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- References [21]
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- Product number
- 13462-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13462-1-AP, RRID:AB_2248953
- Product name
- IL-22RA1 antibody
- Antibody type
- Polyclonal
- Description
- IL-22RA1 antibody (Cat. #13462-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references IL-22/IL-22R signaling attenuates mitochondrial damage in PCOS by modulating granulosa cell lipid metabolism through ETS1.
IL-24 ameliorates cognitive dysfunction via the inhibition PERK-eIF2α Signaling pathway in Alzheimer's disease.
Thymosin β4 released by mast cells under stress conditions impairs intestinal epithelial barrier via IL22RA1/JAK1/STAT3 signaling in irritable bowel syndrome.
Th22 cells promote the transition from homeostatic to reactive microglia in diabetic encephalopathy.
Oral administration of tea-derived exosome-like nanoparticles protects epithelial and immune barrier of intestine from psychological stress.
Interleukin-22 improves ovulation in polycystic ovary syndrome via STAT3 signaling.
Activation of IL1A/IRAK1 axis and downstream proinflammatory signaling in healthy adult and neonatal African American skin.
Ginsenoside CK Alleviates DSS-Induced IBD in Mice by Regulating Tryptophan Metabolism and Activating Aryl Hydrocarbon Receptor via Gut Microbiota Modulation.
Interleukin-22 receptor 1-mediated stimulation of T-type Ca(2+) channels enhances sensory neuronal excitability through the tyrosine-protein kinase Lyn-dependent PKA pathway.
Troxerutin dampened hypothalamic neuroinflammation via microglial IL-22/IL-22R1/IRF3 activation in dihydrotestosterone-induced polycystic ovary syndrome rats.
Role of iron in host-microbiota interaction and its effects on intestinal mucosal growth and immune plasticity in a piglet model.
Aryl hydrocarbon receptor regulates IL-22 receptor expression on thymic epithelial cell and accelerates thymus regeneration.
IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo.
Troxerutin attenuates insulin resistance via pancreatic IL-22/JAK1/STAT3 signaling activation in dihydrotestosterone-induced polycystic ovary syndrome rats.
Th22 cells induce Müller cell activation via the Act1/TRAF6 pathway in diabetic retinopathy.
IL-22 ameliorated cardiomyocyte apoptosis in cardiac ischemia/reperfusion injury by blocking mitochondrial membrane potential decrease, inhibiting ROS and cytochrome C.
Elevated IL-22 in psoriasis plays an anti-apoptotic role in keratinocytes through mediating Bcl-xL/Bax.
The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocytes and imiquimod-induced murine model.
Loss of adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22.
Type 3 innate lymphoid cell: a new player in liver fibrosis progression.
HMGB1-induced autophagy facilitates hepatic stellate cells activation: a new pathway in liver fibrosis.
Luo M, Chen Y, Chen H, Wen Y
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2026 Mar 17;75(1)
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2026 Mar 17;75(1)
IL-24 ameliorates cognitive dysfunction via the inhibition PERK-eIF2α Signaling pathway in Alzheimer's disease.
Du Y, Zheng X, Yue X, Fu P, Diao J, Zhang A, Cheng H, Yang H, Bi J, Zhou Q, Wang P
International immunopharmacology 2026 Jan 15;169:116039
International immunopharmacology 2026 Jan 15;169:116039
Thymosin β4 released by mast cells under stress conditions impairs intestinal epithelial barrier via IL22RA1/JAK1/STAT3 signaling in irritable bowel syndrome.
Sun YS, Bai XQ, Sun KD, Li J, Liu L, Chen YY, Zeng ZY, Wang Q, Guo YB
World journal of gastroenterology 2025 Nov 14;31(42):111706
World journal of gastroenterology 2025 Nov 14;31(42):111706
Th22 cells promote the transition from homeostatic to reactive microglia in diabetic encephalopathy.
Yu SX, Yu HD, Wang YF, Yao TF, Lv SZ, Wang YC, Li JQ, Liu WQ, Ding JY, Liu XZ, Zuo ZF, Liu WP
Acta diabetologica 2025 May;62(5):633-650
Acta diabetologica 2025 May;62(5):633-650
Oral administration of tea-derived exosome-like nanoparticles protects epithelial and immune barrier of intestine from psychological stress.
Gong Q, Sun Y, Liu L, Pu C, Guo Y
Heliyon 2024 Sep 15;10(17):e36812
Heliyon 2024 Sep 15;10(17):e36812
Interleukin-22 improves ovulation in polycystic ovary syndrome via STAT3 signaling.
Liao B, Chen W, Qi X, Yun C, Pang Y
Molecular human reproduction 2024 Oct 12;30(10)
Molecular human reproduction 2024 Oct 12;30(10)
Activation of IL1A/IRAK1 axis and downstream proinflammatory signaling in healthy adult and neonatal African American skin.
Trubetskoy D, Grudzien P, Klopot A, Tsoi LC, Kundu RV, White BEP, Budunova I
bioRxiv : the preprint server for biology 2024 Nov 19;
bioRxiv : the preprint server for biology 2024 Nov 19;
Ginsenoside CK Alleviates DSS-Induced IBD in Mice by Regulating Tryptophan Metabolism and Activating Aryl Hydrocarbon Receptor via Gut Microbiota Modulation.
Liu Y, Bai X, Wu H, Duan Z, Zhu C, Fu R, Fan D
Journal of agricultural and food chemistry 2024 May 1;72(17):9867-9879
Journal of agricultural and food chemistry 2024 May 1;72(17):9867-9879
Interleukin-22 receptor 1-mediated stimulation of T-type Ca(2+) channels enhances sensory neuronal excitability through the tyrosine-protein kinase Lyn-dependent PKA pathway.
Cai H, Chen S, Sun Y, Zheng T, Liu Y, Tao J, Zhang Y
Cell communication and signaling : CCS 2024 Jun 3;22(1):307
Cell communication and signaling : CCS 2024 Jun 3;22(1):307
Troxerutin dampened hypothalamic neuroinflammation via microglial IL-22/IL-22R1/IRF3 activation in dihydrotestosterone-induced polycystic ovary syndrome rats.
Gao Z, Tan H, Song X, Zhuang T, Kong R, Wang Y, Yan X, Yao R
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155280
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155280
Role of iron in host-microbiota interaction and its effects on intestinal mucosal growth and immune plasticity in a piglet model.
Dong Z, Liu S, Deng Q, Li G, Tang Y, Wu X, Wan D, Yin Y
Science China. Life sciences 2023 Sep;66(9):2086-2098
Science China. Life sciences 2023 Sep;66(9):2086-2098
Aryl hydrocarbon receptor regulates IL-22 receptor expression on thymic epithelial cell and accelerates thymus regeneration.
Shen J, Wang Y, Zheng F, Cao S, Lan Q, Xu K, Pan B
NPJ Regenerative medicine 2023 Nov 8;8(1):64
NPJ Regenerative medicine 2023 Nov 8;8(1):64
IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo.
Bai Y, Wu H, Zhang J, Zhang S, Zhang Z, Wang H, Zhang Y, Shen Z
Oxidative medicine and cellular longevity 2022;2022:9635075
Oxidative medicine and cellular longevity 2022;2022:9635075
Troxerutin attenuates insulin resistance via pancreatic IL-22/JAK1/STAT3 signaling activation in dihydrotestosterone-induced polycystic ovary syndrome rats.
Gao Z, Wang G, Ma X, Tan H, Zhang C, Yin X, Suo F, Yao R, Yan X
American journal of physiology. Endocrinology and metabolism 2022 Nov 1;323(5):E405-E417
American journal of physiology. Endocrinology and metabolism 2022 Nov 1;323(5):E405-E417
Th22 cells induce Müller cell activation via the Act1/TRAF6 pathway in diabetic retinopathy.
Wang Y, Yu H, Li J, Liu W, Yu S, Lv P, Zhao L, Wang X, Zuo Z, Liu X
Cell and tissue research 2022 Dec;390(3):367-383
Cell and tissue research 2022 Dec;390(3):367-383
IL-22 ameliorated cardiomyocyte apoptosis in cardiac ischemia/reperfusion injury by blocking mitochondrial membrane potential decrease, inhibiting ROS and cytochrome C.
Che Y, Tian Y, Chen R, Xia L, Liu F, Su Z
Biochimica et biophysica acta. Molecular basis of disease 2021 Sep 1;1867(9):166171
Biochimica et biophysica acta. Molecular basis of disease 2021 Sep 1;1867(9):166171
Elevated IL-22 in psoriasis plays an anti-apoptotic role in keratinocytes through mediating Bcl-xL/Bax.
Wang B, Han D, Li F, Hou W, Wang L, Meng L, Mou K, Lu S, Zhu W, Zhou Y
Apoptosis : an international journal on programmed cell death 2020 Oct;25(9-10):663-673
Apoptosis : an international journal on programmed cell death 2020 Oct;25(9-10):663-673
The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocytes and imiquimod-induced murine model.
Wu S, Zhao M, Sun Y, Xie M, Le K, Xu M, Huang C
Life sciences 2020 Jan 15;241:117115
Life sciences 2020 Jan 15;241:117115
Loss of adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22.
Chen Y, Vandereyken M, Newton IP, Moraga I, Näthke IS, Swamy M
PLoS biology 2019 Nov;17(11):e3000540
PLoS biology 2019 Nov;17(11):e3000540
Type 3 innate lymphoid cell: a new player in liver fibrosis progression.
Wang S, Li J, Wu S, Cheng L, Shen Y, Ma W, She W, Yang C, Wang J, Jiang W
Clinical science (London, England : 1979) 2018 Dec 21;132(24):2565-2582
Clinical science (London, England : 1979) 2018 Dec 21;132(24):2565-2582
HMGB1-induced autophagy facilitates hepatic stellate cells activation: a new pathway in liver fibrosis.
Li J, Zeng C, Zheng B, Liu C, Tang M, Jiang Y, Chang Y, Song W, Wang Y, Yang C
Clinical science (London, England : 1979) 2018 Aug 16;132(15):1645-1667
Clinical science (London, England : 1979) 2018 Aug 16;132(15):1645-1667
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IL22RA1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human IL22RA1. This antibody recognizes human, mouse, rat antigen. The IL22RA1 antibody has been validated for the following applications: ELISA, WB analysis.
