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- Antibody Data
- Antigen structure
- References [10]
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- Validations
- Flow cytometry [1]
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- Product number
- MAB1278-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Human TREM-1 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human TREM-1 in direct ELISAs.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
Q9NP99- Isotype
- IgG
- Antibody clone number
- 193015
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Enriched Cd141+ DCs in the joint are transcriptionally distinct, activated, and contribute to joint pathogenesis.
TREM-1 SNP rs2234246 regulates TREM-1 protein and mRNA levels and is associated with plasma levels of L-selectin.
TREM-1 and its potential ligands in non-infectious diseases: from biology to clinical perspectives.
TREM-1low is a novel characteristic for tumor-associated macrophages in lung cancer.
Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1.
Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo.
Comparison of gene expression profiles between human and mouse monocyte subsets.
Intervention of an inflammation amplifier, triggering receptor expressed on myeloid cells 1, for treatment of autoimmune arthritis.
Soluble triggering receptor expressed on myeloid cell-1 is increased in patients with ventilator-associated pneumonia: a preliminary report.
Effects of TREM-1 activation in human neutrophils: activation of signaling pathways, recruitment into lipid rafts and association with TLR4.
Canavan M, Walsh AM, Bhargava V, Wade SM, McGarry T, Marzaioli V, Moran B, Biniecka M, Convery H, Wade S, Orr C, Mullan R, Fletcher JM, Nagpal S, Veale DJ, Fearon U
JCI insight 2018 Dec 6;3(23)
JCI insight 2018 Dec 6;3(23)
TREM-1 SNP rs2234246 regulates TREM-1 protein and mRNA levels and is associated with plasma levels of L-selectin.
Aldasoro Arguinano AA, Dadé S, Stathopoulou M, Derive M, Coumba Ndiaye N, Xie T, Masson C, Gibot S, Visvikis-Siest S
PloS one 2017;12(8):e0182226
PloS one 2017;12(8):e0182226
TREM-1 and its potential ligands in non-infectious diseases: from biology to clinical perspectives.
Tammaro A, Derive M, Gibot S, Leemans JC, Florquin S, Dessing MC
Pharmacology & therapeutics 2017 Sep;177:81-95
Pharmacology & therapeutics 2017 Sep;177:81-95
TREM-1low is a novel characteristic for tumor-associated macrophages in lung cancer.
Zhang G, Liu H, Huang J, Chen S, Pan X, Huang H, Wang L
Oncotarget 2016 Jun 28;7(26):40508-40517
Oncotarget 2016 Jun 28;7(26):40508-40517
Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1.
Read CB, Kuijper JL, Hjorth SA, Heipel MD, Tang X, Fleetwood AJ, Dantzler JL, Grell SN, Kastrup J, Wang C, Brandt CS, Hansen AJ, Wagtmann NR, Xu W, Stennicke VW
Journal of immunology (Baltimore, Md. : 1950) 2015 Feb 15;194(4):1417-21
Journal of immunology (Baltimore, Md. : 1950) 2015 Feb 15;194(4):1417-21
Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo.
Bosco MC, Pierobon D, Blengio F, Raggi F, Vanni C, Gattorno M, Eva A, Novelli F, Cappello P, Giovarelli M, Varesio L
Blood 2011 Mar 3;117(9):2625-39
Blood 2011 Mar 3;117(9):2625-39
Comparison of gene expression profiles between human and mouse monocyte subsets.
Ingersoll MA, Spanbroek R, Lottaz C, Gautier EL, Frankenberger M, Hoffmann R, Lang R, Haniffa M, Collin M, Tacke F, Habenicht AJ, Ziegler-Heitbrock L, Randolph GJ
Blood 2010 Jan 21;115(3):e10-9
Blood 2010 Jan 21;115(3):e10-9
Intervention of an inflammation amplifier, triggering receptor expressed on myeloid cells 1, for treatment of autoimmune arthritis.
Murakami Y, Akahoshi T, Aoki N, Toyomoto M, Miyasaka N, Kohsaka H
Arthritis and rheumatism 2009 Jun;60(6):1615-23
Arthritis and rheumatism 2009 Jun;60(6):1615-23
Soluble triggering receptor expressed on myeloid cell-1 is increased in patients with ventilator-associated pneumonia: a preliminary report.
Horonenko G, Hoyt JC, Robbins RA, Singarajah CU, Umar A, Pattengill J, Hayden JM
Chest 2007 Jul;132(1):58-63
Chest 2007 Jul;132(1):58-63
Effects of TREM-1 activation in human neutrophils: activation of signaling pathways, recruitment into lipid rafts and association with TLR4.
Fortin CF, Lesur O, Fulop T Jr
International immunology 2007 Jan;19(1):41-50
International immunology 2007 Jan;19(1):41-50
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Supportive validation
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- R&D Systems (provider)
- Main image
- Experimental details
- Detection of TREM-1 in Human Blood Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with Mouse Anti-Human TREM-1 Monoclonal Antibody (Catalog # MAB1278, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B). View our protocol for Staining Membrane-associated Proteins.
