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- Product number
- 25173-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- SAMD9L antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SAMD9L antibody (Cat. #25173-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Ancient convergence with prokaryote defense and recent adaptations to lentiviruses in primates characterize the ancestral immune factors SAMD9s.
Evolutionary characterization of antiviral SAMD9/9L across kingdoms supports ancient convergence and lineage-specific adaptations.
SAMD9L inhibits flavivirus translation independently of its capacity to trigger innate immune response.
SAMD9 senses cytosolic double-stranded nucleic acids in epithelial and mesenchymal cells to induce antiviral immunity.
Overexpression of human SAMD9 inhibits protein translation and alters MYC signaling resulting in cell cycle arrest.
SAMD9L acts as an antiviral factor against HIV-1 and primate lentiviruses by restricting viral and cellular translation.
Integrated Analysis Identifies Upregulated SAMD9L as a Potential Biomarker Correlating with the Severity of Primary Sjögren's Syndrome.
Shared biomarkers of multi-tissue origin for primary Sjogren's syndrome and their importance in immune microenvironment alterations.
Viral host range factors antagonize pathogenic SAMD9 and SAMD9L variants.
New spinocerebellar ataxia subtype caused by SAMD9L mutation triggering mitochondrial dysregulation (SCA49).
Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes.
A paralogous pair of mammalian host restriction factors form a critical host barrier against poxvirus infection.
Legrand A, Demeure R, Chantharath A, Rey C, Baltenneck J, Gilchrist CLM, Rocha JL, Loyer C, Picard L, Cimarelli A, Steinegger M, Rousset F, Sudmant PH, Etienne L
bioRxiv : the preprint server for biology 2025 May 23;
bioRxiv : the preprint server for biology 2025 May 23;
Evolutionary characterization of antiviral SAMD9/9L across kingdoms supports ancient convergence and lineage-specific adaptations.
Legrand A, Demeure R, Chantharath A, Rey C, Baltenneck J, Gilchrist CLM, Rocha JL, Loyer C, Picard L, Cimarelli A, Steinegger M, Rousset F, Sudmant PH, Etienne L
Nature ecology & evolution 2025 Dec;9(12):2206-2222
Nature ecology & evolution 2025 Dec;9(12):2206-2222
SAMD9L inhibits flavivirus translation independently of its capacity to trigger innate immune response.
Cannac M, Zoladek J, Bribes I, Fresneau-Resende M, Legrand A, Demeure R, Zusinaite E, Merits A, Etienne L, Nisole S
PLoS pathogens 2025 Dec;21(12):e1013773
PLoS pathogens 2025 Dec;21(12):e1013773
SAMD9 senses cytosolic double-stranded nucleic acids in epithelial and mesenchymal cells to induce antiviral immunity.
Hou G, Beatty W, Ren L, Ooi YS, Son J, Zhu Y, Sheng Q, Huang W, Li D, Liu C, Welsh OL, Sutherland DM, Dermody TS, Shen C, Liu J, Sibley LD, Ding S
Nature communications 2025 Apr 22;16(1):3756
Nature communications 2025 Apr 22;16(1):3756
Overexpression of human SAMD9 inhibits protein translation and alters MYC signaling resulting in cell cycle arrest.
McSweeney K, Hoover P, Ramirez-Solano M, Liu Q, Schwartz JR
Experimental hematology 2024 Sep;137:104249
Experimental hematology 2024 Sep;137:104249
SAMD9L acts as an antiviral factor against HIV-1 and primate lentiviruses by restricting viral and cellular translation.
Legrand A, Dahoui C, De La Myre Mory C, Noy K, Guiguettaz L, Versapuech M, Loyer C, Pillon M, Wcislo M, Guéguen L, Berlioz-Torrent C, Cimarelli A, Mateo M, Fiorini F, Ricci EP, Etienne L
PLoS biology 2024 Jul;22(7):e3002696
PLoS biology 2024 Jul;22(7):e3002696
Integrated Analysis Identifies Upregulated SAMD9L as a Potential Biomarker Correlating with the Severity of Primary Sjögren's Syndrome.
Zhou D, Yu X, Yu K, Ren Y, Yang K, Wang X, Wang Q
Journal of inflammation research 2023;16:3725-3738
Journal of inflammation research 2023;16:3725-3738
Shared biomarkers of multi-tissue origin for primary Sjogren's syndrome and their importance in immune microenvironment alterations.
Cai T, Xu J, Fang Y, Wu Y, Qin Q, Zhang JA
Immunobiology 2023 Sep;228(5):152726
Immunobiology 2023 Sep;228(5):152726
Viral host range factors antagonize pathogenic SAMD9 and SAMD9L variants.
Gahr S, Perinetti Casoni G, Falk-Paulsen M, Maschkowitz G, Bryceson YT, Voss M
Experimental cell research 2023 Apr 15;425(2):113541
Experimental cell research 2023 Apr 15;425(2):113541
New spinocerebellar ataxia subtype caused by SAMD9L mutation triggering mitochondrial dysregulation (SCA49).
Corral-Juan M, Casquero P, Giraldo-Restrepo N, Laurie S, Martinez-Piñeiro A, Mateo-Montero RC, Ispierto L, Vilas D, Tolosa E, Volpini V, Alvarez-Ramo R, Sánchez I, Matilla-Dueñas A
Brain communications 2022;4(2):fcac030
Brain communications 2022;4(2):fcac030
Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes.
Sahoo SS, Pastor VB, Goodings C, Voss RK, Kozyra EJ, Szvetnik A, Noellke P, Dworzak M, Starý J, Locatelli F, Masetti R, Schmugge M, De Moerloose B, Catala A, Kállay K, Turkiewicz D, Hasle H, Buechner J, Jahnukainen K, Ussowicz M, Polychronopoulou S, Smith OP, Fabri O, Barzilai S, de Haas V, Baumann I, Schwarz-Furlan S, European Working Group of MDS in Children (EWOG-MDS), Niewisch MR, Sauer MG, Burkhardt B, Lang P, Bader P, Beier R, Müller I, Albert MH, Meisel R, Schulz A, Cario G, Panda PK, Wehrle J, Hirabayashi S, Derecka M, Durruthy-Durruthy R, Göhring G, Yoshimi-Noellke A, Ku M, Lebrecht D, Erlacher M, Flotho C, Strahm B, Niemeyer CM, Wlodarski MW
Nature medicine 2021 Oct;27(10):1806-1817
Nature medicine 2021 Oct;27(10):1806-1817
A paralogous pair of mammalian host restriction factors form a critical host barrier against poxvirus infection.
Meng X, Zhang F, Yan B, Si C, Honda H, Nagamachi A, Sun LZ, Xiang Y
PLoS pathogens 2018 Feb;14(2):e1006884
PLoS pathogens 2018 Feb;14(2):e1006884
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- COLO 320 cells were subjected to SDS PAGE followed by western blot with 25173-1-AP( SAMD9L Antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SAMD9L antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human SAMD9L. This antibody recognizes human antigen. The SAMD9L antibody has been validated for the following applications: ELISA, IHC, WB analysis.
