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- Antibody Data
- Antigen structure
- References [10]
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- Western blot [3]
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- Product number
- NBP1-07047 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-07047, RRID:AB_1625832
- Product name
- Rabbit Polyclonal PDK4 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1.35 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references High hepatic expression of PDK4 improves survival upon multimodal treatment of colorectal liver metastases.
Defining the contribution of skeletal muscle pyruvate dehydrogenase α1 to exercise performance and insulin action.
Pyruvate dehydrogenase kinase 4 exhibits a novel role in the activation of mutant KRAS, regulating cell growth in lung and colorectal tumour cells.
Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours.
Remote ischemic preconditioning with a specialized protocol activates the non-neuronal cardiac cholinergic system and increases ATP content in the heart.
Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation.
Myostatin/activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice.
Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells.
Effects of high-fat diet and physical activity on pyruvate dehydrogenase kinase-4 in mouse skeletal muscle.
Regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) gene expression by glucocorticoids and insulin.
Strowitzki MJ, Radhakrishnan P, Pavicevic S, Scheer J, Kimmer G, Ritter AS, Tuffs C, Volz C, Vondran F, Harnoss JM, Klose J, Schmidt T, Schneider M
British journal of cancer 2019 Apr;120(7):675-688
British journal of cancer 2019 Apr;120(7):675-688
Defining the contribution of skeletal muscle pyruvate dehydrogenase α1 to exercise performance and insulin action.
Svensson K, Dent JR, Tahvilian S, Martins VF, Sathe A, Ochala J, Patel MS, Schenk S
American journal of physiology. Endocrinology and metabolism 2018 Nov 1;315(5):E1034-E1045
American journal of physiology. Endocrinology and metabolism 2018 Nov 1;315(5):E1034-E1045
Pyruvate dehydrogenase kinase 4 exhibits a novel role in the activation of mutant KRAS, regulating cell growth in lung and colorectal tumour cells.
Trinidad AG, Whalley N, Rowlinson R, Delpuech O, Dudley P, Rooney C, Critchlow SE
Oncogene 2017 Nov 2;36(44):6164-6176
Oncogene 2017 Nov 2;36(44):6164-6176
Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours.
Golias T, Papandreou I, Sun R, Kumar B, Brown NV, Swanson BJ, Pai R, Jaitin D, Le QT, Teknos TN, Denko NC
Scientific reports 2016 Aug 8;6:31146
Scientific reports 2016 Aug 8;6:31146
Remote ischemic preconditioning with a specialized protocol activates the non-neuronal cardiac cholinergic system and increases ATP content in the heart.
Oikawa S, Mano A, Takahashi R, Kakinuma Y
International immunopharmacology 2015 Nov;29(1):181-4
International immunopharmacology 2015 Nov;29(1):181-4
Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation.
Hou X, Zhang L, Han L, Ge J, Ma R, Zhang X, Moley K, Schedl T, Wang Q
Journal of cell science 2015 Jul 1;128(13):2319-29
Journal of cell science 2015 Jul 1;128(13):2319-29
Myostatin/activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice.
Kainulainen H, Papaioannou KG, Silvennoinen M, Autio R, Saarela J, Oliveira BM, Nyqvist M, Pasternack A, 't Hoen PA, Kujala UM, Ritvos O, Hulmi JJ
Molecular and cellular endocrinology 2015 Jan 5;399:131-42
Molecular and cellular endocrinology 2015 Jan 5;399:131-42
Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells.
Ho N, Coomber BL
Experimental cell research 2015 Feb 1;331(1):73-81
Experimental cell research 2015 Feb 1;331(1):73-81
Effects of high-fat diet and physical activity on pyruvate dehydrogenase kinase-4 in mouse skeletal muscle.
Rinnankoski-Tuikka R, Silvennoinen M, Torvinen S, Hulmi JJ, Lehti M, Kivelä R, Reunanen H, Kainulainen H
Nutrition & metabolism 2012 Jun 9;9(1):53
Nutrition & metabolism 2012 Jun 9;9(1):53
Regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) gene expression by glucocorticoids and insulin.
Connaughton S, Chowdhury F, Attia RR, Song S, Zhang Y, Elam MB, Cook GA, Park EA
Molecular and cellular endocrinology 2010 Feb 5;315(1-2):159-67
Molecular and cellular endocrinology 2010 Feb 5;315(1-2):159-67
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: PDK4 Antibody [NBP1-07047] - Mouse liver. NuPAGE 4-12%. This image was submitted via customer review.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: PDK4 Antibody [NBP1-07047] - Western Blot on human heart protein lysate.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: PDK4 Antibody [NBP1-07047] - The protein expression levels in QF muscle. Representative Western blot images. n = 14-15 animals/group. * = vs. LFsed (P 0.1). Black bars = sedentary, grey bars = running. Image collected and cropped by CiteAb from the following publication (http://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-9-53), licensed under a CC-BY licence.
