10337-1-AP

antibody from Proteintech Group

Targeting: MAD2L1 HSMAD2, MAD2

Provider product page for 10337-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [39]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 10337-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10337-1-AP, RRID:AB_2139365
Product name: MAD2L1 antibody
Antibody type: Polyclonal
Description: KD/KO validated MAD2L1 antibody (Cat. #10337-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MAD2L1 protein structure - 10337-1-AP shown in red.

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A Novel FGFR3-Targeting Antibody-Drug Conjugate Induces Tumor Cell Apoptosis through the cGAS-STING Pathway in Bladder Cancer.

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LncRNA SNHG8 promotes myocardial fibrosis by binding to E2F1 to induce MAD2L1 transcription.

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International journal of biological macromolecules 2025 Nov;331(Pt 1):148362

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Yang Z, Wang B, Guo B, Sun S, Li Y, Lu J, Cao X, Wang H, Wang X, Guo Y, Wu T
Cell death & disease 2025 Nov 17;16(1):843

Identification of MAD2L1 and BUB1B as Potential Biomarkers Associated with Progression and Prognosis of Ovarian Cancer.

Tang R, Tong J, Shang S, Li G, Sun F, Guan X, Yang J
Biochemical genetics 2025 Jun;63(3):2831-2847

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Xu Q, Zhou H, Wu J, Chang B, Gu Y, Li H, Cheng X
Scientific reports 2025 Jul 24;15(1):26860

MAD2L1 supports MYC-driven liver carcinogenesis in mice and predicts poor prognosis in human hepatocarcinoma.

Lu X, Zhang Y, Xue J, Evert M, Calvisi D, Chen X, Wang X
Toxicological sciences : an official journal of the Society of Toxicology 2025 Jan 1;203(1):41-51

A Microtubule-Associated Protein Functions in Preventing Oocytes from Evading the Spindle Assembly Checkpoint.

Zhou C, Zhang X, Xu G, Ran Y, Wang H, Xie X, Li A, Li F, Li X, Ding J, Zhang M, Sun QY, Ou XH
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2413097

Mutual regulation between cell cycle and transcription termination factor TTF2.

Hu Y, Xu L, Feng B, Wu Q, Wang Y, Gong W, Lv M, Zhao H, Chen J, Li J, Zhang W, Zhan Q
Science China. Life sciences 2025 Aug;68(8):2348-2362

Genome-wide CRISPR screen identifies BUB1 kinase as a druggable vulnerability in malignant pleural mesothelioma.

Cakiroglu E, Eris S, Oz O, Karakülah G, Senturk S
Cell death & disease 2025 Apr 3;16(1):241

The cohesin-associated protein Pds5A governs the meiotic spindle assembly via deubiquitination of Kif5B in oocytes.

Zhang Y, Bai J, Xiong B
Science advances 2025 Apr 11;11(15):eadt6159

CCDC68 Maintains Mitotic Checkpoint Activation by Promoting CDC20 Integration into the MCC.

Li Q, Chen Q, Zheng T, Wang F, Teng J, Zhou H, Chen J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(35):e2406009

Circular RNA Circ_0000119 promotes gastric cancer progression via circ_0000119/miR-502-5p/MTBP axis.

Xie M, Gu Y, Xu T, Jing X, Shu Y
Gene 2024 May 25;908:148296

Exosomal miR-493 suppresses MAD2L1 and induces chemoresistance to intraperitoneal paclitaxel therapy in gastric cancer patients with peritoneal metastasis.

Makinoya M, Miyatani K, Matsumi Y, Sakano Y, Shimizu S, Shishido Y, Hanaki T, Kihara K, Matsunaga T, Yamamoto M, Tokuyasu N, Takano S, Sakamoto T, Hasegawa T, Saito H, Nakayama Y, Osaki M, Okada F, Fujiwara Y
Scientific reports 2024 May 2;14(1):10075

Overexpression of TBX3 suppresses tumorigenesis in experimental and human cholangiocarcinoma.

Deng S, Lu X, Wang X, Liang B, Xu H, Yang D, Cui G, Yonemura A, Paine H, Zhou Y, Zhang Y, Simile MM, Urigo F, Evert M, Calvisi DF, Green BL, Chen X
Cell death & disease 2024 Jun 22;15(6):441

PATL2 mutations affect human oocyte maternal mRNA homeostasis and protein interactions in cell cycle regulation.

Zhang YL, Hu Z, Jiang H, Jin J, Zhou Y, Lai M, Ren P, Liu S, Zhang YY, Rong Y, Zheng W, Zhang S, Tong X, Zhang S
Cell & bioscience 2024 Dec 31;14(1):157

Kinesin Family Member-18A (KIF18A) Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma.

Ren J, Yao X, Yang M, Cheng S, Wu D, Xu K, Li R, Zhang H, Zhang D
Digestive diseases and sciences 2024 Apr;69(4):1274-1286

Mitogen-induced defective mitosis transforms neural progenitor cells.

Omairi HK, Grisdale CJ, Meode M, Bohm AK, Black S, Adam NJ, Chapman CP, Maroilley T, Kelly JJ, Tarailo-Graovac M, Jones SJM, Blough MD, Cairncross JG
Neuro-oncology 2023 Oct 3;25(10):1763-1774

Targeting diacylglycerol kinase α impairs lung tumorigenesis by inhibiting cyclin D3.

Zhou D, Liu T, Rao X, Jie X, Chen Y, Wu Z, Deng H, Zhang D, Wang J, Wu G
Thoracic cancer 2023 May;14(13):1179-1191

Therapy-resistant and -sensitive lncRNAs, SNHG1 and UBL7-AS1 promote glioblastoma cell proliferation.

Cao M, Ma R, Li H, Cui J, Zhang C, Zhao J
Oxidative medicine and cellular longevity 2022;2022:2623599

Nivalenol affects Cyclin B1 level and activates SAC for cell cycle progression in mouse oocyte meiosis.

Lu PS, Wang Y, Jiao L, Sun SC
Cell proliferation 2022 Sep;55(9):e13277

Septin 4 controls CCNB1 stabilization via APC/C(CDC20) during meiotic G2/M transition in mouse oocytes.

Chen L, Ouyang YC, Li J, Qiao JY, Gu LJ, Wang ZB, Hou Y, Schatten H, Sun QY
Journal of cellular physiology 2022 Jan;237(1):730-742

Melatonin promotes in vitro maturation of vitrified-warmed mouse GV oocytes potentially by modulating MAD2 protein expression of SAC component through MTRs.

Yang J, Guo S, Pan B, Qazi IH, Qin J, Zang S, Han H, Meng Q, Zhou G
Cryobiology 2021 Oct;102:82-91

Loss of centromeric RNA activates the spindle assembly checkpoint in mammalian female meiosis I.

Wu T, Lane SIR, Morgan SL, Tang F, Jones KT
The Journal of cell biology 2021 Oct 4;220(10)

Identification of Overexpressed Genes in Malignant Pleural Mesothelioma.

Morani F, Bisceglia L, Rosini G, Mutti L, Melaiu O, Landi S, Gemignani F
International journal of molecular sciences 2021 Mar 8;22(5)

Generation of Thyroid Tissues From Embryonic Stem Cells via Blastocyst Complementation In Vivo.

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Frontiers in endocrinology 2020;11:609697

The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I.

Zhou C, Miao Y, Cui Z, ShiYang X, Zhang Y, Xiong B
Science advances 2020 Apr;6(15):eaax3969

miR-30a-3p Targets MAD2L1 and Regulates Proliferation of Gastric Cancer Cells.

Wang Y, Wang F, He J, Du J, Zhang H, Shi H, Chen Y, Wei Y, Xue W, Yan J, Feng Y, Gao Y, Li D, Han J, Zhang J
OncoTargets and therapy 2019;12:11313-11324

ULK1 phosphorylates Mad1 to regulate spindle assembly checkpoint.

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Nucleic acids research 2019 Sep 5;47(15):8096-8110

Nucleoporin35 is a novel microtubule associated protein functioning in oocyte meiotic spindle architecture.

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Experimental cell research 2018 Oct 15;371(2):435-443

KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells.

Zhu ZC, Liu JW, Li K, Zheng J, Xiong ZQ
Oncogene 2018 May;37(22):2936-2952

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Probing the cell death signaling pathway of HepG2 cell line induced by copper-1,10-phenanthroline complex.

Wu J, Chen W, Yin Y, Zheng Z, Zou G
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Expression of the mitotic-arrest deficiency 2 is associated with chemotherapy resistance in ovarian serous adenocarcinoma.

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Oncology reports 2012 Oct;28(4):1200-4

Expression of mitotic-arrest deficiency 2 predicts the efficacy of neoadjuvant chemotherapy for locally advanced uterine cervical cancer.

Morishita M, Sumi T, Nakano Y, Teramae M, Fukuda T, Nobeyama H, Yoshida H, Matsumoto Y, Yasui T, Ishiko O
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Mitotic arrest deficiency 2 induces carcinogenesis in mucinous ovarian tumors.

Nakano Y, Sumi T, Morishita M, Fukuda T, Nobeyama H, Yoshida H, Matsumoto Y, Yasui T, Ishiko O
Oncology letters 2012 Feb;3(2):281-286

Mitotic arrest defective protein 2 expression abnormality and its clinicopathologic significance in human osteosarcoma.

Yu L, Guo WC, Zhao SH, Tang J, Chen JL
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He F, Mo L, Zheng XY, Hu C, Lepor H, Lee EY, Sun TT, Wu XR
Cancer research 2009 Dec 15;69(24):9413-21

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HEK-293 cells were subjected to SDS PAGE followed by western blot with 10337-1-AP(MAD2L1 antibody) at dilution of 1:800
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The MAD2L1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MAD2L1. This antibody recognizes human, mouse, rat antigen. The MAD2L1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 10337-1-AP.pdf

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