SLC39A5

The protein encoded by this gene belongs to the ZIP family of zinc transporters that transport zinc into cells from outside, and play a crucial role in controlling intracellular zinc levels. Zinc is an essential cofactor for many enzymes and proteins involved in gene transcription, growth, development and differentiation. Mutations in this gene have been associated with autosomal dominant high myopia (MYP24). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Description

Solute carrier family 39 member 5

Tissue specificity

Group enriched (intestine, kidney, liver, pancreas)

Subcell location

Nucleoplasm, Vesicles

Predicted location

Intracellular, Membrane

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

12 (56230049 - 56237846)

Ensembl ID

ENSG00000139540  (ver. 103.38)

Orthologs

Mouse Slc39a5: ENSMUSG00000039878

UniProt

Q6ZMH5

neXtProt

NX_Q6ZMH5

Human splice variants
Mouse splice variants

Protein structure