14511-1-AP

antibody from Proteintech Group

Targeting: SYT1 P65, SVP65, SYT

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

14511-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#14511-1-AP, RRID:AB_2199166

Product name

Synaptotagmin-1 antibody

Antibody type

Polyclonal

Description

Synaptotagmin-1 antibody (Cat. #14511-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Tuina Inhibits Synaptic Plasticity Through the Astrocytic NDRG2/GLT-1 Pathway to Alleviate Neuropathic Pain.

Zhang H, Chen L, Jiang J, Huang L, Huang H, Huang L, Chen S, Lin Z
Journal of cellular and molecular medicine 2026 Jan;30(1):e71013

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SP1 recruits TET1 to mediate Kif1a demethylation and synaptic remodeling in a mouse model of chronic migraine.

Jiang W, Yu P, Liang GH, Tian WB, Li YF, Cai MT, Zhang LX, Yang Y, Dong M
The journal of headache and pain 2026 Feb 21;27(1)

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Air pollution decreases postsynaptic PSD-95 and NMDA receptor subunits in synaptosomes from mouse cerebral cortex.

Godoy-Lugo JA, Hicks D, Durra S, Massey ER, Shkirkova K, Sauri AI, Kerstiens E, Chen S, Zhao L, Sioutas C, Mack WJ, Finch CE, Thorwald MA
Environmental pollution (Barking, Essex : 1987) 2025 Oct 15;383:126845

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Opioids induce constipation by prompting alpha-Synuclein hyperphosphorylation in the colonic myenteric plexus.

Jia B, Zhao Y, Ren X, Zhang D, Jia H, Wang D, Wang L, Li J
Neurochemistry international 2025 Nov;190:106036

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Cell type specific differences in transcriptome profiles of adipose derived stem cells and vaginal fibroblasts in patients with pelvic organ prolapse.

Tchoukalova YD, Nair AA, Chen X, Zhang N, Myers CE, Badreldin A, Dudakovic A, Lott LG, Rebecca AM, Yi J, Cornella JL, van Wijnen AJ
Gene 2025 Mar 20;942:149230

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Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2.

Jiang Z, Liu D, Li T, Gai C, Xin D, Zhao Y, Song Y, Cheng Y, Li T, Wang Z
Neural regeneration research 2025 Jun 1;20(6):1776-1788

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Gut-derived bacterial vesicles carrying lipopolysaccharide promote microglia-mediated synaptic pruning.

Zhao X, Yu J, Xu B, Xu Z, Lei X, Han S, Luo S, Zhang C, Peng G, Li J, Yu J, Ling Y, Fan Z, Mo W, Yang Y, Zhang J
Alzheimer's & dementia : the journal of the Alzheimer's Association 2025 Aug;21(8):e70331

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Molecular landscape, subtypes, and therapeutic vulnerabilities of central nervous system solitary fibrous tumors.

Zhao C, Hu X, Guan X, Fu X, Wang T, Li M, Liu X, Zhao J, Wu D, Zhang F, Fu J, Li J, Zhang T, Jiang X, Yan C, Jia W, Yang E, Chen J
Nature communications 2025 Aug 23;16(1):7870

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A guide to selecting high-performing antibodies for Synaptotagmin-1 (Uniprot ID P21579) for use in western blot, immunoprecipitation, immunofluorescence and flow cytometry.

Biddle MS, Alende C, Fotouhi M, Jones C, Ayoubi R, Southern K, Laflamme C, Virk H, NeuroSGC/YCharOS/EDDU collaborative group, ABIF consortium
F1000Research 2024;13:817

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Synaptotagmin-1 antagonizes paraquat intracellular accumulation and nephrocyte toxicity by up-regulating SERBP1/GLUT2 expression.

Yin R, Ke J, Zhao M, Ding Y, Li W, Li M, Hu L, Dai X, Hong G
Chemico-biological interactions 2024 Sep 1;400:111165

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Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated SNARE complex assembly and neurotransmitter release.

Zhang H, Lei M, Zhang Y, Li H, He Z, Xie S, Zhu L, Wang S, Liu J, Li Y, Lu Y, Ma C
Science advances 2024 May 17;10(20):eadi7024

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Programmed cell death factor 4-mediated hippocampal synaptic plasticity is involved in early life stress and susceptibility to depression.

Cheng J, Yuan L, Yu S, Gu B, Luo Q, Wang X, Zhao Y, Gai C, Li T, Liu W, Wang Z, Liu D, Ho RCM, Ho CSH
Behavioural brain research 2024 Jun 25;468:115028

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Membrane remodeling by FAM92A1 during brain development regulates neuronal morphology, synaptic function, and cognition.

Wang L, Yang Z, Satoshi F, Prasanna X, Yan Z, Vihinen H, Chen Y, Zhao Y, He X, Bu Q, Li H, Zhao Y, Jiang L, Qin F, Dai Y, Zhang N, Qin M, Kuang W, Zhao Y, Jokitalo E, Vattulainen I, Kajander T, Zhao H, Cen X
Nature communications 2024 Jul 23;15(1):6209

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Early life stress enhances the susceptibility to depression and interferes with neuroplasticity in the hippocampus of adolescent mice via regulating miR-34c-5p/SYT1 axis.

Yu S, Zhao Y, Luo Q, Gu B, Wang X, Cheng J, Wang Z, Liu D, Ho RCM, Ho CSH
Journal of psychiatric research 2024 Feb;170:262-276

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Neuronal cell populations in circumoral nerve ring of sea cucumber Apostichopus japonicus: Ultrastructure and transcriptional profile.

Zheng Y, Cong X, Liu H, Storey KB, Chen M
Comparative biochemistry and physiology. Part D, Genomics & proteomics 2024 Dec;52:101263

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Buyang huanwu decoction improves synaptic plasticity of ischemic stroke by regulating the cAMP/PKA/CREB pathway.

Mo J, Liao W, Du J, Huang X, Li Y, Su A, Zhong L, Gong M, Wang P, Liu Z, Kuang H, Wang L
Journal of ethnopharmacology 2024 Dec 5;335:118636

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Evaluating the Efficacy of Levetiracetam on Non-Cognitive Symptoms and Pathology in a Tau Mouse Model.

Thompson JC, Levis Rabi M, Novoa M, Nash KR, Joly-Amado A
Biomedicines 2024 Dec 19;12(12)

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Analysis of microisolated frontal cortex excitatory layer III and V pyramidal neurons reveals a neurodegenerative phenotype in individuals with Down syndrome.

Alldred MJ, Pidikiti H, Ibrahim KW, Lee SH, Heguy A, Hoffman GE, Roussos P, Wisniewski T, Wegiel J, Stutzmann GE, Mufson EJ, Ginsberg SD
Acta neuropathologica 2024 Aug 6;148(1):16

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Long-read sequencing and profiling of RNA-binding proteins reveals the pathogenic mechanism of aberrant splicing of an SCN1A poison exon in epilepsy.

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The complement inhibitor CD59 is required for GABAergic synaptic transmission in the dentate gyrus.

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A Class I HDAC Inhibitor BG45 Alleviates Cognitive Impairment through the CaMKII/ITPKA/Ca(2+) Signaling Pathway.

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Theranostics 2020;10(2):516-536

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Hepatic Synaptotagmin 1 is involved in the remodelling of liver plasma- membrane lipid composition and gene expression in male Apoe-deficient mice consuming a Western diet.

Sancho-Knapik S, Pastor O, Barranquero C, Herrera Marcos LV, Guillén N, Arnal C, Gascón S, Navarro MA, Rodríguez-Yoldi MJ, Busto R, Lasunción MA, Osada J
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Quantitative proteomics study of host response to virulent and attenuated pseudorabies virus infection in mouse brain.

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A Stimulation Function of Synaptotagmin-1 in Ternary SNARE Complex Formation Dependent on Munc18 and Munc13.

Li Y, Wang S, Li T, Zhu L, Xu Y, Ma C
Frontiers in molecular neuroscience 2017;10:256

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Identification of protein network alterations upon retinal ischemia-reperfusion injury by quantitative proteomics using a Rattus norvegicus model.

Tian H, Wang L, Cai R, Zheng L, Guo L
PloS one 2014;9(12):e116453

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Quantitative proteomics reveals olfactory input-dependent alterations in the mouse olfactory bulb proteome.

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Journal of proteomics 2014 Sep 23;109:125-42

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

human liver tissue were subjected to SDS PAGE followed by western blot with 14511-1-AP(SYT1 antibody) at dilution of 1:1000

Sample type

tissue

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human liver cancer using 14511-1-AP(SYT1 antibody) at dilution of 1:100 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The Synaptotagmin-1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Synaptotagmin-1. This antibody recognizes human, mouse antigen. The Synaptotagmin-1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

14511-1-AP.pdf

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