HPA005468

antibody from Atlas Antibodies

Targeting: ASAH1 AC, ACDase, ASAH, FLJ21558, PHP32

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

HPA005468

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA005468, RRID:AB_1845062

Product name

Anti-ASAH1

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human ASAH1, Gene description: N-acylsphingosine amidohydrolase (acid ceramidase) 1, Alternative Gene Names: AC, ASAH, FLJ21558, PHP32, Validated applications: WB, IHC, Uniprot ID: Q13510, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.1 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

Proteometabolomics of initial and recurrent glioblastoma highlights an increased immune cell signature with altered lipid metabolism.

Cosenza-Contreras M, Schäfer A, Sing J, Cook L, Stillger MN, Chen CY, Villacorta Hidalgo J, Pinter N, Meyer L, Werner T, Bug D, Haberl Z, Kübeck O, Zhao K, Stei S, Gafencu AV, Ionita R, Brehar FM, Ferrer-Lozano J, Ribas G, Cerdá-Alberich L, Martí-Bonmatí L, Nimsky C, Van Straaten A, Biniossek ML, Föll M, Cabezas-Wallscheid N, Büscher J, Röst H, Arnoux A, Bartsch JW, Schilling O
Neuro-oncology 2024 Mar 4;26(3):488-502

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Acid Ceramidase (ASAH1) Represses Steroidogenic Factor 1-Dependent Gene Transcription in H295R Human Adrenocortical Cells by Binding to the Receptor

Lucki N, Li D, Bandyopadhyay S, Wang E, Merrill A, Sewer M
Molecular and Cellular Biology 2023;32(21):4419-4431

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Ceramide Kinase (CERK) Emerges as a Common Therapeutic Target for Triple Positive and Triple Negative Breast Cancer Cells

Rajput K, Ansari M, Jha S, Pani T, Medatwal N, Chattopadhyay S, Bajaj A, Dasgupta U
Cancers 2022;14(18):4496

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C6 Ceramide (d18:1/6:0) as a Novel Treatment of Cutaneous T Cell Lymphoma

Wilhelm R, Eckes T, Imre G, Kippenberger S, Meissner M, Thomas D, Trautmann S, Merlio J, Chevret E, Kaufmann R, Pfeilschifter J, Koch A, Jäger M
Cancers 2021;13(2):270

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Oxysterol-related-binding-protein related Protein-2 (ORP2) regulates cortisol biosynthesis and cholesterol homeostasis

Escajadillo T, Wang H, Li L, Li D, Sewer M
Molecular and Cellular Endocrinology 2016;427

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Silencing diacylglycerol kinase-theta expression reduces steroid hormone biosynthesis and cholesterol metabolism in human adrenocortical cells

Cai K, Lucki N, Sewer M
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2014;1841(4):552-562

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Acid Ceramidase (ASAH1) Is a Global Regulator of Steroidogenic Capacity and Adrenocortical Gene Expression

Lucki N, Bandyopadhyay S, Wang E, Merrill A, Sewer M
Molecular Endocrinology 2012;26(2):228-243

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Genistein Stimulates MCF-7 Breast Cancer Cell Growth by Inducing Acid Ceramidase (ASAH1) Gene Expression

Lucki N, Sewer M
Journal of Biological Chemistry 2011;286(22):19399-19409

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The cAMP-responsive element binding protein (CREB) regulates the expression of acid ceramidase (ASAH1) in H295R human adrenocortical cells

Lucki N, Sewer M
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2009;1791(8):706-713