HPA020549

antibody from Atlas Antibodies

Targeting: SHMT2 SHMT

Provider product page for HPA020549

Western blot

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [11]
Comments [0]
Validations
Immunohistochemistry [1]

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Product number: HPA020549 - Provider product page
Provider: Atlas Antibodies
Proper citation: Atlas Antibodies Cat#HPA020549, RRID:AB_1856834
Product name: Anti-SHMT2
Antibody type: Polyclonal
Description: Polyclonal Antibody against Human SHMT2, Gene description: serine hydroxymethyltransferase 2 (mitochondrial), Alternative Gene Names: SHMT, Validated applications: WB, IHC, ICC, Uniprot ID: P34897, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µl
Concentration: 0.2 mg/ml
Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Handling: The antibody solution should be gently mixed before use.

SHMT2 protein structure - HPA020549 shown in red.

Submitted references Serine and one-carbon metabolism sustain non-melanoma skin cancer progression

Cappello A, Zuccotti A, Mancini M, Tosetti G, Fania L, Ricci F, Melino G, Candi E
Cell Death Discovery 2023;9(1)

Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells.

Green AC, Marttila P, Kiweler N, Chalkiadaki C, Wiita E, Cookson V, Lesur A, Eiden K, Bernardin F, Vallin KSA, Borhade S, Long M, Ghahe EK, Jiménez-Alonso JJ, Jemth AS, Loseva O, Mortusewicz O, Meyers M, Viry E, Johansson AI, Hodek O, Homan E, Bonagas N, Ramos L, Sandberg L, Frödin M, Moussay E, Slipicevic A, Letellier E, Paggetti J, Sørensen CS, Helleday T, Henriksson M, Meiser J
Nature metabolism 2023 Apr;5(4):642-659

Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis

Kiweler N, Delbrouck C, Pozdeev V, Neises L, Soriano-Baguet L, Eiden K, Xian F, Benzarti M, Haase L, Koncina E, Schmoetten M, Jaeger C, Noman M, Vazquez A, Janji B, Dittmar G, Brenner D, Letellier E, Meiser J
Nature Communications 2022;13(1)

The mitochondrial protein Sideroflexin 3 (SFXN3) influences neurodegeneration pathways in vivo.

Ledahawsky LM, Terzenidou ME, Edwards R, Kline RA, Graham LC, Eaton SL, van der Hoorn D, Chaytow H, Huang YT, Groen EJN, Motyl AAL, Lamont DJ, Tokatlidis K, Wishart TM, Gillingwater TH
The FEBS journal 2022 Jul;289(13):3894-3914

One carbon metabolism in human lung cancer.

Yao S, Peng L, Elakad O, Küffer S, Hinterthaner M, Danner BC, von Hammerstein-Equord A, Ströbel P, Bohnenberger H
Translational lung cancer research 2021 Jun;10(6):2523-2538

LONP1 and ClpP cooperatively regulate mitochondrial proteostasis for cancer cell survival.

Lee YG, Kim HW, Nam Y, Shin KJ, Lee YJ, Park DH, Rhee HW, Seo JK, Chae YC
Oncogenesis 2021 Feb 26;10(2):18

Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness

Choi C, Maher E, Malloy C, Mickey B, Sherry A, DeBerardinis R, Patel T, Pan E, Madden C, Pinho M, Thomas B, Dimitrov I, Levy M, Baxter J, Askari P, Lewis C, Raisanen J, Ganji S, An Z, Zhang S, Gao A, Hatanpaa K, Daoud E, Tiwari V
Neuro-Oncology 2020;22(7):1018-1029

Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers

Soula M, Weber R, Zilka O, Alwaseem H, La K, Yen F, Molina H, Garcia-Bermudez J, Pratt D, Birsoy K
Nature Chemical Biology 2020;16(12):1351-1360

PLPHP deficiency: clinical, genetic, biochemical, and mechanistic insights

Johnstone D, Al-Shekaili H, Tarailo-Graovac M, Wolf N, Ivy A, Demarest S, Roussel Y, Ciapaite J, van Roermund C, Kernohan K, Kosuta C, Ban K, Ito Y, McBride S, Al-Thihli K, Abdelrahim R, Koul R, Al Futaisi A, Haaxma C, Olson H, Sigurdardottir L, Arnold G, Gerkes E, Boon M, Heiner-Fokkema M, Noble S, Bosma M, Jans J, Koolen D, Kamsteeg E, Drögemöller B, Ross C, Majewski J, Cho M, Begtrup A, Wasserman W, Bui T, Brimble E, Violante S, Houten S, Wevers R, van Faassen M, Kema I, Lepage N, Lines M, Dyment D, Wanders R, Verhoeven-Duif N, Ekker M, Boycott K, Friedman J, Pena I, van Karnebeek C
Brain 2019;142(3):542-559

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

Pacold M, Brimacombe K, Chan S, Rohde J, Lewis C, Swier L, Possemato R, Chen W, Sullivan L, Fiske B, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul Y, Liu C, Zhou M, Koh M, Chung H, Davidson S, Luengo A, Wang A, Xu X, Yasgar A, Liu L, Rai G, Westover K, Vander Heiden M, Shen M, Gray N, Boxer M, Sabatini D
Nature Chemical Biology 2016;12(6):452-458

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

Kim D, Fiske B, Birsoy K, Freinkman E, Kami K, Possemato R, Chudnovsky Y, Pacold M, Chen W, Cantor J, Shelton L, Gui D, Kwon M, Ramkissoon S, Ligon K, Kang S, Snuderl M, Vander Heiden M, Sabatini D
Nature 2015;520(7547):363-367