HPA005792

antibody from Atlas Antibodies

Targeting: PCP4 PEP-19

Provider product page for HPA005792

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [59]
Comments [0]
Validations
Immunohistochemistry [1]

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Product number: HPA005792 - Provider product page
Provider: Atlas Antibodies
Proper citation: Atlas Antibodies Cat#HPA005792, RRID:AB_1855086
Product name: Anti-PCP4
Antibody type: Polyclonal
Description: Polyclonal Antibody against Human PCP4, Gene description: Purkinje cell protein 4, Alternative Gene Names: PEP-19, Validated applications: IHC, Uniprot ID: P48539, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µl
Concentration: 0.1 mg/ml
Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Handling: The antibody solution should be gently mixed before use.

PCP4 protein structure - HPA005792 shown in red.

Submitted references

Donahue M, Robson E, Colgin L
2025

The fasciola cinereum of the hippocampal tail as an interventional target in epilepsy

Jamiolkowski R, Nguyen Q, Farrell J, McGinn R, Hartmann D, Nirschl J, Sanchez M, Buch V, Soltesz I
Nature Medicine 2024;30(5):1292-1299

Imbalanced glucocorticoid and mineralocorticoid stress hormone receptor function has sex-dependent and independent regulatory effects in the mouse hippocampus

Oakley R, Riddick N, Moy S, Cidlowski J
Neurobiology of Stress 2024;28

Neural representation of human experimenters in the bat hippocampus

Snyder M, Qi K, Yartsev M
Nature Neuroscience 2024;27(9):1675-1679

Immunohistochemical field parcellation of the human hippocampus along its antero-posterior axis

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Outer layer of Vb neurons in medial entorhinal cortex project to hippocampal dentate gyrus in mice

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Molecular Brain 2024;17(1)

A non-canonical visual cortical-entorhinal pathway contributes to spatial navigation

Shao Q, Chen L, Li X, Li M, Cui H, Li X, Zhao X, Shi Y, Sun Q, Yan K, Wang G
Nature Communications 2024;15(1)

Sex- and cycle-dependent changes in spine density and size in hippocampal CA2 neurons

Jabra S, Rietsche M, Muellerleile J, O’Leary A, Slattery D, Deller T, Fellenz M
Scientific Reports 2024;14(1)

Efr3b is essential for social recognition by modulating the excitability of CA2 pyramidal neurons

Wei X, Wang J, Yang E, Zhang Y, Qian Q, Li X, Huang F, Sun B
Proceedings of the National Academy of Sciences 2024;121(3)

Adult-born granule cells modulate CA2 network activity during retrieval of developmental memories of the mother

Laham B, Gore I, Brown C, Gould E
eLife 2024;12

Kong E, Zabeh E, Liao Z, Mihaila T, Wilson C, Santhirasegaran C, Peterka D, Losonczy A, Geiller T
2024

Robson E, Donahue M, Mably A, Demetrovich P, Hewitt L, Colgin L
2024

Hippocampal representation during collective spatial behaviour in bats

Forli A, Yartsev M
Nature 2023;621(7980):796-803

Reduced Cholecystokinin-Expressing Interneuron Input Contributes to Disinhibition of the Hippocampal CA2 Region in a Mouse Model of Temporal Lobe Epilepsy

Whitebirch A, Santoro B, Barnett A, Lisgaras C, Scharfman H, Siegelbaum S
The Journal of Neuroscience 2023;43(41):6930-6949

Hypothalamic Supramammillary Nucleus Selectively Excites Hippocampal CA3 Interneurons to Suppress CA3 Pyramidal Neuron Activity

Li M, Kinney J, Jiang Y, Lee D, Wu Q, Lee D, Xiong W, Sun Q
The Journal of Neuroscience 2023;43(25):4612-4624

Organization of hippocampal CA3 into correlated cell assemblies supports a stable spatial code

Sheintuch L, Geva N, Deitch D, Rubin A, Ziv Y
Cell Reports 2023;42(2):112119

A new AAV tool for highly preferentially targeting hippocampal CA2

Peng S, Gu W, Zhu W, Zhuang Y, Yang X, Lv Y, Meng S, Xie W, Li M
Molecular Brain 2023;16(1)

Activation of the CA2-ventral CA1 pathway reverses social discrimination dysfunction in Shank3B knockout mice

Cope E, Wang S, Waters R, Gore I, Vasquez B, Laham B, Gould E
Nature Communications 2023;14(1)

Specific AAV2/PHP.eB-mediated gene transduction of CA2 pyramidal cells via injection into the lateral ventricle

Okamoto K, Kamikubo Y, Yamauchi K, Okamoto S, Takahashi M, Ishida Y, Koike M, Ikegaya Y, Sakurai T, Hioki H
Scientific Reports 2023;13(1)

Social odor discrimination and its enhancement by associative learning in the hippocampal CA2 region

Hassan S, Bigler S, Siegelbaum S
Neuron 2023;111(14):2232-2246.e5

Injury primes mutation-bearing astrocytes for dedifferentiation in later life.

Simpson Ragdale H, Clements M, Tang W, Deltcheva E, Andreassi C, Lai AG, Chang WH, Pandrea M, Andrew I, Game L, Uddin I, Ellis M, Enver T, Riccio A, Marguerat S, Parrinello S
Current biology : CB 2023 Mar 27;33(6):1082-1098.e8

The Neurotrophic Receptor Tyrosine Kinase in MEC-mPFC Neurons Contributes to Remote Memory Consolidation

Hong J, Jeong Y, Heo W
The Journal of Neuroscience 2022;42(34):6605-6619

A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility

Sheu S, Upadhyayula S, Dupuy V, Pang S, Deng F, Wan J, Walpita D, Pasolli H, Houser J, Sanchez-Martinez S, Brauchi S, Banala S, Freeman M, Xu C, Kirchhausen T, Hess H, Lavis L, Li Y, Chaumont-Dubel S, Clapham D
Cell 2022;185(18):3390-3407.e18

The Influence of Social Isolation on Social Orientation, Sociability, Social Novelty Preference, and Hippocampal Parvalbumin-Expressing Interneurons in Peripubertal Rats – Understanding the Importance of Meeting Social Needs in Adolescence

Potrebić M, Pavković Ž, Puškaš N, Pešić V
Frontiers in Behavioral Neuroscience 2022;16

Profiling mouse cochlear cell maturation using 10× Genomics single-cell transcriptomics

Xu Z, Tu S, Pass C, Zhang Y, Liu H, Diers J, Fu Y, He D, Zuo J
Frontiers in Cellular Neuroscience 2022;16

Enhanced excitability of the hippocampal CA2 region and its contribution to seizure activity in a mouse model of temporal lobe epilepsy

Whitebirch A, LaFrancois J, Jain S, Leary P, Santoro B, Siegelbaum S, Scharfman H
Neuron 2022;110(19):3121-3138.e8

Optical Fiber-Based Recording of Climbing Fiber Ca2+ Signals in Freely Behaving Mice

Tang J, Xue R, Wang Y, Li M, Jia H, Pakan J, Li L, Chen X, Li X
Biology 2022;11(6):907

Postnatal Developmental Expression Profile Classifies the Indusium Griseum as a Distinct Subfield of the Hippocampal Formation

Sanders M, Petrasch-Parwez E, Habbes H, Düring M, Förster E
Frontiers in Cell and Developmental Biology 2021;8

Robust information routing by dorsal subiculum neurons

Kitanishi T, Umaba R, Mizuseki K
Science Advances 2021;7(11)

Newborn mice form lasting CA2-dependent memories of their mothers

Laham B, Diethorn E, Gould E
Cell Reports 2021;34(4):108668

Enkephalin release from VIP interneurons in the hippocampal CA2/3a region mediates heterosynaptic plasticity and social memory

Leroy F, de Solis C, Boyle L, Bock T, Lofaro O, Buss E, Asok A, Kandel E, Siegelbaum S
Molecular Psychiatry 2021;27(6):2879-2900

An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo

Klausberger T, Sanchez-Aguilera A, Wheeler D, Jurado-Parras T, Valero M, Nokia M, Cid E, Fernandez-Lamo I, Sutton N, García-Rincón D, de la Prida L, Ascoli G
PLOS Biology 2021;19(5):e3001213

Anterograde transneuronal tracing and genetic control with engineered yellow fever vaccine YFV-17D

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Nature Methods 2021;18(12):1542-1551

Combinatorial actions of glucocorticoid and mineralocorticoid stress hormone receptors are required for preventing neurodegeneration of the mouse hippocampus

Oakley R, Whirledge S, Petrillo M, Riddick N, Xu X, Moy S, Cidlowski J
Neurobiology of Stress 2021;15

Laminar Organization of the Entorhinal Cortex in Macaque Monkeys Based on Cell-Type-Specific Markers and Connectivity

Ohara S, Yoshino R, Kimura K, Kawamura T, Tanabe S, Zheng A, Nakamura S, Inoue K, Takada M, Tsutsui K, Witter M
Frontiers in Neural Circuits 2021;15

Complement-associated loss of CA2 inhibitory synapses in the demyelinated hippocampus impairs memory

Ramaglia V, Dubey M, Malpede M, Petersen N, de Vries S, Ahmed S, Lee D, Schenk G, Gold S, Huitinga I, Gommerman J, Geurts J, Kole M
Acta Neuropathologica 2021;142(4):643-667

The hippocampus converts dynamic entorhinal inputs into stable spatial maps

Cholvin T, Hainmueller T, Bartos M
Neuron 2021;109(19):3135-3148.e7

Local circuit allowing hypothalamic control of hippocampal area CA2 activity and consequences for CA1

Robert V, Therreau L, Chevaleyre V, Lepicard E, Viollet C, Cognet J, Huang A, Boehringer R, Polygalov D, McHugh T, Piskorowski R
eLife 2021;10

Septal cholinergic input to CA2 hippocampal region controls social novelty discrimination via nicotinic receptor-mediated disinhibition

Pimpinella D, Mastrorilli V, Giorgi C, Coemans S, Lecca S, Lalive A, Ostermann H, Fuchs E, Monyer H, Mele A, Cherubini E, Griguoli M
eLife 2021;10

Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex

Ohara S, Blankvoort S, Nair R, Nigro M, Nilssen E, Kentros C, Witter M
eLife 2021;10

Hippocampal CA2 sharp-wave ripples reactivate and promote social memory

Oliva A, Fernández-Ruiz A, Leroy F, Siegelbaum S
Nature 2020;587(7833):264-269

Structural Correlates of CA2 and CA3 Pyramidal Cell Activity in Freely-Moving Mice

Ding L, Chen H, Diamantaki M, Coletta S, Preston-Ferrer P, Burgalossi A
The Journal of Neuroscience 2020;40(30):5797-5806

Species-specific differences in synaptic transmission and plasticity

Beed P, Ray S, Velasquez L, Stumpf A, Parthier D, Swaminathan A, Nitzan N, Breustedt J, Las L, Brecht M, Schmitz D
Scientific Reports 2020;10(1)

Proximodistal Organization of the CA2 Hippocampal Area

Fernandez-Lamo I, Gomez-Dominguez D, Sanchez-Aguilera A, Oliva A, Morales A, Valero M, Cid E, Berenyi A, Menendez de la Prida L
Cell Reports 2019;26(7):1734-1746.e6

Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription.

Suh J, Romano DM, Nitschke L, Herrick SP, DiMarzio BA, Dzhala V, Bae JS, Oram MK, Zheng Y, Hooli B, Mullin K, Gennarino VA, Wasco W, Schmahmann JD, Albers MW, Zoghbi HY, Tanzi RE
Cell 2019 Aug 22;178(5):1159-1175.e17

The subiculum is a patchwork of discrete subregions

Cembrowski M, Wang L, Lemire A, Copeland M, DiLisio S, Clements J, Spruston N
eLife 2018;7

A circuit from hippocampal CA2 to lateral septum disinhibits social aggression

Leroy F, Park J, Asok A, Brann D, Meira T, Boyle L, Buss E, Kandel E, Siegelbaum S
Nature 2018;564(7735):213-218

Teneurin-3 controls topographic circuit assembly in the hippocampus

Berns D, DeNardo L, Pederick D, Luo L
Nature 2018;554(7692):328-333

Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory

Leroy F, Brann D, Meira T, Siegelbaum S
Neuron 2017;95(5):1089-1102.e5

Entorhinal-CA3 Dual-Input Control of Spike Timing in the Hippocampus by Theta-Gamma Coupling

Fernández-Ruiz A, Oliva A, Nagy G, Maurer A, Berényi A, Buzsáki G
Neuron 2017;93(5):1213-1226.e5

The Dendrites of CA2 and CA1 Pyramidal Neurons Differentially Regulate Information Flow in the Cortico-Hippocampal Circuit

Srinivas K, Buss E, Sun Q, Santoro B, Takahashi H, Nicholson D, Siegelbaum S
The Journal of Neuroscience 2017;37(12):3276-3293

Complementary Modular Microcircuits of the Rat Medial Entorhinal Cortex

Ray S, Burgalossi A, Brecht M, Naumann R
Frontiers in Systems Neuroscience 2017;11

Structural development and dorsoventral maturation of the medial entorhinal cortex

Ray S, Brecht M
eLife 2016;5

Altered Oscillatory Dynamics of CA1 Parvalbumin Basket Cells during Theta–Gamma Rhythmopathies of Temporal Lobe Epilepsy

Lopez-Pigozzi D, Laurent F, Brotons-Mas J, Valderrama M, Valero M, Fernandez-Lamo I, Cid E, Gomez-Dominguez D, Gal B, Menendez de la Prida L
eneuro 2016;3(6):ENEURO.0284-16.2016

DACH1 , a Zona Glomerulosa Selective Gene in the Human Adrenal, Activates Transforming Growth Factor-β Signaling and Suppresses Aldosterone Secretion

Zhou J, Shaikh L, Neogi S, McFarlane I, Zhao W, Figg N, Brighton C, Maniero C, Teo A, Azizan E, Brown M
Hypertension 2015;65(5):1103-1110

Determinants of different deep and superficial CA1 pyramidal cell dynamics during sharp-wave ripples

Valero M, Cid E, Averkin R, Aguilar J, Sanchez-Aguilera A, Viney T, Gomez-Dominguez D, Bellistri E, de la Prida L
Nature Neuroscience 2015;18(9):1281-1290

Distribution of interneurons in the CA2 region of the rat hippocampus

Botcher N, Falck J, Thomson A, Mercer A
Frontiers in Neuroanatomy 2014;8

The hippocampal CA2 region is essential for social memory

Hitti F, Siegelbaum S
Nature 2014;508(7494):88-92

Cell type–specific genetic and optogenetic tools reveal hippocampal CA2 circuits

Kohara K, Pignatelli M, Rivest A, Jung H, Kitamura T, Suh J, Frank D, Kajikawa K, Mise N, Obata Y, Wickersham I, Tonegawa S
Nature Neuroscience 2013;17(2):269-279

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Supportive validation

Submitted by: Atlas Antibodies (provider)
Enhanced method: Orthogonal validation
Main image
Experimental details: Immunohistochemistry analysis in human cerebral cortex and liver tissues using HPA005792 antibody. Corresponding PCP4 RNA-seq data are presented for the same tissues.
Sample type: Human
Protocol: Protocol
Orthogonal method: Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.

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