orb385997

antibody from Biorbyt

Targeting: KRT10 CK10, K10, KPP

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

orb385997

Provider

Biorbyt

Product name

KRT10 Antibody Cocktail / Cytokeratin 10

Antibody type

Monoclonal

Description

This mAb cocktail recognizes a protein of 56.5kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antibody clone number

KRT10/844 + KRT10/1275

Vial size

20 ug

Storage

Store the Keratin 10 antibody cocktail at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).