NBP1-42322

antibody from Novus Biologicals

Targeting: PGC

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

NBP1-42322

Provider

Novus Biologicals

Proper citation

Novus Cat#NBP1-42322, RRID:AB_2160751

Product name

Mouse Monoclonal Pepsinogen C/PGC/Progastricsin Antibody

Antibody type

Monoclonal

Description

Protein A or G purified. The antibody is specific to human pepsinogen II with no cross reactivity to human pepsinogen I. Pepsinogen II is a group of precursor molecules for pepsin. These proteins are secreted into the gastric lumen by the pyloric glands of the gastric antrum and also by the chief and neck cells of the gastric corpus (oxyntic mucosa). Negative immunohistochemical reaction for pepsinogen I (right) but positive reaction for pepsinogen II (left) is a typical sign of the antral mucosa and, in the presence of atrophic gastritis, this staining pattern indicates that the positive glands and cells are metaplastic and pyloric in differentiation (so called pseudopyloric metaplasia). Monoclonal antibody to pepsinogen II is derived from the hybridoma produced by fusion between myeloma cells and Balb/c spleen cells. Pepsinogen II purified from human tissue was used as an immunogen.

Reactivity

Human

Host

Mouse

Isotype

IgG

Vial size

0.05 mg

Concentration

0.1 mg/ml

Storage

Store at 4C. Do not freeze.