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- References [12]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 11527-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- UCHL5 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated UCHL5 antibody (Cat. #11527-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Ubiquitin C-terminal hydrolase L5 promotes the development of renal cell carcinoma through the glycolysis mediated by the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway.
Proteasomal deubiquitinating enzyme USP14/UCHL5 inhibitor bAP15 suppresses endoplasmic reticulum stress-mediated apoptosis and tumor growth in human chondrosarcoma.
Curcumin modulates β-catenin stabilization via targeting proteasomal deubiquitinating enzyme USP14(☆).
Adipose stem cell exosomes, stimulated by pro-inflammatory factors, enhance immune evasion in triple-negative breast cancer by modulating the HDAC6/STAT3/PD-L1 pathway through the transporter UCHL1.
USP9X-mediated REV1 deubiquitination promotes lung cancer radioresistance via the action of REV1 as a Rad18 molecular scaffold for cystathionine γ-lyase.
Comprehensive pan-cancer analysis indicates UCHL5 as a novel cancer biomarker and promotes cervical cancer progression through the Wnt signaling pathway.
Anti-tumor effects of deubiquitinating enzyme inhibitor PR-619 in human chondrosarcoma through reduced cell proliferation and endoplasmic reticulum stress-related apoptosis.
Caveolin-2 in association with nuclear lamina controls adipocyte hypertrophy.
The UCHL5 inhibitor b-AP15 overcomes cisplatin resistance via suppression of cancer stemness in urothelial carcinoma.
Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/β-Catenin Signaling Pathway.
Proteasome-associated cysteine deubiquitinases are molecular targets of environmental optical brightener compounds.
Computational and biochemical studies of isothiocyanates as inhibitors of proteasomal cysteine deubiquitinases in human cancer cells.
Ruan L, Li S, Xu L
CytoJournal 2025;22:99
CytoJournal 2025;22:99
Proteasomal deubiquitinating enzyme USP14/UCHL5 inhibitor bAP15 suppresses endoplasmic reticulum stress-mediated apoptosis and tumor growth in human chondrosarcoma.
Khoi CS, Chiu YL, Huang KY, Hsu FS, Kuo KL, Chow PM, Hsu CH, Liao SM, Lin YC, Chang KY, Kao YJ, Liu SH, Lin WC
American journal of cancer research 2025;15(9):4043-4053
American journal of cancer research 2025;15(9):4043-4053
Curcumin modulates β-catenin stabilization via targeting proteasomal deubiquitinating enzyme USP14(☆).
Shen M, Chen L, Jiang J, Wang Z, Gong Q, Zhang X, Ke X, Qu Y
Pharmacological research 2025 Jun;216:107745
Pharmacological research 2025 Jun;216:107745
Adipose stem cell exosomes, stimulated by pro-inflammatory factors, enhance immune evasion in triple-negative breast cancer by modulating the HDAC6/STAT3/PD-L1 pathway through the transporter UCHL1.
Zhu Q, Zhang K, Cao Y, Hu Y
Cancer cell international 2024 Nov 20;24(1):385
Cancer cell international 2024 Nov 20;24(1):385
USP9X-mediated REV1 deubiquitination promotes lung cancer radioresistance via the action of REV1 as a Rad18 molecular scaffold for cystathionine γ-lyase.
Chen Y, Feng X, Wu Z, Yang Y, Rao X, Meng R, Zhang S, Dong X, Xu S, Wu G, Jie X
Journal of biomedical science 2024 May 28;31(1):55
Journal of biomedical science 2024 May 28;31(1):55
Comprehensive pan-cancer analysis indicates UCHL5 as a novel cancer biomarker and promotes cervical cancer progression through the Wnt signaling pathway.
Bao L, Wu Y, Ren Z, Huang Y, Jiang Y, Li K, Xu X, Ye Y, Gui Z
Biology direct 2024 Dec 19;19(1):139
Biology direct 2024 Dec 19;19(1):139
Anti-tumor effects of deubiquitinating enzyme inhibitor PR-619 in human chondrosarcoma through reduced cell proliferation and endoplasmic reticulum stress-related apoptosis.
Lin WC, Chiu YL, Kuo KL, Chow PM, Hsu CH, Liao SM, Dong JR, Chang SC, Liu SH, Liu TJ, Hsu FS, Wang KC, Lin YC, Chang CC, Huang KY
American journal of cancer research 2023;13(7):3055-3066
American journal of cancer research 2023;13(7):3055-3066
Caveolin-2 in association with nuclear lamina controls adipocyte hypertrophy.
Choi M, Kwon H, Pak Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Feb;37(2):e22745
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Feb;37(2):e22745
The UCHL5 inhibitor b-AP15 overcomes cisplatin resistance via suppression of cancer stemness in urothelial carcinoma.
Chow PM, Dong JR, Chang YW, Kuo KL, Lin WC, Liu SH, Huang KH
Molecular therapy oncolytics 2022 Sep 15;26:387-398
Molecular therapy oncolytics 2022 Sep 15;26:387-398
Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/β-Catenin Signaling Pathway.
Liu D, Song Z, Wang X, Ouyang L
Frontiers in oncology 2020;10:865
Frontiers in oncology 2020;10:865
Proteasome-associated cysteine deubiquitinases are molecular targets of environmental optical brightener compounds.
Castro I, Ekinci E, Huang X, Cheaito HA, Ahn YH, Olivero-Verbel J, Dou QP
Journal of cellular biochemistry 2019 Aug;120(8):14065-14075
Journal of cellular biochemistry 2019 Aug;120(8):14065-14075
Computational and biochemical studies of isothiocyanates as inhibitors of proteasomal cysteine deubiquitinases in human cancer cells.
Ahmed ZSO, Li X, Li F, Cheaito HA, Patel K, Mosallam EM, Elbargeesy GAEH, Dou QP
Journal of cellular biochemistry 2018 Nov;119(11):9006-9016
Journal of cellular biochemistry 2018 Nov;119(11):9006-9016
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse colon tissue were subjected to SDS PAGE followed by western blot with 11527-1-AP( UCHL5 Antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The UCHL5 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human UCHL5. This antibody recognizes human,mouse,rat antigen. The UCHL5 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
