Antibody data
- Antibody Data
- Antigen structure
- References [27]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 10960-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10960-1-AP, RRID:AB_2291830
- Product name
- Cofilin antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Cofilin antibody (Cat. #10960-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Inhibition of anlotinib-induced autophagy attenuates invasion and migration by regulating epithelial-mesenchymal transition and cytoskeletal rearrangement through ATG5 in human osteosarcoma cells.
The interaction of PRDX1 with Cofilin promotes oral squamous cell carcinoma metastasis.
Neuronal CFL1 upregulation in head and neck squamous cell carcinoma enhances tumor-nerve crosstalk and promotes tumor growth.
PLEK2 mediates metastasis and invasion via α5-nAChR activation in nicotine-induced lung adenocarcinoma.
METTL3-mediated RanGAP1 promotes colorectal cancer progression through the MAPK pathway by recruiting YTHDF1.
N-terminal α-amino SUMOylation of cofilin-1 is critical for its regulation of actin depolymerization.
Stratifin (SFN) Regulates Cervical Cancer Cell Proliferation, Apoptosis, and Cytoskeletal Remodeling and Metastasis Progression Through LIMK2/Cofilin Signaling.
ICP4-Associated Activation of Rap1b Facilitates Herpes Simplex Virus Type I (HSV-1) Infection in Human Corneal Epithelial Cells.
RhoGDIα regulates spermatogenesis through Rac1/cofilin/F-actin signaling.
HIF1A-repressed PUS10 regulates NUDC/Cofilin1 dependent renal cell carcinoma migration by promoting the maturation of miR-194-5p.
TM9SF4 is an F-actin disassembly factor that promotes tumor progression and metastasis.
Avian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization.
NLRP2 inhibits cell proliferation and migration by regulating EMT in lung adenocarcinoma cells.
NudC L279P Mutation Destabilizes Filamin A by Inhibiting the Hsp90 Chaperoning Pathway and Suppresses Cell Migration.
Protein Kinase C Activation Drives a Differentiation Program in an Oligodendroglial Precursor Model through the Modulation of Specific Biological Networks.
JTE-013 supplementation improves erectile dysfunction in rats with streptozotocin-induced type Ⅰ diabetes through the inhibition of the rho-kinase pathway, fibrosis, and apoptosis.
No DCX-positive neurogenesis in the cerebral cortex of the adult primate.
Carbonic Anhydrase XII Expression Is Modulated during Epithelial Mesenchymal Transition and Regulated through Protein Kinase C Signaling.
Nonconserved miR-608 suppresses prostate cancer progression through RAC2/PAK4/LIMK1 and BCL2L1/caspase-3 pathways by targeting the 3'-UTRs of RAC2/BCL2L1 and the coding region of PAK4.
Androgen deficiency impairs erectile function in rats through promotion of corporal fibrosis.
Reduced corporal fibrosis to protect erectile function by inhibiting the Rho-kinase/LIM-kinase/cofilin pathway in the aged transgenic rat harboring human tissue kallikrein 1.
Rabies virus inactivates cofilin to facilitate viral budding and release.
The role of cofilin-l in vulvar squamous cell carcinoma: A marker of carcinogenesis, progression and targeted therapy.
NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1.
A three-protein signature and clinical outcome in esophageal squamous cell carcinoma.
Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma.
The expression of CFL1 and N-WASP in esophageal squamous cell carcinoma and its correlation with clinicopathological features.
Zheng B, Sun X, Zhang L, Qu G, Ren C, Yan P, Zhou C, Yue B
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2024;57:e13152
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2024;57:e13152
The interaction of PRDX1 with Cofilin promotes oral squamous cell carcinoma metastasis.
Shen Y, You Z, Li L, Tang X, Shan X
International journal of cancer 2024 Oct 1;155(7):1290-1302
International journal of cancer 2024 Oct 1;155(7):1290-1302
Neuronal CFL1 upregulation in head and neck squamous cell carcinoma enhances tumor-nerve crosstalk and promotes tumor growth.
Liu R, Wang C, Sun Z, Shi X, Zhang Z, Luo J
Molecular carcinogenesis 2024 May;63(5):874-884
Molecular carcinogenesis 2024 May;63(5):874-884
PLEK2 mediates metastasis and invasion via α5-nAChR activation in nicotine-induced lung adenocarcinoma.
Li Q, Li J, Wang J, Wang J, Lu T, Jia Y, Sun H, Ma X
Molecular carcinogenesis 2024 Feb;63(2):253-265
Molecular carcinogenesis 2024 Feb;63(2):253-265
METTL3-mediated RanGAP1 promotes colorectal cancer progression through the MAPK pathway by recruiting YTHDF1.
Yang R, Yang C, Su D, Song Y, Min J, Qian Z, Shen X, Li J, Su H
Cancer gene therapy 2024 Apr;31(4):562-573
Cancer gene therapy 2024 Apr;31(4):562-573
N-terminal α-amino SUMOylation of cofilin-1 is critical for its regulation of actin depolymerization.
Weng W, Gu X, Yang Y, Zhang Q, Deng Q, Zhou J, Cheng J, Zhu MX, Feng J, Huang O, Li Y
Nature communications 2023 Sep 14;14(1):5688
Nature communications 2023 Sep 14;14(1):5688
Stratifin (SFN) Regulates Cervical Cancer Cell Proliferation, Apoptosis, and Cytoskeletal Remodeling and Metastasis Progression Through LIMK2/Cofilin Signaling.
Du N, Li D, Zhao W, Liu Y
Molecular biotechnology 2023 Nov 9;
Molecular biotechnology 2023 Nov 9;
ICP4-Associated Activation of Rap1b Facilitates Herpes Simplex Virus Type I (HSV-1) Infection in Human Corneal Epithelial Cells.
Zhang B, Ding J, Ma Z
Viruses 2023 Jun 27;15(7)
Viruses 2023 Jun 27;15(7)
RhoGDIα regulates spermatogenesis through Rac1/cofilin/F-actin signaling.
Zhu H, Wen Z, Zhang A, Liu D, Wang H, Cheng Y, Yang X, Xiao Y, Li J, Sun D, Wu B, Gao J
Communications biology 2023 Feb 23;6(1):214
Communications biology 2023 Feb 23;6(1):214
HIF1A-repressed PUS10 regulates NUDC/Cofilin1 dependent renal cell carcinoma migration by promoting the maturation of miR-194-5p.
Luo W, Xu Z, Wang H, Lu Z, Ding L, Wang R, Xie H, Zheng Q, Lin Y, Zhou Z, Li Y, Chen X, Li G, Xia L
Cell & bioscience 2023 Aug 18;13(1):153
Cell & bioscience 2023 Aug 18;13(1):153
TM9SF4 is an F-actin disassembly factor that promotes tumor progression and metastasis.
Meng Z, Li Z, Xie M, Yu H, Jiang L, Yao X
Nature communications 2022 Sep 29;13(1):5728
Nature communications 2022 Sep 29;13(1):5728
Avian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization.
Zhang B, Fan M, Fan J, Luo Y, Wang J, Wang Y, Liu B, Sun Y, Zhao Q, Hiscox JA, Nan Y, Zhou EM
Microbiology spectrum 2022 Feb 23;10(1):e0226521
Microbiology spectrum 2022 Feb 23;10(1):e0226521
NLRP2 inhibits cell proliferation and migration by regulating EMT in lung adenocarcinoma cells.
Li T, Li X, Mao R, Pan L, Que Y, Zhu C, Jin L, Li S
Cell biology international 2022 Apr;46(4):588-598
Cell biology international 2022 Apr;46(4):588-598
NudC L279P Mutation Destabilizes Filamin A by Inhibiting the Hsp90 Chaperoning Pathway and Suppresses Cell Migration.
Liu M, Xu Z, Zhang C, Yang C, Feng J, Lu Y, Zhang W, Chen W, Xu X, Sun X, Yang M, Liu W, Zhou T, Yang Y
Frontiers in cell and developmental biology 2021;9:671233
Frontiers in cell and developmental biology 2021;9:671233
Protein Kinase C Activation Drives a Differentiation Program in an Oligodendroglial Precursor Model through the Modulation of Specific Biological Networks.
Damato M, Cardon T, Wisztorski M, Fournier I, Pieragostino D, Cicalini I, Salzet M, Vergara D, Maffia M
International journal of molecular sciences 2021 May 15;22(10)
International journal of molecular sciences 2021 May 15;22(10)
JTE-013 supplementation improves erectile dysfunction in rats with streptozotocin-induced type Ⅰ diabetes through the inhibition of the rho-kinase pathway, fibrosis, and apoptosis.
Liu K, Cui K, Feng H, Li R, Lin H, Chen Y, Zhang Y, Chen Z, Yuan H, Li M, Wang T, Lan R, Liu J, Rao K, Wen B
Andrology 2020 Mar;8(2):497-508
Andrology 2020 Mar;8(2):497-508
No DCX-positive neurogenesis in the cerebral cortex of the adult primate.
Liu RX, Ma J, Wang B, Tian T, Guo N, Liu SJ
Neural regeneration research 2020 Jul;15(7):1290-1299
Neural regeneration research 2020 Jul;15(7):1290-1299
Carbonic Anhydrase XII Expression Is Modulated during Epithelial Mesenchymal Transition and Regulated through Protein Kinase C Signaling.
Vergara D, Ravaioli S, Fonzi E, Adamo L, Damato M, Bravaccini S, Pirini F, Gaballo A, Barbano R, Pasculli B, Franck J, Fournier I, Salzet M, Maffia M
International journal of molecular sciences 2020 Jan 22;21(3)
International journal of molecular sciences 2020 Jan 22;21(3)
Nonconserved miR-608 suppresses prostate cancer progression through RAC2/PAK4/LIMK1 and BCL2L1/caspase-3 pathways by targeting the 3'-UTRs of RAC2/BCL2L1 and the coding region of PAK4.
Zhang X, Fang J, Chen S, Wang W, Meng S, Liu B
Cancer medicine 2019 Sep;8(12):5716-5734
Cancer medicine 2019 Sep;8(12):5716-5734
Androgen deficiency impairs erectile function in rats through promotion of corporal fibrosis.
Cui K, Li R, Chen R, Li M, Wang T, Yang J, Chen Z, Wang S, Liu J, Rao K
Andrologia 2018 Feb;50(1)
Andrologia 2018 Feb;50(1)
Reduced corporal fibrosis to protect erectile function by inhibiting the Rho-kinase/LIM-kinase/cofilin pathway in the aged transgenic rat harboring human tissue kallikrein 1.
Cui K, Luan Y, Wang T, Zhuan L, Rao K, Wang SG, Ye ZQ, Liu JH, Wang DW
Asian journal of andrology 2017 Jan-Feb;19(1):67-72
Asian journal of andrology 2017 Jan-Feb;19(1):67-72
Rabies virus inactivates cofilin to facilitate viral budding and release.
Zan J, An ST, Mo KK, Zhou JW, Liu J, Wang HL, Yan Y, Liao M, Zhou JY
Biochemical and biophysical research communications 2016 Sep 2;477(4):1045-1050
Biochemical and biophysical research communications 2016 Sep 2;477(4):1045-1050
The role of cofilin-l in vulvar squamous cell carcinoma: A marker of carcinogenesis, progression and targeted therapy.
Wu Q, Jiang Y, Cui S, Wang Y, Wu X
Oncology reports 2016 May;35(5):2743-54
Oncology reports 2016 May;35(5):2743-54
NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1.
Zhang C, Zhang W, Lu Y, Yan X, Yan X, Zhu X, Liu W, Yang Y, Zhou T
Cell research 2016 Feb;26(2):239-53
Cell research 2016 Feb;26(2):239-53
A three-protein signature and clinical outcome in esophageal squamous cell carcinoma.
Cao HH, Zhang SY, Shen JH, Wu ZY, Wu JY, Wang SH, Li EM, Xu LY
Oncotarget 2015 Mar 10;6(7):5435-48
Oncotarget 2015 Mar 10;6(7):5435-48
Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma.
Yang X, Zou P, Yao J, Yun D, Bao H, Du R, Long J, Chen X
Journal of proteome research 2010 Mar 5;9(3):1402-15
Journal of proteome research 2010 Mar 5;9(3):1402-15
The expression of CFL1 and N-WASP in esophageal squamous cell carcinoma and its correlation with clinicopathological features.
Wang WS, Zhong HJ, Xiao DW, Huang X, Liao LD, Xie ZF, Xu XE, Shen ZY, Xu LY, Li EM
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 2010 Aug;23(6):512-21
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 2010 Aug;23(6):512-21
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 10960-1-AP(CFL1 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human cervical cancer using 10960-1-AP(CFL1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Cofilin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Cofilin. This antibody recognizes human,mouse,rat antigen. The Cofilin antibody has been validated for the following applications: ELISA, WB, IHC analysis.