DPABH-15758

antibody from Creative Diagnostics

Targeting: ERBB4 ALS19, HER4

No application information provided.

Antibody Data

Product number

DPABH-15758

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DPABH-15758, RRID:AB_2513564

Product name

Rabbit Anti-Human ERBB4 Polyclonal antibody

Antibody type

Polyclonal

Description

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described