Antibody data
- Antibody Data
- Antigen structure
- References [40]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 15171-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15171-1-AP, RRID:AB_2263537
- Product name
- GPI antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated GPI antibody (Cat. #15171-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references USP5-mediated CD73 deubiquitination drives osimertinib resistance via PI3K/AKT and glycolysis activation in LUAD.
Adipose tissue-derived stromal cells enhance glycolytic metabolism in injured nerve cells via the FOXK1-HK2 axis for spinal cord injury repair.
Macrophage USP14 suppresses Wnt/β-catenin signaling via NLK deubiquitination to enhance immune response.
Molecular signatures of brain glycolysis dysfunction in Alzheimer's disease.
Integrated multi-omics analyses of synaptosomes revealed synapse-associated novel targets in Alzheimer's disease.
Oleanolic acid inhibits M2 macrophage polarization and potentiates anti-PD-1 therapy in hepatocellular carcinoma by targeting miR-130b-3p-PTEN-PI3K-Akt signaling and glycolysis.
A Differential Proteomic Analysis on Patient Sera with Neuromyelitis Spectrum Disorders (NMOSD) and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD) Suggested Shared and Distinct Disease Mechanisms.
Beta sitosterol inhibits the proliferation and migration of synoviocytes in rheumatoid arthritis via lactylation of GPI.
CASC8 activates the pentose phosphate pathway to inhibit disulfidptosis in pancreatic ductal adenocarcinoma though the c-Myc-GLUT1 axis.
Integrated Multi-Omics Analyses of Synaptosomes Revealed Synapse-Centered Novel Targets in Alzheimer's Disease.
Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation.
ITGA3 promotes pancreatic cancer progression through HIF1α- and c-Myc-driven glycolysis in a collagen I-dependent autocrine manner.
TMEM45A enhances palbociclib resistance and cellular glycolysis by activating AKT/mTOR signaling pathway in HR+ breast cancer.
Renalase activates mitochondrial leak metabolism in response to cellular stress and to repair damage after injury.
Hypoxia-induced PRMT1 methylates HIF2β to promote breast tumorigenesis via enhancing glycolytic gene transcription.
Novel cuproptosis metabolism-related molecular clusters and diagnostic signature for Alzheimer's disease.
Sodium citrate targeting Ca(2+)/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer.
Identification of TPI1 As a potential therapeutic target in pancreatic cancer with dependency of TP53 mutation using multi-omics analysis.
Novel Inhibition of Central Carbon Metabolism Pathways by Rac and CDC42 inhibitor MBQ167 and Paclitaxel.
Energy stress-induced circDDX21 promotes glycolysis and facilitates hepatocellular carcinogenesis.
Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells.
The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity.
Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P.
Schwann Cells Accelerate Osteogenesis via the Mif/CD74/FOXO1 Signaling Pathway In Vitro.
Alpha-solanine Anti-tumor Effects in Non-small Cell Lung Cancer Through Regulating the Energy Metabolism Pathway.
Identification and Validation of an Apoptosis-Related Gene Prognostic Signature for Oral Squamous Cell Carcinoma.
Candida tropicalis induces NLRP3 inflammasome activation via glycogen metabolism-dependent glycolysis and JAK-STAT1 signaling pathway in myeloid-derived suppressor cells to promote colorectal carcinogenesis.
Reciprocal regulation of LOXL2 and HIF1α drives the Warburg effect to support pancreatic cancer aggressiveness.
Valproic acid Suppresses Breast Cancer Cell Growth Through Triggering Pyruvate Kinase M2 Isoform Mediated Warburg Effect.
OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development.
A glycolytic shift in Schwann cells supports injured axons.
Low levels of AMPK promote epithelial-mesenchymal transition in lung cancer primarily through HDAC4- and HDAC5-mediated metabolic reprogramming.
Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1.
Proteomics analysis of asthenozoospermia and identification of glucose-6-phosphate isomerase as an important enzyme for sperm motility.
Accelerated Metabolite Levels of Aerobic Glycolysis and the Pentose Phosphate Pathway Are Required for Efficient Replication of Infectious Spleen and Kidney Necrosis Virus in Chinese Perch Brain Cells.
CUE domain-containing protein 2 promotes the Warburg effect and tumorigenesis.
Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.
Proteomic analysis indicates that mitochondrial energy metabolism in skeletal muscle tissue is negatively correlated with feed efficiency in pigs.
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.
FHL2-driven molecular network mediated Septin2 knockdown inducing apoptosis in mesangial cell.
Chen R, Han XH, Zhang Z, Han XJ, Xie J
iScience 2026 Mar 20;29(3):114916
iScience 2026 Mar 20;29(3):114916
Adipose tissue-derived stromal cells enhance glycolytic metabolism in injured nerve cells via the FOXK1-HK2 axis for spinal cord injury repair.
Li F, Li H, Jia Y, Ou L, Fang Y, Pan L, Liu H, Ning B
Journal of translational medicine 2026 Mar 17;24(1)
Journal of translational medicine 2026 Mar 17;24(1)
Macrophage USP14 suppresses Wnt/β-catenin signaling via NLK deubiquitination to enhance immune response.
Zhao M, Shi J, Wei X, Tian W, Chen Y
Cytokine 2026 Feb;198:157079
Cytokine 2026 Feb;198:157079
Molecular signatures of brain glycolysis dysfunction in Alzheimer's disease.
Jia D, Li M, Li L, Wang Q, Zhu XC, Luo J, Yu H
Diabetes, obesity & metabolism 2025 Oct;27(10):5852-5864
Diabetes, obesity & metabolism 2025 Oct;27(10):5852-5864
Integrated multi-omics analyses of synaptosomes revealed synapse-associated novel targets in Alzheimer's disease.
Kumar S, Ramos E, Hidalgo A, Rodarte D, Sharma B, Torres MM, Devara D, Gadad SS
Molecular psychiatry 2025 Nov;30(11):5121-5136
Molecular psychiatry 2025 Nov;30(11):5121-5136
Oleanolic acid inhibits M2 macrophage polarization and potentiates anti-PD-1 therapy in hepatocellular carcinoma by targeting miR-130b-3p-PTEN-PI3K-Akt signaling and glycolysis.
Tu X, Lin W, Zhai X, Liang S, Huang G, Wang J, Jia W, Li S, Li B, Cheng B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156750
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156750
A Differential Proteomic Analysis on Patient Sera with Neuromyelitis Spectrum Disorders (NMOSD) and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD) Suggested Shared and Distinct Disease Mechanisms.
Hu X, Sun X, Yang T, Sun X, Wen M, Chen C, Qiu W, Jin Y
Journal of proteome research 2025 Jul 4;24(7):3697-3714
Journal of proteome research 2025 Jul 4;24(7):3697-3714
Beta sitosterol inhibits the proliferation and migration of synoviocytes in rheumatoid arthritis via lactylation of GPI.
Tan Y, Zhong X, He X, Yuan Y, Deng Y, Huang J, Zhou Y, Xie C, Peng H
Scientific reports 2025 Jul 11;15(1):25045
Scientific reports 2025 Jul 11;15(1):25045
CASC8 activates the pentose phosphate pathway to inhibit disulfidptosis in pancreatic ductal adenocarcinoma though the c-Myc-GLUT1 axis.
Yao HF, Ge J, Chen J, Tang X, Li C, Hu X, Ahmed AA, Pu Y, Zhou G, Zhang T, Cai Z, Jiang C
Journal of experimental & clinical cancer research : CR 2025 Jan 27;44(1):26
Journal of experimental & clinical cancer research : CR 2025 Jan 27;44(1):26
Integrated Multi-Omics Analyses of Synaptosomes Revealed Synapse-Centered Novel Targets in Alzheimer's Disease.
Kumar S, Ramos E, Hidalgo A, Rodarte D, Sharma B, Torres MM, Devara D, Gadad SS
bioRxiv : the preprint server for biology 2025 Jan 13;
bioRxiv : the preprint server for biology 2025 Jan 13;
Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation.
Snaebjornsson MT, Poeller P, Komkova D, Röhrig F, Schlicker L, Winkelkotte AM, Chaves-Filho AB, Al-Shami KM, Caballero CD, Koltsaki I, Vogel FCE, Frias-Soler RC, Rudalska R, Schwarz JD, Wolf E, Dauch D, Steuer R, Schulze A
Nature metabolism 2025 Feb;7(2):348-366
Nature metabolism 2025 Feb;7(2):348-366
ITGA3 promotes pancreatic cancer progression through HIF1α- and c-Myc-driven glycolysis in a collagen I-dependent autocrine manner.
Li R, Ji Q, Fu S, Gu J, Liu D, Wang L, Yuan X, Wen Y, Dai C, Li H
Cancer gene therapy 2025 Feb;32(2):240-253
Cancer gene therapy 2025 Feb;32(2):240-253
TMEM45A enhances palbociclib resistance and cellular glycolysis by activating AKT/mTOR signaling pathway in HR+ breast cancer.
Chen C, Chen Z, Zhao J, Wen X, Yao H, Weng Z, Xiong H, Zheng Z, Wu J
Cell death discovery 2025 Feb 5;11(1):47
Cell death discovery 2025 Feb 5;11(1):47
Renalase activates mitochondrial leak metabolism in response to cellular stress and to repair damage after injury.
Guo X, Chen R, Shugrue C, Shang FF, Milian RG, Moller H, Licznerski P, Chen TM, Kibbey R, M'Saad O, Tian Y, Bewersdorf J, Giordano F, Gorelick FS, Safirstein R, Jonas EA, Desir GV
bioRxiv : the preprint server for biology 2025 Aug 20;
bioRxiv : the preprint server for biology 2025 Aug 20;
Hypoxia-induced PRMT1 methylates HIF2β to promote breast tumorigenesis via enhancing glycolytic gene transcription.
Li WJ, Chen YC, Lin YA, Zou YQ, Hu GS, Yang JJ, Nie XY, Li MY, Wang YR, He YH, Zhao Y, Tan YH, Deng X, He WL, Cheng Y, Fu FM, Liu W
Cell reports 2025 Apr 22;44(4):115487
Cell reports 2025 Apr 22;44(4):115487
Novel cuproptosis metabolism-related molecular clusters and diagnostic signature for Alzheimer's disease.
Jia F, Han W, Gao S, Huang J, Zhao W, Lu Z, Zhao W, Li Z, Wang Z, Guo Y
Frontiers in molecular biosciences 2024;11:1478611
Frontiers in molecular biosciences 2024;11:1478611
Sodium citrate targeting Ca(2+)/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer.
Wu Y, Jia C, Liu W, Zhan W, Chen Y, Lu J, Bao Y, Wang S, Yu C, Zheng L, Sun L, Song Z
Journal of advanced research 2024 Nov;65:89-104
Journal of advanced research 2024 Nov;65:89-104
Identification of TPI1 As a potential therapeutic target in pancreatic cancer with dependency of TP53 mutation using multi-omics analysis.
Toyoda T, Miura N, Kato S, Masuda T, Ohashi R, Matsushita A, Matsuda F, Ohtsuki S, Katakura A, Honda K
Cancer science 2024 Nov;115(11):3622-3635
Cancer science 2024 Nov;115(11):3622-3635
Novel Inhibition of Central Carbon Metabolism Pathways by Rac and CDC42 inhibitor MBQ167 and Paclitaxel.
Cruz-Collazo AM, Katsara O, Grafals-Ruiz N, Colon Gonzalez J, Dorta-Estremera S, Carlo VP, Chorna N, Schneider RJ, Dharmawardhane S
Molecular cancer therapeutics 2024 Nov 4;23(11):1613-1625
Molecular cancer therapeutics 2024 Nov 4;23(11):1613-1625
Energy stress-induced circDDX21 promotes glycolysis and facilitates hepatocellular carcinogenesis.
Luo J, Yang Y, Zhang G, Fang D, Liu K, Mei Y, Wang F
Cell death & disease 2024 May 21;15(5):354
Cell death & disease 2024 May 21;15(5):354
Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells.
Zhuang W, Liu X, Liu G, Lv J, Qin H, Wang C, Xie L, Saimaier K, Han S, Shi C, Hua Q, Zhang R, Du C
International journal of biological sciences 2023;19(11):3576-3594
International journal of biological sciences 2023;19(11):3576-3594
The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity.
Sun X, He L, Liu H, Thorne RF, Zeng T, Liu L, Zhang B, He M, Huang Y, Li M, Gao E, Ma M, Cheng C, Meng F, Lang C, Li H, Xiong W, Pan S, Ren D, Dang B, Yang Y, Wu M, Liu L
Cell metabolism 2023 Sep 5;35(9):1563-1579.e8
Cell metabolism 2023 Sep 5;35(9):1563-1579.e8
Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P.
Ai YL, Wang WJ, Liu FJ, Fang W, Chen HZ, Wu LZ, Hong X, Zhu Y, Zhang CX, Liu LY, Hong WB, Zhou B, Chen QT, Wu Q
Cell research 2023 Dec;33(12):904-922
Cell research 2023 Dec;33(12):904-922
Schwann Cells Accelerate Osteogenesis via the Mif/CD74/FOXO1 Signaling Pathway In Vitro.
Li JQ, Jiang HJ, Su XY, Feng L, Zhan NZ, Li SS, Chen ZJ, Chang BH, Cheng PZ, Yang L, Pei GX
Stem cells international 2022;2022:4363632
Stem cells international 2022;2022:4363632
Alpha-solanine Anti-tumor Effects in Non-small Cell Lung Cancer Through Regulating the Energy Metabolism Pathway.
Zou T, Gu L, Yang L, Wei J, Zhao Y, Shen J, Li M, Wu X, Du F, Chen Y, Ye Y, Xiao Z, Wu Z
Recent patents on anti-cancer drug discovery 2022;17(4):396-409
Recent patents on anti-cancer drug discovery 2022;17(4):396-409
Identification and Validation of an Apoptosis-Related Gene Prognostic Signature for Oral Squamous Cell Carcinoma.
Wang S, Zhang S, Lin Z, Ma J, Zhu L, Liao G
Frontiers in oncology 2022;12:889049
Frontiers in oncology 2022;12:889049
Candida tropicalis induces NLRP3 inflammasome activation via glycogen metabolism-dependent glycolysis and JAK-STAT1 signaling pathway in myeloid-derived suppressor cells to promote colorectal carcinogenesis.
Zhang Z, Chen Y, Yin Y, Chen Y, Chen Q, Bing Z, Zheng Y, Hou Y, Shen S, Chen Y, Wang T
International immunopharmacology 2022 Dec;113(Pt B):109430
International immunopharmacology 2022 Dec;113(Pt B):109430
Reciprocal regulation of LOXL2 and HIF1α drives the Warburg effect to support pancreatic cancer aggressiveness.
Li R, Li H, Zhu L, Zhang X, Liu D, Li Q, Ni B, Hu L, Zhang Z, Zhang Y, Wang X, Jiang SH
Cell death & disease 2021 Nov 26;12(12):1106
Cell death & disease 2021 Nov 26;12(12):1106
Valproic acid Suppresses Breast Cancer Cell Growth Through Triggering Pyruvate Kinase M2 Isoform Mediated Warburg Effect.
Li Z, Yang L, Zhang S, Song J, Sun H, Shan C, Wang D, Liu S
Cell transplantation 2021 Jan-Dec;30:9636897211027524
Cell transplantation 2021 Jan-Dec;30:9636897211027524
OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development.
Wu Z, Zuo M, Zeng L, Cui K, Liu B, Yan C, Chen L, Dong J, Shangguan F, Hu W, He H, Lu B, Song Z
EMBO reports 2021 Jan 7;22(1):e50827
EMBO reports 2021 Jan 7;22(1):e50827
A glycolytic shift in Schwann cells supports injured axons.
Babetto E, Wong KM, Beirowski B
Nature neuroscience 2020 Oct;23(10):1215-1228
Nature neuroscience 2020 Oct;23(10):1215-1228
Low levels of AMPK promote epithelial-mesenchymal transition in lung cancer primarily through HDAC4- and HDAC5-mediated metabolic reprogramming.
Feng S, Zhang L, Liu X, Li G, Zhang B, Wang Z, Zhang H, Ma H
Journal of cellular and molecular medicine 2020 Jul;24(14):7789-7801
Journal of cellular and molecular medicine 2020 Jul;24(14):7789-7801
Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1.
Feng Q, Li X, Sun W, Sun M, Li Z, Sheng H, Xie F, Zhang S, Shan C
Biochemical pharmacology 2020 Aug;178:114092
Biochemical pharmacology 2020 Aug;178:114092
Proteomics analysis of asthenozoospermia and identification of glucose-6-phosphate isomerase as an important enzyme for sperm motility.
Guo Y, Jiang W, Yu W, Niu X, Liu F, Zhou T, Zhang H, Li Y, Zhu H, Zhou Z, Sha J, Guo X, Chen D
Journal of proteomics 2019 Sep 30;208:103478
Journal of proteomics 2019 Sep 30;208:103478
Accelerated Metabolite Levels of Aerobic Glycolysis and the Pentose Phosphate Pathway Are Required for Efficient Replication of Infectious Spleen and Kidney Necrosis Virus in Chinese Perch Brain Cells.
Guo X, Wu S, Li N, Lin Q, Liu L, Liang H, Niu Y, Huang Z, Fu X
Biomolecules 2019 Sep 2;9(9)
Biomolecules 2019 Sep 2;9(9)
CUE domain-containing protein 2 promotes the Warburg effect and tumorigenesis.
Zhong X, Tian S, Zhang X, Diao X, Dong F, Yang J, Li Z, Sun L, Wang L, He X, Wu G, Hu X, Wang L, Song L, Zhang H, Pan X, Li A, Gao P
EMBO reports 2017 May;18(5):809-825
EMBO reports 2017 May;18(5):809-825
Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.
Wang L, Zhang T, Wang L, Cai Y, Zhong X, He X, Hu L, Tian S, Wu M, Hui L, Zhang H, Gao P
The EMBO journal 2017 May 15;36(10):1330-1347
The EMBO journal 2017 May 15;36(10):1330-1347
Proteomic analysis indicates that mitochondrial energy metabolism in skeletal muscle tissue is negatively correlated with feed efficiency in pigs.
Fu L, Xu Y, Hou Y, Qi X, Zhou L, Liu H, Luan Y, Jing L, Miao Y, Zhao S, Liu H, Li X
Scientific reports 2017 Mar 27;7:45291
Scientific reports 2017 Mar 27;7:45291
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.
Sun L, Song L, Wan Q, Wu G, Li X, Wang Y, Wang J, Liu Z, Zhong X, He X, Shen S, Pan X, Li A, Wang Y, Gao P, Tang H, Zhang H
Cell research 2015 Apr;25(4):429-44
Cell research 2015 Apr;25(4):429-44
FHL2-driven molecular network mediated Septin2 knockdown inducing apoptosis in mesangial cell.
Lu Y, Cai G, Cui S, Geng W, Chen D, Wen J, Zhang Y, Zhang F, Xie Y, Fu B, Chen X
Proteomics 2014 Nov;14(21-22):2485-97
Proteomics 2014 Nov;14(21-22):2485-97
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The GPI antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human GPI. This antibody recognizes human,mouse,rat antigen. The GPI antibody has been validated for the following applications: ELISA, WB analysis.