316101

antibody from BioLegend

Targeting: TREM1 CD354, TREM-1

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

316101

Provider

BioLegend

Product name

Purified anti-human CD354 (TREM-1)

Antibody type

Monoclonal

Antigen

Recombinant human TREM-1

Description

TREM-1 is a 30 kD glycoprotein also known as triggering receptor expressed on myeloid cells 1, and triggering receptor expressed on monocytes 1. It is a Type I membrane protein that contains an immunoglobulin-like V-type domain. Alternatively spliced protein variant may be secreted. TREM-1 is highly expressed on peripheral blood myeloid cells (particularly mature monocytes and granulocytes); TREM-1 expression can be further upregulated by bacteria, fungi and lipopolysaccharide. TREM-1 has been shown to interact with the adaptor protein DAP12 to stimulate neutrophil and monocyte-mediated inflammatory responses through the triggering and release of pro-inflammatory cytokines and chemokines. TREM-1 is thought to amplify inflammatory responses to fungal and bacterial infections and potentiate septic shock. This antibody has been shown to be useful for Western blotting, flow cytometric staining, and ELISA pairing with biotinylated TREM-26 antibody (Cat. No. 314904) as a detection antibody.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

25 µg

Concentration

0.5 mg/ml

Storage

The antibody solution should be stored undiluted at 4°C.