MMRN2

This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6. [provided by RefSeq, Aug 2012]

Description

Multimerin 2

Tissue specificity

Low tissue specificity

Subcell location

Vesicles

Predicted location

Intracellular, Secreted to extracellular matrix

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (86935540 - 86969481)

Ensembl ID

ENSG00000173269  (ver. 103.38)

Orthologs

Mouse Mmrn2: ENSMUSG00000041445

UniProt

Q9H8L6

neXtProt

NX_Q9H8L6

Human splice variants
Mouse splice variants

Protein structure