BS6301

antibody from Bioworld Technology, Inc
Targeting: ADRB2 ADRB2R, ADRBR, B2AR, BAR
Provider product page for BS6301
Western blot
Immunohistochemistry

Antibody data

Product number
BS6301 - Provider product page
Provider
Bioworld Technology, Inc
Product name
ADRB2 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human ADRB2.
Description
Adrenergic receptors (ARs) (the term ¡ùadrenergic¡ì reflects the alternative name for epinephrine, adrenaline) include four general types (a1, a2, b1 and b2) which are found in different target tissues and differ in their affinities and responses to various agonists and antagonists. cDNA clones have been isolated for all of the major AR subtypes and a number of closely related receptors have been identified by this approach. Each of the receptors have been shown to consist of single polypeptide chains which transverse the plasma membrane seven times, presumably forming a bundle of helices within the membrane. These transmembrane regions are hydrophobic and are interconnected by extracellular and intracellular hydrophilic loops. The coupling of ARs to specific intracellular effectors is mediated through diverse heterotrimeric G proteins and is regulated by G protein-coupled receptor kinases (GRKs), cAMP-dependent protein kinase A and protein kinase C directed phosphorylation. b2-adrenergic receptors bind cathecholamines (epinephrine, norepinephrine) and influence development, behavior, cardiac function, smooth muscle tone, and metabolism. b2-AR signaling complexes can contain C L-type calcium channel Ca(V)1.2, G protein, adenylyl cyclase, cAMP-dependent kinase, and PP2A phosphatase. b2-AR s are present in
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
ADRB2 protein structure - BS6301 shown in red.