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- Antibody Data
- Antigen structure
- References [11]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 11274-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11274-1-AP, RRID:AB_2058719
- Product name
- ASAH1 antibody
- Antibody type
- Polyclonal
- Description
- ASAH1 antibody (Cat. #11274-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Lipid metabolism-related genes are involved in the occurrence of asthma and regulate the immune microenvironment.
Decreased Sphingosine Due to Down-Regulation of Acid Ceramidase Expression in Airway of Bronchiectasis Patients: A Potential Contributor to Pseudomonas aeruginosa Infection.
Carmofur prevents cell cycle progression by reducing E2F8 transcription in temozolomide-resistant glioblastoma cells.
Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.
Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease.
Hyperbaric Oxygen Treatment Ameliorates Hearing Loss and Auditory Cortex Injury in Noise Exposed Mice by Repressing Local Ceramide Accumulation.
Acid ceramidase inhibition ameliorates α-synuclein accumulation upon loss of GBA1 function.
Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis.
Doxepin Mitigates Noise-induced Neuronal Damage in Primary Auditory Cortex of Mice via Suppression of Acid Sphingomyelinase/Ceramide Pathway.
A reconstructed human epidermal keratinization culture model to characterize ceramide metabolism in the stratum corneum.
Th1 cytokines accentuate but Th2 cytokines attenuate ceramide production in the stratum corneum of human epidermal equivalents: an implication for the disrupted barrier mechanism in atopic dermatitis.
Jia Y, Wang H, Ma B, Zhang Z, Wang J, Wang J, Chen O
BMC genomics 2024 Feb 1;25(1):129
BMC genomics 2024 Feb 1;25(1):129
Decreased Sphingosine Due to Down-Regulation of Acid Ceramidase Expression in Airway of Bronchiectasis Patients: A Potential Contributor to Pseudomonas aeruginosa Infection.
Qi Q, Xu J, Wang Y, Zhang J, Gao M, Li Y, Dong L
Infection and drug resistance 2023;16:2573-2588
Infection and drug resistance 2023;16:2573-2588
Carmofur prevents cell cycle progression by reducing E2F8 transcription in temozolomide-resistant glioblastoma cells.
Hawkins CC, Jones AB, Gordon ER, Harsh Y, Ziebro JK, Willey CD, Griguer C, Crossman DK, Cooper SJ, Ramanadham S, Doan N, Hjelmeland AB
Cell death discovery 2023 Dec 12;9(1):451
Cell death discovery 2023 Dec 12;9(1):451
Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.
Boland S, Swarup S, Ambaw YA, Malia PC, Richards RC, Fischer AW, Singh S, Aggarwal G, Spina S, Nana AL, Grinberg LT, Seeley WW, Surma MA, Klose C, Paulo JA, Nguyen AD, Harper JW, Walther TC, Farese RV Jr
Nature communications 2022 Oct 7;13(1):5924
Nature communications 2022 Oct 7;13(1):5924
Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease.
Lang J, Bohn P, Bhat H, Jastrow H, Walkenfort B, Cansiz F, Fink J, Bauer M, Olszewski D, Ramos-Nascimento A, Duhan V, Friedrich SK, Becker KA, Krawczyk A, Edwards MJ, Burchert A, Huber M, Friebus-Kardash J, Göthert JR, Hardt C, Probst HC, Schumacher F, Köhrer K, Kleuser B, Babiychuk EB, Sodeik B, Seibel J, Greber UF, Lang PA, Gulbins E, Lang KS
Nature communications 2020 Mar 12;11(1):1338
Nature communications 2020 Mar 12;11(1):1338
Hyperbaric Oxygen Treatment Ameliorates Hearing Loss and Auditory Cortex Injury in Noise Exposed Mice by Repressing Local Ceramide Accumulation.
Su YT, Guo YB, Cheng YP, Zhang X, Xie XP, Chang YM, Bao JX
International journal of molecular sciences 2019 Sep 20;20(19)
International journal of molecular sciences 2019 Sep 20;20(19)
Acid ceramidase inhibition ameliorates α-synuclein accumulation upon loss of GBA1 function.
Kim MJ, Jeon S, Burbulla LF, Krainc D
Human molecular genetics 2018 Jun 1;27(11):1972-1988
Human molecular genetics 2018 Jun 1;27(11):1972-1988
Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis.
Tang YC, Yuwen H, Wang K, Bruno PM, Bullock K, Deik A, Santaguida S, Trakala M, Pfau SJ, Zhong N, Huang T, Wang L, Clish CB, Hemann MT, Amon A
Cancer research 2017 Oct 1;77(19):5272-5286
Cancer research 2017 Oct 1;77(19):5272-5286
Doxepin Mitigates Noise-induced Neuronal Damage in Primary Auditory Cortex of Mice via Suppression of Acid Sphingomyelinase/Ceramide Pathway.
Su YT, Meng XX, Zhang X, Guo YB, Zhang HJ, Cheng YP, Xie XP, Chang YM, Bao JX
Anatomical record (Hoboken, N.J. : 2007) 2017 Dec;300(12):2220-2232
Anatomical record (Hoboken, N.J. : 2007) 2017 Dec;300(12):2220-2232
A reconstructed human epidermal keratinization culture model to characterize ceramide metabolism in the stratum corneum.
Yoshida N, Sawada E, Imokawa G
Archives of dermatological research 2012 Sep;304(7):563-77
Archives of dermatological research 2012 Sep;304(7):563-77
Th1 cytokines accentuate but Th2 cytokines attenuate ceramide production in the stratum corneum of human epidermal equivalents: an implication for the disrupted barrier mechanism in atopic dermatitis.
Sawada E, Yoshida N, Sugiura A, Imokawa G
Journal of dermatological science 2012 Oct;68(1):25-35
Journal of dermatological science 2012 Oct;68(1):25-35
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 11274-1-AP(ASAH1 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ASAH1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ASAH1. This antibody recognizes human, mouse, rat antigen. The ASAH1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
