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- References [290]
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- Product number
- 13372-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13372-1-AP, RRID:AB_2199611
- Product name
- TFEB antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TFEB antibody (Cat. #13372-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Schisandrin B Targets PXR to Enhance Bile Acid Metabolism and Alleviate ANIT-Induced Cholestatic Liver Injury via Dual Pathways.
Epigenetic regulation of serine biosynthesis by PHF8 during neurogenesis.
Astragalus Polysaccharide Alleviated Septic Associated Acute Kidney Injury Through Dual Mechanisms of RIPK1-Dependent Necroptosis and Autophagy in Macrophage.
S100A11 regulates microglial inflammatory response in neuropathic pain via H3K27ac-TFEB-mitochondrial autophagy axis.
AMPK promotes TFEB transcriptional activity through dephosphorylation at both MTORC1-dependent and -independent sites.
α-Lipoic Acid Alleviates Non-Alcoholic Fatty Liver Disease by Elevating Chaperone-Mediated Autophagy and Increasing β-Oxidation via AMPK-TFEB Axis.
Low-dose Simvastatin protects pancreatic cancer cells by promoting mitochondrial autophagy through TFEB.
Identification of KHS-101 as a Transcription Factor EB Activator to Promote α-Synuclein Degradation.
Hepatitis E ORF2 Blocks Trophoblast Autophagy to Induce Miscarriage via LC3B Binding Rather than PI3K/Akt/mTOR Pathway Suppression.
tRNA m(2)G methyltransferase complex THUMPD3-TRMT112 promotes pancreatic cancer progression and autophagy via modulating TFEB translation.
Irisin alleviates hepatic steatosis by activating the autophagic SIRT3 pathway.
Disruption of FGL2 induces TFEB-dependent lysosomal degradation of PD-L1 and enhances the efficacy of anti-PD1 therapy in hepatocellular carcinoma.
Electroacupuncture regulates neuronal ferroptosis and ferritinophagy through lysosomal-mediated TFEB activation in cerebral ischemia-reperfusion.
TNFAIP8 targets ATG3 to regulate autophagy and participate in the molecular mechanism of ankylosing spondylitis.
Epigenetic H3K4me3 activation of miR-155-5p promotes intervertebral disc degeneration via autophagy and ageing in nucleus pulposus cells.
Inhibition of SLC11A1-Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke.
SESN2 inhibits tubular exosome secretion and diabetic kidney disease progression by restoring the autophagy‒lysosome pathway.
Piezo1 regulates autophagy in HT22 hippocampal neurons through the Ca2+/Calpain and Calcineurin/TFEB signaling pathways.
PEG-Coated Ceria-Zirconia Nanoparticle Prevent Weight Gain and Obesity-Related Organ Damage Through Autophagy Flux Activation and ROS Scavenging.
Resistance training alleviates muscle atrophy and muscle dysfunction by reducing inflammation and regulating compromised autophagy in aged skeletal muscle.
TFEB promotes Ginkgetin-induced ferroptosis via TRIM25 mediated GPX4 lysosomal degradation in EGFR wide-type lung adenocarcinoma.
Fenofibrate suppresses Mycoplasma bovis infection via autophagy-mediated cholesterol regulation in bovine mammary epithelial cells and murine mammary tissue.
Acetyl-CoA carboxylase activation disrupts iron homeostasis to drive ferroptosis.
Mitochondrial fatty acid oxidation dysfunction impairs autophagic flux through ATP deficiency-caused lysosomal pH abnormity.
Adipose-derived stem cell exosomes promote neurological recovery after subarachnoid hemorrhage via AMPK/mTOR-mediated TFEB activation.
Arylsulfatase K attenuates airway epithelial cell senescence in COPD by regulating parkin-mediated mitophagy.
Maresin1 ameliorates osseointegration in type 2 diabetes mellitus by promoting FAM134B-mediated ER-phagy in osteoblasts.
Mitochondrial and lysosomal signaling orchestrates heterogeneous metabolic states of regulatory T cells.
Lipidomics Revealed the Suppression of 5-PAHSA from Human Milk on Macrophage Foam Cell Formation.
AMPK upregulates SOCS1 to promote TFEB nuclear transfer, enhances autophagy, inhibits macrophage M1 polarization and relieves acute lung injury.
Lysosomal Ca(2+) Release Through TRPML1 Governs Ventricular Arrhythmia After Myocardial Infarction.
Transaldolase 1 impacts Parkinson's disease pathogenesis via metabolic reprogramming and autophagy-lysosomal pathway.
Extracellular vesicles from Yiguanjian-primed bone-marrow mesenchymal stem cells ameliorate chronic liver fibrosis via miR-7045-5p.
Quercetin ameliorates doxorubicin-induced atrial fibrillation via EGFR-mediated restoration of autophagic flux.
TGF-β2 increases eHSP90α secretion via upregulating secretory autophagy pathway.
Deletion of ABIN1-LIR motifs impairs hepatic lipid homeostasis and mitophagy via AMPK-TFEB axis in mice.
Isowalsuranolide targets TrxR1/2 and triggers lysosomal biogenesis and autophagy via the p53-TFEB/TFE3 axis.
Macelignan Improves Functional Recovery After Spinal Cord Injury by Augmenting Autophagy via the AKT-mTOR-TFEB Signaling Pathway.
Lysosomal damage due to cholesterol accumulation triggers immunogenic cell death.
Tomatidine Ameliorates Diabetes-Induced Cognitive Impairment and Tau Hyperphosphorylation Through the AMPK-TFEB Pathway.
Enhanced SIRT1-TFEB Interaction Promotes Lysosome Biogenesis and Autophagy by Reducing TFEB Acetylation: Revealing the Enterotoxicity Disparity of Deoxynivalenol and T-2 Toxin.
The antioxidant stress effect of granulin precursor in vitiligo.
TREM2 deficiency exacerbates cognitive impairment by aggravating α-Synuclein-induced lysosomal dysfunction in Parkinson's disease.
Urolithin A inhibits breast cancer progression via activating TFEB-mediated mitophagy in tumor macrophages.
DNLA Delayed the Appearance of Learning and Memory Impairment of APP/PS1 Mice: Involvement of mTOR/TFEB/v-ATPase Signaling Pathway.
Beyond a ferroptosis inducer: erastin can suppress nutrient deprivation induced cell death in the intervertebral disc.
Bisdemethoxycurcumin mitigates traumatic brain injury in rats by modulating autophagy and oxidative stress via heat shock protein 90 alpha family class A member 1-mediated nuclear translocation of transcription factor EB.
HSP90 N-terminal inhibition promotes mitochondria-derived vesicles related metastasis by reducing TFEB transcription via decreased HSP90AA1-HCFC1 interaction in liver cancer.
SMURF1 mediates damaged lysosomal homeostasis by ubiquitinating PPP3CB to promote the activation of TFEB.
The role of GSK3β signaling mediated lysosomal biosynthesis dysregulation in fluoride-induced neurological impairment.
Cadmium targeting transcription factor EB to inhibit autophagy-lysosome function contributes to acute kidney injury.
Reduction of DNA Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across Species.
Polystyrene nanoplastics trigger pyroptosis in dopaminergic neurons through TSC2/TFEB-mediated disruption of autophagosome-lysosome fusion in Parkinson's disease.
Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV.
Melatonin attenuates kidney injury by alleviating lysosomal damage in diabetic kidney disease.
Activation of TFEB protects against diabetic vascular calcification by improving autophagic flux and activating Nrf2 antioxidant system.
Rag GTPases Suppress Renal Cystic Disease by Inhibiting TFEB Independently of mTORC1.
Paeonol ameliorates diabetic nephropathy by promoting TFEB-mediated lysosome biogenesis and lipophagy.
18β-glycyrrhetinic acid mitigates lipotoxicity-induced premature senescence of tubular epithelial cells by activating SIRT1-TFEB signaling.
Biphasic Cellular Response Triggered by Tetrandrine-Mediated Dysfunction and Lysophagic Clearance of Lysosomes.
Luminescent insulin-Au(III) conjugate retains insulin biological properties in human microglia.
"TFEB-HNRNPA2B1": A positive feedback loop facilitating metastasis in hepatocellular carcinoma cells.
Itaconic acid ameliorates necrotizing enterocolitis through the TFEB-mediated autophagy-lysosomal pathway.
BIN1 deficiency enhances ULK3-dependent autophagic flux and reduces dendritic size in mouse hippocampal neurons.
TMEM106B knockdown exhibits a neuroprotective effect in Parkinson's disease models via regulating autophagy-lysosome pathway.
The cholesterol metabolite 25-hydroxycholesterol suppresses porcine deltacoronavirus via lipophagy inhibition and mTORC1 modulation.
Edaravone promotes motoneuron survival and functional recovery after brachial plexus root avulsion and reimplantation in rats: Involvement of SIRT1/TFEB pathway.
Trehalose enhances macrophage autophagy to promote myelin debris clearance after spinal cord injury.
Manganese exposure induces parkinsonism-like symptoms by Serpina3n-TFEB-v/p-ATPase signaling mediated lysosomal dysfunction.
Knockdown of regulator of Calcineurin 2 promotes transcription factor EB-mediated lipophagy to prevent non-alcoholic fatty liver disease.
CCAAT/Enhancer-Binding Protein Beta Nitration Participates in Hyperhomocysteinemia-Induced Cardiomyocyte Autophagic Flux Blockage by Inhibiting Transcription Factor EB Transcription.
Hyperosmotic Stress Promotes the Nuclear Translocation of TFEB in Tubular Epithelial Cells Depending on Intracellular Ca(2+) Signals via TRPML Channels.
Lysosomal catabolic activity promotes the exit of murine totipotent 2-cell state by silencing early-embryonic retrotransposons.
Overcoming ELDR-mediated cancer cell survival in vitro and in vivo via sphingomyelin-driven TRPML1 inactivation and TFEB suppression through lysosomal HSP70 targeting.
Inhibition of lysosomal LAMTOR1 increases autophagy by suppressing the MTORC1 pathway to ameliorate lipid accumulations in MAFLD.
m6A Methylation-Induced Autophagy Impairment by TFEB Regulation in SOD1-G93A ALS Cell Model.
Characterizing stroke-related cellular changes in the surviving neurons of mouse ischemic stroke.
BLOC1S1 Attenuates B. Melitensis 16M LPS-Triggered Autophagy by Spatial Confinement of TDP-43.
Investigating Nickel-Induced Neurotoxicity: Associations with Gut Microbiota Dysbiosis and Ferroptosis.
STUB1-mediated PGC-1α ubiquitination promotes postoperative cognitive dysfunction in aged mice via modulating autophagy-lysosome machinery.
Apoptotic extracellular vesicles from peripancreatic adipose-derived mesenchymal stem cells ameliorate severe acute pancreatitis through the transcription factor EB-mediated autophagy-lysosomal pathway: an experimental study.
Loss of Atoh8 Impairs Macroautophagy.
SDF2L1 downregulation mediates high glucose-caused Schwann cell dysfunction by inhibiting nuclear import of TFEB and CREB via KPNA3.
RONIN/HCF1-TFEB Axis Protects Against D-Galactose-Induced Cochlear Hair Cell Senescence Through Autophagy Activation.
Mechanism of Huayu Qutan recipe anti-atherosclerosis mediates lipophagymammalian target of rapamycin complex 1/ transcription factor EB signaling pathway in ApoE-/-mice.
Acetyl-CoA synthetase 2 alleviates brain injury following cardiac arrest by promoting autophagy in brain microvascular endothelial cells.
3,4-Dimethoxychalcone alleviates limb ischemia/reperfusion injury by TFEB-mediated autophagy enhancement and antioxidative response.
The role of TFEB-mediated autophagy-lysosome dysfunction in manganese neurotoxicity.
Deficiency of diacylglycerol Kinase ζ promotes Beclin1-mediated autophagy via the mTOR/TFEB signaling pathway: Relevance to maladaptive cardiac hypertrophy.
Impaired TFEB-mediated autophagy-lysosome fusion promotes tubular cell cycle G2/M arrest and renal fibrosis by suppressing ATP6V0C expression and interacting with SNAREs.
MCU promotes the migration of glioma cells by activating p38 through TFEB-mediated autophagy.
Exosomal miR-4645-5p from hypoxic bone marrow mesenchymal stem cells facilitates diabetic wound healing by restoring keratinocyte autophagy.
Tetrahydrocurcumin ameliorates hepatic steatosis by restoring hepatocytes lipophagy through mTORC1-TFEB pathway in nonalcoholic steatohepatitis.
Hypoxia-Preconditioned BMSC-Derived Exosomes Induce Mitophagy via the BNIP3-ANAX2 Axis to Alleviate Intervertebral Disc Degeneration.
Exercise-promoted adiponectin secretion activates autolysosomes to protect the liver of ApoE(-/-) mice from a high-fat diet.
Lactate Contributes to Remote Ischemic Preconditioning-Mediated Protection Against Myocardial Ischemia Reperfusion Injury by Facilitating Autophagy via the AMP-Activated Protein Kinase-Mammalian Target of Rapamycin-Transcription Factor EB-Connexin 43 Axis.
Charge-guided masking of a membrane-destabilizing peptide enables efficient endosomal escape for targeted intracellular delivery of proteins.
Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway.
GL-V9 Promotes Autophagy-Mediated YAP1 Degradation and Activates Mitochondrial Apoptosis in PDAC Cells.
Endo-Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1-Null Rat Hippocampus.
Itaconate uptake via SLC13A3 improves hepatic antibacterial innate immunity.
CRISPR screens unveil nutrient-dependent lysosomal and mitochondrial nodes impacting intestinal tissue-resident memory CD8(+) T cell formation.
Autophagic-lysosomal damage induced by swainsonine is protected by trehalose through activation of TFEB-regulated pathway in renal tubular epithelial cells.
LncRNA XXYLT1-AS2 promotes tumor progression via autophagy inhibition through ubiquitinated degradation of TFEB in hepatocellular carcinoma.
Multidimensional autophagy nano-regulator boosts Alzheimer's disease treatment by improving both extra/intraneuronal homeostasis.
Promotion of transcription factor EB-dependent autophagic process by curcumin alleviates arsenic-caused lung oxidative stress and inflammation in mice.
ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis.
Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome.
Theileria parasites sequester host eIF5A to escape elimination by host-mediated autophagy.
Pparα activation stimulates autophagic flux through lipid catabolism-independent route.
Celastrol enhances the viability of random-pattern skin flaps by regulating autophagy through the AMPK-mTOR-TFEB axis.
Intermittent hypoxia training enhances Aβ endocytosis by plaque associated microglia via VPS35-dependent TREM2 recycling in murine Alzheimer's disease.
20- Deoxyingenol attenuate morphine-induced hippocampus neurotoxicity and memory impairments in rats.
TFEB ameliorates DEHP-induced neurotoxicity by activating GAL3/TRIM16 axis dependent lysophagy and alleviating lysosomal dysfunction.
LDHA contributes to nicotine induced cardiac fibrosis through autophagy flux impairment.
Iron regulatory protein 2 contributes to antimicrobial immunity by preserving lysosomal function in macrophages.
DKK1 loss promotes endometrial fibrosis via autophagy and exosome-mediated macrophage-to-myofibroblast transition.
Targeting PKD2 aggravates ferritinophagy-mediated ferroptosis via promoting autophagosome-lysosome fusion and enhances efficacy of carboplatin in lung adenocarcinoma.
Transcriptional dysregulation of autophagy in the muscle of a mouse model of Duchenne muscular dystrophy.
Naringin Protects against Non-Alcoholic Fatty Liver Disease by Promoting Autophagic Flux and Lipophagy.
Enriched environment ameliorates fear memory impairments induced by sleep deprivation via inhibiting PIEZO1/calpain/autophagy signaling pathway in the basal forebrain.
Ezrin inhibition alleviates oxidative stress and pyroptosis via regulating TRPML1-calcineurin axis mediated enhancement of autophagy in spinal cord injury.
Effects of α7 nicotinic acetylcholine receptor agonist against α-synuclein-induced neurotoxicity.
TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease.
The methyltransferase SETD3 regulates mRNA alternative splicing through interacting with hnRNPK.
Bone marrow mesenchymal stem cells modulate miR-202-3p to suppress neuronal apoptosis following spinal cord injury through autophagy activation via the AMPK, MAPK, and PI3K/AKT/mTOR signaling pathway.
TFEB signaling promotes autophagic degradation of NLRP3 to attenuate neuroinflammation in diabetic encephalopathy.
PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson's disease.
Dehydroandrographolide ameliorates doxorubicin-mediated cardiotoxicity by regulating autophagy through the mTOR-TFEB pathway.
Chemically synthesized osteocalcin alleviates NAFLD via the AMPK-FOXO1/BCL6-CD36 pathway.
Targeted dephosphorylation of TFEB promotes its nuclear translocation.
SMURF1 controls the PPP3/calcineurin complex and TFEB at a regulatory node for lysosomal biogenesis.
Ginsenoside Rb1 alleviates 3-MCPD-induced renal cell pyroptosis by activating mitophagy.
The role of mTORC1/TFEB axis mediated lysosomal biogenesis and autophagy impairment in fluoride neurotoxicity and the intervention effects of resveratrol.
miR-29b-1-5p exacerbates myocardial injury induced by sepsis in a mouse model by targeting TERF2.
TFEB regulates dendritic cell antigen presentation to modulate immune balance in asthma.
Tangshen formula protects against podocyte apoptosis via enhancing the TFEB-mediated autophagy-lysosome pathway in diabetic nephropathy.
HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression.
Lysine methylation of PPP1CA by the methyltransferase SUV39H2 disrupts TFEB-dependent autophagy and promotes intervertebral disc degeneration.
Melatonin Restores Autophagic Flux by Activating the Sirt3/TFEB Signaling Pathway to Attenuate Doxorubicin-Induced Cardiomyopathy.
Increased DNMT1 Involvement in the Activation of LO2 Cell Death Induced by Silver Nanoparticles via Promoting TFEB-Dependent Autophagy.
Optineurin tunes outside-in signaling to regulate lysosome biogenesis and phagocytic clearance in the retina.
Sesquiterpenes from Carpesium faberi triggered ROS-induced apoptosis and protective autophagy in hepatocellular carcinoma cells.
TRIM16-mediated lysophagy suppresses high-glucose-accumulated neuronal Aβ.
VPS41-mediated incomplete autophagy aggravates cadmium-induced apoptosis in mouse hepatocytes.
PACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy.
Intermittent hypoxia therapy ameliorates beta-amyloid pathology via TFEB-mediated autophagy in murine Alzheimer's disease.
Dysregulation of the progranulin-driven autophagy-lysosomal pathway mediates secretion of the nuclear protein TDP-43.
Lipopolysaccharide promotes NLRP3 inflammasome activation by inhibiting TFEB-mediated autophagy in NRK-52E cells.
TFEB SUMOylation in macrophages accelerates atherosclerosis by promoting the formation of foam cells through inhibiting lysosomal activity.
TFEB regulates cellular labile iron and prevents ferroptosis in a TfR1-dependent manner.
Grain-sized moxibustion at Zusanli (ST36) promotes hepatic autophagy in rats with hyperlipidemia by regulating the ULK1 and TFEB expression through the AMPK/mTOR signaling pathway.
Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.
The Protective Effect of (-)-Tetrahydroalstonine against OGD/R-Induced Neuronal Injury via Autophagy Regulation.
TFEB coordinates autophagy and pyroptosis as hepatotoxicity responses to ZnO nanoparticles.
PARP1 promotes NLRP3 activation via blocking TFEB-mediated autophagy in rotenone-induced neurodegeneration.
TFEB attenuates hyperglycemia-induced retinal capillary endothelial cells injury via autophagy regulation.
Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells.
Homoplantaginin attenuates high glucose-induced vascular endothelial cell apoptosis through promoting autophagy via the AMPK/TFEB pathway.
De novo missense variants in RRAGC lead to a fatal mTORopathy of early childhood.
Selective autophagy associated with iron overload aggravates non-alcoholic steatohepatitis via ferroptosis.
Phosphorylation of EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) is indispensable for nuclear translocation of TFEB and TFE3 during ER stress.
Acrylamide interferes with autophagy and induces apoptosis in Neuro-2a cells by interfering with TFEB-regulated lysosomal function.
Progranulin Protects against Hyperglycemia-Induced Neuronal Dysfunction through GSK3β Signaling.
Sulforaphane protects microvascular endothelial cells in lower limb ischemia/reperfusion injury mice.
Resveratrol plays an anti-fibrotic and anti-autophagy role by stimulating miR-192-5p expression in urethral fibrosis.
Restoration of c-Src/Fyn Proteins Rescues Mitochondrial Dysfunction in Huntington's Disease.
Ring domains are essential for GATOR2-dependent mTORC1 activation.
Ginsenoside Rb1 induces autophagic lipid degradation via miR-128 targeting TFEB.
Proteome-Wide Analysis Reveals TFEB Targets for Establishment of a Prognostic Signature to Predict Clinical Outcomes of Colorectal Cancer.
The inhibition of TRPML1/TFEB leads to lysosomal biogenesis disorder, contributes to developmental fluoride neurotoxicity.
Autophagy impairment is involved in midazolam-induced lipid droplet accumulation and consequent phagocytosis decrease in BV2 cells.
Exendin-4 alleviates myocardial ischemia reperfusion injury by enhancing autophagy through promoting nuclear translocation of TFEB.
Doxorubicin induces cardiomyocyte death owing to the accumulation of dysfunctional mitochondria by inhibiting the autophagy fusion process.
KDM1A-mediated upregulation of METTL3 ameliorates Alzheimer's disease via enhancing autophagic clearance of p-Tau through m6A-dependent regulation of STUB1.
Paeoniflorin recued hepatotoxicity under zinc oxide nanoparticles exposure via regulation on gut-liver axis and reversal of pyroptosis.
Abnormal Cholesterol Metabolism and Lysosomal Dysfunction Induce Age-Related Hearing Loss by Inhibiting mTORC1-TFEB-Dependent Autophagy.
Hyperoside attenuates pyrrolizidine alkaloids-induced liver injury by ameliorating TFEB-mediated mitochondrial dysfunction.
Overexpression of hepatic pescadillo 1 in obesity induces lipid dysregulation by inhibiting autophagy.
Targeting ANXA7/LAMP5-mTOR axis attenuates spinal cord injury by inhibiting neuronal apoptosis via enhancing autophagy in mice.
STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages.
Chronic Neuronal Inactivity Utilizes the mTOR-TFEB Pathway to Drive Transcription-Dependent Autophagy for Homeostatic Up-Scaling.
Activation of Transcription Factor EB Is Associated With Adipose Tissue Lipolysis in Dairy Cows With Subclinical Ketosis.
Glutamine Availability Regulates the Development of Aging Mediated by mTOR Signaling and Autophagy.
Quercetin protects against palmitate-induced pancreatic β-cell apoptosis by restoring lysosomal function and autophagic flux.
Berberine-mediated REDD1 down-regulation ameliorates senescence of retinal pigment epithelium by interrupting the ROS-DDR positive feedback loop.
Identification of active natural products that induce lysosomal biogenesis by lysosome-based screening and biological evaluation.
Defective autophagy contributes to endometrial epithelial-mesenchymal transition in intrauterine adhesions.
TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2.
Wolframin is a novel regulator of tau pathology and neurodegeneration.
Bioengineered microglia-targeted exosomes facilitate Aβ clearance via enhancing activity of microglial lysosome for promoting cognitive recovery in Alzheimer's disease.
TFEB ameliorates autophagy flux disturbance induced by PBDE-47 via up-regulating autophagy-lysosome fusion.
Restoration of Autophagic Flux Improves Endothelial Function in Diabetes Through Lowering Mitochondrial ROS-Mediated eNOS Monomerization.
SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.
Lysosomal ATP Transporter SLC17A9 Controls Cell Viability via Regulating Cathepsin D.
Hyperphosphatemia-induced degradation of transcription factor EB exacerbates vascular calcification.
GSK-3β inhibition elicits a neuroprotection by restoring lysosomal dysfunction in neurons via facilitation of TFEB nuclear translocation after ischemic stroke.
By restoring autophagic flux and improving mitochondrial function, corosolic acid protects against Dox-induced cardiotoxicity.
EWI2 promotes endolysosome-mediated turnover of growth factor receptors and integrins to suppress lung cancer.
Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goat.
Effect and mechanism of TFEB on pyroptosis in HK-2 cells induced by high glucose.
Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival.
A racemosin B derivative, C25, suppresses breast cancer growth via lysosomal membrane permeabilization and inhibition of autophagic flux.
CCL20/CCR6 axis mediates macrophages to promote proliferation and migration of ESCs by blocking autophagic flux in endometriosis.
Up-regulation of NMRK2 mediated by TFE3 fusions is the key for energy metabolism adaption of Xp11.2 translocation renal cell carcinoma.
Tianma Gouteng Decoction regulates oxidative stress and inflammation in AngII-induced hypertensive mice via transcription factor EB to exert anti-hypertension effect.
Transcription factor EB enhances autophagy and ameliorates palmitate-induced insulin resistance at least partly via upregulating AMPK activity in skeletal muscle cells.
TLR4-Mediated Inflammatory Responses Regulate Exercise-Induced Molecular Adaptations in Mouse Skeletal Muscle.
Activation of FMS-like tyrosine kinase 3 protects against isoprenaline-induced cardiac hypertrophy by improving autophagy and mitochondrial dynamics.
Metformin Alleviates Epirubicin-Induced Endothelial Impairment by Restoring Mitochondrial Homeostasis.
Vitamin D Attenuates Pain and Cartilage Destruction in OA Animals via Enhancing Autophagic Flux and Attenuating Inflammatory Cell Death.
Phillygenin ameliorates nonalcoholic fatty liver disease via TFEB-mediated lysosome biogenesis and lipophagy.
Harmol promotes α-synuclein degradation and improves motor impairment in Parkinson's models via regulating autophagy-lysosome pathway.
Itaconate is a lysosomal inducer that promotes antibacterial innate immunity.
Aerobic Exercise Alleviates Abnormal Autophagy in Brain Cells of APP/PS1 Mice by Upregulating AdipoR1 Levels.
Elabela ameliorates doxorubicin-induced cardiotoxicity by promoting autophagic flux through TFEB pathway.
Tubastatin A Improves Post-Resuscitation Myocardial Dysfunction by Inhibiting NLRP3-Mediated Pyroptosis Through Enhancing Transcription Factor EB Signaling.
Apigenin Alleviates Intervertebral Disc Degeneration via Restoring Autophagy Flux in Nucleus Pulposus Cells.
Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease.
Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy.
Melibiose Confers a Neuroprotection against Cerebral Ischemia/Reperfusion Injury by Ameliorating Autophagy Flux via Facilitation of TFEB Nuclear Translocation in Neurons.
TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading.
Dysregulation of miR-342-3p in plasma exosomes derived from convalescent AMI patients and its consequences on cardiac repair.
Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy.
TP53/p53-FBXO22-TFEB controls basal autophagy to govern hormesis.
Positive regulation of TFEB and mitophagy by PGC-1α to alleviate LPS-induced acute lung injury in rats.
DNA Repair Inhibition Leads to Active Export of Repetitive Sequences to the Cytoplasm Triggering an Inflammatory Response.
Apple polyphenol extract alleviates lipid accumulation in free-fatty-acid-exposed HepG2 cells via activating autophagy mediated by SIRT1/AMPK signaling.
20-Deoxyingenol alleviates osteoarthritis by activating TFEB in chondrocytes.
Transcription factor EB (TFEB)-mediated autophagy protects bovine mammary epithelial cells against H(2)O(2)-induced oxidative damage in vitro.
YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases.
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Cisplatin remodels the tumor immune microenvironment via the transcription factor EB in ovarian cancer.
Lysosomal nitric oxide determines transition from autophagy to ferroptosis after exposure to plasma-activated Ringer's lactate.
Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway.
Quercetin alleviates Cadmium-induced autophagy inhibition via TFEB-dependent lysosomal restoration in primary proximal tubular cells.
PMEPA1 and NEDD4 control the proton production of osteoclasts by regulating vesicular trafficking.
Swainsonine promotes apoptosis by impairing lysosomal function and inhibiting autophagic degradation in rat primary renal tubular epithelial cells.
Ginsenoside Rb1 alleviates liver injury induced by 3-chloro-1,2-propanediol by stimulating autophagic flux.
Ajugol enhances TFEB-mediated lysosome biogenesis and lipophagy to alleviate non-alcoholic fatty liver disease.
p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease.
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
TFEB phosphorylation on Serine 211 is induced by autophagy in human synovial fibroblasts and by p62/SQSTM1 overexpression in HEK293 cells.
Programmed cell death 4 modulates lysosomal function by inhibiting TFEB translation.
Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging.
Cardamonin Reduces Acetaminophen-Induced Acute Liver Injury in Mice via Activating Autophagy and NFE2L2 Signaling.
3-Acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages.
HGF protected against diabetic nephropathy via autophagy-lysosome pathway in podocyte by modulating PI3K/Akt-GSK3β-TFEB axis.
Wnt/β-Catenin Signaling Axis Is Required for TFEB-Mediated Gastric Cancer Metastasis and Epithelial-Mesenchymal Transition.
PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming.
Blue light-emitting diode irradiation promotes transcription factor EB-mediated lysosome biogenesis and lysosomal cell death in murine photoreceptor-derived cells.
TFEB-NF-κB inflammatory signaling axis: a novel therapeutic pathway of Dihydrotanshinone I in doxorubicin-induced cardiotoxicity.
Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease.
The Establishment and Application Studies on Precise Lysosome pH Indicator Based on Self-Decomposable Nanoparticles.
Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages.
Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway.
A Self-Assembled α-Synuclein Nanoscavenger for Parkinson's Disease.
LSD1 negatively regulates autophagy in myoblast cells by driving PTEN degradation.
The neuroprotective effects of activated α7 nicotinic acetylcholine receptor against mutant copper-zinc superoxide dismutase 1-mediated toxicity.
TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS.
Activation of α7nACh receptor protects against acute pancreatitis through enhancing TFEB-regulated autophagy.
Remote ischemic postconditioning attenuates damage in rats with chronic cerebral ischemia by upregulating the autophagolysosome pathway via the activation of TFEB.
NAD(+) administration decreases microvascular damage following cardiac ischemia/reperfusion by restoring autophagic flux.
Deregulated MTOR (mechanistic target of rapamycin kinase) is responsible for autophagy defects exacerbating kidney stone development.
Trehalose attenuates renal ischemia-reperfusion injury by enhancing autophagy and inhibiting oxidative stress and inflammation.
Loss of spatacsin impairs cholesterol trafficking and calcium homeostasis.
Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology.
TFEB Probably Involved in Midazolam-Disturbed Lysosomal Homeostasis and Its Induced β-Amyloid Accumulation.
Irisin reverses insulin resistance in C2C12 cells via the p38-MAPK-PGC-1α pathway.
TFEB-mediated Enhancement of the Autophagy-lysosomal Pathway Dually Modulates the Process of Amyloid β-Protein Generation in Neurons.
Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress.
NEO212 induces mitochondrial apoptosis and impairs autophagy flux in ovarian cancer.
Overexpression of transcription factor EB regulates mitochondrial autophagy to protect lipopolysaccharide-induced acute lung injury.
Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP1.
mTORC1 inhibition attenuates necroptosis through RIP1 inhibition-mediated TFEB activation.
Effects of transcription factor EB on oxidative stress and apoptosis induced by high glucose in podocytes.
TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells.
CD36 plays a negative role in the regulation of lipophagy in hepatocytes through an AMPK-dependent pathway.
Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency.
A Critical Role of Autophagy in Regulating Microglia Polarization in Neurodegeneration.
Role of c-Abl-GSK3β Signaling in MPP+-Induced Autophagy-Lysosomal Dysfunction.
Autophagic Modulation by Trehalose Reduces Accumulation of TDP-43 in a Cell Model of Amyotrophic Lateral Sclerosis via TFEB Activation.
TFEB, a potential therapeutic target for osteoarthritis via autophagy regulation.
Secretory carrier membrane protein 5 is an autophagy inhibitor that promotes the secretion of α-synuclein via exosome.
Non-thermal plasma induces a stress response in mesothelioma cells resulting in increased endocytosis, lysosome biogenesis and autophagy.
mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases.
Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells.
MAP1LC3B overexpression protects against Hermansky-Pudlak syndrome type-1-induced defective autophagy in vitro.
Increased Apoptosis of Inflamed Odontoblasts Is Associated with CD47 Loss.
A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition.
Zhang Y, Lan H, Yu X, Zhuo L, Zhao B, Liu F, An L, Zhang F, Liu Z, Wang C
International journal of biological sciences 2026;22(1):387-409
International journal of biological sciences 2026;22(1):387-409
Epigenetic regulation of serine biosynthesis by PHF8 during neurogenesis.
Artes MH, Iacobucci S, Barallobre MJ, Carballeira P, Garcia-Cajide M, Pérez-Venteo A, Padilla N, Viegas BS, Díaz-Vásquez A, Nacht AS, Vicent GP, Arbonés ML, de la Cruz X, Nieto M, Agell N, Mauvezin C, Martínez-Balbás MA
EMBO reports 2026 Mar;27(6):1540-1560
EMBO reports 2026 Mar;27(6):1540-1560
Astragalus Polysaccharide Alleviated Septic Associated Acute Kidney Injury Through Dual Mechanisms of RIPK1-Dependent Necroptosis and Autophagy in Macrophage.
Wang L, Zhang W, Wang Z, Zhang W, Zhang L, Li J, Mao Z, Zhang J, Liang T, Ge R, Zhang Y, Yan C, Zhang J, Liang T
Phytotherapy research : PTR 2026 Mar 17;
Phytotherapy research : PTR 2026 Mar 17;
S100A11 regulates microglial inflammatory response in neuropathic pain via H3K27ac-TFEB-mitochondrial autophagy axis.
Zheng H, Tian S, Wu L, Jia G, Xiao Y, Yu X, Zuo Q, Zhou R, Min J, Wu Q, Xie H, Luo Q, Wu W
The journal of headache and pain 2026 Mar 11;27(1)
The journal of headache and pain 2026 Mar 11;27(1)
AMPK promotes TFEB transcriptional activity through dephosphorylation at both MTORC1-dependent and -independent sites.
Negoita F, Fraguas Bringas C, Hellberg K, Luda KM, Liu H, Li Z, Cuenco J, Zhao JF, Sathe G, Ganley IG, Sapkota GP, Sakamoto K
Autophagy 2026 Jun;22(6):1386-1400
Autophagy 2026 Jun;22(6):1386-1400
α-Lipoic Acid Alleviates Non-Alcoholic Fatty Liver Disease by Elevating Chaperone-Mediated Autophagy and Increasing β-Oxidation via AMPK-TFEB Axis.
Dong K, Zhang M, Xu J, Bai X, Yang J
Nutrients 2026 Jan 26;18(3)
Nutrients 2026 Jan 26;18(3)
Low-dose Simvastatin protects pancreatic cancer cells by promoting mitochondrial autophagy through TFEB.
Wang Z, Wu D, Zhang Y, Chen W, Fan S, Yang Y, Yang Y, Zu G, An Y, Jin Y, Kang A, Zou Y, Liu Y, Yu X, Qin Y, Xu X, Chen X
Cellular oncology (Dordrecht, Netherlands) 2026 Jan 19;49(1):28
Cellular oncology (Dordrecht, Netherlands) 2026 Jan 19;49(1):28
Identification of KHS-101 as a Transcription Factor EB Activator to Promote α-Synuclein Degradation.
Zhu H, Ren A, Li T, Zhou T, Li A, Pan X, Chen L, Chen J
International journal of molecular sciences 2026 Jan 16;27(2)
International journal of molecular sciences 2026 Jan 16;27(2)
Hepatitis E ORF2 Blocks Trophoblast Autophagy to Induce Miscarriage via LC3B Binding Rather than PI3K/Akt/mTOR Pathway Suppression.
Chen Y, Yang Y, Bai Q, Tian X, Zhou C, Lu X, Liu T
Microorganisms 2026 Jan 14;14(1)
Microorganisms 2026 Jan 14;14(1)
tRNA m(2)G methyltransferase complex THUMPD3-TRMT112 promotes pancreatic cancer progression and autophagy via modulating TFEB translation.
Yuan W, Li S, Xi Y, Tian R, Liu Y, Chen X, Zhang R, Lyu H, Xiao S, Guo D, Zhang Q, Qin W, Yan C, Chen XZ, Zhou C, Tang J
Molecular cancer 2026 Jan 13;25(1)
Molecular cancer 2026 Jan 13;25(1)
Irisin alleviates hepatic steatosis by activating the autophagic SIRT3 pathway.
Zhao Y, Li J, Ma A, Wang Z, Ni Y, Wu D, Zhou Y, Zhang N, Zhang L, Chang Y, Wang Q
Chinese medical journal 2026 Feb 5;139(3):443-456
Chinese medical journal 2026 Feb 5;139(3):443-456
Disruption of FGL2 induces TFEB-dependent lysosomal degradation of PD-L1 and enhances the efficacy of anti-PD1 therapy in hepatocellular carcinoma.
Han M, Guan Q, Yan F, Wang M, Xi D, Ning Q
Cell communication and signaling : CCS 2026 Feb 2;24(1)
Cell communication and signaling : CCS 2026 Feb 2;24(1)
Electroacupuncture regulates neuronal ferroptosis and ferritinophagy through lysosomal-mediated TFEB activation in cerebral ischemia-reperfusion.
Tang B, Xu X, Zhao W, Zhou Q, Du G, Wang H
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2026 Apr;46(4):963-975
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2026 Apr;46(4):963-975
TNFAIP8 targets ATG3 to regulate autophagy and participate in the molecular mechanism of ankylosing spondylitis.
Zhao Y, Ni M, Zhao H, Ren Y, Li Z, Wu H, Xu L, Li G, Pan F
Immunology letters 2026 Apr;278:107124
Immunology letters 2026 Apr;278:107124
Epigenetic H3K4me3 activation of miR-155-5p promotes intervertebral disc degeneration via autophagy and ageing in nucleus pulposus cells.
Wang X, Sun H, Xiao W, Zhang Y, Lu X, Gong Z, Li D, Liu S, Xia X, Wang H, Shao M, Xu G, Ma X
Non-coding RNA research 2026 Apr;17:112-127
Non-coding RNA research 2026 Apr;17:112-127
Inhibition of SLC11A1-Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke.
Qiu L, Zhang Y, Tang Y, Hu H, Zhang Y, Xue J, Wang H, Wang Y, Liu C, Jia J, Cheng J, Cao Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(19):e11482
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(19):e11482
SESN2 inhibits tubular exosome secretion and diabetic kidney disease progression by restoring the autophagy‒lysosome pathway.
Zheng Z, Chen J, Xue X, Ma X, Zhang S, Wang M, Xue Y, Jia Y
International journal of biological sciences 2025;21(9):4215-4230
International journal of biological sciences 2025;21(9):4215-4230
Piezo1 regulates autophagy in HT22 hippocampal neurons through the Ca2+/Calpain and Calcineurin/TFEB signaling pathways.
Wu Y, Lu Y, Zhang H, Dong S, Zhang Z, Wang S, Li F, Yin S
PloS one 2025;20(8):e0330282
PloS one 2025;20(8):e0330282
PEG-Coated Ceria-Zirconia Nanoparticle Prevent Weight Gain and Obesity-Related Organ Damage Through Autophagy Flux Activation and ROS Scavenging.
Kim EK, Hong SE, Choi YS, Yu SL, Kang J, Park CG, Lee HY, Lee SK, Lee DC, Hwang WM, Yun SR, Park Y, Park MH, Lee J, Yoon KR, Lerman LO, Yoon SH
International journal of nanomedicine 2025;20:8305-8326
International journal of nanomedicine 2025;20:8305-8326
Resistance training alleviates muscle atrophy and muscle dysfunction by reducing inflammation and regulating compromised autophagy in aged skeletal muscle.
Cao Y, Zhou J, Quan H, Li W, Li T, Wang L
Frontiers in immunology 2025;16:1597222
Frontiers in immunology 2025;16:1597222
TFEB promotes Ginkgetin-induced ferroptosis via TRIM25 mediated GPX4 lysosomal degradation in EGFR wide-type lung adenocarcinoma.
Wang HJ, Dong LF, Ding LL, Miao XY, Zhang YW, Zhao LP, Yu LH, Guan ZR, Jiang YP, Tang XQ, Yan YX, Lou JS
Theranostics 2025;15(7):2991-3012
Theranostics 2025;15(7):2991-3012
Fenofibrate suppresses Mycoplasma bovis infection via autophagy-mediated cholesterol regulation in bovine mammary epithelial cells and murine mammary tissue.
Xu M, Wang T, Deng X, Liu Y, Zhu Z, Barkema HW, Cobo ER, Kastelic JP, Zhou X, Han B
Frontiers in cellular and infection microbiology 2025;15:1731492
Frontiers in cellular and infection microbiology 2025;15:1731492
Acetyl-CoA carboxylase activation disrupts iron homeostasis to drive ferroptosis.
Han Z, Han S, Fang X, Lu M, Mao Y, Shi L, Song J, Wang T, Xiao J, Xiang L, Yang C, Zhu Z, Wang Y, Feng J
Free radical biology & medicine 2025 Sep;237:110-130
Free radical biology & medicine 2025 Sep;237:110-130
Mitochondrial fatty acid oxidation dysfunction impairs autophagic flux through ATP deficiency-caused lysosomal pH abnormity.
Zhang YY, Lv ZD, Wang M, Wang JX, Limbu SM, Qiao F, Chen LQ, Zhang ML, Luo Y, Du ZY
The Journal of nutritional biochemistry 2025 Sep;143:109943
The Journal of nutritional biochemistry 2025 Sep;143:109943
Adipose-derived stem cell exosomes promote neurological recovery after subarachnoid hemorrhage via AMPK/mTOR-mediated TFEB activation.
Liu M, Li S, Wu L, Liu M, Zeng C, Shen J, Cai Z, Yin J, Wu G
Neurological research 2025 Sep 22;:1-12
Neurological research 2025 Sep 22;:1-12
Arylsulfatase K attenuates airway epithelial cell senescence in COPD by regulating parkin-mediated mitophagy.
Yang R, Zhan Y, Deng Z, Zhang J, Chen S, Zhang Y, Fu H, Meng X, Wu J, Gu Y, Huang Q, Wang C, Xie J
Redox biology 2025 Oct;86:103793
Redox biology 2025 Oct;86:103793
Maresin1 ameliorates osseointegration in type 2 diabetes mellitus by promoting FAM134B-mediated ER-phagy in osteoblasts.
Gui H, Wang X, Wu A, Li B, Zhang B, Diao J, Chen J, Zhang X, Wu D, He Q, Xu X, Zhang D
Biochemical pharmacology 2025 Oct;240:117099
Biochemical pharmacology 2025 Oct;240:117099
Mitochondrial and lysosomal signaling orchestrates heterogeneous metabolic states of regulatory T cells.
Saravia J, Chapman NM, Sun Y, Meng X, Risch I, Li W, Guy C, Shi H, Hu H, Dhungana Y, Li J, You Z, Kc A, Lim SA, Raynor JL, Shrestha S, Norton EG, La Grange SE, Robinson CG, Vogel P, Chi H
Science immunology 2025 Oct 24;10(112):eads9456
Science immunology 2025 Oct 24;10(112):eads9456
Lipidomics Revealed the Suppression of 5-PAHSA from Human Milk on Macrophage Foam Cell Formation.
Zhang Y, Zhu S, He Y, Lei JN, Wang H, Tan C, Liu YF, Chen M, Xu YJ
Journal of agricultural and food chemistry 2025 Oct 22;73(42):27089-27098
Journal of agricultural and food chemistry 2025 Oct 22;73(42):27089-27098
AMPK upregulates SOCS1 to promote TFEB nuclear transfer, enhances autophagy, inhibits macrophage M1 polarization and relieves acute lung injury.
Nie W, Gong C, Liu Y, Yang J, Dai Q, Liao Y, Li F
Molecular immunology 2025 Nov;187:240-253
Molecular immunology 2025 Nov;187:240-253
Lysosomal Ca(2+) Release Through TRPML1 Governs Ventricular Arrhythmia After Myocardial Infarction.
Xie A, Kang GJ, Liu H, Kim EJ, Feng F, Dobrev D, Dudley SC Jr
Circulation. Arrhythmia and electrophysiology 2025 Nov;18(11):e013964
Circulation. Arrhythmia and electrophysiology 2025 Nov;18(11):e013964
Transaldolase 1 impacts Parkinson's disease pathogenesis via metabolic reprogramming and autophagy-lysosomal pathway.
Tan Z, Hu H, Chen H, Lin Y, Zhou M, Zhang W, Xu P, Chen X
Acta neuropathologica communications 2025 Nov 4;13(1):223
Acta neuropathologica communications 2025 Nov 4;13(1):223
Extracellular vesicles from Yiguanjian-primed bone-marrow mesenchymal stem cells ameliorate chronic liver fibrosis via miR-7045-5p.
Liu Z, Jiang X, You H, Tang Z, Ma Y, Che N, Ma C, Liu W
Stem cell research & therapy 2025 Nov 26;16(1):663
Stem cell research & therapy 2025 Nov 26;16(1):663
Quercetin ameliorates doxorubicin-induced atrial fibrillation via EGFR-mediated restoration of autophagic flux.
Bian WH, Wang SH, Kang ZC, Xu Y, Li YN, Yang MZ, Yang JH, Liu JY, Cheng YL, Chang D, Xie X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157357
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157357
TGF-β2 increases eHSP90α secretion via upregulating secretory autophagy pathway.
Li J, Li J, Xie T, Huang S, Tian H, Liu M, Kong X, Zhang D, Nawaz KI, Wang M, Li H, Zhang J, Yuan F, Guo W, Cui X, Mu H, Hu Y
Cell communication and signaling : CCS 2025 Nov 12;23(1):492
Cell communication and signaling : CCS 2025 Nov 12;23(1):492
Deletion of ABIN1-LIR motifs impairs hepatic lipid homeostasis and mitophagy via AMPK-TFEB axis in mice.
Huber LS, Merline R, Zeng-Brouwers J, Vutukuri R, Kraus N, Ortiz C, Guenther S, Buhl EM, Hahnefeld L, Gurke R, Bein J, Karimova M, Wurzel P, Boor P, Welsch C, Wild P, Pfeilschifter J, Kögel D, Wygrecka M, Trebicka J, Bartoszewski R, Dikic I, Schaefer L
American journal of physiology. Cell physiology 2025 Nov 1;329(5):C1360-C1379
American journal of physiology. Cell physiology 2025 Nov 1;329(5):C1360-C1379
Isowalsuranolide targets TrxR1/2 and triggers lysosomal biogenesis and autophagy via the p53-TFEB/TFE3 axis.
Yang X, Ding X, Zhao Y, Wang Y, Dong X, Niu Z, Gu Z, Fei J, Zhao Y, Hao X
Science China. Life sciences 2025 May;68(5):1437-1451
Science China. Life sciences 2025 May;68(5):1437-1451
Macelignan Improves Functional Recovery After Spinal Cord Injury by Augmenting Autophagy via the AKT-mTOR-TFEB Signaling Pathway.
Zhu Y, Yang S, Su S, Huang Y, Chen Y, Liang H, Miao J, Wu Z, Li X, Xiao J, Wang X
Phytotherapy research : PTR 2025 May;39(5):2091-2109
Phytotherapy research : PTR 2025 May;39(5):2091-2109
Lysosomal damage due to cholesterol accumulation triggers immunogenic cell death.
Alvarez-Valadez K, Sauvat A, Diharce J, Leduc M, Stoll G, Guittat L, Lambertucci F, Paillet J, Motiño O, Ferret L, Muller A, Forveille S, Maiuri MC, Kepp O, de Brevern AG, Wodrich H, Pol JG, Kroemer G, Djavaheri-Mergny M
Autophagy 2025 May;21(5):934-956
Autophagy 2025 May;21(5):934-956
Tomatidine Ameliorates Diabetes-Induced Cognitive Impairment and Tau Hyperphosphorylation Through the AMPK-TFEB Pathway.
Zhang WG, Ding J, Wang L, Wu CJ, Mao JY, Ding K, Zhang C, Hu ZB, Li S, Wang L
Journal of neurochemistry 2025 May;169(5):e70087
Journal of neurochemistry 2025 May;169(5):e70087
Enhanced SIRT1-TFEB Interaction Promotes Lysosome Biogenesis and Autophagy by Reducing TFEB Acetylation: Revealing the Enterotoxicity Disparity of Deoxynivalenol and T-2 Toxin.
Xu Q, Lin R, Jiang T, Deng L, Wu Y, Yuan Q, Qi X, Mu P, Jiang J, Deng Y, Wen J
Journal of agricultural and food chemistry 2025 May 28;73(21):12993-13005
Journal of agricultural and food chemistry 2025 May 28;73(21):12993-13005
The antioxidant stress effect of granulin precursor in vitiligo.
Guo H, Chen J, Jiang L
Scientific reports 2025 May 25;15(1):18189
Scientific reports 2025 May 25;15(1):18189
TREM2 deficiency exacerbates cognitive impairment by aggravating α-Synuclein-induced lysosomal dysfunction in Parkinson's disease.
Zhu B, Feng J, Liang X, Fu Z, Liao M, Deng T, Wang K, Xie J, Chi J, Yang L, Gao Y, Nie K, Wang L, Zhang P, Zhang Y
Cell death discovery 2025 May 20;11(1):243
Cell death discovery 2025 May 20;11(1):243
Urolithin A inhibits breast cancer progression via activating TFEB-mediated mitophagy in tumor macrophages.
Zheng B, Wang Y, Zhou B, Qian F, Liu D, Ye D, Zhou X, Fang L
Journal of advanced research 2025 Mar;69:125-138
Journal of advanced research 2025 Mar;69:125-138
DNLA Delayed the Appearance of Learning and Memory Impairment of APP/PS1 Mice: Involvement of mTOR/TFEB/v-ATPase Signaling Pathway.
Wu Y, Liu X, Luo G, Li Q, Guo B, Li L, Nie J
CNS neuroscience & therapeutics 2025 Mar;31(3):e70300
CNS neuroscience & therapeutics 2025 Mar;31(3):e70300
Beyond a ferroptosis inducer: erastin can suppress nutrient deprivation induced cell death in the intervertebral disc.
Jin J, Chen Y, Chen X, Zhang Z, Wu Y, Tian N, Wu A, Wang X, Shao Z, Zhou Y, Zhang X, Wu Y
The spine journal : official journal of the North American Spine Society 2025 Mar;25(3):597-608
The spine journal : official journal of the North American Spine Society 2025 Mar;25(3):597-608
Bisdemethoxycurcumin mitigates traumatic brain injury in rats by modulating autophagy and oxidative stress via heat shock protein 90 alpha family class A member 1-mediated nuclear translocation of transcription factor EB.
Xu Y, Peng LS, Xiao CQ, Zhou Y, Wang QS, Fu H
Brain research bulletin 2025 Mar;222:111221
Brain research bulletin 2025 Mar;222:111221
HSP90 N-terminal inhibition promotes mitochondria-derived vesicles related metastasis by reducing TFEB transcription via decreased HSP90AA1-HCFC1 interaction in liver cancer.
Liu L, Zheng Z, Huang Y, Su H, Wu G, Deng Z, Li Y, Xie G, Li J, Zou F, Chen X
Autophagy 2025 Mar;21(3):639-663
Autophagy 2025 Mar;21(3):639-663
SMURF1 mediates damaged lysosomal homeostasis by ubiquitinating PPP3CB to promote the activation of TFEB.
Xia Q, Liu X, Zhong L, Qu J, Dong L
Autophagy 2025 Mar;21(3):530-547
Autophagy 2025 Mar;21(3):530-547
The role of GSK3β signaling mediated lysosomal biosynthesis dysregulation in fluoride-induced neurological impairment.
Cheng Y, Du Y, Hu Y, Wang X, Li Q, Yan X, Dou M, Jia W, Yu F, Ba Y, Zhou G
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Mar;197:115267
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Mar;197:115267
Cadmium targeting transcription factor EB to inhibit autophagy-lysosome function contributes to acute kidney injury.
Dong PF, Liu TB, Chen K, Li D, Li Y, Lian CY, Wang ZY, Wang L
Journal of advanced research 2025 Jun;72:653-669
Journal of advanced research 2025 Jun;72:653-669
Reduction of DNA Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across Species.
Zhu M, Ma M, Luo L, Li F, Zheng J, Pan Y, Yang L, Xiao Y, Wang Z, Xian B, Zheng Y, Li H, Yang J
Aging cell 2025 Jun;24(6):e70010
Aging cell 2025 Jun;24(6):e70010
Polystyrene nanoplastics trigger pyroptosis in dopaminergic neurons through TSC2/TFEB-mediated disruption of autophagosome-lysosome fusion in Parkinson's disease.
Liang X, Zeng Y, Zhang P, Zhu B, Feng J, Deng T, Fu Z, Liu C, Chen C, Zhang Y
Journal of translational medicine 2025 Jun 5;23(1):631
Journal of translational medicine 2025 Jun 5;23(1):631
Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV.
Davidson JW, Jain R, Kizzar T, Geoghegan G, Nesbitt DJ, Cavanagh A, Abe A, Nyame K, Hunger A, Chao X, James I, Walesewicz H, Baldwin DA, Wade G, Michorowska S, Verma R, Schueler K, Hinkovska-Galcheva V, Shishkova E, Ding WX, Coon JJ, Shayman JA, Abu-Remaileh M, Simcox JA
Cell metabolism 2025 Jun 3;37(6):1413-1425.e6
Cell metabolism 2025 Jun 3;37(6):1413-1425.e6
Melatonin attenuates kidney injury by alleviating lysosomal damage in diabetic kidney disease.
Chen J, Zhang S, Xue X, Ma X, Chen A, Wu Y, Wang G, Zhang Q, Xue Y, Jia Y, Zheng Z
Acta biochimica et biophysica Sinica 2025 Jun 13;57(10):1589-1600
Acta biochimica et biophysica Sinica 2025 Jun 13;57(10):1589-1600
Activation of TFEB protects against diabetic vascular calcification by improving autophagic flux and activating Nrf2 antioxidant system.
Sun XJ, Xiao SJ, Ma WQ, Jin H, Ren LQ, Yao YY, Chen ZD, Li XX, Chen T, Liu NF
American journal of physiology. Endocrinology and metabolism 2025 Jun 1;328(6):E924-E939
American journal of physiology. Endocrinology and metabolism 2025 Jun 1;328(6):E924-E939
Rag GTPases Suppress Renal Cystic Disease by Inhibiting TFEB Independently of mTORC1.
de Fatima Silva F, Boucher AR Jr, Li H, Chen Q, Gaughan M, Korobkina ED, Isidor MS, Smith AO, Shen K, Allison DB, Tran PV, Pazour GJ, Guertin DA
bioRxiv : the preprint server for biology 2025 Jul 31;
bioRxiv : the preprint server for biology 2025 Jul 31;
Paeonol ameliorates diabetic nephropathy by promoting TFEB-mediated lysosome biogenesis and lipophagy.
Ai S, Tao J, Wang Y, Zhou J, Liu W, Li X, Wang L, Hou J, Zhao L, Wang Z, Peng L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156901
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156901
18β-glycyrrhetinic acid mitigates lipotoxicity-induced premature senescence of tubular epithelial cells by activating SIRT1-TFEB signaling.
Yang M, Qin W, Dai Q, Wu S, Chen Y, Xie W, Jiang X, Song H, Lei Y, Zheng T, Wang Y, Ouyang S, Guan M, Huang G, Liu X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156846
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156846
Biphasic Cellular Response Triggered by Tetrandrine-Mediated Dysfunction and Lysophagic Clearance of Lysosomes.
Yang Z, Takahashi T, Hoshino A, Yamamoto T, Shigemori H, Miyamae Y
ACS chemical biology 2025 Jul 18;20(7):1660-1668
ACS chemical biology 2025 Jul 18;20(7):1660-1668
Luminescent insulin-Au(III) conjugate retains insulin biological properties in human microglia.
Maysinger D, Zhang I, Yuan H, Bonačić-Koutecký V, Sanader Maršić Ž, Antoine R
Nanoscale 2025 Jul 16;17(28):16806-16817
Nanoscale 2025 Jul 16;17(28):16806-16817
"TFEB-HNRNPA2B1": A positive feedback loop facilitating metastasis in hepatocellular carcinoma cells.
Yan X, Wu Y, Dai X, Wen H, Xiang W, Yang M, Zhang Y, Xiang L, Lu L, Chen A, He F, Lian J
Experimental cell research 2025 Jul 15;450(2):114669
Experimental cell research 2025 Jul 15;450(2):114669
Itaconic acid ameliorates necrotizing enterocolitis through the TFEB-mediated autophagy-lysosomal pathway.
Chen B, Liu Y, Luo S, Zhou J, Wang Y, He Q, Zhuang G, Hao H, Ma F, Xiao X, Li S
Free radical biology & medicine 2025 Jan;226:251-265
Free radical biology & medicine 2025 Jan;226:251-265
BIN1 deficiency enhances ULK3-dependent autophagic flux and reduces dendritic size in mouse hippocampal neurons.
Jin Y, Zhao L, Zhang Y, Chen T, Shi H, Sun H, Ding S, Chen S, Cao H, Zhang G, Li Q, Gao J, Xiao M, Sheng C
Autophagy 2025 Jan;21(1):223-242
Autophagy 2025 Jan;21(1):223-242
TMEM106B knockdown exhibits a neuroprotective effect in Parkinson's disease models via regulating autophagy-lysosome pathway.
Liu Y, Qin K, Dou K, Ren J, Hou B, Xie A
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167553
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167553
The cholesterol metabolite 25-hydroxycholesterol suppresses porcine deltacoronavirus via lipophagy inhibition and mTORC1 modulation.
Zhang JL, Wang XF, Li JL, Duan C, Wang JF
Veterinary research 2025 Jan 31;56(1):23
Veterinary research 2025 Jan 31;56(1):23
Edaravone promotes motoneuron survival and functional recovery after brachial plexus root avulsion and reimplantation in rats: Involvement of SIRT1/TFEB pathway.
Jia CJ, Chen MN, Huang DD, Wu SF, Zeng CM, Liu ZQ, Wang MX, Huang YF, Yuan QJ, Zhang X
International immunopharmacology 2025 Jan 3;145:113686
International immunopharmacology 2025 Jan 3;145:113686
Trehalose enhances macrophage autophagy to promote myelin debris clearance after spinal cord injury.
Ma Z, Meng C, Wang X, Zhao Y, Wang J, Chen Y, Li Y, Jiang Y, Ouyang F, Li J, Zheng M, Cheng L, Jing J
Cell & bioscience 2025 Jan 29;15(1):11
Cell & bioscience 2025 Jan 29;15(1):11
Manganese exposure induces parkinsonism-like symptoms by Serpina3n-TFEB-v/p-ATPase signaling mediated lysosomal dysfunction.
Hong H, Liu S, Yang T, Lin J, Luo K, Xu Y, Li T, Xi Y, Yang L, Lu YQ, Yuan W, Zhou Z
Cell biology and toxicology 2025 Jan 23;41(1):34
Cell biology and toxicology 2025 Jan 23;41(1):34
Knockdown of regulator of Calcineurin 2 promotes transcription factor EB-mediated lipophagy to prevent non-alcoholic fatty liver disease.
Shan L, Guo P, Wen M, Sun Y, Gao F, Zhang K, Zhang N, Yang B
Toxicology and applied pharmacology 2025 Feb;495:117210
Toxicology and applied pharmacology 2025 Feb;495:117210
CCAAT/Enhancer-Binding Protein Beta Nitration Participates in Hyperhomocysteinemia-Induced Cardiomyocyte Autophagic Flux Blockage by Inhibiting Transcription Factor EB Transcription.
Chai J, Xu J, Zhang S, Yan W, Chen S, Zhu X, Luo C, Wang W
Antioxidants & redox signaling 2025 Feb;42(4-6):165-183
Antioxidants & redox signaling 2025 Feb;42(4-6):165-183
Hyperosmotic Stress Promotes the Nuclear Translocation of TFEB in Tubular Epithelial Cells Depending on Intracellular Ca(2+) Signals via TRPML Channels.
Miyano T, Suzuki A, Konta H, Sakamoto N
Cellular and molecular bioengineering 2025 Feb;18(1):39-52
Cellular and molecular bioengineering 2025 Feb;18(1):39-52
Lysosomal catabolic activity promotes the exit of murine totipotent 2-cell state by silencing early-embryonic retrotransposons.
Wu H, Cao L, Wen X, Fan J, Wang Y, Hu H, Ji S, Zhang Y, Ye C, Xie W, Zhang J, Xu H, Fu X
Developmental cell 2025 Feb 24;60(4):512-523.e7
Developmental cell 2025 Feb 24;60(4):512-523.e7
Overcoming ELDR-mediated cancer cell survival in vitro and in vivo via sphingomyelin-driven TRPML1 inactivation and TFEB suppression through lysosomal HSP70 targeting.
Chen H, Zhu M, Zhao Z, Jiang Y, Wang H, Liu Y, Chen Y, Li H, Xun C, Hui H
Pharmacological research 2025 Dec;222:108050
Pharmacological research 2025 Dec;222:108050
Inhibition of lysosomal LAMTOR1 increases autophagy by suppressing the MTORC1 pathway to ameliorate lipid accumulations in MAFLD.
Jang Y, Ko M, Lee JY, Kim JY, Lee EW, Kwon HJ
Autophagy 2025 Dec;21(12):2633-2649
Autophagy 2025 Dec;21(12):2633-2649
m6A Methylation-Induced Autophagy Impairment by TFEB Regulation in SOD1-G93A ALS Cell Model.
An D, Wu Y, Han J, Fang P, Bu Y, Ji G, Deng J, Song X
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2025 Dec;198(8):221-229
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2025 Dec;198(8):221-229
Characterizing stroke-related cellular changes in the surviving neurons of mouse ischemic stroke.
Ikegami T, Sasaki T, Shimbo T, Kitayama T, Yamamoto Y, Ouchi Y, Yamazaki S, Sugiyama S, Nishiyama K, Gon Y, Okazaki S, Todo K, Matsumura S, Tamai K, Mochizuki H
Neurochemistry international 2025 Dec;191:106086
Neurochemistry international 2025 Dec;191:106086
BLOC1S1 Attenuates B. Melitensis 16M LPS-Triggered Autophagy by Spatial Confinement of TDP-43.
Wan S, Han M, Zhang M, Chen W, Xie F, Luo X, Wu W, Wang C, Yang D, Han B, Zhu H, Yu H, Li N, Hua J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e05635
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e05635
Investigating Nickel-Induced Neurotoxicity: Associations with Gut Microbiota Dysbiosis and Ferroptosis.
Shen Y, Cao K, Zhang W, Chen C, Gao C, Wang J, Xin T, Li C, Tang S, Pei X, Li D
Antioxidants (Basel, Switzerland) 2025 Dec 9;14(12)
Antioxidants (Basel, Switzerland) 2025 Dec 9;14(12)
STUB1-mediated PGC-1α ubiquitination promotes postoperative cognitive dysfunction in aged mice via modulating autophagy-lysosome machinery.
Shen QH, Xia JY, Ma Y, Xu SS
European journal of medical research 2025 Dec 30;31(1):173
European journal of medical research 2025 Dec 30;31(1):173
Apoptotic extracellular vesicles from peripancreatic adipose-derived mesenchymal stem cells ameliorate severe acute pancreatitis through the transcription factor EB-mediated autophagy-lysosomal pathway: an experimental study.
Wang A, An Y, Wang X, Gou W, Xu F, Li Y, Wang C, Tu Z, Hou W, Cui Y
International journal of surgery (London, England) 2025 Dec 17;112(4):9262-81
International journal of surgery (London, England) 2025 Dec 17;112(4):9262-81
Loss of Atoh8 Impairs Macroautophagy.
Divvela SSK, Offei EB, Kadr H, Hausherr M, Eggers B, Rozanova S, Eisenacher M, Nguyen HD, Tuoc T, Bader V, Yang X, Zaehres H, Chen A, Nguyen HP, Winklhofer KF, Marcus K, Brand-Saberi B
Cells 2025 Dec 15;14(24)
Cells 2025 Dec 15;14(24)
SDF2L1 downregulation mediates high glucose-caused Schwann cell dysfunction by inhibiting nuclear import of TFEB and CREB via KPNA3.
Jin T, Li F, Wei W, Li Q, Gao Y, Yuwen C, Sun Y, Li W, Zhu L, Hao J
Experimental neurology 2025 Aug;390:115273
Experimental neurology 2025 Aug;390:115273
RONIN/HCF1-TFEB Axis Protects Against D-Galactose-Induced Cochlear Hair Cell Senescence Through Autophagy Activation.
Wei Y, Zhang Y, Cao W, Cheng N, Xiao Y, Zhu Y, Xu Y, Zhang L, Guo L, Song J, Sha SH, Shao B, Ma F, Yang J, Ying Z, He Z, Chai R, Fang Q, Yang J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e2407880
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e2407880
Mechanism of Huayu Qutan recipe anti-atherosclerosis mediates lipophagymammalian target of rapamycin complex 1/ transcription factor EB signaling pathway in ApoE-/-mice.
Yue LI, Jiaxiang P, Guanlin Y, Jiajia YU, Xize WU, Dongyu M, Meijia C, Dongdong YU, Minghua N, Xiaoyu G, Linlin P, Lihong G, Lianqun J
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Apr;45(2):291-302
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Apr;45(2):291-302
Acetyl-CoA synthetase 2 alleviates brain injury following cardiac arrest by promoting autophagy in brain microvascular endothelial cells.
Zhang W, Yu X, Lin Y, Wu C, Zhu R, Jiang X, Tao J, Chen Z, He J, Zhang X, Xu J, Zhang M
Cellular and molecular life sciences : CMLS 2025 Apr 17;82(1):160
Cellular and molecular life sciences : CMLS 2025 Apr 17;82(1):160
3,4-Dimethoxychalcone alleviates limb ischemia/reperfusion injury by TFEB-mediated autophagy enhancement and antioxidative response.
Qiu YH, Zhang YH, Wu ZC, Huang JY, Chen BC, Xiao J, Chen FF
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Apr 15;39(7):e70496
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Apr 15;39(7):e70496
The role of TFEB-mediated autophagy-lysosome dysfunction in manganese neurotoxicity.
Lu J, Su P, Zhao F, Yu K, Yang X, Lv H, Wang D, Zhang J
Current research in toxicology 2024;7:100193
Current research in toxicology 2024;7:100193
Deficiency of diacylglycerol Kinase ζ promotes Beclin1-mediated autophagy via the mTOR/TFEB signaling pathway: Relevance to maladaptive cardiac hypertrophy.
Liu Y, Zhang H, Lin Y, Qian P, Yin Y, Zou G, Zhang J, Zhang H
International journal of medical sciences 2024;21(3):439-453
International journal of medical sciences 2024;21(3):439-453
Impaired TFEB-mediated autophagy-lysosome fusion promotes tubular cell cycle G2/M arrest and renal fibrosis by suppressing ATP6V0C expression and interacting with SNAREs.
Ren X, Wang J, Wei H, Li X, Tian Y, Wang Z, Yin Y, Guo Z, Qin Z, Wu M, Zeng X
International journal of biological sciences 2024;20(5):1905-1926
International journal of biological sciences 2024;20(5):1905-1926
MCU promotes the migration of glioma cells by activating p38 through TFEB-mediated autophagy.
Chen J, Lu R, Peng Y, Lai Y, Cai Z, Zheng D, Xie A, Huang K, Liang C, Zhang H
Journal of Cancer 2024;15(5):1257-1270
Journal of Cancer 2024;15(5):1257-1270
Exosomal miR-4645-5p from hypoxic bone marrow mesenchymal stem cells facilitates diabetic wound healing by restoring keratinocyte autophagy.
Shi Y, Wang S, Liu D, Wang Z, Zhu Y, Li J, Xu K, Li F, Wen H, Yang R
Burns & trauma 2024;12:tkad058
Burns & trauma 2024;12:tkad058
Tetrahydrocurcumin ameliorates hepatic steatosis by restoring hepatocytes lipophagy through mTORC1-TFEB pathway in nonalcoholic steatohepatitis.
Wu J, Guan F, Huang H, Chen H, Liu Y, Zhang S, Li M, Chen J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117297
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117297
Hypoxia-Preconditioned BMSC-Derived Exosomes Induce Mitophagy via the BNIP3-ANAX2 Axis to Alleviate Intervertebral Disc Degeneration.
Jin Y, Wu O, Chen Q, Chen L, Zhang Z, Tian H, Zhou H, Zhang K, Gao J, Wang X, Guo Z, Sun J, Kwan KYH, Jones M, Li YM, Zare EN, Makvandi P, Wang X, Shen S, Wu A
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(34):e2404275
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(34):e2404275
Exercise-promoted adiponectin secretion activates autolysosomes to protect the liver of ApoE(-/-) mice from a high-fat diet.
Wu W, Jian Y, Yuan S, Li X, Tang Y, Zeng F, Liu W, Zhao Z, Wang Y, Wang Y, Liu W
Food & function 2024 Sep 30;15(19):9796-9812
Food & function 2024 Sep 30;15(19):9796-9812
Lactate Contributes to Remote Ischemic Preconditioning-Mediated Protection Against Myocardial Ischemia Reperfusion Injury by Facilitating Autophagy via the AMP-Activated Protein Kinase-Mammalian Target of Rapamycin-Transcription Factor EB-Connexin 43 Axis.
Yang ZJ, Zhang WF, Jin QQ, Wu ZR, Du YY, Shi H, Qu ZS, Han XJ, Jiang LP
The American journal of pathology 2024 Oct;194(10):1857-1878
The American journal of pathology 2024 Oct;194(10):1857-1878
Charge-guided masking of a membrane-destabilizing peptide enables efficient endosomal escape for targeted intracellular delivery of proteins.
Zhao Y, Jiang H, Chen H, Yu J, Wang L, Zhou W, Du J
Acta pharmaceutica Sinica. B 2024 Oct;14(10):4478-4492
Acta pharmaceutica Sinica. B 2024 Oct;14(10):4478-4492
Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway.
Sweeney N, Kim TY, Morrison CT, Li L, Acosta D, Liang J, Datla NV, Fitzgerald JA, Huang H, Liu X, Tan GH, Wu M, Karelina K, Bray CE, Weil ZM, Scharre DW, Serrano GE, Saito T, Saido TC, Beach TG, Kokiko-Cochran ON, Godbout JP, Johnson GVW, Fu H
Acta neuropathologica 2024 Oct 11;148(1):52
Acta neuropathologica 2024 Oct 11;148(1):52
GL-V9 Promotes Autophagy-Mediated YAP1 Degradation and Activates Mitochondrial Apoptosis in PDAC Cells.
Liu H, Lin Z, Guo Y, Zhou Y, Li W
Pharmaceuticals (Basel, Switzerland) 2024 Oct 10;17(10)
Pharmaceuticals (Basel, Switzerland) 2024 Oct 10;17(10)
Endo-Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1-Null Rat Hippocampus.
Wang Y, Yang Y, Cai Y, Aobulikasimu A, Wang Y, Hu C, Miao Z, Shao Y, Zhao M, Hu Y, Xu C, Chen X, Li Z, Chen J, Wang L, Chen S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2407709
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2407709
Itaconate uptake via SLC13A3 improves hepatic antibacterial innate immunity.
Chen C, Liu C, Sun P, Zhang Z, Wang Z, Liu P, Li X
Developmental cell 2024 Nov 4;59(21):2807-2817.e8
Developmental cell 2024 Nov 4;59(21):2807-2817.e8
CRISPR screens unveil nutrient-dependent lysosomal and mitochondrial nodes impacting intestinal tissue-resident memory CD8(+) T cell formation.
Raynor JL, Collins N, Shi H, Guy C, Saravia J, Ah Lim S, Chapman NM, Zhou P, Wang Y, Sun Y, Risch I, Hu H, Kc A, Sun R, Shrestha S, Huang H, Connelly JP, Pruett-Miller SM, Reina-Campos M, Goldrath AW, Belkaid Y, Chi H
Immunity 2024 Nov 12;57(11):2597-2614.e13
Immunity 2024 Nov 12;57(11):2597-2614.e13
Autophagic-lysosomal damage induced by swainsonine is protected by trehalose through activation of TFEB-regulated pathway in renal tubular epithelial cells.
Zhang S, Yin H, Zhang Y, Zhu Y, Zhu X, Zhu W, Tang L, Liu Y, Wu K, Zhao B, Tian Y, Lu H
Chemico-biological interactions 2024 May 1;394:110990
Chemico-biological interactions 2024 May 1;394:110990
LncRNA XXYLT1-AS2 promotes tumor progression via autophagy inhibition through ubiquitinated degradation of TFEB in hepatocellular carcinoma.
Li X, Wu Y, Wang P, Li Y, Gu J, Zhang Y, Yan S, Hu P
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2024 Mar;26(3):698-708
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2024 Mar;26(3):698-708
Multidimensional autophagy nano-regulator boosts Alzheimer's disease treatment by improving both extra/intraneuronal homeostasis.
Li Y, Yang P, Meng R, Xu S, Zhou L, Qian K, Wang P, Cheng Y, Sheng D, Xu M, Wang T, Wu J, Cao J, Zhang Q
Acta pharmaceutica Sinica. B 2024 Mar;14(3):1380-1399
Acta pharmaceutica Sinica. B 2024 Mar;14(3):1380-1399
Promotion of transcription factor EB-dependent autophagic process by curcumin alleviates arsenic-caused lung oxidative stress and inflammation in mice.
Xu G, Chen H, Cong Z, Wang R, Li X, Xie Y, Wang Y, Li B
The Journal of nutritional biochemistry 2024 Mar;125:109550
The Journal of nutritional biochemistry 2024 Mar;125:109550
ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis.
Chen C, Zhang Z, Liu C, Sun P, Liu P, Li X
Cell metabolism 2024 Mar 5;36(3):498-510.e11
Cell metabolism 2024 Mar 5;36(3):498-510.e11
Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome.
Barrow ER, Valionyte E, Baxter CR, Yang Y, Herath S, O'Connell WA, Lopatecka J, Strachan A, Woznica W, Stephenson HN, Fejer G, Sharma V, Lu B, Luo S
Cell reports 2024 Mar 26;43(3):113935
Cell reports 2024 Mar 26;43(3):113935
Theileria parasites sequester host eIF5A to escape elimination by host-mediated autophagy.
Villares M, Lourenço N, Ktorza I, Berthelet J, Panagiotou A, Richard A, Amo A, Koziy Y, Medjkane S, Valente S, Fioravanti R, Pioche-Durieu C, Lignière L, Chevreux G, Mai A, Weitzman JB
Nature communications 2024 Mar 12;15(1):2235
Nature communications 2024 Mar 12;15(1):2235
Pparα activation stimulates autophagic flux through lipid catabolism-independent route.
Zhang YY, Wang JX, Qiao F, Zhang ML, Luo Y, Du ZY
Fish physiology and biochemistry 2024 Jun;50(3):1141-1155
Fish physiology and biochemistry 2024 Jun;50(3):1141-1155
Celastrol enhances the viability of random-pattern skin flaps by regulating autophagy through the AMPK-mTOR-TFEB axis.
Gu M, Li C, Deng Q, Chen X, Lei R
Phytotherapy research : PTR 2024 Jun;38(6):3020-3036
Phytotherapy research : PTR 2024 Jun;38(6):3020-3036
Intermittent hypoxia training enhances Aβ endocytosis by plaque associated microglia via VPS35-dependent TREM2 recycling in murine Alzheimer's disease.
Wang X, Xie Y, Fan X, Wu X, Wang D, Zhu L
Alzheimer's research & therapy 2024 Jun 3;16(1):121
Alzheimer's research & therapy 2024 Jun 3;16(1):121
20- Deoxyingenol attenuate morphine-induced hippocampus neurotoxicity and memory impairments in rats.
Ma J, Zou L, Lou Y, Lin Y, Zhou J, Ju N, Pan J, Zhang X, Qi D
Heliyon 2024 Jun 15;10(11):e31605
Heliyon 2024 Jun 15;10(11):e31605
TFEB ameliorates DEHP-induced neurotoxicity by activating GAL3/TRIM16 axis dependent lysophagy and alleviating lysosomal dysfunction.
Xing H, Xu P, Ma Y, Li T, Zhang Y, Ding X, Liu L, Keerman M, Niu Q
Environmental toxicology 2024 Jul;39(7):3779-3789
Environmental toxicology 2024 Jul;39(7):3779-3789
LDHA contributes to nicotine induced cardiac fibrosis through autophagy flux impairment.
Wu HH, Du JM, Liu P, Meng FL, Li YY, Li WJ, Wang SX, Du NL, Zheng Y, Zhang L, Wang HY, Liu YR, Song CH, Ni X, Li Y, Su GH
International immunopharmacology 2024 Jul 30;136:112338
International immunopharmacology 2024 Jul 30;136:112338
Iron regulatory protein 2 contributes to antimicrobial immunity by preserving lysosomal function in macrophages.
Cheng C, Xing Z, Zhang W, Zheng L, Zhao H, Zhang X, Ding Y, Qiao T, Li Y, Meyron-Holtz EG, Missirlis F, Fan Z, Li K
Proceedings of the National Academy of Sciences of the United States of America 2024 Jul 30;121(31):e2321929121
Proceedings of the National Academy of Sciences of the United States of America 2024 Jul 30;121(31):e2321929121
DKK1 loss promotes endometrial fibrosis via autophagy and exosome-mediated macrophage-to-myofibroblast transition.
Zhang Z, Hu J
Journal of translational medicine 2024 Jul 3;22(1):617
Journal of translational medicine 2024 Jul 3;22(1):617
Targeting PKD2 aggravates ferritinophagy-mediated ferroptosis via promoting autophagosome-lysosome fusion and enhances efficacy of carboplatin in lung adenocarcinoma.
Liu Y, Pang Z, Wang Y, Liu J, Wang G, Du J
Chemico-biological interactions 2024 Jan 5;387:110794
Chemico-biological interactions 2024 Jan 5;387:110794
Transcriptional dysregulation of autophagy in the muscle of a mouse model of Duchenne muscular dystrophy.
Nakashima R, Hosoda R, Tatekoshi Y, Iwahara N, Saga Y, Kuno A
Scientific reports 2024 Jan 16;14(1):1365
Scientific reports 2024 Jan 16;14(1):1365
Naringin Protects against Non-Alcoholic Fatty Liver Disease by Promoting Autophagic Flux and Lipophagy.
Guan L, Guo L, Zhang H, Liu H, Zhou W, Zhai Y, Yan X, Men X, Peng L
Molecular nutrition & food research 2024 Feb;68(3):e2200812
Molecular nutrition & food research 2024 Feb;68(3):e2200812
Enriched environment ameliorates fear memory impairments induced by sleep deprivation via inhibiting PIEZO1/calpain/autophagy signaling pathway in the basal forebrain.
Zhang ZQ, Lu Y, Zhang H, Dong SH, Wu YT, Wang SN, Huang AH, Jiang QS, Yin SM
CNS neuroscience & therapeutics 2024 Feb;30(2):e14365
CNS neuroscience & therapeutics 2024 Feb;30(2):e14365
Ezrin inhibition alleviates oxidative stress and pyroptosis via regulating TRPML1-calcineurin axis mediated enhancement of autophagy in spinal cord injury.
Lou J, Jin M, Zhou C, Fan Y, Ni L, Mao Y, Shen H, Li J, Zhang H, Fu C, Mao X, Chen Y, Zhong J, Zhou K, Wang L, Wu J
Free radical biology & medicine 2024 Feb 20;212:133-148
Free radical biology & medicine 2024 Feb 20;212:133-148
Effects of α7 nicotinic acetylcholine receptor agonist against α-synuclein-induced neurotoxicity.
Takizawa S, Ohuchi K, Fujimaki A, Ito T, Murakami T, Kurita H, Inden M
Neuroscience letters 2024 Feb 16;823:137654
Neuroscience letters 2024 Feb 16;823:137654
TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease.
Du Y, Wu M, Song S, Bian Y, Shi Y
Renal failure 2024 Dec;46(1):2338933
Renal failure 2024 Dec;46(1):2338933
The methyltransferase SETD3 regulates mRNA alternative splicing through interacting with hnRNPK.
Kong YY, Shu WJ, Wang S, Yin ZH, Duan H, Li K, Du HN
Cell insight 2024 Dec;3(6):100198
Cell insight 2024 Dec;3(6):100198
Bone marrow mesenchymal stem cells modulate miR-202-3p to suppress neuronal apoptosis following spinal cord injury through autophagy activation via the AMPK, MAPK, and PI3K/AKT/mTOR signaling pathway.
Huang K, Fang J, Sun W, Zeng Y, Shi B, Ren B, Bi H, Shuai L
Scientific reports 2024 Dec 3;14(1):30099
Scientific reports 2024 Dec 3;14(1):30099
TFEB signaling promotes autophagic degradation of NLRP3 to attenuate neuroinflammation in diabetic encephalopathy.
Lin Y, Cheng L, Chen Y, Li W, Guo Q, Miao Y
American journal of physiology. Cell physiology 2024 Dec 1;327(6):C1481-C1496
American journal of physiology. Cell physiology 2024 Dec 1;327(6):C1481-C1496
PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson's disease.
Cao B, Chen X, Li Y, Zhou T, Chen N, Guo Y, Zhao M, Guo C, Shi Y, Wang Q, Du X, Zhang L, Li Y
NPJ Parkinson's disease 2024 Aug 6;10(1):146
NPJ Parkinson's disease 2024 Aug 6;10(1):146
Dehydroandrographolide ameliorates doxorubicin-mediated cardiotoxicity by regulating autophagy through the mTOR-TFEB pathway.
Duan Y, Huang P, Sun L, Wang P, Cai Y, Shi T, Li Y, Zhou Y, Yu S
Chemico-biological interactions 2024 Aug 25;399:111132
Chemico-biological interactions 2024 Aug 25;399:111132
Chemically synthesized osteocalcin alleviates NAFLD via the AMPK-FOXO1/BCL6-CD36 pathway.
Zhang M, Dong K, Du Q, Xu J, Bai X, Chen L, Yang J
Journal of translational medicine 2024 Aug 22;22(1):782
Journal of translational medicine 2024 Aug 22;22(1):782
Targeted dephosphorylation of TFEB promotes its nuclear translocation.
Zhao JF, Shpiro N, Sathe G, Brewer A, Macartney TJ, Wood NT, Negoita F, Sakamoto K, Sapkota GP
iScience 2024 Aug 16;27(8):110432
iScience 2024 Aug 16;27(8):110432
SMURF1 controls the PPP3/calcineurin complex and TFEB at a regulatory node for lysosomal biogenesis.
Xia Q, Zheng H, Li Y, Xu W, Wu C, Xu J, Li S, Zhang L, Dong L
Autophagy 2024 Apr;20(4):735-751
Autophagy 2024 Apr;20(4):735-751
Ginsenoside Rb1 alleviates 3-MCPD-induced renal cell pyroptosis by activating mitophagy.
Zhang R, Guan S, Meng Z, Zhang D, Lu J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114522
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114522
The role of mTORC1/TFEB axis mediated lysosomal biogenesis and autophagy impairment in fluoride neurotoxicity and the intervention effects of resveratrol.
Tang H, Hou H, Song L, Tian Z, Liu W, Xia T, Wang A
Journal of hazardous materials 2024 Apr 5;467:133634
Journal of hazardous materials 2024 Apr 5;467:133634
miR-29b-1-5p exacerbates myocardial injury induced by sepsis in a mouse model by targeting TERF2.
Jiang Y, Xu J, Zeng H, Lin Z, Yi Q, Guo J, Xiao F
Acta biochimica et biophysica Sinica 2024 Apr 25;56(4):607-620
Acta biochimica et biophysica Sinica 2024 Apr 25;56(4):607-620
TFEB regulates dendritic cell antigen presentation to modulate immune balance in asthma.
Xiang J, Liu B, Li Y, Ren Y, Li Y, Zhou M, Yu J, Luo Z, Liu E, Fu Z, Ding F
Respiratory research 2024 Apr 25;25(1):182
Respiratory research 2024 Apr 25;25(1):182
Tangshen formula protects against podocyte apoptosis via enhancing the TFEB-mediated autophagy-lysosome pathway in diabetic nephropathy.
Wang Y, Peng L, Lu X, Zhang H, Zhao H, Zhao T, Yang L, Mao H, Ma F, Liu T, Li P, Zhan Y
Journal of ethnopharmacology 2024 Apr 24;324:117721
Journal of ethnopharmacology 2024 Apr 24;324:117721
HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progression.
He L, Li H, Li C, Liu ZK, Lu M, Zhang RY, Wu D, Wei D, Shao J, Liu M, Wei HL, Zhang C, Wang Z, Kong LM, Chen ZN, Bian H
Cancer communications (London, England) 2023 Sep;43(9):981-1002
Cancer communications (London, England) 2023 Sep;43(9):981-1002
Lysine methylation of PPP1CA by the methyltransferase SUV39H2 disrupts TFEB-dependent autophagy and promotes intervertebral disc degeneration.
Liang H, Luo R, Li G, Zhang W, Zhu D, Wu D, Zhou X, Tong B, Wang B, Feng X, Wang K, Song Y, Yang C
Cell death and differentiation 2023 Sep;30(9):2135-2150
Cell death and differentiation 2023 Sep;30(9):2135-2150
Melatonin Restores Autophagic Flux by Activating the Sirt3/TFEB Signaling Pathway to Attenuate Doxorubicin-Induced Cardiomyopathy.
Ma Y, Ma J, Lu L, Xiong X, Shao Y, Ren J, Yang J, Liu J
Antioxidants (Basel, Switzerland) 2023 Sep 4;12(9)
Antioxidants (Basel, Switzerland) 2023 Sep 4;12(9)
Increased DNMT1 Involvement in the Activation of LO2 Cell Death Induced by Silver Nanoparticles via Promoting TFEB-Dependent Autophagy.
Chen J, Zheng D, Cai Z, Zhong B, Zhang H, Pan Z, Ling X, Han Y, Meng J, Li H, Chen X, Zhang H, Liu L
Toxics 2023 Sep 4;11(9)
Toxics 2023 Sep 4;11(9)
Optineurin tunes outside-in signaling to regulate lysosome biogenesis and phagocytic clearance in the retina.
Tan LX, Germer CJ, Thamban T, La Cunza N, Lakkaraju A
Current biology : CB 2023 Sep 25;33(18):3805-3820.e7
Current biology : CB 2023 Sep 25;33(18):3805-3820.e7
Sesquiterpenes from Carpesium faberi triggered ROS-induced apoptosis and protective autophagy in hepatocellular carcinoma cells.
Yan Y, Chen J, Peng M, Zhang X, Feng E, Li Q, Guo B, Ding X, Zhang Y, Tang L
Phytochemistry 2023 Oct;214:113805
Phytochemistry 2023 Oct;214:113805
TRIM16-mediated lysophagy suppresses high-glucose-accumulated neuronal Aβ.
Chae CW, Yoon JH, Lim JR, Park JY, Cho JH, Jung YH, Choi GE, Lee HJ, Han HJ
Autophagy 2023 Oct;19(10):2752-2768
Autophagy 2023 Oct;19(10):2752-2768
VPS41-mediated incomplete autophagy aggravates cadmium-induced apoptosis in mouse hepatocytes.
Wang T, Yan L, Wang L, Sun J, Qu H, Ma Y, Song R, Tong X, Zhu J, Yuan Y, Gu J, Bian J, Liu Z, Zou H
Journal of hazardous materials 2023 Oct 5;459:132243
Journal of hazardous materials 2023 Oct 5;459:132243
PACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy.
Yang J, Li L, Li C, Chen W, Liu Y, Luo S, Zhao C, Han Y, Yang M, Zhao H, Jiang N, Xi Y, Tang C, Cai J, Xiao L, Liu H, Sun L
Cell death & disease 2023 Oct 4;14(10):649
Cell death & disease 2023 Oct 4;14(10):649
Intermittent hypoxia therapy ameliorates beta-amyloid pathology via TFEB-mediated autophagy in murine Alzheimer's disease.
Wang X, Xie Y, Chen G, Lu Y, Wang D, Zhu L
Journal of neuroinflammation 2023 Oct 20;20(1):240
Journal of neuroinflammation 2023 Oct 20;20(1):240
Dysregulation of the progranulin-driven autophagy-lysosomal pathway mediates secretion of the nuclear protein TDP-43.
Tanaka Y, Ito SI, Honma Y, Hasegawa M, Kametani F, Suzuki G, Kozuma L, Takeya K, Eto M
The Journal of biological chemistry 2023 Nov;299(11):105272
The Journal of biological chemistry 2023 Nov;299(11):105272
Lipopolysaccharide promotes NLRP3 inflammasome activation by inhibiting TFEB-mediated autophagy in NRK-52E cells.
Song D, Tao W, Liu F, Wu X, Bi H, Shu J, Wang D, Li X
Molecular immunology 2023 Nov;163:127-135
Molecular immunology 2023 Nov;163:127-135
TFEB SUMOylation in macrophages accelerates atherosclerosis by promoting the formation of foam cells through inhibiting lysosomal activity.
Wang K, Zhou W, Hu G, Wang L, Cai R, Tian T
Cellular and molecular life sciences : CMLS 2023 Nov 11;80(12):358
Cellular and molecular life sciences : CMLS 2023 Nov 11;80(12):358
TFEB regulates cellular labile iron and prevents ferroptosis in a TfR1-dependent manner.
Chen L, Ma Y, Ma X, Liu L, Jv X, Li A, Shen Q, Jia W, Qu L, Shi L, Xie J
Free radical biology & medicine 2023 Nov 1;208:445-457
Free radical biology & medicine 2023 Nov 1;208:445-457
Grain-sized moxibustion at Zusanli (ST36) promotes hepatic autophagy in rats with hyperlipidemia by regulating the ULK1 and TFEB expression through the AMPK/mTOR signaling pathway.
Xu Q, Wu H, Zhu H, Lu C, Tao J, Zhou Z, Zhang J
Heliyon 2023 May;9(5):e15316
Heliyon 2023 May;9(5):e15316
Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.
Sampognaro PJ, Arya S, Knudsen GM, Gunderson EL, Sandoval-Perez A, Hodul M, Bowles K, Craik CS, Jacobson MP, Kao AW
Molecular neurodegeneration 2023 May 2;18(1):29
Molecular neurodegeneration 2023 May 2;18(1):29
The Protective Effect of (-)-Tetrahydroalstonine against OGD/R-Induced Neuronal Injury via Autophagy Regulation.
Liao Y, Wang JY, Pan Y, Zou X, Wang C, Peng Y, Ao YL, Lam MF, Zhang X, Zhang XQ, Shi L, Zhang S
Molecules (Basel, Switzerland) 2023 Mar 4;28(5)
Molecules (Basel, Switzerland) 2023 Mar 4;28(5)
TFEB coordinates autophagy and pyroptosis as hepatotoxicity responses to ZnO nanoparticles.
Pei X, Liu D, Li J, Li L, Ding X, Zhang W, Li Z, Xu G, Li C, Li D
The Science of the total environment 2023 Mar 20;865:161242
The Science of the total environment 2023 Mar 20;865:161242
PARP1 promotes NLRP3 activation via blocking TFEB-mediated autophagy in rotenone-induced neurodegeneration.
Zhang H, Xie Z, Peng Y, Xie A, Fu C, Zheng D, Cai Z, Zhong J, Ming Q, Li M, Lu R, Liu X, Chen J
Ecotoxicology and environmental safety 2023 Mar 1;252:114630
Ecotoxicology and environmental safety 2023 Mar 1;252:114630
TFEB attenuates hyperglycemia-induced retinal capillary endothelial cells injury via autophagy regulation.
Cheng Y, Fan H, Liu K, Liu J, Zou H, You Z
Cell biology international 2023 Jun;47(6):1092-1105
Cell biology international 2023 Jun;47(6):1092-1105
Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells.
Li ZB, Jiang L, Ni JD, Xu YH, Liu F, Liu WM, Wang SG, Liu ZQ, Wang CY
Acta pharmacologica Sinica 2023 Jun;44(6):1191-1205
Acta pharmacologica Sinica 2023 Jun;44(6):1191-1205
Homoplantaginin attenuates high glucose-induced vascular endothelial cell apoptosis through promoting autophagy via the AMPK/TFEB pathway.
Fan L, Zhang X, Huang Y, Zhang B, Li W, Shi Q, Lin Y, Wu F
Phytotherapy research : PTR 2023 Jul;37(7):3025-3041
Phytotherapy research : PTR 2023 Jul;37(7):3025-3041
De novo missense variants in RRAGC lead to a fatal mTORopathy of early childhood.
Reijnders MRF, Seibt A, Brugger M, Lamers IJC, Ott T, Klaas O, Horváth J, Rose AMS, Craghill IM, Brunet T, Graf E, Mayerhanser K, Hellebrekers D, Pauck D, Neuen-Jacob E, Rodenburg RJT, Wieczorek D, Klee D, Mayatepek E, Driessen G, Bindermann R, Averdunk L, Lohmeier K, Sinnema M, Stegmann APA, Roepman R, Poulter JA, Distelmaier F
Genetics in medicine : official journal of the American College of Medical Genetics 2023 Jul;25(7):100838
Genetics in medicine : official journal of the American College of Medical Genetics 2023 Jul;25(7):100838
Selective autophagy associated with iron overload aggravates non-alcoholic steatohepatitis via ferroptosis.
Honma K, Kirihara S, Nakayama H, Fukuoka T, Ohara T, Kitamori K, Sato I, Hirohata S, Fujii M, Yamamoto S, Ran S, Watanabe S
Experimental biology and medicine (Maywood, N.J.) 2023 Jul;248(13):1112-1123
Experimental biology and medicine (Maywood, N.J.) 2023 Jul;248(13):1112-1123
Phosphorylation of EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) is indispensable for nuclear translocation of TFEB and TFE3 during ER stress.
Dang TT, Kim MJ, Lee YY, Le HT, Kim KH, Nam S, Hyun SH, Kim HL, Chung SW, Chung HT, Jho EH, Yoshida H, Kim K, Park CY, Lee MS, Back SH
Autophagy 2023 Jul;19(7):2111-2142
Autophagy 2023 Jul;19(7):2111-2142
Acrylamide interferes with autophagy and induces apoptosis in Neuro-2a cells by interfering with TFEB-regulated lysosomal function.
Pang P, Zhang X, Yuan J, Yan H, Yan D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113818
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113818
Progranulin Protects against Hyperglycemia-Induced Neuronal Dysfunction through GSK3β Signaling.
Dedert C, Salih L, Xu F
Cells 2023 Jul 7;12(13)
Cells 2023 Jul 7;12(13)
Sulforaphane protects microvascular endothelial cells in lower limb ischemia/reperfusion injury mice.
Chen F, Zhan J, Al Mamun A, Tao Y, Huang S, Zhao J, Zhang Y, Xu Y, Du S, Lu W, Li X, Chen Z, Xiao J
Food & function 2023 Jul 31;14(15):7176-7194
Food & function 2023 Jul 31;14(15):7176-7194
Resveratrol plays an anti-fibrotic and anti-autophagy role by stimulating miR-192-5p expression in urethral fibrosis.
Lv J, Zhang R, Li D, Liu Y
Functional & integrative genomics 2023 Jul 14;23(3):241
Functional & integrative genomics 2023 Jul 14;23(3):241
Restoration of c-Src/Fyn Proteins Rescues Mitochondrial Dysfunction in Huntington's Disease.
Fão L, Coelho P, Duarte L, Vilaça R, Hayden MR, Mota SI, Rego AC
Antioxidants & redox signaling 2023 Jan;38(1-3):95-114
Antioxidants & redox signaling 2023 Jan;38(1-3):95-114
Ring domains are essential for GATOR2-dependent mTORC1 activation.
Jiang C, Dai X, He S, Zhou H, Fang L, Guo J, Liu S, Zhang T, Pan W, Yu H, Fu T, Li D, Inuzuka H, Wang P, Xiao J, Wei W
Molecular cell 2023 Jan 5;83(1):74-89.e9
Molecular cell 2023 Jan 5;83(1):74-89.e9
Ginsenoside Rb1 induces autophagic lipid degradation via miR-128 targeting TFEB.
Meng Z, Lu J, Ge G, Wang G, Zhang R, Li Y, Guan S, Lu J
Food & function 2023 Jan 3;14(1):240-249
Food & function 2023 Jan 3;14(1):240-249
Proteome-Wide Analysis Reveals TFEB Targets for Establishment of a Prognostic Signature to Predict Clinical Outcomes of Colorectal Cancer.
Huang Z, Zhu S, Han Z, Li C, Liang J, Wang Y, Zhang S, Zhang J
Cancers 2023 Jan 25;15(3)
Cancers 2023 Jan 25;15(3)
The inhibition of TRPML1/TFEB leads to lysosomal biogenesis disorder, contributes to developmental fluoride neurotoxicity.
Zhang J, Tang Y, Hu Z, Xu W, Ma Y, Xu P, Xing H, Niu Q
Ecotoxicology and environmental safety 2023 Jan 15;250:114511
Ecotoxicology and environmental safety 2023 Jan 15;250:114511
Autophagy impairment is involved in midazolam-induced lipid droplet accumulation and consequent phagocytosis decrease in BV2 cells.
Zhu XL, Zhang HW, Peng WJ, Gao S, Yang ZL, Zhang JQ, Liu XS
Biochemical and biophysical research communications 2023 Feb 5;643:147-156
Biochemical and biophysical research communications 2023 Feb 5;643:147-156
Exendin-4 alleviates myocardial ischemia reperfusion injury by enhancing autophagy through promoting nuclear translocation of TFEB.
He W, Tong G, Fan H, Zhen C, Zeng L, Xue L, Chen J, Sun Z, He P
Experimental cell research 2023 Feb 15;423(2):113469
Experimental cell research 2023 Feb 15;423(2):113469
Doxorubicin induces cardiomyocyte death owing to the accumulation of dysfunctional mitochondria by inhibiting the autophagy fusion process.
Toda N, Sato T, Muraoka M, Lin D, Saito M, Li G, Song QC, Yanagisawa T, Yamauchi M
Free radical biology & medicine 2023 Feb 1;195:47-57
Free radical biology & medicine 2023 Feb 1;195:47-57
KDM1A-mediated upregulation of METTL3 ameliorates Alzheimer's disease via enhancing autophagic clearance of p-Tau through m6A-dependent regulation of STUB1.
Tang Z, Cao J, Yao J, Fan X, Zhao J, Zhao M, Duan Q, Han B, Duan S
Free radical biology & medicine 2023 Feb 1;195:343-358
Free radical biology & medicine 2023 Feb 1;195:343-358
Paeoniflorin recued hepatotoxicity under zinc oxide nanoparticles exposure via regulation on gut-liver axis and reversal of pyroptosis.
Pei X, Tang S, Jiang H, Zhang W, Xu G, Zuo Z, Ren Z, Chen C, Shen Y, Li C, Li D
The Science of the total environment 2023 Dec 15;904:166885
The Science of the total environment 2023 Dec 15;904:166885
Abnormal Cholesterol Metabolism and Lysosomal Dysfunction Induce Age-Related Hearing Loss by Inhibiting mTORC1-TFEB-Dependent Autophagy.
Lee YY, Ha J, Kim YS, Ramani S, Sung S, Gil ES, Choo OS, Jang JH, Choung YH
International journal of molecular sciences 2023 Dec 15;24(24)
International journal of molecular sciences 2023 Dec 15;24(24)
Hyperoside attenuates pyrrolizidine alkaloids-induced liver injury by ameliorating TFEB-mediated mitochondrial dysfunction.
Xu J, Xiong A, Wang X, Yan X, Chen Y, Ye X, Wang Z, Ding L, Yang L
Archives of pharmacal research 2023 Aug;46(8):694-712
Archives of pharmacal research 2023 Aug;46(8):694-712
Overexpression of hepatic pescadillo 1 in obesity induces lipid dysregulation by inhibiting autophagy.
Zhou J, Lu Y, Lin Y, Li C, Liu J, Jiang Z, Chen K
Translational research : the journal of laboratory and clinical medicine 2023 Aug;258:1-15
Translational research : the journal of laboratory and clinical medicine 2023 Aug;258:1-15
Targeting ANXA7/LAMP5-mTOR axis attenuates spinal cord injury by inhibiting neuronal apoptosis via enhancing autophagy in mice.
Li N, Chen L, Zhao X, Gu C, Chang Y, Feng S
Cell death discovery 2023 Aug 24;9(1):309
Cell death discovery 2023 Aug 24;9(1):309
STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages.
Liu Y, Sun Q, Zhang C, Ding M, Wang C, Zheng Q, Ma Z, Xu H, Zhou G, Wang X, Cheng Z, Xia H
iScience 2023 Aug 18;26(8):107376
iScience 2023 Aug 18;26(8):107376
Chronic Neuronal Inactivity Utilizes the mTOR-TFEB Pathway to Drive Transcription-Dependent Autophagy for Homeostatic Up-Scaling.
Wang Y, Lin J, Li J, Yan L, Li W, He X, Ma H
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Apr 12;43(15):2631-2652
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023 Apr 12;43(15):2631-2652
Activation of Transcription Factor EB Is Associated With Adipose Tissue Lipolysis in Dairy Cows With Subclinical Ketosis.
Yu H, Gao X, Loor JJ, Jiang Q, Fang Z, Hao X, Shi Z, Fan M, Chen M, Li X, Liu G, Wang Z, Li X, Du X
Frontiers in veterinary science 2022;9:816064
Frontiers in veterinary science 2022;9:816064
Glutamine Availability Regulates the Development of Aging Mediated by mTOR Signaling and Autophagy.
Zhou J, Chen H, Du J, Tai H, Han X, Huang N, Wang X, Gong H, Yang M, Xiao H
Frontiers in pharmacology 2022;13:924081
Frontiers in pharmacology 2022;13:924081
Quercetin protects against palmitate-induced pancreatic β-cell apoptosis by restoring lysosomal function and autophagic flux.
Liu H, Zhou W, Guo L, Zhang H, Guan L, Yan X, Zhai Y, Qiao Y, Wang Z, Zhao J, Lyu K, Li P, Wang H, Peng L
The Journal of nutritional biochemistry 2022 Sep;107:109060
The Journal of nutritional biochemistry 2022 Sep;107:109060
Berberine-mediated REDD1 down-regulation ameliorates senescence of retinal pigment epithelium by interrupting the ROS-DDR positive feedback loop.
Chen Q, Xin G, Li S, Dong Y, Yu X, Wan C, Wei Z, Zhu Y, Zhang K, Wang Y, Li F, Zhang C, Wen E, Li Y, Niu H, Huang W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154181
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154181
Identification of active natural products that induce lysosomal biogenesis by lysosome-based screening and biological evaluation.
Ding X, Yang X, Zhao Y, Wang Y, Fei J, Niu Z, Dong X, Wang X, Liu B, Li H, Hao X, Zhao Y
Heliyon 2022 Oct;8(10):e11179
Heliyon 2022 Oct;8(10):e11179
Defective autophagy contributes to endometrial epithelial-mesenchymal transition in intrauterine adhesions.
Zhou Z, Wang H, Zhang X, Song M, Yao S, Jiang P, Liu D, Wang Z, Lv H, Li R, Hong Y, Dai J, Hu Y, Zhao G
Autophagy 2022 Oct;18(10):2427-2442
Autophagy 2022 Oct;18(10):2427-2442
TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2.
Yang CB, Liu J, Tong BC, Wang ZY, Zhu Z, Su CF, Sreenivasmurthy SG, Wu JX, Iyaswamy A, Krishnamoorthi S, Huang SY, Cheung KH, Song JX, Tan JQ, Lu JH, Li M
Acta pharmacologica Sinica 2022 May;43(5):1251-1263
Acta pharmacologica Sinica 2022 May;43(5):1251-1263
Wolframin is a novel regulator of tau pathology and neurodegeneration.
Chen S, Acosta D, Li L, Liang J, Chang Y, Wang C, Fitzgerald J, Morrison C, Goulbourne CN, Nakano Y, Villegas NCH, Venkataraman L, Brown C, Serrano GE, Bell E, Wemlinger T, Wu M, Kokiko-Cochran ON, Popovich P, Flowers XE, Honig LS, Vonsattel JP, Scharre DW, Beach TG, Ma Q, Kuret J, Kõks S, Urano F, Duff KE, Fu H
Acta neuropathologica 2022 May;143(5):547-569
Acta neuropathologica 2022 May;143(5):547-569
Bioengineered microglia-targeted exosomes facilitate Aβ clearance via enhancing activity of microglial lysosome for promoting cognitive recovery in Alzheimer's disease.
Hao Y, Su C, Liu X, Sui H, Shi Y, Zhao L
Biomaterials advances 2022 May;136:212770
Biomaterials advances 2022 May;136:212770
TFEB ameliorates autophagy flux disturbance induced by PBDE-47 via up-regulating autophagy-lysosome fusion.
Tang H, Huang H, Wang D, Li P, Tian Z, Li D, Wang S, Ma R, Xia T, Wang A
Journal of hazardous materials 2022 May 15;430:128483
Journal of hazardous materials 2022 May 15;430:128483
Restoration of Autophagic Flux Improves Endothelial Function in Diabetes Through Lowering Mitochondrial ROS-Mediated eNOS Monomerization.
Zhao L, Zhang CL, He L, Chen Q, Liu L, Kang L, Liu J, Luo JY, Gou L, Qu D, Song W, Lau CW, Ko H, Mok VCT, Tian XY, Wang L, Huang Y
Diabetes 2022 May 1;71(5):1099-1114
Diabetes 2022 May 1;71(5):1099-1114
SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.
Zhao Y, Mao A, Zhang R, Guan S, Lu J
Environmental toxicology 2022 Mar;37(3):549-563
Environmental toxicology 2022 Mar;37(3):549-563
Lysosomal ATP Transporter SLC17A9 Controls Cell Viability via Regulating Cathepsin D.
Huang P, Cao Q, Xu M, Dong XP
Cells 2022 Mar 4;11(5)
Cells 2022 Mar 4;11(5)
Hyperphosphatemia-induced degradation of transcription factor EB exacerbates vascular calcification.
Ishiwata R, Morimoto Y
Biochimica et biophysica acta. Molecular basis of disease 2022 Mar 1;1868(3):166323
Biochimica et biophysica acta. Molecular basis of disease 2022 Mar 1;1868(3):166323
GSK-3β inhibition elicits a neuroprotection by restoring lysosomal dysfunction in neurons via facilitation of TFEB nuclear translocation after ischemic stroke.
Zhang Y, Wu Z, Huang Z, Liu Y, Chen X, Zhao X, He H, Deng Y
Brain research 2022 Mar 1;1778:147768
Brain research 2022 Mar 1;1778:147768
By restoring autophagic flux and improving mitochondrial function, corosolic acid protects against Dox-induced cardiotoxicity.
Che Y, Wang Z, Yuan Y, Zhou H, Wu H, Wang S, Tang Q
Cell biology and toxicology 2022 Jun;38(3):451-467
Cell biology and toxicology 2022 Jun;38(3):451-467
EWI2 promotes endolysosome-mediated turnover of growth factor receptors and integrins to suppress lung cancer.
Wang J, Wren JD, Ding Y, Chen J, Mittal N, Xu C, Li X, Zeng C, Wang M, Shi J, Zhang YH, Han SJ, Zhang XA
Cancer letters 2022 Jun 28;536:215641
Cancer letters 2022 Jun 28;536:215641
Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goat.
Wang M, Qi Y, Cao Y, Zhang X, Wang Y, Liu Q, Zhang J, Zhou G, Ai Y, Wei S, Wang L, Liu G, Lian Z, Han H
eLife 2022 Jun 28;11
eLife 2022 Jun 28;11
Effect and mechanism of TFEB on pyroptosis in HK-2 cells induced by high glucose.
Han N, Wang Z, Luo H, Chi Y, Zhang T, Wang B, Li Y
Biochemical and biophysical research communications 2022 Jun 25;610:162-169
Biochemical and biophysical research communications 2022 Jun 25;610:162-169
Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival.
Chen Z, Wu H, Yang J, Li B, Ding J, Cheng S, Bsoul N, Zhang C, Li J, Liu H, Lin D, Gao W
Communications biology 2022 Jun 22;5(1):616
Communications biology 2022 Jun 22;5(1):616
A racemosin B derivative, C25, suppresses breast cancer growth via lysosomal membrane permeabilization and inhibition of autophagic flux.
Xiao X, Chung PED, Xu M, Hu A, Ju Y, Yang X, Song J, Song J, Wang C, Zacksenhaus E, Liu S, He Z, Ben-David Y
Biochemical pharmacology 2022 Jul;201:115060
Biochemical pharmacology 2022 Jul;201:115060
CCL20/CCR6 axis mediates macrophages to promote proliferation and migration of ESCs by blocking autophagic flux in endometriosis.
Tan J, Xu T, Gou Y, Wang H, Liang Z, Cao Y, Wang H, Yu Y, Jiao N, Zhang Z
Stem cell research & therapy 2022 Jul 15;13(1):294
Stem cell research & therapy 2022 Jul 15;13(1):294
Up-regulation of NMRK2 mediated by TFE3 fusions is the key for energy metabolism adaption of Xp11.2 translocation renal cell carcinoma.
Chen Y, Yang L, Lu Y, Liu N, Ma W, Fan H, Hu Q, Han X, Gan W, Li D
Cancer letters 2022 Jul 10;538:215689
Cancer letters 2022 Jul 10;538:215689
Tianma Gouteng Decoction regulates oxidative stress and inflammation in AngII-induced hypertensive mice via transcription factor EB to exert anti-hypertension effect.
Deng L, Liu W, Xu Q, Guo R, Zhang D, Ni J, Li L, Cai X, Fan G, Zhao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jan;145:112383
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jan;145:112383
Transcription factor EB enhances autophagy and ameliorates palmitate-induced insulin resistance at least partly via upregulating AMPK activity in skeletal muscle cells.
Wang P, Li CG, Zhou X, Ding S
Clinical and experimental pharmacology & physiology 2022 Feb;49(2):302-310
Clinical and experimental pharmacology & physiology 2022 Feb;49(2):302-310
TLR4-Mediated Inflammatory Responses Regulate Exercise-Induced Molecular Adaptations in Mouse Skeletal Muscle.
Fujiyoshi H, Egawa T, Kurogi E, Yokokawa T, Kido K, Hayashi T
International journal of molecular sciences 2022 Feb 7;23(3)
International journal of molecular sciences 2022 Feb 7;23(3)
Activation of FMS-like tyrosine kinase 3 protects against isoprenaline-induced cardiac hypertrophy by improving autophagy and mitochondrial dynamics.
Jiang X, Zhang K, Gao C, Ma W, Liu M, Guo X, Bao G, Han B, Hu H, Zhao Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Dec;36(12):e22672
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Dec;36(12):e22672
Metformin Alleviates Epirubicin-Induced Endothelial Impairment by Restoring Mitochondrial Homeostasis.
Sun Q, Jia H, Cheng S, Wang Y, Wang J
International journal of molecular sciences 2022 Dec 25;24(1)
International journal of molecular sciences 2022 Dec 25;24(1)
Vitamin D Attenuates Pain and Cartilage Destruction in OA Animals via Enhancing Autophagic Flux and Attenuating Inflammatory Cell Death.
Jhun J, Woo JS, Kwon JY, Na HS, Cho KH, Kim SA, Kim SJ, Moon SJ, Park SH, Cho ML
Immune network 2022 Aug;22(4):e34
Immune network 2022 Aug;22(4):e34
Phillygenin ameliorates nonalcoholic fatty liver disease via TFEB-mediated lysosome biogenesis and lipophagy.
Zhou W, Yan X, Zhai Y, Liu H, Guan L, Qiao Y, Jiang J, Peng L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Aug;103:154235
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Aug;103:154235
Harmol promotes α-synuclein degradation and improves motor impairment in Parkinson's models via regulating autophagy-lysosome pathway.
Xu J, Ao YL, Huang C, Song X, Zhang G, Cui W, Wang Y, Zhang XQ, Zhang Z
NPJ Parkinson's disease 2022 Aug 6;8(1):100
NPJ Parkinson's disease 2022 Aug 6;8(1):100
Itaconate is a lysosomal inducer that promotes antibacterial innate immunity.
Zhang Z, Chen C, Yang F, Zeng YX, Sun P, Liu P, Li X
Molecular cell 2022 Aug 4;82(15):2844-2857.e10
Molecular cell 2022 Aug 4;82(15):2844-2857.e10
Aerobic Exercise Alleviates Abnormal Autophagy in Brain Cells of APP/PS1 Mice by Upregulating AdipoR1 Levels.
Jian Y, Yuan S, Yang J, Lei Y, Li X, Liu W
International journal of molecular sciences 2022 Aug 31;23(17)
International journal of molecular sciences 2022 Aug 31;23(17)
Elabela ameliorates doxorubicin-induced cardiotoxicity by promoting autophagic flux through TFEB pathway.
Chen D, Yu W, Zhong C, Hong Q, Huang G, Que D, Wang Y, Yang Y, Rui B, Zhuang Z, Liang M, Ye Z, Yan X, Lv J, Zhang R, Yan J, Yang P
Pharmacological research 2022 Apr;178:106186
Pharmacological research 2022 Apr;178:106186
Tubastatin A Improves Post-Resuscitation Myocardial Dysfunction by Inhibiting NLRP3-Mediated Pyroptosis Through Enhancing Transcription Factor EB Signaling.
Xu J, Zhao X, Jiang X, He L, Wu X, Wang J, Chen Q, Li Y, Zhang M
Journal of the American Heart Association 2022 Apr 5;11(7):e024205
Journal of the American Heart Association 2022 Apr 5;11(7):e024205
Apigenin Alleviates Intervertebral Disc Degeneration via Restoring Autophagy Flux in Nucleus Pulposus Cells.
Xie C, Shi Y, Chen Z, Zhou X, Luo P, Hong C, Tian N, Wu Y, Zhou Y, Lin Y, Dou H, Wu A, Huang Q, Zhang X, Wang X
Frontiers in cell and developmental biology 2021;9:787278
Frontiers in cell and developmental biology 2021;9:787278
Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease.
Hu D, Sun X, Magpusao A, Fedorov Y, Thompson M, Wang B, Lundberg K, Adams DJ, Qi X
Nature communications 2021 Sep 6;12(1):5305
Nature communications 2021 Sep 6;12(1):5305
Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy.
Shyam R, Ogando DG, Choi M, Liton PB, Bonanno JA
Investigative ophthalmology & visual science 2021 Sep 2;62(12):15
Investigative ophthalmology & visual science 2021 Sep 2;62(12):15
Melibiose Confers a Neuroprotection against Cerebral Ischemia/Reperfusion Injury by Ameliorating Autophagy Flux via Facilitation of TFEB Nuclear Translocation in Neurons.
Wu Z, Zhang Y, Liu Y, Chen X, Huang Z, Zhao X, He H, Deng Y
Life (Basel, Switzerland) 2021 Sep 10;11(9)
Life (Basel, Switzerland) 2021 Sep 10;11(9)
TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading.
Xu Y, Du S, Marsh JA, Horie K, Sato C, Ballabio A, Karch CM, Holtzman DM, Zheng H
Molecular psychiatry 2021 Oct;26(10):5925-5939
Molecular psychiatry 2021 Oct;26(10):5925-5939
Dysregulation of miR-342-3p in plasma exosomes derived from convalescent AMI patients and its consequences on cardiac repair.
Wang B, Cao C, Han D, Bai J, Guo J, Guo Q, Li D, Zhang J, Zhang Z, Wang Y, Tang J, Shen D, Zhang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Oct;142:112056
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Oct;142:112056
Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy.
Han Y, Xiong S, Zhao H, Yang S, Yang M, Zhu X, Jiang N, Xiong X, Gao P, Wei L, Xiao Y, Sun L
Cell death & disease 2021 Oct 30;12(11):1031
Cell death & disease 2021 Oct 30;12(11):1031
TP53/p53-FBXO22-TFEB controls basal autophagy to govern hormesis.
Suzuki N, Johmura Y, Wang TW, Migita T, Wu W, Noguchi R, Yamaguchi K, Furukawa Y, Nakamura S, Miyoshi I, Yoshimori T, Ohta T, Nakanishi M
Autophagy 2021 Nov;17(11):3776-3793
Autophagy 2021 Nov;17(11):3776-3793
Positive regulation of TFEB and mitophagy by PGC-1α to alleviate LPS-induced acute lung injury in rats.
Liu W, Li Y, Bo L, Li C, Jin F
Biochemical and biophysical research communications 2021 Nov 5;577:1-5
Biochemical and biophysical research communications 2021 Nov 5;577:1-5
DNA Repair Inhibition Leads to Active Export of Repetitive Sequences to the Cytoplasm Triggering an Inflammatory Response.
Song X, Aw JTM, Ma F, Cheung MF, Leung D, Herrup K
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Nov 10;41(45):9286-9307
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Nov 10;41(45):9286-9307
Apple polyphenol extract alleviates lipid accumulation in free-fatty-acid-exposed HepG2 cells via activating autophagy mediated by SIRT1/AMPK signaling.
Li D, Cui Y, Wang X, Liu F, Li X
Phytotherapy research : PTR 2021 Mar;35(3):1416-1431
Phytotherapy research : PTR 2021 Mar;35(3):1416-1431
20-Deoxyingenol alleviates osteoarthritis by activating TFEB in chondrocytes.
Gu M, Jin J, Ren C, Chen X, Pan Z, Wu Y, Tian N, Sun L, Wu A, Gao W, Zhou Y, Lin Z, Zhang X
Pharmacological research 2021 Mar;165:105361
Pharmacological research 2021 Mar;165:105361
Transcription factor EB (TFEB)-mediated autophagy protects bovine mammary epithelial cells against H(2)O(2)-induced oxidative damage in vitro.
Sun X, Chang R, Tang Y, Luo S, Jiang C, Jia H, Xu Q, Dong Z, Liang Y, Loor JJ, Xu C
Journal of animal science and biotechnology 2021 Mar 9;12(1):35
Journal of animal science and biotechnology 2021 Mar 9;12(1):35
YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases.
Ikeda S, Nah J, Shirakabe A, Zhai P, Oka SI, Sciarretta S, Guan KL, Shimokawa H, Sadoshima J
The Journal of clinical investigation 2021 Mar 1;131(5)
The Journal of clinical investigation 2021 Mar 1;131(5)
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Zhang X, Wei M, Fan J, Yan W, Zha X, Song H, Wan R, Yin Y, Wang W
Autophagy 2021 Jun;17(6):1519-1542
Autophagy 2021 Jun;17(6):1519-1542
Cisplatin remodels the tumor immune microenvironment via the transcription factor EB in ovarian cancer.
Liu W, Wang Y, Xie Y, Dai T, Fan M, Li C, Zou Y
Cell death discovery 2021 Jun 5;7(1):136
Cell death discovery 2021 Jun 5;7(1):136
Lysosomal nitric oxide determines transition from autophagy to ferroptosis after exposure to plasma-activated Ringer's lactate.
Jiang L, Zheng H, Lyu Q, Hayashi S, Sato K, Sekido Y, Nakamura K, Tanaka H, Ishikawa K, Kajiyama H, Mizuno M, Hori M, Toyokuni S
Redox biology 2021 Jul;43:101989
Redox biology 2021 Jul;43:101989
Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway.
Fang S, Wan X, Zou X, Sun S, Hao X, Liang C, Zhang Z, Zhang F, Sun B, Li H, Yu B
Cell death & disease 2021 Jan 18;12(1):88
Cell death & disease 2021 Jan 18;12(1):88
Quercetin alleviates Cadmium-induced autophagy inhibition via TFEB-dependent lysosomal restoration in primary proximal tubular cells.
Zhao Y, Li ZF, Zhang D, Wang ZY, Wang L
Ecotoxicology and environmental safety 2021 Jan 15;208:111743
Ecotoxicology and environmental safety 2021 Jan 15;208:111743
PMEPA1 and NEDD4 control the proton production of osteoclasts by regulating vesicular trafficking.
Hirata H, Xu X, Nishioka K, Matsuhisa F, Kitajima S, Kukita T, Murayama M, Urano Y, Miyamoto H, Mawatari M, Kukita A
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21281
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21281
Swainsonine promotes apoptosis by impairing lysosomal function and inhibiting autophagic degradation in rat primary renal tubular epithelial cells.
Wang S, Guo R, Su Y, Yang C, Guo Y, Tan C, Zhao B
Chemico-biological interactions 2021 Feb 25;336:109319
Chemico-biological interactions 2021 Feb 25;336:109319
Ginsenoside Rb1 alleviates liver injury induced by 3-chloro-1,2-propanediol by stimulating autophagic flux.
Lu J, Lu J, Bu X, Li Y, Ge G, Guan S
Journal of food science 2021 Dec;86(12):5503-5515
Journal of food science 2021 Dec;86(12):5503-5515
Ajugol enhances TFEB-mediated lysosome biogenesis and lipophagy to alleviate non-alcoholic fatty liver disease.
Zhang H, Lu J, Liu H, Guan L, Xu S, Wang Z, Qiu Y, Liu H, Peng L, Men X
Pharmacological research 2021 Dec;174:105964
Pharmacological research 2021 Dec;174:105964
p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease.
Chen J, Mao K, Yu H, Wen Y, She H, Zhang H, Liu L, Li M, Li W, Zou F
Journal of neuroinflammation 2021 Dec 20;18(1):295
Journal of neuroinflammation 2021 Dec 20;18(1):295
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Kataura T, Tashiro E, Nishikawa S, Shibahara K, Muraoka Y, Miura M, Sakai S, Katoh N, Totsuka M, Onodera M, Shin-Ya K, Miyamoto K, Sasazawa Y, Hattori N, Saiki S, Imoto M
Autophagy 2021 Aug;17(8):1856-1872
Autophagy 2021 Aug;17(8):1856-1872
TFEB phosphorylation on Serine 211 is induced by autophagy in human synovial fibroblasts and by p62/SQSTM1 overexpression in HEK293 cells.
Relic B, Deroyer C, Malaise O, Plener Z, Gillet P, de Seny D, Malaise MG
The Biochemical journal 2021 Aug 27;478(16):3145-3155
The Biochemical journal 2021 Aug 27;478(16):3145-3155
Programmed cell death 4 modulates lysosomal function by inhibiting TFEB translation.
Chen X, Guan Y, Zhang Y, Jia Y, Li W, Guo C, Li Y, Wang X, Shi Y, Wang Q, Zhu F, Li Y, Zhang L
Cell death and differentiation 2021 Apr;28(4):1237-1250
Cell death and differentiation 2021 Apr;28(4):1237-1250
Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging.
Zhang S, Zhang Y, Zhang X, Luo C, Cao Y, Ji D, Yan W, Xue K, Chai J, Dai H, Wang W
Oxidative medicine and cellular longevity 2020;2020:4252047
Oxidative medicine and cellular longevity 2020;2020:4252047
Cardamonin Reduces Acetaminophen-Induced Acute Liver Injury in Mice via Activating Autophagy and NFE2L2 Signaling.
Xu Q, Fan Y, Loor JJ, Liang Y, Sun X, Jia H, Zhao C, Xu C
Frontiers in pharmacology 2020;11:601716
Frontiers in pharmacology 2020;11:601716
3-Acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages.
Liu N, Yang Y, Chen J, Jia H, Zhang Y, Jiang D, Wu G, Wu Z
Environmental pollution (Barking, Essex : 1987) 2020 Oct;265(Pt B):114697
Environmental pollution (Barking, Essex : 1987) 2020 Oct;265(Pt B):114697
HGF protected against diabetic nephropathy via autophagy-lysosome pathway in podocyte by modulating PI3K/Akt-GSK3β-TFEB axis.
Hou B, Li Y, Li X, Zhang C, Zhao Z, Chen Q, Zhang N, Li H
Cellular signalling 2020 Nov;75:109744
Cellular signalling 2020 Nov;75:109744
Wnt/β-Catenin Signaling Axis Is Required for TFEB-Mediated Gastric Cancer Metastasis and Epithelial-Mesenchymal Transition.
Li S, Liu F, Xu L, Li C, Yang X, Guo B, Gu J, Wang L
Molecular cancer research : MCR 2020 Nov;18(11):1650-1659
Molecular cancer research : MCR 2020 Nov;18(11):1650-1659
PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming.
Ma WQ, Sun XJ, Zhu Y, Liu NF
Cell death & disease 2020 Nov 17;11(11):991
Cell death & disease 2020 Nov 17;11(11):991
Blue light-emitting diode irradiation promotes transcription factor EB-mediated lysosome biogenesis and lysosomal cell death in murine photoreceptor-derived cells.
Otsu W, Ishida K, Nakamura S, Shimazawa M, Tsusaki H, Hara H
Biochemical and biophysical research communications 2020 May 28;526(2):479-484
Biochemical and biophysical research communications 2020 May 28;526(2):479-484
TFEB-NF-κB inflammatory signaling axis: a novel therapeutic pathway of Dihydrotanshinone I in doxorubicin-induced cardiotoxicity.
Wang X, Wang Q, Li W, Zhang Q, Jiang Y, Guo D, Sun X, Lu W, Li C, Wang Y
Journal of experimental & clinical cancer research : CR 2020 May 24;39(1):93
Journal of experimental & clinical cancer research : CR 2020 May 24;39(1):93
Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease.
Mao K, Chen J, Yu H, Li H, Ren Y, Wu X, Wen Y, Zou F, Li W
Aging cell 2020 Jun;19(6):e13163
Aging cell 2020 Jun;19(6):e13163
The Establishment and Application Studies on Precise Lysosome pH Indicator Based on Self-Decomposable Nanoparticles.
Pang C, Song C, Li Y, Wang Q, Zhu X, Wu J, Tian Y, Fan H, Hu J, Li C, Wang B, Li X, Liu W, Fan L
Nanoscale research letters 2020 Jul 8;15(1):143
Nanoscale research letters 2020 Jul 8;15(1):143
Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages.
He X, Chen S, Li C, Ban J, Wei Y, He Y, Liu F, Chen Y, Chen J
Cells 2020 Jan 4;9(1)
Cells 2020 Jan 4;9(1)
Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway.
Sun X, Zhou Y, Zhang R, Wang Z, Xu M, Zhang D, Huang J, Luo F, Li F, Ni Z, Zhou S, Chen H, Chen S, Chen L, Du X, Chen B, Huang H, Liu P, Yin L, Qiu J, Chen D, Deng C, Xie Y, Luo L, Chen L
Nature communications 2020 Jan 24;11(1):479
Nature communications 2020 Jan 24;11(1):479
A Self-Assembled α-Synuclein Nanoscavenger for Parkinson's Disease.
Liu J, Liu C, Zhang J, Zhang Y, Liu K, Song JX, Sreenivasmurthy SG, Wang Z, Shi Y, Chu C, Zhang Y, Wu C, Deng X, Liu X, Song J, Zhuang R, Huang S, Zhang P, Li M, Wen L, Zhang YW, Liu G
ACS nano 2020 Feb 25;14(2):1533-1549
ACS nano 2020 Feb 25;14(2):1533-1549
LSD1 negatively regulates autophagy in myoblast cells by driving PTEN degradation.
Shi YX, He YJ, Zhou Y, Li HK, Yang D, Li RY, Deng ZL, Gao YF
Biochemical and biophysical research communications 2020 Feb 19;522(4):924-930
Biochemical and biophysical research communications 2020 Feb 19;522(4):924-930
The neuroprotective effects of activated α7 nicotinic acetylcholine receptor against mutant copper-zinc superoxide dismutase 1-mediated toxicity.
Ito T, Inden M, Ueda T, Asaka Y, Kurita H, Hozumi I
Scientific reports 2020 Dec 17;10(1):22157
Scientific reports 2020 Dec 17;10(1):22157
TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS.
Cunningham KM, Maulding K, Ruan K, Senturk M, Grima JC, Sung H, Zuo Z, Song H, Gao J, Dubey S, Rothstein JD, Zhang K, Bellen HJ, Lloyd TE
eLife 2020 Dec 10;9
eLife 2020 Dec 10;9
Activation of α7nACh receptor protects against acute pancreatitis through enhancing TFEB-regulated autophagy.
Li B, Wu J, Bao J, Han X, Shen S, Ye X, Dai J, Wu Z, Niu M, He Y, Ni J, Wen L, Wang X, Hu G
Biochimica et biophysica acta. Molecular basis of disease 2020 Dec 1;1866(12):165971
Biochimica et biophysica acta. Molecular basis of disease 2020 Dec 1;1866(12):165971
Remote ischemic postconditioning attenuates damage in rats with chronic cerebral ischemia by upregulating the autophagolysosome pathway via the activation of TFEB.
Li Z, Cui X, Lv H, Liu J, Di W, Jiang F, Liu Y, Cheng X
Experimental and molecular pathology 2020 Aug;115:104475
Experimental and molecular pathology 2020 Aug;115:104475
NAD(+) administration decreases microvascular damage following cardiac ischemia/reperfusion by restoring autophagic flux.
Zhang YJ, Zhang M, Zhao X, Shi K, Ye M, Tian J, Guan S, Ying W, Qu X
Basic research in cardiology 2020 Aug 10;115(5):57
Basic research in cardiology 2020 Aug 10;115(5):57
Deregulated MTOR (mechanistic target of rapamycin kinase) is responsible for autophagy defects exacerbating kidney stone development.
Unno R, Kawabata T, Taguchi K, Sugino T, Hamamoto S, Ando R, Okada A, Kohri K, Yoshimori T, Yasui T
Autophagy 2020 Apr;16(4):709-723
Autophagy 2020 Apr;16(4):709-723
Trehalose attenuates renal ischemia-reperfusion injury by enhancing autophagy and inhibiting oxidative stress and inflammation.
Liu S, Yang Y, Gao H, Zhou N, Wang P, Zhang Y, Zhang A, Jia Z, Huang S
American journal of physiology. Renal physiology 2020 Apr 1;318(4):F994-F1005
American journal of physiology. Renal physiology 2020 Apr 1;318(4):F994-F1005
Loss of spatacsin impairs cholesterol trafficking and calcium homeostasis.
Boutry M, Pierga A, Matusiak R, Branchu J, Houllegatte M, Ibrahim Y, Balse E, El Hachimi KH, Brice A, Stevanin G, Darios F
Communications biology 2019;2:380
Communications biology 2019;2:380
Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology.
Xue M, Liang H, Ji X, Liu Y, Ge Y, Hou L, Sun T
Nutrition & metabolism 2019;16:87
Nutrition & metabolism 2019;16:87
TFEB Probably Involved in Midazolam-Disturbed Lysosomal Homeostasis and Its Induced β-Amyloid Accumulation.
Cheng D, Tan Q, Zhu Q, Zhang J, Han X, Fang P, Jin W, Liu X
Frontiers in human neuroscience 2019;13:108
Frontiers in human neuroscience 2019;13:108
Irisin reverses insulin resistance in C2C12 cells via the p38-MAPK-PGC-1α pathway.
Ye X, Shen Y, Ni C, Ye J, Xin Y, Zhang W, Ren Y
Peptides 2019 Sep;119:170120
Peptides 2019 Sep;119:170120
TFEB-mediated Enhancement of the Autophagy-lysosomal Pathway Dually Modulates the Process of Amyloid β-Protein Generation in Neurons.
Yamamoto F, Taniguchi K, Mamada N, Tamaoka A, Kametani F, Lakshmana MK, Araki W
Neuroscience 2019 Mar 15;402:11-22
Neuroscience 2019 Mar 15;402:11-22
Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress.
Chakraborty D, Felzen V, Hiebel C, Stürner E, Perumal N, Manicam C, Sehn E, Grus F, Wolfrum U, Behl C
Redox biology 2019 Jun;24:101181
Redox biology 2019 Jun;24:101181
NEO212 induces mitochondrial apoptosis and impairs autophagy flux in ovarian cancer.
Song X, Liu L, Chang M, Geng X, Wang X, Wang W, Chen TC, Xie L, Song X
Journal of experimental & clinical cancer research : CR 2019 Jun 7;38(1):239
Journal of experimental & clinical cancer research : CR 2019 Jun 7;38(1):239
Overexpression of transcription factor EB regulates mitochondrial autophagy to protect lipopolysaccharide-induced acute lung injury.
Liu W, Li CC, Lu X, Bo LY, Jin FG
Chinese medical journal 2019 Jun 5;132(11):1298-1304
Chinese medical journal 2019 Jun 5;132(11):1298-1304
Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP1.
Wang X, Li C, Wang Q, Li W, Guo D, Zhang X, Shao M, Chen X, Ma L, Zhang Q, Wang W, Wang Y
Cancers 2019 Jun 28;11(7)
Cancers 2019 Jun 28;11(7)
mTORC1 inhibition attenuates necroptosis through RIP1 inhibition-mediated TFEB activation.
Abe K, Yano T, Tanno M, Miki T, Kuno A, Sato T, Kouzu H, Nakata K, Ohwada W, Kimura Y, Sugawara H, Shibata S, Igaki Y, Ino S, Miura T
Biochimica et biophysica acta. Molecular basis of disease 2019 Dec 1;1865(12):165552
Biochimica et biophysica acta. Molecular basis of disease 2019 Dec 1;1865(12):165552
Effects of transcription factor EB on oxidative stress and apoptosis induced by high glucose in podocytes.
Kang Y, Li Y, Zhang T, Chi Y, Liu M
International journal of molecular medicine 2019 Aug;44(2):447-456
International journal of molecular medicine 2019 Aug;44(2):447-456
TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells.
He R, Wang M, Zhao C, Shen M, Yu Y, He L, Zhao Y, Chen H, Shi X, Zhou M, Pan S, Liu Y, Guo X, Li X, Qin R
Journal of experimental & clinical cancer research : CR 2019 Aug 6;38(1):340
Journal of experimental & clinical cancer research : CR 2019 Aug 6;38(1):340
CD36 plays a negative role in the regulation of lipophagy in hepatocytes through an AMPK-dependent pathway.
Li Y, Yang P, Zhao L, Chen Y, Zhang X, Zeng S, Wei L, Varghese Z, Moorhead JF, Chen Y, Ruan XZ
Journal of lipid research 2019 Apr;60(4):844-855
Journal of lipid research 2019 Apr;60(4):844-855
Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency.
Lotfi P, Tse DY, Di Ronza A, Seymour ML, Martano G, Cooper JD, Pereira FA, Passafaro M, Wu SM, Sardiello M
Autophagy 2018;14(8):1419-1434
Autophagy 2018;14(8):1419-1434
A Critical Role of Autophagy in Regulating Microglia Polarization in Neurodegeneration.
Jin MM, Wang F, Qi D, Liu WW, Gu C, Mao CJ, Yang YP, Zhao Z, Hu LF, Liu CF
Frontiers in aging neuroscience 2018;10:378
Frontiers in aging neuroscience 2018;10:378
Role of c-Abl-GSK3β Signaling in MPP+-Induced Autophagy-Lysosomal Dysfunction.
Ren Y, Chen J, Wu X, Gui C, Mao K, Zou F, Li W
Toxicological sciences : an official journal of the Society of Toxicology 2018 Sep 1;165(1):232-243
Toxicological sciences : an official journal of the Society of Toxicology 2018 Sep 1;165(1):232-243
Autophagic Modulation by Trehalose Reduces Accumulation of TDP-43 in a Cell Model of Amyotrophic Lateral Sclerosis via TFEB Activation.
Wang Y, Liu FT, Wang YX, Guan RY, Chen C, Li DK, Bu LL, Song J, Yang YJ, Dong Y, Chen Y, Wang J
Neurotoxicity research 2018 Jul;34(1):109-120
Neurotoxicity research 2018 Jul;34(1):109-120
TFEB, a potential therapeutic target for osteoarthritis via autophagy regulation.
Zheng G, Zhan Y, Li X, Pan Z, Zheng F, Zhang Z, Zhou Y, Wu Y, Wang X, Gao W, Xu H, Tian N, Zhang X
Cell death & disease 2018 Aug 28;9(9):858
Cell death & disease 2018 Aug 28;9(9):858
Secretory carrier membrane protein 5 is an autophagy inhibitor that promotes the secretion of α-synuclein via exosome.
Yang Y, Qin M, Bao P, Xu W, Xu J
PloS one 2017;12(7):e0180892
PloS one 2017;12(7):e0180892
Non-thermal plasma induces a stress response in mesothelioma cells resulting in increased endocytosis, lysosome biogenesis and autophagy.
Shi L, Ito F, Wang Y, Okazaki Y, Tanaka H, Mizuno M, Hori M, Hirayama T, Nagasawa H, Richardson DR, Toyokuni S
Free radical biology & medicine 2017 Jul;108:904-917
Free radical biology & medicine 2017 Jul;108:904-917
mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases.
Palmieri M, Pal R, Nelvagal HR, Lotfi P, Stinnett GR, Seymour ML, Chaudhury A, Bajaj L, Bondar VV, Bremner L, Saleem U, Tse DY, Sanagasetti D, Wu SM, Neilson JR, Pereira FA, Pautler RG, Rodney GG, Cooper JD, Sardiello M
Nature communications 2017 Feb 6;8:14338
Nature communications 2017 Feb 6;8:14338
Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells.
Kobayashi T, Tsutsui H, Shimabukuro-Demoto S, Yoshida-Sugitani R, Karyu H, Furuyama-Tanaka K, Ohshima D, Kato N, Okamura T, Toyama-Sorimachi N
International immunology 2017 Dec 31;29(12):551-566
International immunology 2017 Dec 31;29(12):551-566
MAP1LC3B overexpression protects against Hermansky-Pudlak syndrome type-1-induced defective autophagy in vitro.
Ahuja S, Knudsen L, Chillappagari S, Henneke I, Ruppert C, Korfei M, Gochuico BR, Bellusci S, Seeger W, Ochs M, Guenther A, Mahavadi P
American journal of physiology. Lung cellular and molecular physiology 2016 Mar 15;310(6):L519-31
American journal of physiology. Lung cellular and molecular physiology 2016 Mar 15;310(6):L519-31
Increased Apoptosis of Inflamed Odontoblasts Is Associated with CD47 Loss.
Wang HS, Pei F, Chen Z, Zhang L
Journal of dental research 2016 Jun;95(6):697-703
Journal of dental research 2016 Jun;95(6):697-703
A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition.
Song JX, Sun YR, Peluso I, Zeng Y, Yu X, Lu JH, Xu Z, Wang MZ, Liu LF, Huang YY, Chen LL, Durairajan SS, Zhang HJ, Zhou B, Zhang HQ, Lu A, Ballabio A, Medina DL, Guo Z, Li M
Autophagy 2016 Aug 2;12(8):1372-89
Autophagy 2016 Aug 2;12(8):1372-89
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 13372-1-AP(TFEB antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using TFEB antibody 13372-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-TFEB (IP:13372-1-AP, 3ug; Detection:13372-1-AP 1:1000) with NIH/3T3 cells lysate 3300ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human renal cell carcinoma using 13372-1-AP(TFEB antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- cell line
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human renal cell carcinoma using 13372-1-AP(TFEB antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- cell line
