20355-1-AP

antibody from Proteintech Group

Targeting: SLC16A7 MCT2

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

20355-1-AP

Provider

Proteintech Group

Product name

MCT2 antibody

Antibody type

Polyclonal

Description

MCT2 antibody (Cat. #20355-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB, ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice.

Ji K, Wei H, Wang R, Wu Y, Li C, Gao H, Zhao L
Aging cell 2026 Mar;25(3):e70423

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Investigating the Effect and Mechanism of Protocatechuic Aldehyde on Vascular Dementia Based on Multi-Omics Approach.

Xiao T, Tao J, Tan J, Yi X, Wang Z, Duan X
Biomolecules 2026 Mar 11;16(3)

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Tregs Promote Astrocyte-Neuron Lactate Shuttle via Inhibiting STING Pathway to Improve Neurological Recovery After Ischemic Stroke.

Meng Y, Li X, Bi Y, Duan P, Jin Z, Luo L, Feng W, Li H, Zhao X, Zuo K, Chen J, Li L, Xing Y, Yu M, Cui M, Yu Y, Zhang B
CNS neuroscience & therapeutics 2026 Jan;32(1):e70753

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Structure-guided screening identifies Tucatinib as dual inhibitor for MCT1/2.

Xu B, Zhou X, Shan Y, Shi S, Li J, Liang Q, Wang Z, Zhang M, Wang Y, Pei D, Ye S
EMBO reports 2026 Feb;27(3):677-703

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Targeting AARS1-dependent lactylation improves neuronal process plasticity and mitigates cognitive deficits in sepsis-associated encephalopathy.

Luo S, Lyu Z, Huang H, Zhao J, Li Y, Luo Y
Brain, behavior, and immunity 2026 Feb 17;135:106493

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Designed bone-targeting ROS-responsive nanoplatform for precision glycolysis inhibition in postmenopausal osteoporosis.

Wu Q, Miao J, Chen Y, Yang Y, Liang H, Yu C, Wang C, Tu Y, Wu Y, Xu Y, Yang X, Kwan KYH, Shi C, Wang X, Xu J, Jin H
Bioactive materials 2026 Apr;58:1-18

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Strengthening monocarboxylate transporters by adiponectin receptor agonist ameliorates diabetic peripheral neuropathy.

Kim TW, Oum SJ, Lim JH, Kim Y, Kim EN, Jin Y, Hong YA, Chae SY, Choi BS, Kim HW, Park CW
Cell communication and signaling : CCS 2025 Jul 16;23(1):342

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Monitoring Acidification Preceding Aβ Deposition in Alzheimer's Disease.

Zhu G, Zhang H, Xie R, Younis MR, Fu S, Wang X, Liu B, Li K, Lui S, Wu M
Advanced healthcare materials 2025 Apr;14(11):e2404907

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RPE-specific MCT2 expression promotes cone survival in models of retinitis pigmentosa.

Chandler LC, Gardner A, Cepko CL
Proceedings of the National Academy of Sciences of the United States of America 2025 Apr 8;122(14):e2421978122

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Lactate shuttling links histone lactylation to adult hippocampal neurogenesis in mice.

Li Z, Liang Z, Qi H, Luo X, Wang M, Du Z, Guo W
Developmental cell 2025 Apr 21;60(8):1182-1198.e8

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Acetate enables metabolic fitness and cognitive performance during sleep disruption.

He Q, Ji L, Wang Y, Zhang Y, Wang H, Wang J, Zhu Q, Xie M, Ou W, Liu J, Tang K, Lu K, Liu Q, Zhou J, Zhao R, Cai X, Li N, Cao Y, Li T
Cell metabolism 2024 Sep 3;36(9):1998-2014.e15

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Endo-Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1-Null Rat Hippocampus.

Wang Y, Yang Y, Cai Y, Aobulikasimu A, Wang Y, Hu C, Miao Z, Shao Y, Zhao M, Hu Y, Xu C, Chen X, Li Z, Chen J, Wang L, Chen S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2407709

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Fibroblast growth factor 21 enhances learning and memory performance in mice by regulating hippocampal L-lactate homeostasis.

Xie J, Yan J, Ji K, Guo Y, Xu S, Shen D, Li C, Gao H, Zhao L
International journal of biological macromolecules 2024 Jun;271(Pt 2):132667

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Fibroblast growth factor 21 protects the liver from apoptosis in a type 1 diabetes mouse model via regulating L-lactate homeostasis.

Yan J, Xie J, Xu S, Guo Y, Ji K, Li C, Gao H, Zhao L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115737

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Autoregulation of H(+)/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production.

Blaszczak W, Williams H, Swietach P
British journal of cancer 2022 Oct;127(7):1365-1377

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ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.

Dong S, Liang S, Cheng Z, Zhang X, Luo L, Li L, Zhang W, Li S, Xu Q, Zhong M, Zhu J, Zhang G, Hu S
Journal of experimental & clinical cancer research : CR 2022 Jan 8;41(1):15

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MCT2 overexpression promotes recovery of cognitive function by increasing mitochondrial biogenesis in a rat model of stroke.

Yu X, Zhang R, Wei C, Gao Y, Yu Y, Wang L, Jiang J, Zhang X, Li J, Chen X
Animal cells and systems 2021;25(2):93-101