Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Immunohistochemistry [1]
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Validation data
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- Product number
- 10-7564 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-FLT1 Antibody
- Antibody type
- Monoclonal
- Description
- FLT-1 (fms-related tyrosine kinase 1) is an endogenous inhibitor of vascular endothelial growth factor, which is involved in cardiovascular remodeling and atherosclerosis development. It potently inhibits angiogenesis by binding extracellularly to VEGF (vascular endothelial growth factor). FLT-1 is expressed on tumor cells and is implicated in tumor growth and progression. It is overexpressed in primary tumors and nodal metastasis. FLT-1 regulates monocyte migration, recruits endothelial cell progenitors, increases the adhesive properties of natural killer cells and induces growth factors. It is observed in many diseases with endothelial dysfunction, including pre-eclampsia and diabetic retinopathy, but whether it contributes to endothelial injury in IgAN requires further exploration.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
A partial length recombinant FLT1 p
rotein (amino acids 102-321) was us
ed as the immunogen for this antibo
dy.- Isotype
- IgG
- Antibody clone number
- ABM4A56
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
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Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Immunohistochemical analysis of FLT-1 in human Placenta tissue using FLT-1 antibody (Clone: ABM4A56) at 5 µg/ml.
- Protocol
- Protocol