16623-1-AP

antibody from Proteintech Group

Targeting: ACADS ACAD3, SCAD

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

16623-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#16623-1-AP, RRID:AB_10666165

Product name

ACADS antibody

Antibody type

Polyclonal

Description

KD/KO validated ACADS antibody (Cat. #16623-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, monkey and has been validated for the following applications: IHC, IP, WB,ELISA.

Reactivity

Human, Mouse, Rat, Simian

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Apocrine carcinoma of the breast: distinctive metabolic reprogramming and high-frequency PIK3CA mutations revealed by molecular and immunohistochemical analysis.

Nakamura H, Kukita Y, Kittaka N, Kusama H, Nakayama T, Tamaki Y, Yoshida KI, Kunimasa K, Imamura F, Yagi T
Histopathology 2026 Mar;88(4):790-809

---

Short-chain acyl-CoA dehydrogenase initiates mtDNA demethylation and leakage to fuel antitumor immunity in colorectal cancer.

Yang F, Wang M, Hu S, Guan X, Zhao K, Zhou Y, Yao H, Zhang T, Li L, Gao Y, Zhao S, Liu N, Xiao W, Xiang Y, Miao H
Signal transduction and targeted therapy 2026 Mar 26;11(1)

---

NAT10 regulates heart development and function by maintaining the expression of genes related to fatty acid β-oxidation and heart contraction.

Shi L, Zhang M, Yang H, Li X, He S, Chu Y, Gao M, Zhang Z, Zhang JZ, Li Z, Chen Z
Cell death and differentiation 2026 Feb;33(2):358-373

---

Artemether ameliorates type 1 diabetes mellitus by modulating glycolipid metabolism in skeletal muscle.

Dong Y, Fu Q, Zhang Y, Weng W, Han P, Cai Y, Sun H
American journal of translational research 2025;17(8):5871-5884

---

ACADS Suppresses Proliferation of Colorectal Cancer Cells via ROS-Triggered Autophagy and Degradation of CDK2.

Ma Y, Tong M, Zhu B, Chen L, Xu C, Cao G, Wang J, Xue Z, Xie Q, Zhang X, Huang C, Zhao L, Huang H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 31;39(14):e70878

---

Multi-omics integrated analysis to generate transcriptome and protome profiles of resveratrol improving Paraquat-induced acute lung injury.

Xu Z, Huang L, Yu Z, Gao Y, Wang R, Du B, Cui X, Yuan J
Ecotoxicology and environmental safety 2025 Jul 15;300:118459

---

Artemether regulates liver glycogen and lipid utilization through mitochondrial pyruvate oxidation in db/db mice.

Weng W, Shen L, Yu X, Yuan R, Shao M, Han P, Sun H
American journal of translational research 2024;16(1):27-38

---

Targeting Erbin-mitochondria axis in platelets/megakaryocytes promotes B cell-mediated antitumor immunity.

Zhang Z, Xu X, Zhang D, Zhao S, Wang C, Zhang G, Chen W, Liu J, Gong H, Rixiati Y, Li S, Shen T, Li J
Cell metabolism 2024 Mar 5;36(3):541-556.e9

---

Mitochondrial glycerol 3-phosphate dehydrogenase deficiency exacerbates lipotoxic cardiomyopathy.

Qu H, Liu X, Zhu J, He N, He Q, Zhang L, Wang Y, Gong X, Xiong X, Liu J, Wang C, Yang G, Yang Q, Luo G, Zhu Z, Zheng Y, Zheng H
iScience 2024 Jun 21;27(6):109796

---

YBX1 as a prognostic biomarker and potential therapeutic target in hepatocellular carcinoma: A comprehensive investigation through bioinformatics analysis and in vitro study.

Li Z, Lu W, Yin F, Huang A
Translational oncology 2024 Jul;45:101965

---

Ginsenoside Rb1 regulates CPT1A deacetylation to inhibit intramuscular fat infiltration after rotator cuff tear.

Yin Y, Wang Z, Yang Y, Shen M, Hu H, Chen C, Zhou H, Li Z, Wu S
iScience 2024 Jul 19;27(7):110331

---

Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation.

Mao Y, Zhang J, Zhou Q, He X, Zheng Z, Wei Y, Zhou K, Lin Y, Yu H, Zhang H, Zhou Y, Lin P, Wu B, Yuan Y, Zhao J, Xu W, Zhao S
Cell research 2024 Jan;34(1):13-30

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Comparison of the stage-dependent mitochondrial changes in response to pressure overload between the diseased right and left ventricle in the rat.

Li L, Niemann B, Knapp F, Werner S, Mühlfeld C, Schneider JP, Jurida LM, Molenda N, Schmitz ML, Yin X, Mayr M, Schulz R, Kracht M, Rohrbach S
Basic research in cardiology 2024 Aug;119(4):587-611

---

Riboflavin ameliorates pathological cardiac hypertrophy and fibrosis through the activation of short-chain acyl-CoA dehydrogenase.

Peng H, Xie M, Zhong X, Su Y, Qin X, Xu Q, Zhou S
European journal of pharmacology 2023 Sep 5;954:175849

---

Short-chain acyl-CoA dehydrogenase is a potential target for the treatment of vascular remodelling.

Zhong X, Li Z, Xu Q, Peng H, Su Y, Le K, Shu Z, Liao Y, Ma Z, Pan X, Xu S, Zhou S
Journal of hypertension 2023 May 1;41(5):775-793

---

Riboflavin protects against heart failure via SCAD-dependent DJ-1-Keap1-Nrf2 signalling pathway.

Xu Q, Cao Y, Zhong X, Qin X, Feng J, Peng H, Su Y, Ma Z, Zhou S
British journal of pharmacology 2023 Dec;180(23):3024-3044

---

Dietary iron overload mitigates atherosclerosis in high-fat diet-fed apolipoprotein E knockout mice: Role of dysregulated hepatic fatty acid metabolism.

Xiao L, Luo G, Li H, Yao P, Tang Y
Biochimica et biophysica acta. Molecular and cell biology of lipids 2021 Oct;1866(10):159004

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Increased fatty acid oxidation enzyme activity in the hearts of mice fed a high fat diet does not correlate with improved cardiac contractile function.

Thapa D, Manning JR, Mushala BAS, Stoner MW, Zhang M, Scott I
Current research in physiology 2020 Dec;3:44-49

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Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.

Zhang Y, Li C, Hu C, Wu Q, Cai Y, Xing S, Lu H, Wang L, Huang D, Sun L, Li T, He X, Zhong X, Wang J, Gao P, Smith ZJ, Jia W, Zhang H
EMBO reports 2019 Oct 4;20(10):e48115

---

ACADS acts as a potential methylation biomarker associated with the proliferation and metastasis of hepatocellular carcinomas.

Chen D, Feng X, Lv Z, Xu X, Lu Y, Wu W, Wu H, Liu H, Cao L, Ye S, Chen J, Wu J
Aging 2019 Oct 25;11(20):8825-8844

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Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.

Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2019 Aug 1;10(8):5240-5241

---

Acetylation of mitochondrial proteins by GCN5L1 promotes enhanced fatty acid oxidation in the heart.

Thapa D, Zhang M, Manning JR, Guimarães DA, Stoner MW, O'Doherty RM, Shiva S, Scott I
American journal of physiology. Heart and circulatory physiology 2017 Aug 1;313(2):H265-H274

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Potent effects of dioscin against obesity in mice.

Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, Zhao Y, Sun H, Yao J, Lin Y, Liu K, Peng J
Scientific reports 2015 Jan 22;5:7973

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HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression.

Huang D, Li T, Li X, Zhang L, Sun L, He X, Zhong X, Jia D, Song L, Semenza GL, Gao P, Zhang H
Cell reports 2014 Sep 25;8(6):1930-1942

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Protective effects of dioscin against alcohol-induced liver injury.

Xu T, Zheng L, Xu L, Yin L, Qi Y, Xu Y, Han X, Peng J
Archives of toxicology 2014 Mar;88(3):739-53

---

Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.

Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2014 Dec;5(12):3065-3075

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

human brain tissue were subjected to SDS PAGE followed by western blot with 16623-1-AP(ACADS antibody) at dilution of 1:500

Sample type

tissue

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human kidney using 16623-1-AP(ACADS antibody) at dilution of 1:100 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The ACADS antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human ACADS. This antibody recognizes human,mouse,rat, monkey antigen. The ACADS antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

16623-1-AP.pdf

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