Antibody data
- Antibody Data
- Antigen structure
- References [177]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 13372-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13372-1-AP, RRID:AB_2199611
- Product name
- TFEB antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TFEB antibody (Cat. #13372-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Deficiency of diacylglycerol Kinase ζ promotes Beclin1-mediated autophagy via the mTOR/TFEB signaling pathway: Relevance to maladaptive cardiac hypertrophy.
Impaired TFEB-mediated autophagy-lysosome fusion promotes tubular cell cycle G2/M arrest and renal fibrosis by suppressing ATP6V0C expression and interacting with SNAREs.
MCU promotes the migration of glioma cells by activating p38 through TFEB-mediated autophagy.
Exosomal miR-4645-5p from hypoxic bone marrow mesenchymal stem cells facilitates diabetic wound healing by restoring keratinocyte autophagy.
Autophagic-lysosomal damage induced by swainsonine is protected by trehalose through activation of TFEB-regulated pathway in renal tubular epithelial cells.
LncRNA XXYLT1-AS2 promotes tumor progression via autophagy inhibition through ubiquitinated degradation of TFEB in hepatocellular carcinoma.
Multidimensional autophagy nano-regulator boosts Alzheimer's disease treatment by improving both extra/intraneuronal homeostasis.
Promotion of transcription factor EB-dependent autophagic process by curcumin alleviates arsenic-caused lung oxidative stress and inflammation in mice.
ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis.
Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome.
Theileria parasites sequester host eIF5A to escape elimination by host-mediated autophagy.
Pparα activation stimulates autophagic flux through lipid catabolism-independent route.
Celastrol enhances the viability of random-pattern skin flaps by regulating autophagy through the AMPK-mTOR-TFEB axis.
TFEB ameliorates DEHP-induced neurotoxicity by activating GAL3/TRIM16 axis dependent lysophagy and alleviating lysosomal dysfunction.
Targeting PKD2 aggravates ferritinophagy-mediated ferroptosis via promoting autophagosome-lysosome fusion and enhances efficacy of carboplatin in lung adenocarcinoma.
Transcriptional dysregulation of autophagy in the muscle of a mouse model of Duchenne muscular dystrophy.
Naringin Protects against Non-Alcoholic Fatty Liver Disease by Promoting Autophagic Flux and Lipophagy.
Enriched environment ameliorates fear memory impairments induced by sleep deprivation via inhibiting PIEZO1/calpain/autophagy signaling pathway in the basal forebrain.
Ezrin inhibition alleviates oxidative stress and pyroptosis via regulating TRPML1-calcineurin axis mediated enhancement of autophagy in spinal cord injury.
Effects of α7 nicotinic acetylcholine receptor agonist against α-synuclein-induced neurotoxicity.
TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease.
SMURF1 controls the PPP3/calcineurin complex and TFEB at a regulatory node for lysosomal biogenesis.
Ginsenoside Rb1 alleviates 3-MCPD-induced renal cell pyroptosis by activating mitophagy.
The role of mTORC1/TFEB axis mediated lysosomal biogenesis and autophagy impairment in fluoride neurotoxicity and the intervention effects of resveratrol.
Tangshen formula protects against podocyte apoptosis via enhancing the TFEB-mediated autophagy-lysosome pathway in diabetic nephropathy.
Urolithin A inhibits breast cancer progression via activating TFEB-mediated mitophagy in tumor macrophages.
HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression.
Lysine methylation of PPP1CA by the methyltransferase SUV39H2 disrupts TFEB-dependent autophagy and promotes intervertebral disc degeneration.
Melatonin Restores Autophagic Flux by Activating the Sirt3/TFEB Signaling Pathway to Attenuate Doxorubicin-Induced Cardiomyopathy.
Increased DNMT1 Involvement in the Activation of LO2 Cell Death Induced by Silver Nanoparticles via Promoting TFEB-Dependent Autophagy.
Optineurin tunes outside-in signaling to regulate lysosome biogenesis and phagocytic clearance in the retina.
Sesquiterpenes from Carpesium faberi triggered ROS-induced apoptosis and protective autophagy in hepatocellular carcinoma cells.
TRIM16-mediated lysophagy suppresses high-glucose-accumulated neuronal Aβ.
VPS41-mediated incomplete autophagy aggravates cadmium-induced apoptosis in mouse hepatocytes.
PACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy.
Intermittent hypoxia therapy ameliorates beta-amyloid pathology via TFEB-mediated autophagy in murine Alzheimer's disease.
Dysregulation of the progranulin-driven autophagy-lysosomal pathway mediates secretion of the nuclear protein TDP-43.
Lipopolysaccharide promotes NLRP3 inflammasome activation by inhibiting TFEB-mediated autophagy in NRK-52E cells.
TFEB SUMOylation in macrophages accelerates atherosclerosis by promoting the formation of foam cells through inhibiting lysosomal activity.
TFEB regulates cellular labile iron and prevents ferroptosis in a TfR1-dependent manner.
Grain-sized moxibustion at Zusanli (ST36) promotes hepatic autophagy in rats with hyperlipidemia by regulating the ULK1 and TFEB expression through the AMPK/mTOR signaling pathway.
Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.
The Protective Effect of (-)-Tetrahydroalstonine against OGD/R-Induced Neuronal Injury via Autophagy Regulation.
TFEB coordinates autophagy and pyroptosis as hepatotoxicity responses to ZnO nanoparticles.
PARP1 promotes NLRP3 activation via blocking TFEB-mediated autophagy in rotenone-induced neurodegeneration.
TFEB attenuates hyperglycemia-induced retinal capillary endothelial cells injury via autophagy regulation.
Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells.
Homoplantaginin attenuates high glucose-induced vascular endothelial cell apoptosis through promoting autophagy via the AMPK/TFEB pathway.
De novo missense variants in RRAGC lead to a fatal mTORopathy of early childhood.
Selective autophagy associated with iron overload aggravates non-alcoholic steatohepatitis via ferroptosis.
Phosphorylation of EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) is indispensable for nuclear translocation of TFEB and TFE3 during ER stress.
Acrylamide interferes with autophagy and induces apoptosis in Neuro-2a cells by interfering with TFEB-regulated lysosomal function.
Progranulin Protects against Hyperglycemia-Induced Neuronal Dysfunction through GSK3β Signaling.
Sulforaphane protects microvascular endothelial cells in lower limb ischemia/reperfusion injury mice.
Resveratrol plays an anti-fibrotic and anti-autophagy role by stimulating miR-192-5p expression in urethral fibrosis.
Restoration of c-Src/Fyn Proteins Rescues Mitochondrial Dysfunction in Huntington's Disease.
Ring domains are essential for GATOR2-dependent mTORC1 activation.
Ginsenoside Rb1 induces autophagic lipid degradation via miR-128 targeting TFEB.
Proteome-Wide Analysis Reveals TFEB Targets for Establishment of a Prognostic Signature to Predict Clinical Outcomes of Colorectal Cancer.
The inhibition of TRPML1/TFEB leads to lysosomal biogenesis disorder, contributes to developmental fluoride neurotoxicity.
Autophagy impairment is involved in midazolam-induced lipid droplet accumulation and consequent phagocytosis decrease in BV2 cells.
Exendin-4 alleviates myocardial ischemia reperfusion injury by enhancing autophagy through promoting nuclear translocation of TFEB.
Doxorubicin induces cardiomyocyte death owing to the accumulation of dysfunctional mitochondria by inhibiting the autophagy fusion process.
KDM1A-mediated upregulation of METTL3 ameliorates Alzheimer's disease via enhancing autophagic clearance of p-Tau through m6A-dependent regulation of STUB1.
Paeoniflorin recued hepatotoxicity under zinc oxide nanoparticles exposure via regulation on gut-liver axis and reversal of pyroptosis.
Abnormal Cholesterol Metabolism and Lysosomal Dysfunction Induce Age-Related Hearing Loss by Inhibiting mTORC1-TFEB-Dependent Autophagy.
Hyperoside attenuates pyrrolizidine alkaloids-induced liver injury by ameliorating TFEB-mediated mitochondrial dysfunction.
Overexpression of hepatic pescadillo 1 in obesity induces lipid dysregulation by inhibiting autophagy.
Targeting ANXA7/LAMP5-mTOR axis attenuates spinal cord injury by inhibiting neuronal apoptosis via enhancing autophagy in mice.
STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages.
Chronic Neuronal Inactivity Utilizes the mTOR-TFEB Pathway to Drive Transcription-Dependent Autophagy for Homeostatic Up-Scaling.
Activation of Transcription Factor EB Is Associated With Adipose Tissue Lipolysis in Dairy Cows With Subclinical Ketosis.
Glutamine Availability Regulates the Development of Aging Mediated by mTOR Signaling and Autophagy.
Quercetin protects against palmitate-induced pancreatic β-cell apoptosis by restoring lysosomal function and autophagic flux.
Berberine-mediated REDD1 down-regulation ameliorates senescence of retinal pigment epithelium by interrupting the ROS-DDR positive feedback loop.
Identification of active natural products that induce lysosomal biogenesis by lysosome-based screening and biological evaluation.
Defective autophagy contributes to endometrial epithelial-mesenchymal transition in intrauterine adhesions.
TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2.
Wolframin is a novel regulator of tau pathology and neurodegeneration.
Bioengineered microglia-targeted exosomes facilitate Aβ clearance via enhancing activity of microglial lysosome for promoting cognitive recovery in Alzheimer's disease.
TFEB ameliorates autophagy flux disturbance induced by PBDE-47 via up-regulating autophagy-lysosome fusion.
Restoration of Autophagic Flux Improves Endothelial Function in Diabetes Through Lowering Mitochondrial ROS-Mediated eNOS Monomerization.
SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.
Lysosomal ATP Transporter SLC17A9 Controls Cell Viability via Regulating Cathepsin D.
Hyperphosphatemia-induced degradation of transcription factor EB exacerbates vascular calcification.
GSK-3β inhibition elicits a neuroprotection by restoring lysosomal dysfunction in neurons via facilitation of TFEB nuclear translocation after ischemic stroke.
By restoring autophagic flux and improving mitochondrial function, corosolic acid protects against Dox-induced cardiotoxicity.
EWI2 promotes endolysosome-mediated turnover of growth factor receptors and integrins to suppress lung cancer.
Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goat.
Effect and mechanism of TFEB on pyroptosis in HK-2 cells induced by high glucose.
Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival.
A racemosin B derivative, C25, suppresses breast cancer growth via lysosomal membrane permeabilization and inhibition of autophagic flux.
CCL20/CCR6 axis mediates macrophages to promote proliferation and migration of ESCs by blocking autophagic flux in endometriosis.
Up-regulation of NMRK2 mediated by TFE3 fusions is the key for energy metabolism adaption of Xp11.2 translocation renal cell carcinoma.
Tianma Gouteng Decoction regulates oxidative stress and inflammation in AngII-induced hypertensive mice via transcription factor EB to exert anti-hypertension effect.
Transcription factor EB enhances autophagy and ameliorates palmitate-induced insulin resistance at least partly via upregulating AMPK activity in skeletal muscle cells.
TLR4-Mediated Inflammatory Responses Regulate Exercise-Induced Molecular Adaptations in Mouse Skeletal Muscle.
Activation of FMS-like tyrosine kinase 3 protects against isoprenaline-induced cardiac hypertrophy by improving autophagy and mitochondrial dynamics.
Metformin Alleviates Epirubicin-Induced Endothelial Impairment by Restoring Mitochondrial Homeostasis.
Vitamin D Attenuates Pain and Cartilage Destruction in OA Animals via Enhancing Autophagic Flux and Attenuating Inflammatory Cell Death.
Phillygenin ameliorates nonalcoholic fatty liver disease via TFEB-mediated lysosome biogenesis and lipophagy.
Harmol promotes α-synuclein degradation and improves motor impairment in Parkinson's models via regulating autophagy-lysosome pathway.
Itaconate is a lysosomal inducer that promotes antibacterial innate immunity.
Aerobic Exercise Alleviates Abnormal Autophagy in Brain Cells of APP/PS1 Mice by Upregulating AdipoR1 Levels.
Elabela ameliorates doxorubicin-induced cardiotoxicity by promoting autophagic flux through TFEB pathway.
Tubastatin A Improves Post-Resuscitation Myocardial Dysfunction by Inhibiting NLRP3-Mediated Pyroptosis Through Enhancing Transcription Factor EB Signaling.
Apigenin Alleviates Intervertebral Disc Degeneration via Restoring Autophagy Flux in Nucleus Pulposus Cells.
Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy.
Melibiose Confers a Neuroprotection against Cerebral Ischemia/Reperfusion Injury by Ameliorating Autophagy Flux via Facilitation of TFEB Nuclear Translocation in Neurons.
TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading.
Dysregulation of miR-342-3p in plasma exosomes derived from convalescent AMI patients and its consequences on cardiac repair.
Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy.
TP53/p53-FBXO22-TFEB controls basal autophagy to govern hormesis.
Positive regulation of TFEB and mitophagy by PGC-1α to alleviate LPS-induced acute lung injury in rats.
Apple polyphenol extract alleviates lipid accumulation in free-fatty-acid-exposed HepG2 cells via activating autophagy mediated by SIRT1/AMPK signaling.
20-Deoxyingenol alleviates osteoarthritis by activating TFEB in chondrocytes.
Transcription factor EB (TFEB)-mediated autophagy protects bovine mammary epithelial cells against H(2)O(2)-induced oxidative damage in vitro.
YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases.
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Cisplatin remodels the tumor immune microenvironment via the transcription factor EB in ovarian cancer.
Lysosomal nitric oxide determines transition from autophagy to ferroptosis after exposure to plasma-activated Ringer's lactate.
Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway.
Quercetin alleviates Cadmium-induced autophagy inhibition via TFEB-dependent lysosomal restoration in primary proximal tubular cells.
PMEPA1 and NEDD4 control the proton production of osteoclasts by regulating vesicular trafficking.
Swainsonine promotes apoptosis by impairing lysosomal function and inhibiting autophagic degradation in rat primary renal tubular epithelial cells.
Ginsenoside Rb1 alleviates liver injury induced by 3-chloro-1,2-propanediol by stimulating autophagic flux.
Ajugol enhances TFEB-mediated lysosome biogenesis and lipophagy to alleviate non-alcoholic fatty liver disease.
p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease.
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
TFEB phosphorylation on Serine 211 is induced by autophagy in human synovial fibroblasts and by p62/SQSTM1 overexpression in HEK293 cells.
Programmed cell death 4 modulates lysosomal function by inhibiting TFEB translation.
Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging.
Cardamonin Reduces Acetaminophen-Induced Acute Liver Injury in Mice via Activating Autophagy and NFE2L2 Signaling.
3-Acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages.
HGF protected against diabetic nephropathy via autophagy-lysosome pathway in podocyte by modulating PI3K/Akt-GSK3β-TFEB axis.
Wnt/β-Catenin Signaling Axis Is Required for TFEB-Mediated Gastric Cancer Metastasis and Epithelial-Mesenchymal Transition.
PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming.
Blue light-emitting diode irradiation promotes transcription factor EB-mediated lysosome biogenesis and lysosomal cell death in murine photoreceptor-derived cells.
TFEB-NF-κB inflammatory signaling axis: a novel therapeutic pathway of Dihydrotanshinone I in doxorubicin-induced cardiotoxicity.
Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease.
The Establishment and Application Studies on Precise Lysosome pH Indicator Based on Self-Decomposable Nanoparticles.
Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages.
Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway.
A Self-Assembled α-Synuclein Nanoscavenger for Parkinson's Disease.
LSD1 negatively regulates autophagy in myoblast cells by driving PTEN degradation.
The neuroprotective effects of activated α7 nicotinic acetylcholine receptor against mutant copper-zinc superoxide dismutase 1-mediated toxicity.
TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS.
Activation of α7nACh receptor protects against acute pancreatitis through enhancing TFEB-regulated autophagy.
Remote ischemic postconditioning attenuates damage in rats with chronic cerebral ischemia by upregulating the autophagolysosome pathway via the activation of TFEB.
NAD(+) administration decreases microvascular damage following cardiac ischemia/reperfusion by restoring autophagic flux.
Deregulated MTOR (mechanistic target of rapamycin kinase) is responsible for autophagy defects exacerbating kidney stone development.
Trehalose attenuates renal ischemia-reperfusion injury by enhancing autophagy and inhibiting oxidative stress and inflammation.
Loss of spatacsin impairs cholesterol trafficking and calcium homeostasis.
Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology.
TFEB Probably Involved in Midazolam-Disturbed Lysosomal Homeostasis and Its Induced β-Amyloid Accumulation.
Irisin reverses insulin resistance in C2C12 cells via the p38-MAPK-PGC-1α pathway.
TFEB-mediated Enhancement of the Autophagy-lysosomal Pathway Dually Modulates the Process of Amyloid β-Protein Generation in Neurons.
Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress.
NEO212 induces mitochondrial apoptosis and impairs autophagy flux in ovarian cancer.
Overexpression of transcription factor EB regulates mitochondrial autophagy to protect lipopolysaccharide-induced acute lung injury.
Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP1.
mTORC1 inhibition attenuates necroptosis through RIP1 inhibition-mediated TFEB activation.
Effects of transcription factor EB on oxidative stress and apoptosis induced by high glucose in podocytes.
TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells.
CD36 plays a negative role in the regulation of lipophagy in hepatocytes through an AMPK-dependent pathway.
Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency.
A Critical Role of Autophagy in Regulating Microglia Polarization in Neurodegeneration.
Role of c-Abl-GSK3β Signaling in MPP+-Induced Autophagy-Lysosomal Dysfunction.
Autophagic Modulation by Trehalose Reduces Accumulation of TDP-43 in a Cell Model of Amyotrophic Lateral Sclerosis via TFEB Activation.
TFEB, a potential therapeutic target for osteoarthritis via autophagy regulation.
Secretory carrier membrane protein 5 is an autophagy inhibitor that promotes the secretion of α-synuclein via exosome.
Non-thermal plasma induces a stress response in mesothelioma cells resulting in increased endocytosis, lysosome biogenesis and autophagy.
mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases.
Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells.
MAP1LC3B overexpression protects against Hermansky-Pudlak syndrome type-1-induced defective autophagy in vitro.
Increased Apoptosis of Inflamed Odontoblasts Is Associated with CD47 Loss.
A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition.
Liu Y, Zhang H, Lin Y, Qian P, Yin Y, Zou G, Zhang J, Zhang H
International journal of medical sciences 2024;21(3):439-453
International journal of medical sciences 2024;21(3):439-453
Impaired TFEB-mediated autophagy-lysosome fusion promotes tubular cell cycle G2/M arrest and renal fibrosis by suppressing ATP6V0C expression and interacting with SNAREs.
Ren X, Wang J, Wei H, Li X, Tian Y, Wang Z, Yin Y, Guo Z, Qin Z, Wu M, Zeng X
International journal of biological sciences 2024;20(5):1905-1926
International journal of biological sciences 2024;20(5):1905-1926
MCU promotes the migration of glioma cells by activating p38 through TFEB-mediated autophagy.
Chen J, Lu R, Peng Y, Lai Y, Cai Z, Zheng D, Xie A, Huang K, Liang C, Zhang H
Journal of Cancer 2024;15(5):1257-1270
Journal of Cancer 2024;15(5):1257-1270
Exosomal miR-4645-5p from hypoxic bone marrow mesenchymal stem cells facilitates diabetic wound healing by restoring keratinocyte autophagy.
Shi Y, Wang S, Liu D, Wang Z, Zhu Y, Li J, Xu K, Li F, Wen H, Yang R
Burns & trauma 2024;12:tkad058
Burns & trauma 2024;12:tkad058
Autophagic-lysosomal damage induced by swainsonine is protected by trehalose through activation of TFEB-regulated pathway in renal tubular epithelial cells.
Zhang S, Yin H, Zhang Y, Zhu Y, Zhu X, Zhu W, Tang L, Liu Y, Wu K, Zhao B, Tian Y, Lu H
Chemico-biological interactions 2024 May 1;394:110990
Chemico-biological interactions 2024 May 1;394:110990
LncRNA XXYLT1-AS2 promotes tumor progression via autophagy inhibition through ubiquitinated degradation of TFEB in hepatocellular carcinoma.
Li X, Wu Y, Wang P, Li Y, Gu J, Zhang Y, Yan S, Hu P
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2024 Mar;26(3):698-708
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2024 Mar;26(3):698-708
Multidimensional autophagy nano-regulator boosts Alzheimer's disease treatment by improving both extra/intraneuronal homeostasis.
Li Y, Yang P, Meng R, Xu S, Zhou L, Qian K, Wang P, Cheng Y, Sheng D, Xu M, Wang T, Wu J, Cao J, Zhang Q
Acta pharmaceutica Sinica. B 2024 Mar;14(3):1380-1399
Acta pharmaceutica Sinica. B 2024 Mar;14(3):1380-1399
Promotion of transcription factor EB-dependent autophagic process by curcumin alleviates arsenic-caused lung oxidative stress and inflammation in mice.
Xu G, Chen H, Cong Z, Wang R, Li X, Xie Y, Wang Y, Li B
The Journal of nutritional biochemistry 2024 Mar;125:109550
The Journal of nutritional biochemistry 2024 Mar;125:109550
ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis.
Chen C, Zhang Z, Liu C, Sun P, Liu P, Li X
Cell metabolism 2024 Mar 5;36(3):498-510.e11
Cell metabolism 2024 Mar 5;36(3):498-510.e11
Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome.
Barrow ER, Valionyte E, Baxter CR, Yang Y, Herath S, O'Connell WA, Lopatecka J, Strachan A, Woznica W, Stephenson HN, Fejer G, Sharma V, Lu B, Luo S
Cell reports 2024 Mar 26;43(3):113935
Cell reports 2024 Mar 26;43(3):113935
Theileria parasites sequester host eIF5A to escape elimination by host-mediated autophagy.
Villares M, Lourenço N, Ktorza I, Berthelet J, Panagiotou A, Richard A, Amo A, Koziy Y, Medjkane S, Valente S, Fioravanti R, Pioche-Durieu C, Lignière L, Chevreux G, Mai A, Weitzman JB
Nature communications 2024 Mar 12;15(1):2235
Nature communications 2024 Mar 12;15(1):2235
Pparα activation stimulates autophagic flux through lipid catabolism-independent route.
Zhang YY, Wang JX, Qiao F, Zhang ML, Luo Y, Du ZY
Fish physiology and biochemistry 2024 Jun;50(3):1141-1155
Fish physiology and biochemistry 2024 Jun;50(3):1141-1155
Celastrol enhances the viability of random-pattern skin flaps by regulating autophagy through the AMPK-mTOR-TFEB axis.
Gu M, Li C, Deng Q, Chen X, Lei R
Phytotherapy research : PTR 2024 Jun;38(6):3020-3036
Phytotherapy research : PTR 2024 Jun;38(6):3020-3036
TFEB ameliorates DEHP-induced neurotoxicity by activating GAL3/TRIM16 axis dependent lysophagy and alleviating lysosomal dysfunction.
Xing H, Xu P, Ma Y, Li T, Zhang Y, Ding X, Liu L, Keerman M, Niu Q
Environmental toxicology 2024 Jul;39(7):3779-3789
Environmental toxicology 2024 Jul;39(7):3779-3789
Targeting PKD2 aggravates ferritinophagy-mediated ferroptosis via promoting autophagosome-lysosome fusion and enhances efficacy of carboplatin in lung adenocarcinoma.
Liu Y, Pang Z, Wang Y, Liu J, Wang G, Du J
Chemico-biological interactions 2024 Jan 5;387:110794
Chemico-biological interactions 2024 Jan 5;387:110794
Transcriptional dysregulation of autophagy in the muscle of a mouse model of Duchenne muscular dystrophy.
Nakashima R, Hosoda R, Tatekoshi Y, Iwahara N, Saga Y, Kuno A
Scientific reports 2024 Jan 16;14(1):1365
Scientific reports 2024 Jan 16;14(1):1365
Naringin Protects against Non-Alcoholic Fatty Liver Disease by Promoting Autophagic Flux and Lipophagy.
Guan L, Guo L, Zhang H, Liu H, Zhou W, Zhai Y, Yan X, Men X, Peng L
Molecular nutrition & food research 2024 Feb;68(3):e2200812
Molecular nutrition & food research 2024 Feb;68(3):e2200812
Enriched environment ameliorates fear memory impairments induced by sleep deprivation via inhibiting PIEZO1/calpain/autophagy signaling pathway in the basal forebrain.
Zhang ZQ, Lu Y, Zhang H, Dong SH, Wu YT, Wang SN, Huang AH, Jiang QS, Yin SM
CNS neuroscience & therapeutics 2024 Feb;30(2):e14365
CNS neuroscience & therapeutics 2024 Feb;30(2):e14365
Ezrin inhibition alleviates oxidative stress and pyroptosis via regulating TRPML1-calcineurin axis mediated enhancement of autophagy in spinal cord injury.
Lou J, Jin M, Zhou C, Fan Y, Ni L, Mao Y, Shen H, Li J, Zhang H, Fu C, Mao X, Chen Y, Zhong J, Zhou K, Wang L, Wu J
Free radical biology & medicine 2024 Feb 20;212:133-148
Free radical biology & medicine 2024 Feb 20;212:133-148
Effects of α7 nicotinic acetylcholine receptor agonist against α-synuclein-induced neurotoxicity.
Takizawa S, Ohuchi K, Fujimaki A, Ito T, Murakami T, Kurita H, Inden M
Neuroscience letters 2024 Feb 16;823:137654
Neuroscience letters 2024 Feb 16;823:137654
TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease.
Du Y, Wu M, Song S, Bian Y, Shi Y
Renal failure 2024 Dec;46(1):2338933
Renal failure 2024 Dec;46(1):2338933
SMURF1 controls the PPP3/calcineurin complex and TFEB at a regulatory node for lysosomal biogenesis.
Xia Q, Zheng H, Li Y, Xu W, Wu C, Xu J, Li S, Zhang L, Dong L
Autophagy 2024 Apr;20(4):735-751
Autophagy 2024 Apr;20(4):735-751
Ginsenoside Rb1 alleviates 3-MCPD-induced renal cell pyroptosis by activating mitophagy.
Zhang R, Guan S, Meng Z, Zhang D, Lu J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114522
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114522
The role of mTORC1/TFEB axis mediated lysosomal biogenesis and autophagy impairment in fluoride neurotoxicity and the intervention effects of resveratrol.
Tang H, Hou H, Song L, Tian Z, Liu W, Xia T, Wang A
Journal of hazardous materials 2024 Apr 5;467:133634
Journal of hazardous materials 2024 Apr 5;467:133634
Tangshen formula protects against podocyte apoptosis via enhancing the TFEB-mediated autophagy-lysosome pathway in diabetic nephropathy.
Wang Y, Peng L, Lu X, Zhang H, Zhao H, Zhao T, Yang L, Mao H, Ma F, Liu T, Li P, Zhan Y
Journal of ethnopharmacology 2024 Apr 24;324:117721
Journal of ethnopharmacology 2024 Apr 24;324:117721
Urolithin A inhibits breast cancer progression via activating TFEB-mediated mitophagy in tumor macrophages.
Zheng B, Wang Y, Zhou B, Qian F, Liu D, Ye D, Zhou X, Fang L
Journal of advanced research 2024 Apr 12;
Journal of advanced research 2024 Apr 12;
HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression.
He L, Li H, Li C, Liu ZK, Lu M, Zhang RY, Wu D, Wei D, Shao J, Liu M, Wei HL, Zhang C, Wang Z, Kong LM, Chen ZN, Bian H
Cancer communications (London, England) 2023 Sep;43(9):981-1002
Cancer communications (London, England) 2023 Sep;43(9):981-1002
Lysine methylation of PPP1CA by the methyltransferase SUV39H2 disrupts TFEB-dependent autophagy and promotes intervertebral disc degeneration.
Liang H, Luo R, Li G, Zhang W, Zhu D, Wu D, Zhou X, Tong B, Wang B, Feng X, Wang K, Song Y, Yang C
Cell death and differentiation 2023 Sep;30(9):2135-2150
Cell death and differentiation 2023 Sep;30(9):2135-2150
Melatonin Restores Autophagic Flux by Activating the Sirt3/TFEB Signaling Pathway to Attenuate Doxorubicin-Induced Cardiomyopathy.
Ma Y, Ma J, Lu L, Xiong X, Shao Y, Ren J, Yang J, Liu J
Antioxidants (Basel, Switzerland) 2023 Sep 4;12(9)
Antioxidants (Basel, Switzerland) 2023 Sep 4;12(9)
Increased DNMT1 Involvement in the Activation of LO2 Cell Death Induced by Silver Nanoparticles via Promoting TFEB-Dependent Autophagy.
Chen J, Zheng D, Cai Z, Zhong B, Zhang H, Pan Z, Ling X, Han Y, Meng J, Li H, Chen X, Zhang H, Liu L
Toxics 2023 Sep 4;11(9)
Toxics 2023 Sep 4;11(9)
Optineurin tunes outside-in signaling to regulate lysosome biogenesis and phagocytic clearance in the retina.
Tan LX, Germer CJ, Thamban T, La Cunza N, Lakkaraju A
Current biology : CB 2023 Sep 25;33(18):3805-3820.e7
Current biology : CB 2023 Sep 25;33(18):3805-3820.e7
Sesquiterpenes from Carpesium faberi triggered ROS-induced apoptosis and protective autophagy in hepatocellular carcinoma cells.
Yan Y, Chen J, Peng M, Zhang X, Feng E, Li Q, Guo B, Ding X, Zhang Y, Tang L
Phytochemistry 2023 Oct;214:113805
Phytochemistry 2023 Oct;214:113805
TRIM16-mediated lysophagy suppresses high-glucose-accumulated neuronal Aβ.
Chae CW, Yoon JH, Lim JR, Park JY, Cho JH, Jung YH, Choi GE, Lee HJ, Han HJ
Autophagy 2023 Oct;19(10):2752-2768
Autophagy 2023 Oct;19(10):2752-2768
VPS41-mediated incomplete autophagy aggravates cadmium-induced apoptosis in mouse hepatocytes.
Wang T, Yan L, Wang L, Sun J, Qu H, Ma Y, Song R, Tong X, Zhu J, Yuan Y, Gu J, Bian J, Liu Z, Zou H
Journal of hazardous materials 2023 Oct 5;459:132243
Journal of hazardous materials 2023 Oct 5;459:132243
PACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy.
Yang J, Li L, Li C, Chen W, Liu Y, Luo S, Zhao C, Han Y, Yang M, Zhao H, Jiang N, Xi Y, Tang C, Cai J, Xiao L, Liu H, Sun L
Cell death & disease 2023 Oct 4;14(10):649
Cell death & disease 2023 Oct 4;14(10):649
Intermittent hypoxia therapy ameliorates beta-amyloid pathology via TFEB-mediated autophagy in murine Alzheimer's disease.
Wang X, Xie Y, Chen G, Lu Y, Wang D, Zhu L
Journal of neuroinflammation 2023 Oct 20;20(1):240
Journal of neuroinflammation 2023 Oct 20;20(1):240
Dysregulation of the progranulin-driven autophagy-lysosomal pathway mediates secretion of the nuclear protein TDP-43.
Tanaka Y, Ito SI, Honma Y, Hasegawa M, Kametani F, Suzuki G, Kozuma L, Takeya K, Eto M
The Journal of biological chemistry 2023 Nov;299(11):105272
The Journal of biological chemistry 2023 Nov;299(11):105272
Lipopolysaccharide promotes NLRP3 inflammasome activation by inhibiting TFEB-mediated autophagy in NRK-52E cells.
Song D, Tao W, Liu F, Wu X, Bi H, Shu J, Wang D, Li X
Molecular immunology 2023 Nov;163:127-135
Molecular immunology 2023 Nov;163:127-135
TFEB SUMOylation in macrophages accelerates atherosclerosis by promoting the formation of foam cells through inhibiting lysosomal activity.
Wang K, Zhou W, Hu G, Wang L, Cai R, Tian T
Cellular and molecular life sciences : CMLS 2023 Nov 11;80(12):358
Cellular and molecular life sciences : CMLS 2023 Nov 11;80(12):358
TFEB regulates cellular labile iron and prevents ferroptosis in a TfR1-dependent manner.
Chen L, Ma Y, Ma X, Liu L, Jv X, Li A, Shen Q, Jia W, Qu L, Shi L, Xie J
Free radical biology & medicine 2023 Nov 1;208:445-457
Free radical biology & medicine 2023 Nov 1;208:445-457
Grain-sized moxibustion at Zusanli (ST36) promotes hepatic autophagy in rats with hyperlipidemia by regulating the ULK1 and TFEB expression through the AMPK/mTOR signaling pathway.
Xu Q, Wu H, Zhu H, Lu C, Tao J, Zhou Z, Zhang J
Heliyon 2023 May;9(5):e15316
Heliyon 2023 May;9(5):e15316
Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.
Sampognaro PJ, Arya S, Knudsen GM, Gunderson EL, Sandoval-Perez A, Hodul M, Bowles K, Craik CS, Jacobson MP, Kao AW
Molecular neurodegeneration 2023 May 2;18(1):29
Molecular neurodegeneration 2023 May 2;18(1):29
The Protective Effect of (-)-Tetrahydroalstonine against OGD/R-Induced Neuronal Injury via Autophagy Regulation.
Liao Y, Wang JY, Pan Y, Zou X, Wang C, Peng Y, Ao YL, Lam MF, Zhang X, Zhang XQ, Shi L, Zhang S
Molecules (Basel, Switzerland) 2023 Mar 4;28(5)
Molecules (Basel, Switzerland) 2023 Mar 4;28(5)
TFEB coordinates autophagy and pyroptosis as hepatotoxicity responses to ZnO nanoparticles.
Pei X, Liu D, Li J, Li L, Ding X, Zhang W, Li Z, Xu G, Li C, Li D
The Science of the total environment 2023 Mar 20;865:161242
The Science of the total environment 2023 Mar 20;865:161242
PARP1 promotes NLRP3 activation via blocking TFEB-mediated autophagy in rotenone-induced neurodegeneration.
Zhang H, Xie Z, Peng Y, Xie A, Fu C, Zheng D, Cai Z, Zhong J, Ming Q, Li M, Lu R, Liu X, Chen J
Ecotoxicology and environmental safety 2023 Mar 1;252:114630
Ecotoxicology and environmental safety 2023 Mar 1;252:114630
TFEB attenuates hyperglycemia-induced retinal capillary endothelial cells injury via autophagy regulation.
Cheng Y, Fan H, Liu K, Liu J, Zou H, You Z
Cell biology international 2023 Jun;47(6):1092-1105
Cell biology international 2023 Jun;47(6):1092-1105
Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells.
Li ZB, Jiang L, Ni JD, Xu YH, Liu F, Liu WM, Wang SG, Liu ZQ, Wang CY
Acta pharmacologica Sinica 2023 Jun;44(6):1191-1205
Acta pharmacologica Sinica 2023 Jun;44(6):1191-1205
Homoplantaginin attenuates high glucose-induced vascular endothelial cell apoptosis through promoting autophagy via the AMPK/TFEB pathway.
Fan L, Zhang X, Huang Y, Zhang B, Li W, Shi Q, Lin Y, Wu F
Phytotherapy research : PTR 2023 Jul;37(7):3025-3041
Phytotherapy research : PTR 2023 Jul;37(7):3025-3041
De novo missense variants in RRAGC lead to a fatal mTORopathy of early childhood.
Reijnders MRF, Seibt A, Brugger M, Lamers IJC, Ott T, Klaas O, Horváth J, Rose AMS, Craghill IM, Brunet T, Graf E, Mayerhanser K, Hellebrekers D, Pauck D, Neuen-Jacob E, Rodenburg RJT, Wieczorek D, Klee D, Mayatepek E, Driessen G, Bindermann R, Averdunk L, Lohmeier K, Sinnema M, Stegmann APA, Roepman R, Poulter JA, Distelmaier F
Genetics in medicine : official journal of the American College of Medical Genetics 2023 Jul;25(7):100838
Genetics in medicine : official journal of the American College of Medical Genetics 2023 Jul;25(7):100838
Selective autophagy associated with iron overload aggravates non-alcoholic steatohepatitis via ferroptosis.
Honma K, Kirihara S, Nakayama H, Fukuoka T, Ohara T, Kitamori K, Sato I, Hirohata S, Fujii M, Yamamoto S, Ran S, Watanabe S
Experimental biology and medicine (Maywood, N.J.) 2023 Jul;248(13):1112-1123
Experimental biology and medicine (Maywood, N.J.) 2023 Jul;248(13):1112-1123
Phosphorylation of EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) is indispensable for nuclear translocation of TFEB and TFE3 during ER stress.
Dang TT, Kim MJ, Lee YY, Le HT, Kim KH, Nam S, Hyun SH, Kim HL, Chung SW, Chung HT, Jho EH, Yoshida H, Kim K, Park CY, Lee MS, Back SH
Autophagy 2023 Jul;19(7):2111-2142
Autophagy 2023 Jul;19(7):2111-2142
Acrylamide interferes with autophagy and induces apoptosis in Neuro-2a cells by interfering with TFEB-regulated lysosomal function.
Pang P, Zhang X, Yuan J, Yan H, Yan D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113818
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113818
Progranulin Protects against Hyperglycemia-Induced Neuronal Dysfunction through GSK3β Signaling.
Dedert C, Salih L, Xu F
Cells 2023 Jul 7;12(13)
Cells 2023 Jul 7;12(13)
Sulforaphane protects microvascular endothelial cells in lower limb ischemia/reperfusion injury mice.
Chen F, Zhan J, Al Mamun A, Tao Y, Huang S, Zhao J, Zhang Y, Xu Y, Du S, Lu W, Li X, Chen Z, Xiao J
Food & function 2023 Jul 31;14(15):7176-7194
Food & function 2023 Jul 31;14(15):7176-7194
Resveratrol plays an anti-fibrotic and anti-autophagy role by stimulating miR-192-5p expression in urethral fibrosis.
Lv J, Zhang R, Li D, Liu Y
Functional & integrative genomics 2023 Jul 14;23(3):241
Functional & integrative genomics 2023 Jul 14;23(3):241
Restoration of c-Src/Fyn Proteins Rescues Mitochondrial Dysfunction in Huntington's Disease.
Fão L, Coelho P, Duarte L, Vilaça R, Hayden MR, Mota SI, Rego AC
Antioxidants & redox signaling 2023 Jan;38(1-3):95-114
Antioxidants & redox signaling 2023 Jan;38(1-3):95-114
Ring domains are essential for GATOR2-dependent mTORC1 activation.
Jiang C, Dai X, He S, Zhou H, Fang L, Guo J, Liu S, Zhang T, Pan W, Yu H, Fu T, Li D, Inuzuka H, Wang P, Xiao J, Wei W
Molecular cell 2023 Jan 5;83(1):74-89.e9
Molecular cell 2023 Jan 5;83(1):74-89.e9
Ginsenoside Rb1 induces autophagic lipid degradation via miR-128 targeting TFEB.
Meng Z, Lu J, Ge G, Wang G, Zhang R, Li Y, Guan S, Lu J
Food & function 2023 Jan 3;14(1):240-249
Food & function 2023 Jan 3;14(1):240-249
Proteome-Wide Analysis Reveals TFEB Targets for Establishment of a Prognostic Signature to Predict Clinical Outcomes of Colorectal Cancer.
Huang Z, Zhu S, Han Z, Li C, Liang J, Wang Y, Zhang S, Zhang J
Cancers 2023 Jan 25;15(3)
Cancers 2023 Jan 25;15(3)
The inhibition of TRPML1/TFEB leads to lysosomal biogenesis disorder, contributes to developmental fluoride neurotoxicity.
Zhang J, Tang Y, Hu Z, Xu W, Ma Y, Xu P, Xing H, Niu Q
Ecotoxicology and environmental safety 2023 Jan 15;250:114511
Ecotoxicology and environmental safety 2023 Jan 15;250:114511
Autophagy impairment is involved in midazolam-induced lipid droplet accumulation and consequent phagocytosis decrease in BV2 cells.
Zhu XL, Zhang HW, Peng WJ, Gao S, Yang ZL, Zhang JQ, Liu XS
Biochemical and biophysical research communications 2023 Feb 5;643:147-156
Biochemical and biophysical research communications 2023 Feb 5;643:147-156
Exendin-4 alleviates myocardial ischemia reperfusion injury by enhancing autophagy through promoting nuclear translocation of TFEB.
He W, Tong G, Fan H, Zhen C, Zeng L, Xue L, Chen J, Sun Z, He P
Experimental cell research 2023 Feb 15;423(2):113469
Experimental cell research 2023 Feb 15;423(2):113469
Doxorubicin induces cardiomyocyte death owing to the accumulation of dysfunctional mitochondria by inhibiting the autophagy fusion process.
Toda N, Sato T, Muraoka M, Lin D, Saito M, Li G, Song QC, Yanagisawa T, Yamauchi M
Free radical biology & medicine 2023 Feb 1;195:47-57
Free radical biology & medicine 2023 Feb 1;195:47-57
KDM1A-mediated upregulation of METTL3 ameliorates Alzheimer's disease via enhancing autophagic clearance of p-Tau through m6A-dependent regulation of STUB1.
Tang Z, Cao J, Yao J, Fan X, Zhao J, Zhao M, Duan Q, Han B, Duan S
Free radical biology & medicine 2023 Feb 1;195:343-358
Free radical biology & medicine 2023 Feb 1;195:343-358
Paeoniflorin recued hepatotoxicity under zinc oxide nanoparticles exposure via regulation on gut-liver axis and reversal of pyroptosis.
Pei X, Tang S, Jiang H, Zhang W, Xu G, Zuo Z, Ren Z, Chen C, Shen Y, Li C, Li D
The Science of the total environment 2023 Dec 15;904:166885
The Science of the total environment 2023 Dec 15;904:166885
Abnormal Cholesterol Metabolism and Lysosomal Dysfunction Induce Age-Related Hearing Loss by Inhibiting mTORC1-TFEB-Dependent Autophagy.
Lee YY, Ha J, Kim YS, Ramani S, Sung S, Gil ES, Choo OS, Jang JH, Choung YH
International journal of molecular sciences 2023 Dec 15;24(24)
International journal of molecular sciences 2023 Dec 15;24(24)
Hyperoside attenuates pyrrolizidine alkaloids-induced liver injury by ameliorating TFEB-mediated mitochondrial dysfunction.
Xu J, Xiong A, Wang X, Yan X, Chen Y, Ye X, Wang Z, Ding L, Yang L
Archives of pharmacal research 2023 Aug;46(8):694-712
Archives of pharmacal research 2023 Aug;46(8):694-712
Overexpression of hepatic pescadillo 1 in obesity induces lipid dysregulation by inhibiting autophagy.
Zhou J, Lu Y, Lin Y, Li C, Liu J, Jiang Z, Chen K
Translational research : the journal of laboratory and clinical medicine 2023 Aug;258:1-15
Translational research : the journal of laboratory and clinical medicine 2023 Aug;258:1-15
Targeting ANXA7/LAMP5-mTOR axis attenuates spinal cord injury by inhibiting neuronal apoptosis via enhancing autophagy in mice.
Li N, Chen L, Zhao X, Gu C, Chang Y, Feng S
Cell death discovery 2023 Aug 24;9(1):309
Cell death discovery 2023 Aug 24;9(1):309
STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages.
Liu Y, Sun Q, Zhang C, Ding M, Wang C, Zheng Q, Ma Z, Xu H, Zhou G, Wang X, Cheng Z, Xia H
iScience 2023 Aug 18;26(8):107376
iScience 2023 Aug 18;26(8):107376
Chronic Neuronal Inactivity Utilizes the mTOR-TFEB Pathway to Drive Transcription-Dependent Autophagy for Homeostatic Up-Scaling.
Wang Y, Lin J, Li J, Yan L, Li W, He X, Ma H
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Apr 12;43(15):2631-2652
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Apr 12;43(15):2631-2652
Activation of Transcription Factor EB Is Associated With Adipose Tissue Lipolysis in Dairy Cows With Subclinical Ketosis.
Yu H, Gao X, Loor JJ, Jiang Q, Fang Z, Hao X, Shi Z, Fan M, Chen M, Li X, Liu G, Wang Z, Li X, Du X
Frontiers in veterinary science 2022;9:816064
Frontiers in veterinary science 2022;9:816064
Glutamine Availability Regulates the Development of Aging Mediated by mTOR Signaling and Autophagy.
Zhou J, Chen H, Du J, Tai H, Han X, Huang N, Wang X, Gong H, Yang M, Xiao H
Frontiers in pharmacology 2022;13:924081
Frontiers in pharmacology 2022;13:924081
Quercetin protects against palmitate-induced pancreatic β-cell apoptosis by restoring lysosomal function and autophagic flux.
Liu H, Zhou W, Guo L, Zhang H, Guan L, Yan X, Zhai Y, Qiao Y, Wang Z, Zhao J, Lyu K, Li P, Wang H, Peng L
The Journal of nutritional biochemistry 2022 Sep;107:109060
The Journal of nutritional biochemistry 2022 Sep;107:109060
Berberine-mediated REDD1 down-regulation ameliorates senescence of retinal pigment epithelium by interrupting the ROS-DDR positive feedback loop.
Chen Q, Xin G, Li S, Dong Y, Yu X, Wan C, Wei Z, Zhu Y, Zhang K, Wang Y, Li F, Zhang C, Wen E, Li Y, Niu H, Huang W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154181
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154181
Identification of active natural products that induce lysosomal biogenesis by lysosome-based screening and biological evaluation.
Ding X, Yang X, Zhao Y, Wang Y, Fei J, Niu Z, Dong X, Wang X, Liu B, Li H, Hao X, Zhao Y
Heliyon 2022 Oct;8(10):e11179
Heliyon 2022 Oct;8(10):e11179
Defective autophagy contributes to endometrial epithelial-mesenchymal transition in intrauterine adhesions.
Zhou Z, Wang H, Zhang X, Song M, Yao S, Jiang P, Liu D, Wang Z, Lv H, Li R, Hong Y, Dai J, Hu Y, Zhao G
Autophagy 2022 Oct;18(10):2427-2442
Autophagy 2022 Oct;18(10):2427-2442
TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2.
Yang CB, Liu J, Tong BC, Wang ZY, Zhu Z, Su CF, Sreenivasmurthy SG, Wu JX, Iyaswamy A, Krishnamoorthi S, Huang SY, Cheung KH, Song JX, Tan JQ, Lu JH, Li M
Acta pharmacologica Sinica 2022 May;43(5):1251-1263
Acta pharmacologica Sinica 2022 May;43(5):1251-1263
Wolframin is a novel regulator of tau pathology and neurodegeneration.
Chen S, Acosta D, Li L, Liang J, Chang Y, Wang C, Fitzgerald J, Morrison C, Goulbourne CN, Nakano Y, Villegas NCH, Venkataraman L, Brown C, Serrano GE, Bell E, Wemlinger T, Wu M, Kokiko-Cochran ON, Popovich P, Flowers XE, Honig LS, Vonsattel JP, Scharre DW, Beach TG, Ma Q, Kuret J, Kõks S, Urano F, Duff KE, Fu H
Acta neuropathologica 2022 May;143(5):547-569
Acta neuropathologica 2022 May;143(5):547-569
Bioengineered microglia-targeted exosomes facilitate Aβ clearance via enhancing activity of microglial lysosome for promoting cognitive recovery in Alzheimer's disease.
Hao Y, Su C, Liu X, Sui H, Shi Y, Zhao L
Biomaterials advances 2022 May;136:212770
Biomaterials advances 2022 May;136:212770
TFEB ameliorates autophagy flux disturbance induced by PBDE-47 via up-regulating autophagy-lysosome fusion.
Tang H, Huang H, Wang D, Li P, Tian Z, Li D, Wang S, Ma R, Xia T, Wang A
Journal of hazardous materials 2022 May 15;430:128483
Journal of hazardous materials 2022 May 15;430:128483
Restoration of Autophagic Flux Improves Endothelial Function in Diabetes Through Lowering Mitochondrial ROS-Mediated eNOS Monomerization.
Zhao L, Zhang CL, He L, Chen Q, Liu L, Kang L, Liu J, Luo JY, Gou L, Qu D, Song W, Lau CW, Ko H, Mok VCT, Tian XY, Wang L, Huang Y
Diabetes 2022 May 1;71(5):1099-1114
Diabetes 2022 May 1;71(5):1099-1114
SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.
Zhao Y, Mao A, Zhang R, Guan S, Lu J
Environmental toxicology 2022 Mar;37(3):549-563
Environmental toxicology 2022 Mar;37(3):549-563
Lysosomal ATP Transporter SLC17A9 Controls Cell Viability via Regulating Cathepsin D.
Huang P, Cao Q, Xu M, Dong XP
Cells 2022 Mar 4;11(5)
Cells 2022 Mar 4;11(5)
Hyperphosphatemia-induced degradation of transcription factor EB exacerbates vascular calcification.
Ishiwata R, Morimoto Y
Biochimica et biophysica acta. Molecular basis of disease 2022 Mar 1;1868(3):166323
Biochimica et biophysica acta. Molecular basis of disease 2022 Mar 1;1868(3):166323
GSK-3β inhibition elicits a neuroprotection by restoring lysosomal dysfunction in neurons via facilitation of TFEB nuclear translocation after ischemic stroke.
Zhang Y, Wu Z, Huang Z, Liu Y, Chen X, Zhao X, He H, Deng Y
Brain research 2022 Mar 1;1778:147768
Brain research 2022 Mar 1;1778:147768
By restoring autophagic flux and improving mitochondrial function, corosolic acid protects against Dox-induced cardiotoxicity.
Che Y, Wang Z, Yuan Y, Zhou H, Wu H, Wang S, Tang Q
Cell biology and toxicology 2022 Jun;38(3):451-467
Cell biology and toxicology 2022 Jun;38(3):451-467
EWI2 promotes endolysosome-mediated turnover of growth factor receptors and integrins to suppress lung cancer.
Wang J, Wren JD, Ding Y, Chen J, Mittal N, Xu C, Li X, Zeng C, Wang M, Shi J, Zhang YH, Han SJ, Zhang XA
Cancer letters 2022 Jun 28;536:215641
Cancer letters 2022 Jun 28;536:215641
Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goat.
Wang M, Qi Y, Cao Y, Zhang X, Wang Y, Liu Q, Zhang J, Zhou G, Ai Y, Wei S, Wang L, Liu G, Lian Z, Han H
eLife 2022 Jun 28;11
eLife 2022 Jun 28;11
Effect and mechanism of TFEB on pyroptosis in HK-2 cells induced by high glucose.
Han N, Wang Z, Luo H, Chi Y, Zhang T, Wang B, Li Y
Biochemical and biophysical research communications 2022 Jun 25;610:162-169
Biochemical and biophysical research communications 2022 Jun 25;610:162-169
Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival.
Chen Z, Wu H, Yang J, Li B, Ding J, Cheng S, Bsoul N, Zhang C, Li J, Liu H, Lin D, Gao W
Communications biology 2022 Jun 22;5(1):616
Communications biology 2022 Jun 22;5(1):616
A racemosin B derivative, C25, suppresses breast cancer growth via lysosomal membrane permeabilization and inhibition of autophagic flux.
Xiao X, Chung PED, Xu M, Hu A, Ju Y, Yang X, Song J, Song J, Wang C, Zacksenhaus E, Liu S, He Z, Ben-David Y
Biochemical pharmacology 2022 Jul;201:115060
Biochemical pharmacology 2022 Jul;201:115060
CCL20/CCR6 axis mediates macrophages to promote proliferation and migration of ESCs by blocking autophagic flux in endometriosis.
Tan J, Xu T, Gou Y, Wang H, Liang Z, Cao Y, Wang H, Yu Y, Jiao N, Zhang Z
Stem cell research & therapy 2022 Jul 15;13(1):294
Stem cell research & therapy 2022 Jul 15;13(1):294
Up-regulation of NMRK2 mediated by TFE3 fusions is the key for energy metabolism adaption of Xp11.2 translocation renal cell carcinoma.
Chen Y, Yang L, Lu Y, Liu N, Ma W, Fan H, Hu Q, Han X, Gan W, Li D
Cancer letters 2022 Jul 10;538:215689
Cancer letters 2022 Jul 10;538:215689
Tianma Gouteng Decoction regulates oxidative stress and inflammation in AngII-induced hypertensive mice via transcription factor EB to exert anti-hypertension effect.
Deng L, Liu W, Xu Q, Guo R, Zhang D, Ni J, Li L, Cai X, Fan G, Zhao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jan;145:112383
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jan;145:112383
Transcription factor EB enhances autophagy and ameliorates palmitate-induced insulin resistance at least partly via upregulating AMPK activity in skeletal muscle cells.
Wang P, Li CG, Zhou X, Ding S
Clinical and experimental pharmacology & physiology 2022 Feb;49(2):302-310
Clinical and experimental pharmacology & physiology 2022 Feb;49(2):302-310
TLR4-Mediated Inflammatory Responses Regulate Exercise-Induced Molecular Adaptations in Mouse Skeletal Muscle.
Fujiyoshi H, Egawa T, Kurogi E, Yokokawa T, Kido K, Hayashi T
International journal of molecular sciences 2022 Feb 7;23(3)
International journal of molecular sciences 2022 Feb 7;23(3)
Activation of FMS-like tyrosine kinase 3 protects against isoprenaline-induced cardiac hypertrophy by improving autophagy and mitochondrial dynamics.
Jiang X, Zhang K, Gao C, Ma W, Liu M, Guo X, Bao G, Han B, Hu H, Zhao Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Dec;36(12):e22672
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Dec;36(12):e22672
Metformin Alleviates Epirubicin-Induced Endothelial Impairment by Restoring Mitochondrial Homeostasis.
Sun Q, Jia H, Cheng S, Wang Y, Wang J
International journal of molecular sciences 2022 Dec 25;24(1)
International journal of molecular sciences 2022 Dec 25;24(1)
Vitamin D Attenuates Pain and Cartilage Destruction in OA Animals via Enhancing Autophagic Flux and Attenuating Inflammatory Cell Death.
Jhun J, Woo JS, Kwon JY, Na HS, Cho KH, Kim SA, Kim SJ, Moon SJ, Park SH, Cho ML
Immune network 2022 Aug;22(4):e34
Immune network 2022 Aug;22(4):e34
Phillygenin ameliorates nonalcoholic fatty liver disease via TFEB-mediated lysosome biogenesis and lipophagy.
Zhou W, Yan X, Zhai Y, Liu H, Guan L, Qiao Y, Jiang J, Peng L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Aug;103:154235
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Aug;103:154235
Harmol promotes α-synuclein degradation and improves motor impairment in Parkinson's models via regulating autophagy-lysosome pathway.
Xu J, Ao YL, Huang C, Song X, Zhang G, Cui W, Wang Y, Zhang XQ, Zhang Z
NPJ Parkinson's disease 2022 Aug 6;8(1):100
NPJ Parkinson's disease 2022 Aug 6;8(1):100
Itaconate is a lysosomal inducer that promotes antibacterial innate immunity.
Zhang Z, Chen C, Yang F, Zeng YX, Sun P, Liu P, Li X
Molecular cell 2022 Aug 4;82(15):2844-2857.e10
Molecular cell 2022 Aug 4;82(15):2844-2857.e10
Aerobic Exercise Alleviates Abnormal Autophagy in Brain Cells of APP/PS1 Mice by Upregulating AdipoR1 Levels.
Jian Y, Yuan S, Yang J, Lei Y, Li X, Liu W
International journal of molecular sciences 2022 Aug 31;23(17)
International journal of molecular sciences 2022 Aug 31;23(17)
Elabela ameliorates doxorubicin-induced cardiotoxicity by promoting autophagic flux through TFEB pathway.
Chen D, Yu W, Zhong C, Hong Q, Huang G, Que D, Wang Y, Yang Y, Rui B, Zhuang Z, Liang M, Ye Z, Yan X, Lv J, Zhang R, Yan J, Yang P
Pharmacological research 2022 Apr;178:106186
Pharmacological research 2022 Apr;178:106186
Tubastatin A Improves Post-Resuscitation Myocardial Dysfunction by Inhibiting NLRP3-Mediated Pyroptosis Through Enhancing Transcription Factor EB Signaling.
Xu J, Zhao X, Jiang X, He L, Wu X, Wang J, Chen Q, Li Y, Zhang M
Journal of the American Heart Association 2022 Apr 5;11(7):e024205
Journal of the American Heart Association 2022 Apr 5;11(7):e024205
Apigenin Alleviates Intervertebral Disc Degeneration via Restoring Autophagy Flux in Nucleus Pulposus Cells.
Xie C, Shi Y, Chen Z, Zhou X, Luo P, Hong C, Tian N, Wu Y, Zhou Y, Lin Y, Dou H, Wu A, Huang Q, Zhang X, Wang X
Frontiers in cell and developmental biology 2021;9:787278
Frontiers in cell and developmental biology 2021;9:787278
Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy.
Shyam R, Ogando DG, Choi M, Liton PB, Bonanno JA
Investigative ophthalmology & visual science 2021 Sep 2;62(12):15
Investigative ophthalmology & visual science 2021 Sep 2;62(12):15
Melibiose Confers a Neuroprotection against Cerebral Ischemia/Reperfusion Injury by Ameliorating Autophagy Flux via Facilitation of TFEB Nuclear Translocation in Neurons.
Wu Z, Zhang Y, Liu Y, Chen X, Huang Z, Zhao X, He H, Deng Y
Life (Basel, Switzerland) 2021 Sep 10;11(9)
Life (Basel, Switzerland) 2021 Sep 10;11(9)
TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading.
Xu Y, Du S, Marsh JA, Horie K, Sato C, Ballabio A, Karch CM, Holtzman DM, Zheng H
Molecular psychiatry 2021 Oct;26(10):5925-5939
Molecular psychiatry 2021 Oct;26(10):5925-5939
Dysregulation of miR-342-3p in plasma exosomes derived from convalescent AMI patients and its consequences on cardiac repair.
Wang B, Cao C, Han D, Bai J, Guo J, Guo Q, Li D, Zhang J, Zhang Z, Wang Y, Tang J, Shen D, Zhang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Oct;142:112056
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Oct;142:112056
Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy.
Han Y, Xiong S, Zhao H, Yang S, Yang M, Zhu X, Jiang N, Xiong X, Gao P, Wei L, Xiao Y, Sun L
Cell death & disease 2021 Oct 30;12(11):1031
Cell death & disease 2021 Oct 30;12(11):1031
TP53/p53-FBXO22-TFEB controls basal autophagy to govern hormesis.
Suzuki N, Johmura Y, Wang TW, Migita T, Wu W, Noguchi R, Yamaguchi K, Furukawa Y, Nakamura S, Miyoshi I, Yoshimori T, Ohta T, Nakanishi M
Autophagy 2021 Nov;17(11):3776-3793
Autophagy 2021 Nov;17(11):3776-3793
Positive regulation of TFEB and mitophagy by PGC-1α to alleviate LPS-induced acute lung injury in rats.
Liu W, Li Y, Bo L, Li C, Jin F
Biochemical and biophysical research communications 2021 Nov 5;577:1-5
Biochemical and biophysical research communications 2021 Nov 5;577:1-5
Apple polyphenol extract alleviates lipid accumulation in free-fatty-acid-exposed HepG2 cells via activating autophagy mediated by SIRT1/AMPK signaling.
Li D, Cui Y, Wang X, Liu F, Li X
Phytotherapy research : PTR 2021 Mar;35(3):1416-1431
Phytotherapy research : PTR 2021 Mar;35(3):1416-1431
20-Deoxyingenol alleviates osteoarthritis by activating TFEB in chondrocytes.
Gu M, Jin J, Ren C, Chen X, Pan Z, Wu Y, Tian N, Sun L, Wu A, Gao W, Zhou Y, Lin Z, Zhang X
Pharmacological research 2021 Mar;165:105361
Pharmacological research 2021 Mar;165:105361
Transcription factor EB (TFEB)-mediated autophagy protects bovine mammary epithelial cells against H(2)O(2)-induced oxidative damage in vitro.
Sun X, Chang R, Tang Y, Luo S, Jiang C, Jia H, Xu Q, Dong Z, Liang Y, Loor JJ, Xu C
Journal of animal science and biotechnology 2021 Mar 9;12(1):35
Journal of animal science and biotechnology 2021 Mar 9;12(1):35
YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases.
Ikeda S, Nah J, Shirakabe A, Zhai P, Oka SI, Sciarretta S, Guan KL, Shimokawa H, Sadoshima J
The Journal of clinical investigation 2021 Mar 1;131(5)
The Journal of clinical investigation 2021 Mar 1;131(5)
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Zhang X, Wei M, Fan J, Yan W, Zha X, Song H, Wan R, Yin Y, Wang W
Autophagy 2021 Jun;17(6):1519-1542
Autophagy 2021 Jun;17(6):1519-1542
Cisplatin remodels the tumor immune microenvironment via the transcription factor EB in ovarian cancer.
Liu W, Wang Y, Xie Y, Dai T, Fan M, Li C, Zou Y
Cell death discovery 2021 Jun 5;7(1):136
Cell death discovery 2021 Jun 5;7(1):136
Lysosomal nitric oxide determines transition from autophagy to ferroptosis after exposure to plasma-activated Ringer's lactate.
Jiang L, Zheng H, Lyu Q, Hayashi S, Sato K, Sekido Y, Nakamura K, Tanaka H, Ishikawa K, Kajiyama H, Mizuno M, Hori M, Toyokuni S
Redox biology 2021 Jul;43:101989
Redox biology 2021 Jul;43:101989
Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway.
Fang S, Wan X, Zou X, Sun S, Hao X, Liang C, Zhang Z, Zhang F, Sun B, Li H, Yu B
Cell death & disease 2021 Jan 18;12(1):88
Cell death & disease 2021 Jan 18;12(1):88
Quercetin alleviates Cadmium-induced autophagy inhibition via TFEB-dependent lysosomal restoration in primary proximal tubular cells.
Zhao Y, Li ZF, Zhang D, Wang ZY, Wang L
Ecotoxicology and environmental safety 2021 Jan 15;208:111743
Ecotoxicology and environmental safety 2021 Jan 15;208:111743
PMEPA1 and NEDD4 control the proton production of osteoclasts by regulating vesicular trafficking.
Hirata H, Xu X, Nishioka K, Matsuhisa F, Kitajima S, Kukita T, Murayama M, Urano Y, Miyamoto H, Mawatari M, Kukita A
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21281
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21281
Swainsonine promotes apoptosis by impairing lysosomal function and inhibiting autophagic degradation in rat primary renal tubular epithelial cells.
Wang S, Guo R, Su Y, Yang C, Guo Y, Tan C, Zhao B
Chemico-biological interactions 2021 Feb 25;336:109319
Chemico-biological interactions 2021 Feb 25;336:109319
Ginsenoside Rb1 alleviates liver injury induced by 3-chloro-1,2-propanediol by stimulating autophagic flux.
Lu J, Lu J, Bu X, Li Y, Ge G, Guan S
Journal of food science 2021 Dec;86(12):5503-5515
Journal of food science 2021 Dec;86(12):5503-5515
Ajugol enhances TFEB-mediated lysosome biogenesis and lipophagy to alleviate non-alcoholic fatty liver disease.
Zhang H, Lu J, Liu H, Guan L, Xu S, Wang Z, Qiu Y, Liu H, Peng L, Men X
Pharmacological research 2021 Dec;174:105964
Pharmacological research 2021 Dec;174:105964
p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease.
Chen J, Mao K, Yu H, Wen Y, She H, Zhang H, Liu L, Li M, Li W, Zou F
Journal of neuroinflammation 2021 Dec 20;18(1):295
Journal of neuroinflammation 2021 Dec 20;18(1):295
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Kataura T, Tashiro E, Nishikawa S, Shibahara K, Muraoka Y, Miura M, Sakai S, Katoh N, Totsuka M, Onodera M, Shin-Ya K, Miyamoto K, Sasazawa Y, Hattori N, Saiki S, Imoto M
Autophagy 2021 Aug;17(8):1856-1872
Autophagy 2021 Aug;17(8):1856-1872
TFEB phosphorylation on Serine 211 is induced by autophagy in human synovial fibroblasts and by p62/SQSTM1 overexpression in HEK293 cells.
Relic B, Deroyer C, Malaise O, Plener Z, Gillet P, de Seny D, Malaise MG
The Biochemical journal 2021 Aug 27;478(16):3145-3155
The Biochemical journal 2021 Aug 27;478(16):3145-3155
Programmed cell death 4 modulates lysosomal function by inhibiting TFEB translation.
Chen X, Guan Y, Zhang Y, Jia Y, Li W, Guo C, Li Y, Wang X, Shi Y, Wang Q, Zhu F, Li Y, Zhang L
Cell death and differentiation 2021 Apr;28(4):1237-1250
Cell death and differentiation 2021 Apr;28(4):1237-1250
Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging.
Zhang S, Zhang Y, Zhang X, Luo C, Cao Y, Ji D, Yan W, Xue K, Chai J, Dai H, Wang W
Oxidative medicine and cellular longevity 2020;2020:4252047
Oxidative medicine and cellular longevity 2020;2020:4252047
Cardamonin Reduces Acetaminophen-Induced Acute Liver Injury in Mice via Activating Autophagy and NFE2L2 Signaling.
Xu Q, Fan Y, Loor JJ, Liang Y, Sun X, Jia H, Zhao C, Xu C
Frontiers in pharmacology 2020;11:601716
Frontiers in pharmacology 2020;11:601716
3-Acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages.
Liu N, Yang Y, Chen J, Jia H, Zhang Y, Jiang D, Wu G, Wu Z
Environmental pollution (Barking, Essex : 1987) 2020 Oct;265(Pt B):114697
Environmental pollution (Barking, Essex : 1987) 2020 Oct;265(Pt B):114697
HGF protected against diabetic nephropathy via autophagy-lysosome pathway in podocyte by modulating PI3K/Akt-GSK3β-TFEB axis.
Hou B, Li Y, Li X, Zhang C, Zhao Z, Chen Q, Zhang N, Li H
Cellular signalling 2020 Nov;75:109744
Cellular signalling 2020 Nov;75:109744
Wnt/β-Catenin Signaling Axis Is Required for TFEB-Mediated Gastric Cancer Metastasis and Epithelial-Mesenchymal Transition.
Li S, Liu F, Xu L, Li C, Yang X, Guo B, Gu J, Wang L
Molecular cancer research : MCR 2020 Nov;18(11):1650-1659
Molecular cancer research : MCR 2020 Nov;18(11):1650-1659
PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming.
Ma WQ, Sun XJ, Zhu Y, Liu NF
Cell death & disease 2020 Nov 17;11(11):991
Cell death & disease 2020 Nov 17;11(11):991
Blue light-emitting diode irradiation promotes transcription factor EB-mediated lysosome biogenesis and lysosomal cell death in murine photoreceptor-derived cells.
Otsu W, Ishida K, Nakamura S, Shimazawa M, Tsusaki H, Hara H
Biochemical and biophysical research communications 2020 May 28;526(2):479-484
Biochemical and biophysical research communications 2020 May 28;526(2):479-484
TFEB-NF-κB inflammatory signaling axis: a novel therapeutic pathway of Dihydrotanshinone I in doxorubicin-induced cardiotoxicity.
Wang X, Wang Q, Li W, Zhang Q, Jiang Y, Guo D, Sun X, Lu W, Li C, Wang Y
Journal of experimental & clinical cancer research : CR 2020 May 24;39(1):93
Journal of experimental & clinical cancer research : CR 2020 May 24;39(1):93
Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease.
Mao K, Chen J, Yu H, Li H, Ren Y, Wu X, Wen Y, Zou F, Li W
Aging cell 2020 Jun;19(6):e13163
Aging cell 2020 Jun;19(6):e13163
The Establishment and Application Studies on Precise Lysosome pH Indicator Based on Self-Decomposable Nanoparticles.
Pang C, Song C, Li Y, Wang Q, Zhu X, Wu J, Tian Y, Fan H, Hu J, Li C, Wang B, Li X, Liu W, Fan L
Nanoscale research letters 2020 Jul 8;15(1):143
Nanoscale research letters 2020 Jul 8;15(1):143
Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages.
He X, Chen S, Li C, Ban J, Wei Y, He Y, Liu F, Chen Y, Chen J
Cells 2020 Jan 4;9(1)
Cells 2020 Jan 4;9(1)
Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway.
Sun X, Zhou Y, Zhang R, Wang Z, Xu M, Zhang D, Huang J, Luo F, Li F, Ni Z, Zhou S, Chen H, Chen S, Chen L, Du X, Chen B, Huang H, Liu P, Yin L, Qiu J, Chen D, Deng C, Xie Y, Luo L, Chen L
Nature communications 2020 Jan 24;11(1):479
Nature communications 2020 Jan 24;11(1):479
A Self-Assembled α-Synuclein Nanoscavenger for Parkinson's Disease.
Liu J, Liu C, Zhang J, Zhang Y, Liu K, Song JX, Sreenivasmurthy SG, Wang Z, Shi Y, Chu C, Zhang Y, Wu C, Deng X, Liu X, Song J, Zhuang R, Huang S, Zhang P, Li M, Wen L, Zhang YW, Liu G
ACS nano 2020 Feb 25;14(2):1533-1549
ACS nano 2020 Feb 25;14(2):1533-1549
LSD1 negatively regulates autophagy in myoblast cells by driving PTEN degradation.
Shi YX, He YJ, Zhou Y, Li HK, Yang D, Li RY, Deng ZL, Gao YF
Biochemical and biophysical research communications 2020 Feb 19;522(4):924-930
Biochemical and biophysical research communications 2020 Feb 19;522(4):924-930
The neuroprotective effects of activated α7 nicotinic acetylcholine receptor against mutant copper-zinc superoxide dismutase 1-mediated toxicity.
Ito T, Inden M, Ueda T, Asaka Y, Kurita H, Hozumi I
Scientific reports 2020 Dec 17;10(1):22157
Scientific reports 2020 Dec 17;10(1):22157
TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS.
Cunningham KM, Maulding K, Ruan K, Senturk M, Grima JC, Sung H, Zuo Z, Song H, Gao J, Dubey S, Rothstein JD, Zhang K, Bellen HJ, Lloyd TE
eLife 2020 Dec 10;9
eLife 2020 Dec 10;9
Activation of α7nACh receptor protects against acute pancreatitis through enhancing TFEB-regulated autophagy.
Li B, Wu J, Bao J, Han X, Shen S, Ye X, Dai J, Wu Z, Niu M, He Y, Ni J, Wen L, Wang X, Hu G
Biochimica et biophysica acta. Molecular basis of disease 2020 Dec 1;1866(12):165971
Biochimica et biophysica acta. Molecular basis of disease 2020 Dec 1;1866(12):165971
Remote ischemic postconditioning attenuates damage in rats with chronic cerebral ischemia by upregulating the autophagolysosome pathway via the activation of TFEB.
Li Z, Cui X, Lv H, Liu J, Di W, Jiang F, Liu Y, Cheng X
Experimental and molecular pathology 2020 Aug;115:104475
Experimental and molecular pathology 2020 Aug;115:104475
NAD(+) administration decreases microvascular damage following cardiac ischemia/reperfusion by restoring autophagic flux.
Zhang YJ, Zhang M, Zhao X, Shi K, Ye M, Tian J, Guan S, Ying W, Qu X
Basic research in cardiology 2020 Aug 10;115(5):57
Basic research in cardiology 2020 Aug 10;115(5):57
Deregulated MTOR (mechanistic target of rapamycin kinase) is responsible for autophagy defects exacerbating kidney stone development.
Unno R, Kawabata T, Taguchi K, Sugino T, Hamamoto S, Ando R, Okada A, Kohri K, Yoshimori T, Yasui T
Autophagy 2020 Apr;16(4):709-723
Autophagy 2020 Apr;16(4):709-723
Trehalose attenuates renal ischemia-reperfusion injury by enhancing autophagy and inhibiting oxidative stress and inflammation.
Liu S, Yang Y, Gao H, Zhou N, Wang P, Zhang Y, Zhang A, Jia Z, Huang S
American journal of physiology. Renal physiology 2020 Apr 1;318(4):F994-F1005
American journal of physiology. Renal physiology 2020 Apr 1;318(4):F994-F1005
Loss of spatacsin impairs cholesterol trafficking and calcium homeostasis.
Boutry M, Pierga A, Matusiak R, Branchu J, Houllegatte M, Ibrahim Y, Balse E, El Hachimi KH, Brice A, Stevanin G, Darios F
Communications biology 2019;2:380
Communications biology 2019;2:380
Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology.
Xue M, Liang H, Ji X, Liu Y, Ge Y, Hou L, Sun T
Nutrition & metabolism 2019;16:87
Nutrition & metabolism 2019;16:87
TFEB Probably Involved in Midazolam-Disturbed Lysosomal Homeostasis and Its Induced β-Amyloid Accumulation.
Cheng D, Tan Q, Zhu Q, Zhang J, Han X, Fang P, Jin W, Liu X
Frontiers in human neuroscience 2019;13:108
Frontiers in human neuroscience 2019;13:108
Irisin reverses insulin resistance in C2C12 cells via the p38-MAPK-PGC-1α pathway.
Ye X, Shen Y, Ni C, Ye J, Xin Y, Zhang W, Ren Y
Peptides 2019 Sep;119:170120
Peptides 2019 Sep;119:170120
TFEB-mediated Enhancement of the Autophagy-lysosomal Pathway Dually Modulates the Process of Amyloid β-Protein Generation in Neurons.
Yamamoto F, Taniguchi K, Mamada N, Tamaoka A, Kametani F, Lakshmana MK, Araki W
Neuroscience 2019 Mar 15;402:11-22
Neuroscience 2019 Mar 15;402:11-22
Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress.
Chakraborty D, Felzen V, Hiebel C, Stürner E, Perumal N, Manicam C, Sehn E, Grus F, Wolfrum U, Behl C
Redox biology 2019 Jun;24:101181
Redox biology 2019 Jun;24:101181
NEO212 induces mitochondrial apoptosis and impairs autophagy flux in ovarian cancer.
Song X, Liu L, Chang M, Geng X, Wang X, Wang W, Chen TC, Xie L, Song X
Journal of experimental & clinical cancer research : CR 2019 Jun 7;38(1):239
Journal of experimental & clinical cancer research : CR 2019 Jun 7;38(1):239
Overexpression of transcription factor EB regulates mitochondrial autophagy to protect lipopolysaccharide-induced acute lung injury.
Liu W, Li CC, Lu X, Bo LY, Jin FG
Chinese medical journal 2019 Jun 5;132(11):1298-1304
Chinese medical journal 2019 Jun 5;132(11):1298-1304
Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP1.
Wang X, Li C, Wang Q, Li W, Guo D, Zhang X, Shao M, Chen X, Ma L, Zhang Q, Wang W, Wang Y
Cancers 2019 Jun 28;11(7)
Cancers 2019 Jun 28;11(7)
mTORC1 inhibition attenuates necroptosis through RIP1 inhibition-mediated TFEB activation.
Abe K, Yano T, Tanno M, Miki T, Kuno A, Sato T, Kouzu H, Nakata K, Ohwada W, Kimura Y, Sugawara H, Shibata S, Igaki Y, Ino S, Miura T
Biochimica et biophysica acta. Molecular basis of disease 2019 Dec 1;1865(12):165552
Biochimica et biophysica acta. Molecular basis of disease 2019 Dec 1;1865(12):165552
Effects of transcription factor EB on oxidative stress and apoptosis induced by high glucose in podocytes.
Kang Y, Li Y, Zhang T, Chi Y, Liu M
International journal of molecular medicine 2019 Aug;44(2):447-456
International journal of molecular medicine 2019 Aug;44(2):447-456
TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells.
He R, Wang M, Zhao C, Shen M, Yu Y, He L, Zhao Y, Chen H, Shi X, Zhou M, Pan S, Liu Y, Guo X, Li X, Qin R
Journal of experimental & clinical cancer research : CR 2019 Aug 6;38(1):340
Journal of experimental & clinical cancer research : CR 2019 Aug 6;38(1):340
CD36 plays a negative role in the regulation of lipophagy in hepatocytes through an AMPK-dependent pathway.
Li Y, Yang P, Zhao L, Chen Y, Zhang X, Zeng S, Wei L, Varghese Z, Moorhead JF, Chen Y, Ruan XZ
Journal of lipid research 2019 Apr;60(4):844-855
Journal of lipid research 2019 Apr;60(4):844-855
Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency.
Lotfi P, Tse DY, Di Ronza A, Seymour ML, Martano G, Cooper JD, Pereira FA, Passafaro M, Wu SM, Sardiello M
Autophagy 2018;14(8):1419-1434
Autophagy 2018;14(8):1419-1434
A Critical Role of Autophagy in Regulating Microglia Polarization in Neurodegeneration.
Jin MM, Wang F, Qi D, Liu WW, Gu C, Mao CJ, Yang YP, Zhao Z, Hu LF, Liu CF
Frontiers in aging neuroscience 2018;10:378
Frontiers in aging neuroscience 2018;10:378
Role of c-Abl-GSK3β Signaling in MPP+-Induced Autophagy-Lysosomal Dysfunction.
Ren Y, Chen J, Wu X, Gui C, Mao K, Zou F, Li W
Toxicological sciences : an official journal of the Society of Toxicology 2018 Sep 1;165(1):232-243
Toxicological sciences : an official journal of the Society of Toxicology 2018 Sep 1;165(1):232-243
Autophagic Modulation by Trehalose Reduces Accumulation of TDP-43 in a Cell Model of Amyotrophic Lateral Sclerosis via TFEB Activation.
Wang Y, Liu FT, Wang YX, Guan RY, Chen C, Li DK, Bu LL, Song J, Yang YJ, Dong Y, Chen Y, Wang J
Neurotoxicity research 2018 Jul;34(1):109-120
Neurotoxicity research 2018 Jul;34(1):109-120
TFEB, a potential therapeutic target for osteoarthritis via autophagy regulation.
Zheng G, Zhan Y, Li X, Pan Z, Zheng F, Zhang Z, Zhou Y, Wu Y, Wang X, Gao W, Xu H, Tian N, Zhang X
Cell death & disease 2018 Aug 28;9(9):858
Cell death & disease 2018 Aug 28;9(9):858
Secretory carrier membrane protein 5 is an autophagy inhibitor that promotes the secretion of α-synuclein via exosome.
Yang Y, Qin M, Bao P, Xu W, Xu J
PloS one 2017;12(7):e0180892
PloS one 2017;12(7):e0180892
Non-thermal plasma induces a stress response in mesothelioma cells resulting in increased endocytosis, lysosome biogenesis and autophagy.
Shi L, Ito F, Wang Y, Okazaki Y, Tanaka H, Mizuno M, Hori M, Hirayama T, Nagasawa H, Richardson DR, Toyokuni S
Free radical biology & medicine 2017 Jul;108:904-917
Free radical biology & medicine 2017 Jul;108:904-917
mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases.
Palmieri M, Pal R, Nelvagal HR, Lotfi P, Stinnett GR, Seymour ML, Chaudhury A, Bajaj L, Bondar VV, Bremner L, Saleem U, Tse DY, Sanagasetti D, Wu SM, Neilson JR, Pereira FA, Pautler RG, Rodney GG, Cooper JD, Sardiello M
Nature communications 2017 Feb 6;8:14338
Nature communications 2017 Feb 6;8:14338
Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells.
Kobayashi T, Tsutsui H, Shimabukuro-Demoto S, Yoshida-Sugitani R, Karyu H, Furuyama-Tanaka K, Ohshima D, Kato N, Okamura T, Toyama-Sorimachi N
International immunology 2017 Dec 31;29(12):551-566
International immunology 2017 Dec 31;29(12):551-566
MAP1LC3B overexpression protects against Hermansky-Pudlak syndrome type-1-induced defective autophagy in vitro.
Ahuja S, Knudsen L, Chillappagari S, Henneke I, Ruppert C, Korfei M, Gochuico BR, Bellusci S, Seeger W, Ochs M, Guenther A, Mahavadi P
American journal of physiology. Lung cellular and molecular physiology 2016 Mar 15;310(6):L519-31
American journal of physiology. Lung cellular and molecular physiology 2016 Mar 15;310(6):L519-31
Increased Apoptosis of Inflamed Odontoblasts Is Associated with CD47 Loss.
Wang HS, Pei F, Chen Z, Zhang L
Journal of dental research 2016 Jun;95(6):697-703
Journal of dental research 2016 Jun;95(6):697-703
A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition.
Song JX, Sun YR, Peluso I, Zeng Y, Yu X, Lu JH, Xu Z, Wang MZ, Liu LF, Huang YY, Chen LL, Durairajan SS, Zhang HJ, Zhou B, Zhang HQ, Lu A, Ballabio A, Medina DL, Guo Z, Li M
Autophagy 2016 Aug 2;12(8):1372-89
Autophagy 2016 Aug 2;12(8):1372-89
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 13372-1-AP(TFEB antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using TFEB antibody 13372-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-TFEB (IP:13372-1-AP, 3ug; Detection:13372-1-AP 1:1000) with NIH/3T3 cells lysate 3300ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human renal cell carcinoma using 13372-1-AP(TFEB antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- cell line
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human renal cell carcinoma using 13372-1-AP(TFEB antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- cell line