022 Apr;29(4):2706-2718

Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span.

Grunewald M, Kumar S, Sharife H, Volinsky E, Gileles-Hillel A, Licht T, Permyakova A, Hinden L, Azar S, Friedmann Y, Kupetz P, Tzuberi R, Anisimov A, Alitalo K, Horwitz M, Leebhoff S, Khoma OZ, Hlushchuk R, Djonov V, Abramovitch R, Tam J, Keshet E
Science (New York, N.Y.) 2021 Jul 30;373(6554)

Soluble fms-Like Tyrosine Kinase 1 Localization in Renal Biopsies of CKD.

Zsengellér ZK, Lo A, Tavasoli M, Pernicone E, Karumanchi SA, Rosen S
Kidney international reports 2019 Dec;4(12):1735-1741

VEGF vascularization pathway in human intervertebral disc does not change during the disc degeneration process.

Capossela S, Bertolo A, Gunasekera K, Pötzel T, Baur M, Stoyanov JV
BMC research notes 2018 May 22;11(1):333

CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase.

He W, Bai G, Zhou H, Wei N, White NM, Lauer J, Liu H, Shi Y, Dumitru CD, Lettieri K, Shubayev V, Jordanova A, Guergueltcheva V, Griffin PR, Burgess RW, Pfaff SL, Yang XL
Nature 2015 Oct 29;526(7575):710-4

Role of VEGF-A and its receptors in sporadic and MEN2-associated pheochromocytoma.

Ferreira CV, Siqueira DR, Romitti M, Ceolin L, Brasil BA, Meurer L, Capp C, Maia AL
International journal of molecular sciences 2014 Mar 26;15(4):5323-36

Expression of receptors for VEGFs on normal human thyroid follicular cells and their role in follicle formation.

Susarla R, Gonzalez AM, Watkinson JC, Eggo MC
Journal of cellular physiology 2012 May;227(5):1992-2002

Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1.

Boeckel JN, Guarani V, Koyanagi M, Roexe T, Lengeling A, Schermuly RT, Gellert P, Braun T, Zeiher A, Dimmeler S
Proceedings of the National Academy of Sciences of the United States of America 2011 Feb 22;108(8):3276-81

Local retention versus systemic release of soluble VEGF receptor-1 are mediated by heparin-binding and regulated by heparanase.

Sela S, Natanson-Yaron S, Zcharia E, Vlodavsky I, Yagel S, Keshet E
Circulation research 2011 Apr 29;108(9):1063-70

Novel soluble Flt-1 isoforms in plasma and cultured placental explants from normotensive pregnant and preeclamptic women.

Rajakumar A, Powers RW, Hubel CA, Shibata E, von Versen-Höynck F, Plymire D, Jeyabalan A
Placenta 2009 Jan;30(1):25-34

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Supportive validation

Submitted by: Invitrogen Antibodies (provider)
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Experimental details: Western blot analysis of SW480 cell lysates using Rb anti-Soluble VEGF Receptor-1 (Product # 36-1100)

Supportive validation

Submitted by: Invitrogen Antibodies (provider)
Main image
Experimental details: NULL

Supportive validation

Submitted by: Invitrogen Antibodies (provider)
Main image
Experimental details: Extended Data Figure 5 CMT2D mutant embryos have overall normal morphology but exhibit facial motor neuron migration defects a , Lateral view of WT and CMT2D mutant embryos at E12.5. Motor neurons are specifically labeled by a transgenic fluorescence reporter, Hb9:GFP (green). Note overall normal morphology of CMT2D mutant embryos (CMT) compared to their littermate controls (WT). b , Western-bolt analysis of protein expression in E12.5 mouse neural tissues. The expression levels of various neuronal proteins appear normal in CMT2D mutants compared to their littermate controls. c , The facial motor neuron migration phenotype is quantified by measuring the relative distance of the facial motor nucleus between WT and CMT littermate embryos (Each dot represents one facial motor nucleus, n=6 embryos for WT; n=8 embryos for CMT2D). We find the migration of facial motor neurons is significantly disrupted in CMT embryos. Data are presented as the mean +- SEM. **p < 0.01 (t-test).

Supportive validation

Submitted by: Invitrogen Antibodies (provider)
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Experimental details: Figure 1. Representative immunohistochemical detection of vascular endothelial growth factor (VEGF-A), vascular endothelial growth factor receptor 1 and 2 (VEGFR-1 and VEGFR-2) and microvessels in tumor cells from PHEO samples (all images were acquired using a magnification of 400x). ( A ) VEGF-A in a malignant tumor sample; ( B ) VEGFR-1 and ( C ) VEGFR-2 in a sample of sporadic tumor; and ( D ) CD31-positively stained microvessels in a sample of MEN 2B-associated PHEO.

Supportive validation

Submitted by: Invitrogen Antibodies (provider)
Main image
Experimental details: Figure 2. Immunohistochemical intensity of ( A ) VEGF-A; ( B ) VEGFR-1; ( C ) VEGFR-2; and ( D ) MVD in benign and malignant PHEO samples.

Supportive validation

Submitted by: Invitrogen Antibodies (provider)
Main image
Experimental details: Figure 3. Immunohistochemical intensity of ( A ) VEGF-A; ( B ) VEGFR-1; ( C ) VEGFR-2; and ( D ) MVD in MEN2-associated and sporadic PHEO samples.

Supportive validation

Submitted by: Invitrogen Antibodies (provider)
Main image
Experimental details: Fig. 1 VEGFR1 isoforms in human degenerated and bovine healthy discs. A representative immunoblotting assay showed the expression of the full-length membrane form (~ 200 kDa), the soluble form (~ 130 kDa) and a cytoplasmic fragment (~ 60 kDa) in human degenerated ( a ) and healthy bovine ( c ) disc cells. beta-Actin was used as control. Western blot quantification of membrane and soluble VEGFR1 was performed on human ( b ; n = 3) and bovine ( d ; n = 2) disc cells. Results represent an average of area (square pixels) +- SD normalized on betaActin. White bars represent AF, grey bars NP. No statistical significance with non-parametric Mann-Whitney-Wilcoxon U test for independent variables

Supportive validation

Submitted by: Invitrogen Antibodies (provider)
Main image
Experimental details: Figure 2 The expression of soluble fms-like tyrosine kinase 1 (sFLT1) in kidney biopsies is positively correlated with kidney inflammation (n = 52 biopsies). sFLT1 protein expression localized in kidney biopsies by immunohistochemistry. A 4-tier grading system was used to semiquantitatively measure sFLT1 and inflammation in the kidney biopsies.

36-1100

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