55031-1-AP

antibody from Proteintech Group

Targeting: CDC25A

Provider product page for 55031-1-AP

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Immunocytochemistry

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [31]
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Validations
Western blot [1]

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Product number: 55031-1-AP - Provider product page
Provider: Proteintech Group
Product name: CDC25A antibody
Antibody type: Polyclonal
Description: KD/KO validated CDC25A antibody (Cat. #55031-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CDC25A protein structure - 55031-1-AP shown in red.

Submitted references Dihydroartemisinin-driven selective anti-lung cancer proliferation by binding to EGFR and inhibition of NRAS signaling pathway-induced DNA damage.

Li LG, Peng XC, Yang ZY, Han N, Gou CL, Shi J, Yu LL, Chen NN, Yu TT, Li TF, Li XY, Hu J
Scientific reports 2024 May 22;14(1):11704

Cynaroside Induces G1 Cell Cycle Arrest by Downregulating Cell Division Cycle 25A in Colorectal Cancer.

Lei S, Cao W, Zeng Z, Wang L, Lan J, Chen T
Molecules (Basel, Switzerland) 2024 Mar 28;29(7)

Ginsenoside 20(S)-Rg3 reduces KIF20A expression and promotes CDC25A proteasomal degradation in epithelial ovarian cancer.

Zhang R, Li L, Li H, Bai H, Suo Y, Cui J, Wang Y
Journal of ginseng research 2024 Jan;48(1):40-51

A modified nucleoside O6-methyl-2'-deoxyguanosine-5'-triphosphate exhibits anti-glioblastoma activity in a caspase-independent manner.

Wang ZH, Li J, Liu Q, Qian JC, Li QQ, Wang QY, Zeng LT, Li SJ, Gao X, Pan JX, Gao XF, Wu K, Hu GX, Iwakuma T, Cai JP
Pharmacological research 2024 Jan;199:106990

B-Myb deficiency boosts bortezomib-induced immunogenic cell death in colorectal cancer.

Hui YJ, Yu TT, Li LG, Peng XC, Di MJ, Liu H, Gu WL, Li TF, Zhao KL, Wang WX
Scientific reports 2024 Apr 2;14(1):7733

Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity.

Luo Q, Pan Y, Fu Q, Zhang X, Zhou S, Yu P, Tian H, Liu P, Chen S, Zhang H, Qin T
Cell biology and toxicology 2023 Oct;39(5):2069-2087

ATM deficiency aggravates the progression of liver fibrosis induced by carbon tetrachloride in mice.

Li M, Yang Z, Song Z, Bo C, Wang S, Jia Q
Toxicology 2023 Jan 15;484:153397

Silibinin Therapy Improves Cholangiocarcinoma Outcomes by Regulating ERK/Mitochondrial Pathway.

Bai Y, Chen J, Hu W, Wang L, Wu Y, Yu S
Frontiers in pharmacology 2022;13:847905

Sulfate oligosaccharide of Gracilaria lemaneiformis modulates type 1 immunity by restraining T cell activation.

Liu Q, Zhou Y, Ma L, Gu F, Liao K, Liu Y, Zhang Y, Liu H, Hong Y, Cao M, Liu WH, Liu C, Liu G
Carbohydrate polymers 2022 Jul 15;288:119377

Blocking glycine utilization inhibits multiple myeloma progression by disrupting glutathione balance.

Xia J, Zhang J, Wu X, Du W, Zhu Y, Liu X, Liu Z, Meng B, Guo J, Yang Q, Wang Y, Wang Q, Feng X, Xie G, Shen Y, He Y, Xiang J, Wu M, An G, Qiu L, Jia W, Zhou W
Nature communications 2022 Jul 11;13(1):4007

BRD7 Promotes Cell Proliferation and Tumor Growth Through Stabilization of c-Myc in Colorectal Cancer.

Zhao R, Liu Y, Wu C, Li M, Wei Y, Niu W, Yang J, Fan S, Xie Y, Li H, Wang W, Zeng Z, Xiong W, Li X, Li G, Zhou M
Frontiers in cell and developmental biology 2021;9:659392

Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis.

Chandrasekaran AP, Woo SH, Sarodaya N, Rhie BH, Tyagi A, Das S, Suresh B, Ko NR, Oh SJ, Kim KS, Ramakrishna S
International journal of molecular sciences 2021 May 28;22(11)

YTHDF1 Promotes Gastric Carcinogenesis by Controlling Translation of FZD7.

Pi J, Wang W, Ji M, Wang X, Wei X, Jin J, Liu T, Qiang J, Qi Z, Li F, Liu Y, Ma Y, Si Y, Huo Y, Gao Y, Chen Y, Dong L, Su R, Chen J, Rao S, Yi P, Yu S, Wang F, Yu J
Cancer research 2021 May 15;81(10):2651-2665

Hypericin-mediated photodynamic therapy inhibits growth of colorectal cancer cells via inducing S phase cell cycle arrest and apoptosis.

Hu J, Song J, Tang Z, Wei S, Chen L, Zhou R
European journal of pharmacology 2021 Jun 5;900:174071

6-Shogaol from ginger shows anti-tumor effect in cervical carcinoma via PI3K/Akt/mTOR pathway.

Pei XD, He ZL, Yao HL, Xiao JS, Li L, Gu JZ, Shi PZ, Wang JH, Jiang LH
European journal of nutrition 2021 Aug;60(5):2781-2793

USP48 Governs Cell Cycle Progression by Regulating the Protein Level of Aurora B.

Antao AM, Kaushal K, Das S, Singh V, Suresh B, Kim KS, Ramakrishna S
International journal of molecular sciences 2021 Aug 7;22(16)

LINC00671 suppresses cell proliferation and metastasis in pancreatic cancer by inhibiting AKT and ERK signaling pathway.

Qu S, Niu K, Wang J, Dai J, Ganguly A, Gao C, Tian Y, Lin Z, Yang X, Zhang X, Liu Z, Li H
Cancer gene therapy 2021 Apr;28(3-4):221-233

CLPTM1L induces estrogen receptor β signaling-mediated radioresistance in non-small cell lung cancer cells.

Li H, Che J, Jiang M, Cui M, Feng G, Dong J, Zhang S, Lu L, Liu W, Fan S
Cell communication and signaling : CCS 2020 Sep 17;18(1):152

Cdc14a has a role in spermatogenesis, sperm maturation and male fertility.

Wen Z, Zhu H, Zhang A, Lin J, Zhang G, Liu D, Xiao Y, Ye C, Sun D, Wu B, Zhang J, Gao J
Experimental cell research 2020 Oct 1;395(1):112178

Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer.

Das S, Chandrasekaran AP, Suresh B, Haq S, Kang JH, Lee SJ, Kim J, Kim J, Lee S, Kim HH, Kim KS, Ramakrishna S
Cell death and differentiation 2020 Nov;27(11):3004-3020

HAUSP stabilizes Cdc25A and protects cervical cancer cells from DNA damage response.

Das S, Chandrasekaran AP, Jo KS, Ko NR, Oh SJ, Kim KS, Ramakrishna S
Biochimica et biophysica acta. Molecular cell research 2020 Dec;1867(12):118835

The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells.

Gao X, Wang Q, Wang Y, Liu J, Liu S, Liu J, Zhou X, Zhou L, Chen H, Pan L, Chen J, Wang D, Zhang Q, Shen S, Xiao Y, Wu Z, Cheng Y, Chen G, Kubra S, Qin J, Huang L, Zhang P, Wang C, Moses RE, Lonard DM, Malley BWO, Fares F, Zhang B, Li X, Li L, Xiao J
Nature communications 2020 Aug 6;11(1):3904

Decreased expression of miR-184 restrains the growth and invasion of endometrial carcinoma cells through CDC25A-dependent Notch signaling pathway.

Chen Z, Zhu Y, Fan X, Liu Y, Feng Q
American journal of translational research 2019;11(2):755-764

RNA sequencing analysis of the CAL-27 cell response to over-expressed ZNF750 gene revealed an extensive regulation on cell cycle.

Liu X, Yang Y, Xu C, Yang H, Chen S, Chen H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109377

A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer.

Wang Y, Han T, Gan M, Guo M, Xie C, Jin J, Zhang S, Wang P, Cao J, Wang JB
Cell cycle (Georgetown, Tex.) 2019 May;18(9):1019-1032

Cholesterol depletion sensitizes gallbladder cancer to cisplatin by impairing DNA damage response.

Zhang Y, Liu Y, Duan J, Wang H, Zhang Y, Qiao K, Wang J
Cell cycle (Georgetown, Tex.) 2019 Dec;18(23):3337-3350

PTBP3 splicing factor promotes hepatocellular carcinoma by destroying the splicing balance of NEAT1 and pre-miR-612.

Yang X, Qu S, Wang L, Zhang H, Yang Z, Wang J, Dai B, Tao K, Shang R, Liu Z, Li X, Zhang Z, Xia C, Ma B, Liu W, Li H, Dou K
Oncogene 2018 Dec;37(50):6399-6413

2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino) phenyl carbamoylsulfanyl] propionic acid, a glutathione reductase inhibitor, induces G(2)/M cell cycle arrest through generation of thiol oxidative stress in human esophageal cancer cells.

Li X, Jiang Z, Feng J, Zhang X, Wu J, Chen W
Oncotarget 2017 Sep 22;8(37):61846-61860

A critical role of Hrd1 in the regulation of optineurin degradation and aggresome formation.

Mao J, Xia Q, Liu C, Ying Z, Wang H, Wang G
Human molecular genetics 2017 May 15;26(10):1877-1889

Cell proliferation downregulated by TGF-β2-triggered G1/S checkpoint in clinical CAFs.

Wu J, Fu R, Liu Z, Li G, Huang X, Xue Y, Xu Y, Sun Y, Zhao J, Mi J
Cell cycle (Georgetown, Tex.) 2017 Jan 17;16(2):172-178

Inhibiting CREPT reduces the proliferation and migration of non-small cell lung cancer cells by down-regulating cell cycle related protein.

Liu T, Li WM, Wang WP, Sun Y, Ni YF, Xing H, Xia JH, Wang XJ, Zhang ZP, Li XF
American journal of translational research 2016;8(5):2097-113

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The CDC25A antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human CDC25A. This antibody recognizes human, mouse antigen. The CDC25A antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 55031-1-AP.pdf

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