11791-1-AP

antibody from Proteintech Group

Targeting: TREM1 CD354, TREM-1

Provider product page for 11791-1-AP

Western blot

ELISA

Immunocytochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [27]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

Submit

Product number: 11791-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11791-1-AP, RRID:AB_2208556
Product name: TREM1 antibody
Antibody type: Polyclonal
Description: TREM1 antibody (Cat. #11791-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TREM1 protein structure - 11791-1-AP shown in red.

Submitted references Jianpi-huayu Decotion regulates TREM1/DAP12 pathway to improve the immunosuppressive tumor microenvironment and enhance the anti-hepatocellular carcinoma effect of PD-1 inhibitors.

Yao R, Zhang Y, Yu W, Chen X, Shi H, Luo R, Fang C, Zhao X, Zhu X, Lai Y, Xiao S, Chen Y, Zhang J, Zhong C
Journal of ethnopharmacology 2026 Feb 10;356:120846

TREM1 is essential for maintaining stemness of liver cancer stem-like cells in hepatocellular carcinoma.

Sreekumar A, Ajith A, Mamouni K, Horuzsko DD, Horuzsko A
Frontiers in immunology 2025;16:1618342

Neutrophil extracellular traps induce endothelial damage and exacerbate vasospasm in traumatic brain injury.

Wang J, Li L, Xu J, Gheyret D, Li K, Zhang X, Jia H, Tian Y, Liu X, Li S, Yang G, Gao Y, Peng R, Liu H, Liu B, Zhuang J, Wang C, Chen X, Liu Y, Chen B, Huang C, Li Y, Chen X, Zhang J, Zhang S
Theranostics 2025;15(17):9221-9239

Age-Specific Biomarkers TREM1 and KLF4 in Ischemic Stroke: From Transcriptomic Discovery to Therapeutic Drug Screening.

Zhou X, Bi J, Chen H, Wang Y, Li Y, Huang D, Ma X, Cai W, Jiang D, Guan T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 15;39(19):e71080

Epithelial pyroptosis-induced TREM1(+) macrophages activate Th17 cells to accelerate oral mucosal inflammation.

Shang Q, Wang Z, Peng J, Yang D, Li W, Huang X, Qing M, Cheng H, Liu J, Dan H, Zeng X, Zhou Y, Zhang D, Xu H, Chen Q
Cell death discovery 2025 Nov 29;12(1):26

Early intervention with pericyte Fli-1 post-TBI attenuates hippocampal BBB disruption and subsequent neuroinflammation with neurological deficits.

Li J, Du M, Dong G, Hu D, Zhang H, Yu Z, Lu Y, Yang Y
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167671

JNK kinase promotes inflammatory responses by inducing the expression of the inflammatory amplifier TREM1 during influenza a virus infection.

Chen N, Jin J, Qiao B, Gao Z, Tian Y, Ping J
Virus research 2025 Jun;356:199577

Phenotypic plasticity and increased infiltration of peripheral blood-derived TREM1(+) mono-macrophages following radiotherapy in rectal cancer.

Wang H, Zhai M, Li M, Han C, Liu L, Huang C, Zhao L, Yu D, Tao K, Ren J, Lin Z, Zhang T
Cell reports. Medicine 2025 Jan 21;6(1):101887

Pilot Screening of TREM1 Inhibitors in Cell-Based Reporter Assays Reflecting TREM1/DAP12 Receptor Assembly and Functionality.

Filippova N, Hromov R, Shi J, King PH, Nabors LB
ACS chemical neuroscience 2025 Jan 1;16(1):52-65

Osteoclast-derived exosomes influence osteoblast differentiation in osteoporosis progression via the lncRNA AW011738/ miR-24-2-5p/ TREM1 axis.

Liu J, Wang B, Chen H, Yu X, Cao X, Zhang H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117231

Hypoxia-induced TREM1 promotes mesenchymal-like states of glioma stem cells via alternatively activating tumor-associated macrophages.

Dong M, Zhang X, Peng P, Chen Z, Zhang Y, Wan L, Xiang W, Liu G, Guo Y, Xiao Q, Wang B, Guo D, Zhu M, Yu X, Wan F
Cancer letters 2024 May 28;590:216801

Salvianolic acid C attenuates cerebral ischemic injury through inhibiting neuroinflammation via the TLR4-TREM1-NF-κB pathway.

Guo W, Xu X, Xiao Y, Zhang J, Shen P, Lu X, Fan X
Chinese medicine 2024 Mar 11;19(1):46

H3K4me3-Mediated FOXJ2/SLAMF8 Axis Aggravates Thrombosis and Inflammation in β2GPI/Anti-β2GPI-Treated Monocytes.

Tan Y, Qiao J, Yang S, Liu H, Wang Q, Liu Q, Feng W, Cui L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(24):e2309140

TREM1(+) tumor-associated macrophages secrete CCL7 to promote hepatocellular carcinoma metastasis.

Huang S, He L, Zhao Y, Wei Y, Wang Q, Gao Y, Jiang X
Journal of cancer research and clinical oncology 2024 Jun 25;150(6):320

TREM1 facilitates the development of gastric cancer through regulating neutrophil extracellular traps-mediated macrophage polarization.

Yu C, Zhou G, Shi Z, Yu L, Zhou X
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2024 Jul;56(7):1237-1247

CGRP is essential for protection against alveolar epithelial cell necroptosis by activating the AMPK/L-OPA1 signaling pathway during acute lung injury.

Jiang HL, Yang HH, Liu YB, Duan JX, Guan XX, Zhang CY, Zhong WJ, Jin L, Li D, Li Q, Zhou Y, Guan CX
Journal of cellular physiology 2024 Feb;239(2):e31169

Inhibition of TREM-1 ameliorates angiotensin II-induced atrial fibrillation by attenuating macrophage infiltration and inflammation through the PI3K/AKT/FoxO3a signaling pathway.

Chen X, Yu L, Meng S, Zhao J, Huang X, Wang Z, Zhou Z, Huang Y, Hong T, Duan J, Su T, Cao Z, Chi Y, Huang T, Wang H
Cellular signalling 2024 Dec;124:111458

Triggering receptor expressed on myeloid cells-1 aggravates obliterative bronchiolitis via enhancing the proinflammatory phenotype of macrophages.

Wan J, Yang F, Tong S, Zhou T, Wang S
International immunopharmacology 2024 Dec 25;143(Pt 1):113274

Increased serum levels of high-mobility group box 1 protein and the location characteristics in the patients of intracranial aneurysms.

Lyu Y, Tu H, Luo J, Wang C, Li A, Zhou Y, Zhao J, Wang H, Hu J
Brain research 2024 Apr 1;1828:148759

Overexpression of TREM1 is Associated with the Immune-Suppressive Microenvironment and Unfavorable Prognosis in Pan-Cancer.

Zhou X, Lin K, Fu L, Liu F, Lin H, Chen Y, Zhuang B, Liang H, Deng Q, Wang Z, Chen W, Luo J, Cao J, Li P
Journal of inflammation research 2023;16:1375-1391

Malaria-derived exosomes exacerbate liver injury during blood stage of Plasmodium berghei infection.

Zhang X, Zhang M, Wang QR, Hou X, Zhou T, Liu J, Wang Q, Liu W, Liu X, Jin X, Liu Z, Huang B
Acta tropica 2023 Mar;239:106815

Candidalysin amplifies the immune inflammatory response in Candida albicans keratitis through the TREM-1/DAP12 pathway.

Hu L, Bai G, Xu Q, Zhao G, Jiang N, Yao H, Liu X, Du Z
International immunopharmacology 2023 Jun;119:110195

Jo-1 Antibodies From Myositis Induce Complement-Dependent Cytotoxicity and TREM-1 Upregulation in Muscle Endothelial Cells.

Honda M, Shimizu F, Sato R, Mizukami Y, Watanabe K, Takeshita Y, Maeda T, Koga M, Kanda T
Neurology(R) neuroimmunology & neuroinflammation 2023 Jul;10(4)

Inhibition of TREM-1 ameliorates Lipopolysaccharide-induced depressive-like behaviors by alleviating neuroinflammation in the PFC via PI3K/Akt signaling pathway.

Fu A, Qiao F, Feng H, Luo Q
Behavioural brain research 2023 Jul 9;449:114464

Translocated HMGB3 is involved in papillary thyroid cancer progression by activating cytoplasmic TLR3 and transmembrane TREM1.

Zhao Y, Lv HJ, Deng XY, Chen P, Garstka MA, Shi BY, Fu J
Cell cycle (Georgetown, Tex.) 2023 Dec-Dec;22(23-24):2584-2601

A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation.

Yang HH, Duan JX, Liu SK, Xiong JB, Guan XX, Zhong WJ, Sun CC, Zhang CY, Luo XQ, Zhang YF, Chen P, Hammock BD, Hwang SH, Jiang JX, Zhou Y, Guan CX
Theranostics 2020;10(11):4749-4761

Activation of NLRP3 inflammasome up-regulates TREM-1 expression in murine macrophages via HMGB1 and IL-18.

Zhong WJ, Duan JX, Liu T, Yang HH, Guan XX, Zhang CY, Yang JT, Xiong JB, Zhou Y, Guan CX, Li Q
International immunopharmacology 2020 Dec;89(Pt A):107045

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: PC-3 cells were subjected to SDS PAGE followed by western blot with 11791-1-AP(TREM1 antibody) at dilution of 1:400
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using TREM1 antibody 11791-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line