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- Antibody Data
- Antigen structure
- References [18]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- 15023-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15023-1-AP, RRID:AB_2084544
- Product name
- CPSF4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CPSF4 antibody (Cat. #15023-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Knockdown of STK39 inhibits lung cancer brain metastasis by suppressing the CPSF4/NFκB/COX2 pathway.
ELF3-AS1 promotes the carcinogenesis of hepatocellular carcinoma cells by inhibiting miR-98-5p/CPSF4 axis.
RNA polymerase III transcription-associated polyadenylation promotes the accumulation of noncoding retrotransposons during infection.
Sustained cancer-relevant alternative RNA splicing events driven by PRMT5 in high-risk neuroblastoma.
Mediator regulates transcriptional termination through crosstalk with pre-mRNA 3' end processing factors.
RNA polymerase III transcription-associated polyadenylation promotes the accumulation of noncoding retrotransposons during infection.
CPSF4-mediated regulation of alternative splicing of HMG20B facilitates the progression of triple-negative breast cancer.
LINC00921 reduces lung cancer radiosensitivity by destabilizing NUDT21 and driving aberrant MED23 alternative polyadenylation.
Nuclear m(6) A reader YTHDC1 suppresses proximal alternative polyadenylation sites by interfering with the 3' processing machinery.
Key pituitary miRNAs mediate the expression of pig GHRHR splice variants by regulating splice factors.
CPSF4 promotes tumor-initiating phenotype by enhancing VEGF/NRP2/TAZ signaling in lung cancer.
Cleavage and polyadenylation specific factor 4 promotes colon cancer progression by transcriptionally activating hTERT.
The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis.
MiR-4458 inhibits breast cancer cell growth, migration, and invasiveness by targeting CPSF4.
Cleavage and polyadenylation specific factor 4 targets NF-κB/cyclooxygenase-2 signaling to promote lung cancer growth and progression.
CREB-binding protein regulates lung cancer growth by targeting MAPK and CPSF4 signaling pathway.
CPSF4 activates telomerase reverse transcriptase and predicts poor prognosis in human lung adenocarcinomas.
Upregulation of cleavage and polyadenylation specific factor 4 in lung adenocarcinoma and its critical role for cancer cell survival and proliferation.
Shu Y, Dong Y, Li B, Wang Y, Liao Q, Su Z, Wang J, Zuo P, Yuan H, Wang C, Li S, Fan Y, Su X
Journal of neuro-oncology 2025 Sep;174(2):411-430
Journal of neuro-oncology 2025 Sep;174(2):411-430
ELF3-AS1 promotes the carcinogenesis of hepatocellular carcinoma cells by inhibiting miR-98-5p/CPSF4 axis.
Ge P, Niu S, Fang M, Xu Q, Zhang W, Xu J, Yang F, Wang Y, Shi T, Liu H
Nucleosides, nucleotides & nucleic acids 2025 Nov 24;:1-20
Nucleosides, nucleotides & nucleic acids 2025 Nov 24;:1-20
RNA polymerase III transcription-associated polyadenylation promotes the accumulation of noncoding retrotransposons during infection.
Lari A, Shah SB, Mao X, Sanghrajka P, Karijolich J, Lareau LF, Glaunsinger BA
bioRxiv : the preprint server for biology 2025 May 15;
bioRxiv : the preprint server for biology 2025 May 15;
Sustained cancer-relevant alternative RNA splicing events driven by PRMT5 in high-risk neuroblastoma.
Bate-Eya LT, Albayrak G, Carr SM, Shrestha A, Kanapin A, Samsonova A, La Thangue NB
Molecular oncology 2025 Mar;19(3):741-763
Molecular oncology 2025 Mar;19(3):741-763
Mediator regulates transcriptional termination through crosstalk with pre-mRNA 3' end processing factors.
Lu C, Bai X, Zhang H, Zhang Y, Yang M, Zheng Y, Jin Z, Yang W, Guo G, Huang Q, Huang Y, Wu L, Fu XD, Zhang Z, Wang G
Molecular cell 2025 Jun 5;85(11):2147-2164.e10
Molecular cell 2025 Jun 5;85(11):2147-2164.e10
RNA polymerase III transcription-associated polyadenylation promotes the accumulation of noncoding retrotransposons during infection.
Lari A, Shah SB, Mao X, Sanghrajka P, Karijolich J, Lareau LF, Glaunsinger BA
Proceedings of the National Academy of Sciences of the United States of America 2025 Aug 12;122(32):e2507186122
Proceedings of the National Academy of Sciences of the United States of America 2025 Aug 12;122(32):e2507186122
CPSF4-mediated regulation of alternative splicing of HMG20B facilitates the progression of triple-negative breast cancer.
Zhong G, Shen Q, Zheng X, Yu K, Lu H, Wei B, Cui H, Dai Z, Lou W
Journal of translational medicine 2024 Dec 27;22(1):1149
Journal of translational medicine 2024 Dec 27;22(1):1149
LINC00921 reduces lung cancer radiosensitivity by destabilizing NUDT21 and driving aberrant MED23 alternative polyadenylation.
Zhang N, Liu X, Huang L, Zeng J, Ma C, Han L, Li W, Yu J, Yang M
Cell reports 2023 Dec 26;42(12):113479
Cell reports 2023 Dec 26;42(12):113479
Nuclear m(6) A reader YTHDC1 suppresses proximal alternative polyadenylation sites by interfering with the 3' processing machinery.
Chen L, Fu Y, Hu Z, Deng K, Song Z, Liu S, Li M, Ou X, Wu R, Liu M, Li R, Gao S, Cheng L, Chen S, Xu A
EMBO reports 2022 Nov 7;23(11):e54686
EMBO reports 2022 Nov 7;23(11):e54686
Key pituitary miRNAs mediate the expression of pig GHRHR splice variants by regulating splice factors.
Teng Z, Hao L, Yang R, Song J, Wang Z, Jiao Y, Fang J, Zheng S, Ma Z, Chen X, Liu S, Cheng Y
International journal of biological macromolecules 2022 May 31;208:208-218
International journal of biological macromolecules 2022 May 31;208:208-218
CPSF4 promotes tumor-initiating phenotype by enhancing VEGF/NRP2/TAZ signaling in lung cancer.
Song Y, Sun K, Gong L, Shi L, Qin T, Wang S, Deng W, Chen W, Zheng F, Li G
Medical oncology (Northwood, London, England) 2022 Dec 26;40(1):62
Medical oncology (Northwood, London, England) 2022 Dec 26;40(1):62
Cleavage and polyadenylation specific factor 4 promotes colon cancer progression by transcriptionally activating hTERT.
Yang Q, Fan W, Zheng Z, Lin S, Liu C, Wang R, Li W, Zuo Y, Sun Y, Hu S, Chen M, Guo P, Pan J, Tian C, Zhu T, Diao C, Hao J, Yu W, Li L, Li Y, Guo W, Deng W, Wu X
Biochimica et biophysica acta. Molecular cell research 2019 Oct;1866(10):1533-1543
Biochimica et biophysica acta. Molecular cell research 2019 Oct;1866(10):1533-1543
The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis.
Ashraf S, Radhi M, Gowler P, Burston JJ, Gandhi RD, Thorn GJ, Piccinini AM, Walsh DA, Chapman V, de Moor CH
Scientific reports 2019 Mar 18;9(1):4696
Scientific reports 2019 Mar 18;9(1):4696
MiR-4458 inhibits breast cancer cell growth, migration, and invasiveness by targeting CPSF4.
Wu J, Miao J, Ding Y, Zhang Y, Huang X, Zhou X, Tang R
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Dec;97(6):722-730
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Dec;97(6):722-730
Cleavage and polyadenylation specific factor 4 targets NF-κB/cyclooxygenase-2 signaling to promote lung cancer growth and progression.
Yi C, Wang Y, Zhang C, Xuan Y, Zhao S, Liu T, Li W, Liao Y, Feng X, Hao J, Gao Y, Yu W, Chen Y, Zhang C, Guo W, Tang B, Deng W
Cancer letters 2016 Oct 10;381(1):1-13
Cancer letters 2016 Oct 10;381(1):1-13
CREB-binding protein regulates lung cancer growth by targeting MAPK and CPSF4 signaling pathway.
Tang Z, Yu W, Zhang C, Zhao S, Yu Z, Xiao X, Tang R, Xuan Y, Yang W, Hao J, Xu T, Zhang Q, Huang W, Deng W, Guo W
Molecular oncology 2016 Feb;10(2):317-29
Molecular oncology 2016 Feb;10(2):317-29
CPSF4 activates telomerase reverse transcriptase and predicts poor prognosis in human lung adenocarcinomas.
Chen W, Qin L, Wang S, Li M, Shi D, Tian Y, Wang J, Fu L, Li Z, Guo W, Yu W, Yuan Y, Kang T, Huang W, Deng W
Molecular oncology 2014 May;8(3):704-16
Molecular oncology 2014 May;8(3):704-16
Upregulation of cleavage and polyadenylation specific factor 4 in lung adenocarcinoma and its critical role for cancer cell survival and proliferation.
Chen W, Guo W, Li M, Shi D, Tian Y, Li Z, Wang J, Fu L, Xiao X, Liu QQ, Wang S, Huang W, Deng W
PloS one 2013;8(12):e82728
PloS one 2013;8(12):e82728
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 15023-1-AP(CPSF4 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using CPSF4 antibody 15023-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-CPSF4 (IP:15023-1-AP, 3ug; Detection:15023-1-AP 1:400) with HeLa cells lysate 1000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human endometrial cancer using 15023-1-AP(CPSF4 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
