BS60348

antibody from Bioworld Technology, Inc
Targeting: GPR182 ADMR, AM-R, G10D, hrhAMR
Provider product page for BS60348

Antibody data

Product number
BS60348 - Provider product page
Provider
Bioworld Technology, Inc
Product name
GPR182 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human GPR182.
Description
Adrenomedullin (ADM) is a hypotensive peptide that belongs to a peptide superfamily, which includes the calcitonin gene-related peptide (CGRP) and amylin . ADM was originally identified in the adrenal medulla, where it is highly expressed . It is also produced by most contractile cells and is upregulated during sepsis and ischemia. Three distinct receptors have the ability to bind ADM and are designated ADM receptor (also designated L1), RDC-1 and the Calcitonin Receptor-Like Receptor (CRLR) . The CRLR associates with receptor activity-modifying proteins (RAMPs), which determine the specificity of CRLR binding . Co-expression with RAMP1 results in CRLR binding to CGRP, whereas association with RAMP2 or 3 results in ADM binding . The ADM receptor, a seven transmembrane G protein-coupled receptor, specifically binds ADM and is highly expressed in heart, brain, skeletal muscle, the immune system, adrenal gland and liver. The ADM receptor mediates the signals produced by ADM through G proteins, which activate adenylate cyclase .
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
GPR182 protein structure - BS60348 shown in red.