Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 513004 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#513004, RRID:AB_2249025
- Product name
- PE anti-human IL-21
- Antibody type
- Monoclonal
- Antigen
- Recombinant full length human IL-21
- Description
- Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularly the inflammatory Th17 subset, and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells. It can also be proapoptotic for B cells and NK cells. Studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation, suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.
- Reactivity
- Human, Simian
- Host
- Mouse
- Conjugate
- Yellow dye
- Isotype
- IgG
- Vial size
- 100 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- PMA+ionomycin-stimulated (5 hours) human PBMCs intracellular stained with 3A3-N2 PE and CD3 APC (top panel), bottom data shows the staining of 3A3-N2 PE can be blocked by preincubation of the cells with purified 3A3-N2
- Conjugate
- Yellow dye