Antibody data
- Antibody Data
- Antigen structure
- References [20]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 11099-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11099-1-AP, RRID:AB_2188452
- Product name
- SHMT2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SHMT2 antibody (Cat. #11099-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references CYP3A5 unexpectedly regulates glucose metabolism through the AKT-TXNIP-GLUT1 axis in pancreatic cancer.
Comparative Analysis of Two NNMT Bisubstrate Inhibitors through Chemoproteomic Studies: Uncovering the Role of Unconventional SAM Analogue Moiety for Improved Selectivity.
Construction and validation of a folate metabolism-related gene signature for predicting prognosis in HNSCC.
Multi-omics reveals that green pea (Pisum sativum L.) hull supplementation ameliorates non-alcoholic fatty liver disease via the SHMT2/glycine/mTOR/PPAR-γ signaling pathway.
Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming.
Transcriptome and Proteome Analysis in LUHMES Cells Overexpressing Alpha-Synuclein.
SHMT2 promotes the tumorigenesis of renal cell carcinoma by regulating the m6A modification of PPAT.
Overexpression of SHMT2 Predicts a Poor Prognosis and Promotes Tumor Cell Growth in Bladder Cancer.
Derangement of hepatic polyamine, folate, and methionine cycle metabolism in cystathionine beta-synthase-deficient homocystinuria in the presence and absence of treatment: Possible implications for pathogenesis.
Melatonin modulates metabolic remodeling in HNSCC by suppressing MTHFD1L-formate axis.
Generation of SHMT2 knockout human embryonic stem cell line (WAe009-A-67) using CRISPR/Cas9 technique.
TGF-β Promotes Metabolic Reprogramming in Lung Fibroblasts via mTORC1-dependent ATF4 Activation.
Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death.
De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues.
Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis.
SHMT2 and the BRCC36/BRISC deubiquitinase regulate HIV-1 Tat K63-ubiquitylation and destruction by autophagy.
Vascular endothelial growth factor signaling requires glycine to promote angiogenesis.
Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production.
'Rod and ring' formation from IMP dehydrogenase is regulated through the one-carbon metabolic pathway.
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.
Shao M, Pan Q, Tan H, Wu J, Lee HW, Huber AD, Wright WC, Cho JH, Yu J, Peng J, Chen T
Genes & diseases 2024 Jul;11(4):101079
Genes & diseases 2024 Jul;11(4):101079
Comparative Analysis of Two NNMT Bisubstrate Inhibitors through Chemoproteomic Studies: Uncovering the Role of Unconventional SAM Analogue Moiety for Improved Selectivity.
Meng Y, Iyamu ID, Ahmed NAM, Huang R
ACS chemical biology 2024 Jan 19;19(1):89-100
ACS chemical biology 2024 Jan 19;19(1):89-100
Construction and validation of a folate metabolism-related gene signature for predicting prognosis in HNSCC.
Wang L, He Y, Bai Y, Zhang S, Pang B, Chen A, Wu X
Journal of cancer research and clinical oncology 2024 Apr 16;150(4):198
Journal of cancer research and clinical oncology 2024 Apr 16;150(4):198
Multi-omics reveals that green pea (Pisum sativum L.) hull supplementation ameliorates non-alcoholic fatty liver disease via the SHMT2/glycine/mTOR/PPAR-γ signaling pathway.
Guo F, Xiong H, Tsao R, Wen X, Liu J, Chen D, Jiang L, Sun Y
Food & function 2023 Jul 31;14(15):7195-7208
Food & function 2023 Jul 31;14(15):7195-7208
Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming.
Liu Z, Fan M, Hou J, Pan S, Xu Y, Zhang H, Liu C, Hao X, Li X, Wang H
Cell death & disease 2023 Feb 20;14(2):144
Cell death & disease 2023 Feb 20;14(2):144
Transcriptome and Proteome Analysis in LUHMES Cells Overexpressing Alpha-Synuclein.
Höllerhage M, Stepath M, Kohl M, Pfeiffer K, Chua OWH, Duan L, Hopfner F, Eisenacher M, Marcus K, Höglinger GU
Frontiers in neurology 2022;13:787059
Frontiers in neurology 2022;13:787059
SHMT2 promotes the tumorigenesis of renal cell carcinoma by regulating the m6A modification of PPAT.
Huo FC, Xie M, Zhu ZM, Zheng JN, Pei DS
Genomics 2022 Jul;114(4):110424
Genomics 2022 Jul;114(4):110424
Overexpression of SHMT2 Predicts a Poor Prognosis and Promotes Tumor Cell Growth in Bladder Cancer.
Zhang P, Yang Q
Frontiers in genetics 2021;12:682856
Frontiers in genetics 2021;12:682856
Derangement of hepatic polyamine, folate, and methionine cycle metabolism in cystathionine beta-synthase-deficient homocystinuria in the presence and absence of treatment: Possible implications for pathogenesis.
Maclean KN, Jiang H, Phinney WN, Mclagan BM, Roede JR, Stabler SP
Molecular genetics and metabolism 2021 Feb;132(2):128-138
Molecular genetics and metabolism 2021 Feb;132(2):128-138
Melatonin modulates metabolic remodeling in HNSCC by suppressing MTHFD1L-formate axis.
Cui L, Zhao X, Jin Z, Wang H, Yang SF, Hu S
Journal of pineal research 2021 Dec;71(4):e12767
Journal of pineal research 2021 Dec;71(4):e12767
Generation of SHMT2 knockout human embryonic stem cell line (WAe009-A-67) using CRISPR/Cas9 technique.
Li J, Zhang B, Gan M, Li Y, He L, Yue W, Qiao H, Pei X, Li Y
Stem cell research 2021 Dec;57:102581
Stem cell research 2021 Dec;57:102581
TGF-β Promotes Metabolic Reprogramming in Lung Fibroblasts via mTORC1-dependent ATF4 Activation.
O'Leary EM, Tian Y, Nigdelioglu R, Witt LJ, Cetin-Atalay R, Meliton AY, Woods PS, Kimmig LM, Sun KA, Gökalp GA, Mutlu GM, Hamanaka RB
American journal of respiratory cell and molecular biology 2020 Nov;63(5):601-612
American journal of respiratory cell and molecular biology 2020 Nov;63(5):601-612
Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death.
Balsa E, Perry EA, Bennett CF, Jedrychowski M, Gygi SP, Doench JG, Puigserver P
Nature communications 2020 Jun 1;11(1):2714
Nature communications 2020 Jun 1;11(1):2714
De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues.
Fan TWM, Bruntz RC, Yang Y, Song H, Chernyavskaya Y, Deng P, Zhang Y, Shah PP, Beverly LJ, Qi Z, Mahan AL, Higashi RM, Dang CV, Lane AN
The Journal of biological chemistry 2019 Sep 6;294(36):13464-13477
The Journal of biological chemistry 2019 Sep 6;294(36):13464-13477
Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis.
Hamanaka RB, Nigdelioglu R, Meliton AY, Tian Y, Witt LJ, O'Leary E, Sun KA, Woods PS, Wu D, Ansbro B, Ard S, Rohde JM, Dulin NO, Guzy RD, Mutlu GM
American journal of respiratory cell and molecular biology 2018 May;58(5):585-593
American journal of respiratory cell and molecular biology 2018 May;58(5):585-593
SHMT2 and the BRCC36/BRISC deubiquitinase regulate HIV-1 Tat K63-ubiquitylation and destruction by autophagy.
Xu M, Moresco JJ, Chang M, Mukim A, Smith D, Diedrich JK, Yates JR 3rd, Jones KA
PLoS pathogens 2018 May;14(5):e1007071
PLoS pathogens 2018 May;14(5):e1007071
Vascular endothelial growth factor signaling requires glycine to promote angiogenesis.
Guo D, Murdoch CE, Xu H, Shi H, Duan DD, Ahmed A, Gu Y
Scientific reports 2017 Nov 7;7(1):14749
Scientific reports 2017 Nov 7;7(1):14749
Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production.
Nigdelioglu R, Hamanaka RB, Meliton AY, O'Leary E, Witt LJ, Cho T, Sun K, Bonham C, Wu D, Woods PS, Husain AN, Wolfgeher D, Dulin NO, Chandel NS, Mutlu GM
The Journal of biological chemistry 2016 Dec 30;291(53):27239-27251
The Journal of biological chemistry 2016 Dec 30;291(53):27239-27251
'Rod and ring' formation from IMP dehydrogenase is regulated through the one-carbon metabolic pathway.
Calise SJ, Purich DL, Nguyen T, Saleem DA, Krueger C, Yin JD, Chan EK
Journal of cell science 2016 Aug 1;129(15):3042-52
Journal of cell science 2016 Aug 1;129(15):3042-52
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.
Sun L, Song L, Wan Q, Wu G, Li X, Wang Y, Wang J, Liu Z, Zhong X, He X, Shen S, Pan X, Li A, Wang Y, Gao P, Tang H, Zhang H
Cell research 2015 Apr;25(4):429-44
Cell research 2015 Apr;25(4):429-44
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 11099-1-AP(SHMT2 antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SHMT2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SHMT2. This antibody recognizes human, mouse, rat antigen. The SHMT2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.