orb67195

antibody from Biorbyt
Targeting: IDH2
Provider product page for orb67195
Western blot

Antibody data

Product number
orb67195 - Provider product page
Provider
Biorbyt
Product name
IDH2 antibody
Antibody type
Polyclonal
Description
Rabbit polyclonal to IDH2.Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate.These enzymes belong to two distinct subclasses, one utilizes NAD(+) as the electron acceptor andthe other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependentwhich localize to the mitochondrial matrix; and two NADP(+)-dependent, one of which is mitochondrialand the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. IDH2 isthe NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria, which plays a role inintermediary metabolism and energy production. IDH2 may tightly associate or interact with thepyruvate dehydrogenase complex. Defects in IDH2 are the cause of D-2-hydroxyglutaric aciduria type2 (D2HGA2), a neurometabolic disorder causing developmental delay, epilepsy, hypotonia, anddysmorphic features.
Reactivity
Human, Mouse
Host
Rabbit
Conjugate
Unconjugated
Vial size
100 ul
Storage
-20°C
IDH2 protein structure - orb67195 shown in red.