15816-1-AP

antibody from Proteintech Group

Targeting: PRDX1 NKEFA, PAGA

Provider product page for 15816-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [37]
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Validations
Western blot [1]
Immunocytochemistry [1]
Immunoprecipitation [1]

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Product number: 15816-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#15816-1-AP, RRID:AB_2170318
Product name: PRDX1 antibody
Antibody type: Polyclonal
Description: KD/KO validated PRDX1 antibody (Cat. #15816-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PRDX1 protein structure - 15816-1-AP shown in red.

Submitted references Peroxiredoxin-1 as a molecular chaperone that regulates glutathione S-transferase P1 activity and drives mutidrug resistance in ovarian cancer cells.

Fan C, Yuan S, Zhang Y, Nie Y, Xiang L, Luo T, Xi Q, Zhang Y, Gu Z, Wang P, Zhou H
Biochemistry and biophysics reports 2024 Mar;37:101639

Induction of Peroxiredoxin 1 by Hypoxia Promotes Cellular Autophagy and Cell Proliferation in Oral Leukoplakia via HIF-1α/BNIP3 Pathway.

Li J, Li W, Li L, Wang W, Zhang M, Tang X
Journal of molecular histology 2024 Aug;55(4):403-413

Physalin H ameliorates LPS-induced acute lung injury via KEAP1/NRF2 axis.

Cai Y, Zhu J, Zhu L, Hong L, Zhang J, Kong L, Chen C, Luo J
International immunopharmacology 2024 Apr 20;131:111789

A novel cuproptosis pattern and tumor immune microenvironment characterization in urothelial carcinoma of the bladder.

Feng H, Deng Z, Huang Y, Liu Z, Ruan Y, Wang T, Liu J
Frontiers in immunology 2023;14:1219209

Chronic exposure to low-dose deltamethrin can lead to colon tissue injury through PRDX1 inactivation-induced mitochondrial oxidative stress injury and gut microbial dysbiosis.

Ma R, Sun T, Wang X, Ren K, Min T, Xie X, Wang D, Li K, Zhang Y, Zhu K, Mo C, Dang C, Yang Y, Zhang H
Ecotoxicology and environmental safety 2023 Oct 1;264:115475

Effect of peroxiredoxin 1 on the regulation of trophoblast function by affecting autophagy and oxidative stress in preeclampsia.

Zhou M, Guo J, Li S, Li A, Fang Z, Zhao M, Zhang M, Wang X
Journal of assisted reproduction and genetics 2023 Jul;40(7):1573-1587

Conoidin A, a Covalent Inhibitor of Peroxiredoxin 2, Reduces Growth of Glioblastoma Cells by Triggering ROS Production.

Szeliga M, Rola R
Cells 2023 Jul 26;12(15)

Periplocin exerts antitumor activity by regulating Nrf2-mediated signaling pathway in gemcitabine-resistant pancreatic cancer cells.

Bae ES, Byun WS, Ock CW, Kim WK, Park HJ, Lee SK
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jan;157:114039

EEF1A2 accelerates the protein translation of chemokine in rat myocardial cells induced by ischemia-reperfusion.

Zhang ZJ, Sun ZX, Liu HJ
Heliyon 2023 Apr;9(4):e15305

Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells.

Li J, Sun Y, Zhao X, Ma Y, Xie Y, Liu S, Hui B, Shi X, Sun X, Zhang X
Cell death & disease 2023 Apr 8;14(4):259

Hepatic AMPK signaling dynamic activation in response to REDOX balance are sentinel biomarkers of exercise and antioxidant intervention to improve blood glucose control.

Wu M, Zhao A, Yan X, Gao H, Zhang C, Liu X, Luo Q, Xie F, Liu S, Shi D
eLife 2022 Sep 26;11

Oxidative stress as a candidate mechanism for accelerated neuroectodermal differentiation due to trisomy 21.

Prutton KM, Marentette JO, Leifheit BA, Esquer H, LaBarbera DV, Anderson CC, Maclean KN, Roede JR
Free radical biology & medicine 2022 Jun;186:32-42

Selenium Status in Diet Affects Nephrotoxicity Induced by Cisplatin in Mice.

Liu S, Wen X, Huang Q, Zhu M, Lu J
Antioxidants (Basel, Switzerland) 2022 Jun 10;11(6)

Methylene blue prevents osteoarthritis progression and relieves pain in rats via upregulation of Nrf2/PRDX1.

Li JW, Wang RL, Xu J, Sun KY, Jiang HM, Sun ZY, Lv ZY, Xu XQ, Wu R, Guo H, Jiang Q, Shi DQ
Acta pharmacologica Sinica 2022 Feb;43(2):417-428

Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance.

Huang H, Zhang S, Li Y, Liu Z, Mi L, Cai Y, Wang X, Chen L, Ran H, Xiao D, Li F, Wu J, Li T, Han Q, Chen L, Pan X, Li H, Li T, He K, Li A, Zhang X, Zhou T, Xia Q, Man J
Nature communications 2021 Jun 17;12(1):3720

Selenium Status in Diet Affects Acetaminophen-Induced Hepatotoxicity via Interruption of Redox Environment.

Li J, Cheng P, Li S, Zhao P, Han B, Ren X, Zhong JL, Lloyd MD, Pourzand C, Holmgren A, Lu J
Antioxidants & redox signaling 2021 Jun 10;34(17):1355-1367

Maneb alters central carbon metabolism and thiol redox status in a toxicant model of Parkinson's disease.

Anderson CC, Marentette JO, Rauniyar AK, Prutton KM, Khatri M, Matheson C, Reisz JA, Reigan P, D'Alessandro A, Roede JR
Free radical biology & medicine 2021 Jan;162:65-76

Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon.

Chowdhury AR, Zielonka J, Kalyanaraman B, Hartley RC, Murphy MP, Avadhani NG
Redox biology 2020 Sep;36:101606

Short hairpin RNA attenuates liver fibrosis by regulating the PPAR‑γ and NF‑κB pathways in HBV‑induced liver fibrosis in mice.

Ye L, Chen T, Cao J, Sun L, Li W, Zhang C
International journal of oncology 2020 Nov;57(5):1116-1128

Peroxiredoxins are involved in the pathogenesis of multiple sclerosis and neuromyelitis optica spectrum disorder.

Uzawa A, Mori M, Masuda H, Ohtani R, Uchida T, Aoki R, Kuwabara S
Clinical and experimental immunology 2020 Nov;202(2):239-248

Direct Proteomic Mapping of Cysteine Persulfidation.

Fu L, Liu K, He J, Tian C, Yu X, Yang J
Antioxidants & redox signaling 2020 Nov 20;33(15):1061-1076

MS-275 combined with cisplatin exerts synergistic antitumor effects in human esophageal squamous cell carcinoma cells.

Liu T, Guan F, Wang Y, Zhang Z, Li Y, Cui Y, Li Z, Liu H, Zhang Y, Wang Y, Ma S
Toxicology and applied pharmacology 2020 May 15;395:114971

β-Elemene enhances radiosensitivity in non-small-cell lung cancer by inhibiting epithelial-mesenchymal transition and cancer stem cell traits via Prx-1/NF-kB/iNOS signaling pathway.

Zou K, Li Z, Zhang Y, Mu L, Chen M, Wang R, Deng W, Zou L, Liu J
Aging 2020 Dec 9;13(2):2575-2592

Cyclovirobuxine D protects against diabetic cardiomyopathy by activating Nrf2-mediated antioxidant responses.

Jiang Z, Fu L, Xu Y, Hu X, Yang H, Zhang Y, Luo H, Gan S, Tao L, Liang G, Shen X
Scientific reports 2020 Apr 14;10(1):6427

The double inhibition of PDK1 and STAT3-Y705 prevents liver metastasis in colorectal cancer.

Qin W, Tian Y, Zhang J, Liu W, Zhou Q, Hu S, Yang F, Lu L, Lu H, Cui S, Wen L, Wei S
Scientific reports 2019 Sep 10;9(1):12973

MicroRNA-596 acts as a tumor suppressor in gastric cancer and is upregulated by promotor demethylation.

Zhang Z, Dai DQ
World journal of gastroenterology 2019 Mar 14;25(10):1224-1237

Proteomic analysis of retinal pigment epithelium cells after exposure to UVA radiation.

Chen JL, Hung CT, Keller JJ, Lin HC, Wu YJ
BMC ophthalmology 2019 Aug 2;19(1):168

Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin.

Zhu H, Wang B, Kong L, An T, Li G, Zhou H, Gong L, Zhao Z, Gong Y, Sun H, Puno P, Li Y
Cell chemical biology 2019 Aug 15;26(8):1122-1132.e6

Luteolin ameliorates rat myocardial ischaemia-reperfusion injury through activation of peroxiredoxin II.

Wei B, Lin Q, Ji YG, Zhao YC, Ding LN, Zhou WJ, Zhang LH, Gao CY, Zhao W
British journal of pharmacology 2018 Aug;175(16):3315-3332

Inhibition of HDAC6 increases acetylation of peroxiredoxin1/2 and ameliorates 6-OHDA induced dopaminergic injury.

Jian W, Wei X, Chen L, Wang Z, Sun Y, Zhu S, Lou H, Yan S, Li X, Zhou J, Zhang B
Neuroscience letters 2017 Sep 29;658:114-120

Nucleophosmin Regulates Intracellular Oxidative Stress Homeostasis via Antioxidant PRDX6.

Liu GY, Shi JX, Shi SL, Liu F, Rui G, Li X, Gao LB, Deng XL, Li QF
Journal of cellular biochemistry 2017 Dec;118(12):4697-4707

The role of peroxiredoxin I in cisplatin-induced ototoxicity.

Le Q, Tabuchi K, Warabi E, Hara A
Auris, nasus, larynx 2017 Apr;44(2):205-212

Glutaredoxins concomitant with optimal ROS activate AMPK through S-glutathionylation to improve glucose metabolism in type 2 diabetes.

Dong K, Wu M, Liu X, Huang Y, Zhang D, Wang Y, Yan LJ, Shi D
Free radical biology & medicine 2016 Dec;101:334-347

Proteomic study reveals a co-occurrence of gallic acid-induced apoptosis and glycolysis in B16F10 melanoma cells.

Liu C, Lin JJ, Yang ZY, Tsai CC, Hsu JL, Wu YJ
Journal of agricultural and food chemistry 2014 Dec 3;62(48):11672-80

The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.

Wu H, Xiao Y, Zhang S, Ji S, Wei L, Fan F, Geng J, Tian J, Sun X, Qin F, Jin C, Lin J, Yin ZY, Zhang T, Luo L, Li Y, Song S, Lin SC, Deng X, Camargo F, Avruch J, Chen L, Zhou D
Cell reports 2013 May 30;3(5):1663-77

Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo.

Zhao X, Cong X, Zheng L, Xu L, Yin L, Peng J
Toxicology letters 2012 Oct 2;214(1):69-80

Identification of human host proteins contributing to H5N1 influenza virus propagation by membrane proteomics.

Liu C, Zhang A, Guo J, Yang J, Zhou H, Chen H, Jin M
Journal of proteome research 2012 Nov 2;11(11):5396-405

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HEK-293 cells were subjected to SDS PAGE followed by western blot with 15816-1-AP(PRDX1 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The PRDX1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PRDX1. This antibody recognizes human, mouse, rat antigen. The PRDX1 antibody has been validated for the following applications: ELISA, WB, IF, IHC, IP analysis.
Appendix: 15816-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-PRDX1 (IP:15816-1-AP, 3ug; Detection:15816-1-AP 1:1000) with HeLa cells lysate 2400ug.
Sample type: cell line