Antibody data
- Antibody Data
- Antigen structure
- References [13]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 14511-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14511-1-AP, RRID:AB_2199166
- Product name
- Synaptotagmin-1 antibody
- Antibody type
- Polyclonal
- Description
- Synaptotagmin-1 antibody (Cat. #14511-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Phosphorylation of Doc2 by EphB2 modulates Munc13-mediated SNARE complex assembly and neurotransmitter release.
Programmed cell death factor 4-mediated hippocampal synaptic plasticity is involved in early life stress and susceptibility to depression.
Early life stress enhances the susceptibility to depression and interferes with neuroplasticity in the hippocampus of adolescent mice via regulating miR-34c-5p/SYT1 axis.
Long-read sequencing and profiling of RNA-binding proteins reveals the pathogenic mechanism of aberrant splicing of an SCN1A poison exon in epilepsy.
The complement inhibitor CD59 is required for GABAergic synaptic transmission in the dentate gyrus.
A Class I HDAC Inhibitor BG45 Alleviates Cognitive Impairment through the CaMKII/ITPKA/Ca(2+) Signaling Pathway.
Discrimination of the Activity of Low-Affinity Wild-Type and High-Affinity Mutant Recombinant BoNT/B by a SIMA Cell-Based Reporter Release Assay.
ANKRD22, a novel tumor microenvironment-induced mitochondrial protein promotes metabolic reprogramming of colorectal cancer cells.
Hepatic Synaptotagmin 1 is involved in the remodelling of liver plasma- membrane lipid composition and gene expression in male Apoe-deficient mice consuming a Western diet.
Quantitative proteomics study of host response to virulent and attenuated pseudorabies virus infection in mouse brain.
A Stimulation Function of Synaptotagmin-1 in Ternary SNARE Complex Formation Dependent on Munc18 and Munc13.
Identification of protein network alterations upon retinal ischemia-reperfusion injury by quantitative proteomics using a Rattus norvegicus model.
Quantitative proteomics reveals olfactory input-dependent alterations in the mouse olfactory bulb proteome.
Zhang H, Lei M, Zhang Y, Li H, He Z, Xie S, Zhu L, Wang S, Liu J, Li Y, Lu Y, Ma C
Science advances 2024 May 17;10(20):eadi7024
Science advances 2024 May 17;10(20):eadi7024
Programmed cell death factor 4-mediated hippocampal synaptic plasticity is involved in early life stress and susceptibility to depression.
Cheng J, Yuan L, Yu S, Gu B, Luo Q, Wang X, Zhao Y, Gai C, Li T, Liu W, Wang Z, Liu D, Ho RCM, Ho CSH
Behavioural brain research 2024 Jun 25;468:115028
Behavioural brain research 2024 Jun 25;468:115028
Early life stress enhances the susceptibility to depression and interferes with neuroplasticity in the hippocampus of adolescent mice via regulating miR-34c-5p/SYT1 axis.
Yu S, Zhao Y, Luo Q, Gu B, Wang X, Cheng J, Wang Z, Liu D, Ho RCM, Ho CSH
Journal of psychiatric research 2024 Feb;170:262-276
Journal of psychiatric research 2024 Feb;170:262-276
Long-read sequencing and profiling of RNA-binding proteins reveals the pathogenic mechanism of aberrant splicing of an SCN1A poison exon in epilepsy.
Happ HC, Schneider PN, Hong JH, Goes E, Bandouil M, Biar CG, Ramamurthy A, Reese F, Engel K, Weckhuysen S, Scheffer IE, Mefford HC, Calhoun JD, Carvill GL
bioRxiv : the preprint server for biology 2023 May 4;
bioRxiv : the preprint server for biology 2023 May 4;
The complement inhibitor CD59 is required for GABAergic synaptic transmission in the dentate gyrus.
Wen L, Yang X, Wu Z, Fu S, Zhan Y, Chen Z, Bi D, Shen Y
Cell reports 2023 Apr 25;42(4):112349
Cell reports 2023 Apr 25;42(4):112349
A Class I HDAC Inhibitor BG45 Alleviates Cognitive Impairment through the CaMKII/ITPKA/Ca(2+) Signaling Pathway.
Liu J, Zhang C, Wang J, Huang Y, Shen D, Hu Y, Chu H, Yu X, Zhang L, Ma H
Pharmaceuticals (Basel, Switzerland) 2022 Nov 28;15(12)
Pharmaceuticals (Basel, Switzerland) 2022 Nov 28;15(12)
Discrimination of the Activity of Low-Affinity Wild-Type and High-Affinity Mutant Recombinant BoNT/B by a SIMA Cell-Based Reporter Release Assay.
Neuschäfer-Rube F, Pathe-Neuschäfer-Rube A, Püschel GP
Toxins 2022 Jan 17;14(1)
Toxins 2022 Jan 17;14(1)
ANKRD22, a novel tumor microenvironment-induced mitochondrial protein promotes metabolic reprogramming of colorectal cancer cells.
Pan T, Liu J, Xu S, Yu Q, Wang H, Sun H, Wu J, Zhu Y, Zhou J, Zhu Y
Theranostics 2020;10(2):516-536
Theranostics 2020;10(2):516-536
Hepatic Synaptotagmin 1 is involved in the remodelling of liver plasma- membrane lipid composition and gene expression in male Apoe-deficient mice consuming a Western diet.
Sancho-Knapik S, Pastor O, Barranquero C, Herrera Marcos LV, Guillén N, Arnal C, Gascón S, Navarro MA, Rodríguez-Yoldi MJ, Busto R, Lasunción MA, Osada J
Biochimica et biophysica acta. Molecular and cell biology of lipids 2020 Dec;1865(12):158790
Biochimica et biophysica acta. Molecular and cell biology of lipids 2020 Dec;1865(12):158790
Quantitative proteomics study of host response to virulent and attenuated pseudorabies virus infection in mouse brain.
Zeng HL, Yu FL, Zhang Z, Yang Q, Jin S, He X, Chen X, Shen Y, Cheng L, Guo L, Xu F
Biochimica et biophysica acta. Proteins and proteomics 2018 Feb;1866(2):307-315
Biochimica et biophysica acta. Proteins and proteomics 2018 Feb;1866(2):307-315
A Stimulation Function of Synaptotagmin-1 in Ternary SNARE Complex Formation Dependent on Munc18 and Munc13.
Li Y, Wang S, Li T, Zhu L, Xu Y, Ma C
Frontiers in molecular neuroscience 2017;10:256
Frontiers in molecular neuroscience 2017;10:256
Identification of protein network alterations upon retinal ischemia-reperfusion injury by quantitative proteomics using a Rattus norvegicus model.
Tian H, Wang L, Cai R, Zheng L, Guo L
PloS one 2014;9(12):e116453
PloS one 2014;9(12):e116453
Quantitative proteomics reveals olfactory input-dependent alterations in the mouse olfactory bulb proteome.
Zeng HL, Rao X, Zhang LK, Zhao X, Zhang WP, Wang J, Xu F, Guo L
Journal of proteomics 2014 Sep 23;109:125-42
Journal of proteomics 2014 Sep 23;109:125-42
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human liver tissue were subjected to SDS PAGE followed by western blot with 14511-1-AP(SYT1 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 14511-1-AP(SYT1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Synaptotagmin-1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Synaptotagmin-1. This antibody recognizes human, mouse antigen. The Synaptotagmin-1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.