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- References [6]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 19565-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19565-1-AP, RRID:AB_10638485
- Product name
- KCC2/SLC12A5-Specific antibody
- Antibody type
- Polyclonal
- Description
- KCC2/SLC12A5-Specific antibody (Cat. #19565-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references 1,2-Dichloroethane causes anxiety and cognitive dysfunction in mice by disturbing GABA metabolism and inhibiting the cAMP-PKA-CREB signaling pathway.
Partially brain effects of injection of human umbilical cord mesenchymal stem cells at injury sites in a mouse model of thoracic spinal cord contusion.
Time-restricted feeding entrains long-term behavioral changes through the IGF2-KCC2 pathway.
Involvement of the BDNF-TrkB-KCC2 pathway in neuropathic pain after brachial plexus avulsion.
Restoration of KCC2 Membrane Localization in Striatal Dopamine D2 Receptor-Expressing Medium Spiny Neurons Rescues Locomotor Deficits in HIV Tat-Transgenic Mice.
HIV and opiates dysregulate K(+)- Cl(-) cotransporter 2 (KCC2) to cause GABAergic dysfunction in primary human neurons and Tat-transgenic mice.
Qin Y, Huang W, Wang Z, Wang C, Wang C, Zhang M, Wu S, Wang G, Zhao F
Ecotoxicology and environmental safety 2024 Jul 1;279:116464
Ecotoxicology and environmental safety 2024 Jul 1;279:116464
Partially brain effects of injection of human umbilical cord mesenchymal stem cells at injury sites in a mouse model of thoracic spinal cord contusion.
Hu H, Long H, Ren Z, Liu T, Xu J, Xiao F
Frontiers in molecular neuroscience 2023;16:1179175
Frontiers in molecular neuroscience 2023;16:1179175
Time-restricted feeding entrains long-term behavioral changes through the IGF2-KCC2 pathway.
Zhai Q, Zeng Y, Gu Y, Li Z, Zhang T, Yuan B, Wang T, Yan J, Qin H, Yang L, Chen X, Vidal-Puig A, Xu Y
iScience 2022 May 20;25(5):104267
iScience 2022 May 20;25(5):104267
Involvement of the BDNF-TrkB-KCC2 pathway in neuropathic pain after brachial plexus avulsion.
Zhao S, Wang F, Wang L, Xu Y, Lv L, Duan W, Bai R, Meng Z, Shao X
Brain and behavior 2022 Mar;12(3):e2464
Brain and behavior 2022 Mar;12(3):e2464
Restoration of KCC2 Membrane Localization in Striatal Dopamine D2 Receptor-Expressing Medium Spiny Neurons Rescues Locomotor Deficits in HIV Tat-Transgenic Mice.
Barbour AJ, Nass SR, Hahn YK, Hauser KF, Knapp PE
ASN neuro 2021 Jan-Dec;13:17590914211022089
ASN neuro 2021 Jan-Dec;13:17590914211022089
HIV and opiates dysregulate K(+)- Cl(-) cotransporter 2 (KCC2) to cause GABAergic dysfunction in primary human neurons and Tat-transgenic mice.
Barbour AJ, Hauser KF, McQuiston AR, Knapp PE
Neurobiology of disease 2020 Jul;141:104878
Neurobiology of disease 2020 Jul;141:104878
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 19565-1-AP(SLC12A5-Specific antibody) at dilution of 1:300
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 19565-1-AP(SLC12A5-Specific antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SLC12A5-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human SLC12A5-Specific. This antibody recognizes human, mouse, rat antigen. The SLC12A5-Specific antibody has been validated for the following applications: ELISA, WB, IHC analysis.
