314907

antibody from BioLegend

Targeting: TREM1 CD354, TREM-1

Western blot

Antibody data

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Validation data

Product number: 314907 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#314907, RRID:AB_2272277
Product name: LEAF™ Purified anti-human CD354 (TREM-1) [TREM-26]
Antibody type: Monoclonal
Antigen: Recombinant human TREM-1
Description: TREM-1 is a 30 kD glycoprotein also known as triggering receptor expressed on myeloid cells 1, and triggering receptor expressed on monocytes 1. It is a Type I membrane protein that contains an immunoglobulin-like V-type domain. Alternatively spliced protein variant may be secreted. TREM-1 is highly expressed on peripheral blood myeloid cells (particularly mature monocytes and granulocytes); TREM-1 expression can be further upregulated by bacteria, fungi and lipopolysaccharide. TREM-1 has been shown to interact with the adaptor protein DAP12 to stimulate neutrophil and monocyte-mediated inflammatory responses through the triggering and release of pro-inflammatory cytokines and chemokines. TREM-1 is thought to amplify inflammatory responses to fungal and bacterial infections and potentiate septic shock. This antibody has been shown to be useful for flow cytometry and activation of monocytes and granulocytes.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µg
Concentration: 1 mg/ml
Storage: The antibody solution should be stored undiluted at 4 °C. This LEAF™ solution contains no preservative; handle under aseptic conditions.

TREM1 protein structure - 314907 shown in red.