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- References [34]
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- Product number
- 12842-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12842-1-AP, RRID:AB_2103572
- Product name
- FBP1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated FBP1 antibody (Cat. #12842-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Improving erectile function in diabetic male mice by rescuing depalmitoylated FBP1 to reduce cavernosal lactate.
RAC1 directly phosphorylates both PKM2 and FBP1 to promote radioresistance in hepatocellular carcinoma.
Salvianolic acid C alleviates acute kidney injury by restoring fructose-1,6-bisphosphatase 1-mediated gluconeogenesis.
Cross-Disease Identification of FBP1 in Atherosclerosis and Calcific Aortic Valve Disease via Integrated Bioinformatics and Validation: Functional Analysis and Therapeutic Target Exploration.
Taurodeoxycholic, taurocholic, and glycocholic acids promote hepatic gluconeogenesis via TGR5 in dairy cows.
Patient-derived organotypic tissue cultures as a platform to evaluate metabolic reprogramming in breast cancer patients.
Circulating glycerate predicts resilience to fructose-induced hepatic steatosis.
The Ancient Drug Salicylate Indirectly Targets Fructose-1,6-Bisphosphatase to Suppress Liver Glucose Production in Diet-Induced Obese Mice.
Echinacoside alleviates type 2 diabetes mellitus through inhibiting hepatic gluconeogenesis via gut bacterial-fungal trans-kingdom network reconstruction.
FBP1 as a key regulator of focal adhesion kinase-mediated hepatic stellate cell activation: Multi-omics and experimental validation.
Eurotium cristatum Ameliorates Glucolipid Metabolic Dysfunction of Obese Mice in Association with Regulating Intestinal Gluconeogenesis and Microbiome.
Single-cell spatiotemporal analysis of the lungs reveals Slamf9(+) macrophages involved in viral clearance and inflammation resolution.
Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression.
Prognostic and immunotherapeutic implications of bilirubin metabolism-associated genes in lung adenocarcinoma.
Sterol Regulatory Element Binding Protein 1: A Mediator for High-Fat Diet-Induced Hepatic Gluconeogenesis and Glucose Intolerance in Fish.
FBP1 orchestrates keratinocyte proliferation/differentiation and suppresses psoriasis through metabolic control of histone acetylation.
Inhibition of FBP1 expression by KMT5A through TWIST1 methylation is one of the mechanisms leading to chemoresistance in breast cancer.
A novel risk model of three gefitinib-related genes FBP1, SBK1 and AURKA is related to the immune microenvironment and is predicting prognosis of lung adenocarcinoma patients.
A novel variant in the FBP1 gene causes fructose-1,6-bisphosphatase deficiency through increased ubiquitination.
Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice.
Down-regulation of FBP1 in lung adenocarcinoma cells promotes proliferation and invasion through SLUG mediated epithelial mesenchymal transformation.
Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth.
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Novel candidate factors predicting the effect of S-1 adjuvant chemotherapy of pancreatic cancer.
LncRNA MT1JP plays a protective role in intrahepatic cholangiocarcinoma by regulating miR-18a-5p/FBP1 axis.
Knockdown of FBP1 enhances radiosensitivity in prostate cancer cells by activating autophagy.
Discovery of N-Arylsulfonyl-Indole-2-Carboxamide Derivatives as Potent, Selective, and Orally Bioavailable Fructose-1,6-Bisphosphatase Inhibitors-Design, Synthesis, In Vivo Glucose Lowering Effects, and X-ray Crystal Complex Analysis.
Hypoxia-induced GBE1 expression promotes tumor progression through metabolic reprogramming in lung adenocarcinoma.
Measurement of Organ-Specific and Acute-Phase Blood Protein Levels in Early Lyme Disease.
HSF2 regulates aerobic glycolysis by suppression of FBP1 in hepatocellular carcinoma.
Functional genetic variants of RUVBL1 predict overall survival of Chinese patients with epithelial ovarian cancer.
Forced overexpression of FBP1 inhibits proliferation and metastasis in cholangiocarcinoma cells via Wnt/β-catenin pathway.
The Promoting Effect of Radiation on Glucose Metabolism in Breast Cancer Cells under the Treatment of Cobalt Chloride.
Betaine supplementation in maternal diet modulates the epigenetic regulation of hepatic gluconeogenic genes in neonatal piglets.
Xiao M, Guo W, Zeng R, Wu S, Jin X
Nature communications 2026 Jan 16;17(1):1740
Nature communications 2026 Jan 16;17(1):1740
RAC1 directly phosphorylates both PKM2 and FBP1 to promote radioresistance in hepatocellular carcinoma.
Jiang Y, Zhou K, Wei X, Feng J, Zhou B, Liu C, Sun J, Zhu H, Liu Z, Yuan N, Li Y, Meng X, Cao J, Jiao Y, Cheng S
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Feb 4;34(2):1201-1214
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Feb 4;34(2):1201-1214
Salvianolic acid C alleviates acute kidney injury by restoring fructose-1,6-bisphosphatase 1-mediated gluconeogenesis.
Chen J, Li Y, Zhou P, Zou S, Zhao J, Wu M, Wang L
Renal failure 2026 Dec;48(1):2629902
Renal failure 2026 Dec;48(1):2629902
Cross-Disease Identification of FBP1 in Atherosclerosis and Calcific Aortic Valve Disease via Integrated Bioinformatics and Validation: Functional Analysis and Therapeutic Target Exploration.
Xu H, Xu Y, Wang X, Yan Z, Geng T, Wu J, Li Y, Guo M
Journal of inflammation research 2025;18:16135-16156
Journal of inflammation research 2025;18:16135-16156
Taurodeoxycholic, taurocholic, and glycocholic acids promote hepatic gluconeogenesis via TGR5 in dairy cows.
Zhu M, Zheng Y, Lou S, Zhang R, Feng D, Lei X, Chen L, Wang J, Yao J, Deng L
Journal of animal science and biotechnology 2025 Oct 30;16(1):142
Journal of animal science and biotechnology 2025 Oct 30;16(1):142
Patient-derived organotypic tissue cultures as a platform to evaluate metabolic reprogramming in breast cancer patients.
Fan TW, Yan J, Goncalves CFL, Islam JMM, Lin P, Kaddah MMY, Higashi RM, Lane AN, Wang X, Zhu C
The Journal of biological chemistry 2025 May;301(5):108495
The Journal of biological chemistry 2025 May;301(5):108495
Circulating glycerate predicts resilience to fructose-induced hepatic steatosis.
Ramirez CB, Ahn IS, Rubtsova VI, Cely I, Le J, Kim J, Jung S, Kelly ME, Kim Y, Bae H, Song WS, Alam YH, Zhang G, Diamante G, Chao A, Hoffner L, Anica A, Le I, Lopez ML, Tamburini IJ, Moyer EM, Tsai A, Yang Q, Dai X, Piomelli D, Lee G, Yang X, Jang C
Cell metabolism 2025 May 6;37(5):1223-1234.e5
Cell metabolism 2025 May 6;37(5):1223-1234.e5
The Ancient Drug Salicylate Indirectly Targets Fructose-1,6-Bisphosphatase to Suppress Liver Glucose Production in Diet-Induced Obese Mice.
Nisr RB, Atrih A, Lara EJG, Lamont D, Luda KM, McCrimmon RJ, Sakamoto K, Rena G, McNeilly AD
Acta physiologica (Oxford, England) 2025 Jun;241(6):e70058
Acta physiologica (Oxford, England) 2025 Jun;241(6):e70058
Echinacoside alleviates type 2 diabetes mellitus through inhibiting hepatic gluconeogenesis via gut bacterial-fungal trans-kingdom network reconstruction.
Fan L, Liu J, Li L, Yang X, Zhao Q, Zhao L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156802
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156802
FBP1 as a key regulator of focal adhesion kinase-mediated hepatic stellate cell activation: Multi-omics and experimental validation.
Wu HY, Han L, Ran T, Sun Y, Zhang QX, Huang T, Zou GL, Zhang Y, Zhou YM, Lin GY, Chen SJ, Wang JL, Pan C, Lu F, Pu HF, Zhao XK
World journal of gastroenterology 2025 Jul 28;31(28):107361
World journal of gastroenterology 2025 Jul 28;31(28):107361
Eurotium cristatum Ameliorates Glucolipid Metabolic Dysfunction of Obese Mice in Association with Regulating Intestinal Gluconeogenesis and Microbiome.
Yang W, Han N, Zhang X
Foods (Basel, Switzerland) 2025 Dec 12;14(24)
Foods (Basel, Switzerland) 2025 Dec 12;14(24)
Single-cell spatiotemporal analysis of the lungs reveals Slamf9(+) macrophages involved in viral clearance and inflammation resolution.
Cong B, Dong X, Yang Z, Yu P, Chai Y, Liu J, Zhang M, Zang Y, Kang J, Feng Y, Liu Y, Feng W, Wang D, Deng W, Li F, Song Z, Wang Z, Chen X, Qin H, Yu Q, Li Z, Liu S, Xu X, Zhong N, Ren X, Qin C, Liu L, Wang J, Cao X
Cell discovery 2024 Oct 16;10(1):104
Cell discovery 2024 Oct 16;10(1):104
Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression.
Li M, Wang Z, Tao J, Jiang H, Yang H, Guo D, Zhao H, He X, Luo S, Jiang X, Yuan L, Xiao L, He H, Yu R, Fang J, Liang T, Mao Z, Xu D, Lu Z
Nature chemical biology 2024 Nov;20(11):1505-1513
Nature chemical biology 2024 Nov;20(11):1505-1513
Prognostic and immunotherapeutic implications of bilirubin metabolism-associated genes in lung adenocarcinoma.
Ren K, Ling X, Chen L, Li Z, Huang T
Journal of cellular and molecular medicine 2024 May;28(9):e18346
Journal of cellular and molecular medicine 2024 May;28(9):e18346
Sterol Regulatory Element Binding Protein 1: A Mediator for High-Fat Diet-Induced Hepatic Gluconeogenesis and Glucose Intolerance in Fish.
Zhao Z, Xiang X, Chen Q, Du J, Zhu S, Xu X, Shen Y, Wen S, Li Y, Xu W, Mai K, Ai Q
The Journal of nutrition 2024 May;154(5):1505-1516
The Journal of nutrition 2024 May;154(5):1505-1516
FBP1 orchestrates keratinocyte proliferation/differentiation and suppresses psoriasis through metabolic control of histone acetylation.
Zhang P, Yang J, Liu X, Huang C, Tao Y, Shen P, Bai Z, Xiao C, Zhou L, Li G, Zhang L, Zhou W, Gao Y
Cell death & disease 2024 Jun 4;15(6):392
Cell death & disease 2024 Jun 4;15(6):392
Inhibition of FBP1 expression by KMT5A through TWIST1 methylation is one of the mechanisms leading to chemoresistance in breast cancer.
Peng X, Ma L, Chen X, Tang F, Zong X
Oncology reports 2024 Aug;52(2)
Oncology reports 2024 Aug;52(2)
A novel risk model of three gefitinib-related genes FBP1, SBK1 and AURKA is related to the immune microenvironment and is predicting prognosis of lung adenocarcinoma patients.
Guo Q, Li K, Jiang N, Zhou R, Rao XR, Wu CY
Aging 2023 Sep 21;15(18):9633-9660
Aging 2023 Sep 21;15(18):9633-9660
A novel variant in the FBP1 gene causes fructose-1,6-bisphosphatase deficiency through increased ubiquitination.
Liang X, Liu X, Li W, Zhang L, Zhang B, Lai G, Zhao Y
Archives of biochemistry and biophysics 2023 Jul 1;742:109619
Archives of biochemistry and biophysics 2023 Jul 1;742:109619
Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice.
Rome FI, Shobert GL, Voigt WC, Stagg DB, Puchalska P, Burgess SC, Crawford PA, Hughey CC
American journal of physiology. Endocrinology and metabolism 2023 Jan 1;324(1):E9-E23
American journal of physiology. Endocrinology and metabolism 2023 Jan 1;324(1):E9-E23
Down-regulation of FBP1 in lung adenocarcinoma cells promotes proliferation and invasion through SLUG mediated epithelial mesenchymal transformation.
Wang Z, He T, Lv W, Hu J
Translational cancer research 2023 Feb 28;12(2):236-246
Translational cancer research 2023 Feb 28;12(2):236-246
Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth.
Wang Z, Li M, Jiang H, Luo S, Shao F, Xia Y, Yang M, Ren X, Liu T, Yan M, Qian X, He H, Guo D, Duan Y, Wu K, Wang L, Ji G, Shen Y, Li L, Zheng P, Dong B, Fang J, Zheng M, Liang T, Li H, Yu R, Xu D, Lu Z
Nature cell biology 2022 Nov;24(11):1655-1665
Nature cell biology 2022 Nov;24(11):1655-1665
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Fan TW, Daneshmandi S, Cassel TA, Uddin MB, Sledziona J, Thompson PT, Lin P, Higashi RM, Lane AN
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
Novel candidate factors predicting the effect of S-1 adjuvant chemotherapy of pancreatic cancer.
Mitachi K, Ariake K, Shima H, Sato S, Miura T, Maeda S, Ishida M, Mizuma M, Ohtsuka H, Kamei T, Igarashi K, Unno M
Scientific reports 2021 Mar 22;11(1):6541
Scientific reports 2021 Mar 22;11(1):6541
LncRNA MT1JP plays a protective role in intrahepatic cholangiocarcinoma by regulating miR-18a-5p/FBP1 axis.
Zhao W, Zhao J, Guo X, Feng Y, Zhang B, Tian L
BMC cancer 2021 Feb 8;21(1):142
BMC cancer 2021 Feb 8;21(1):142
Knockdown of FBP1 enhances radiosensitivity in prostate cancer cells by activating autophagy.
Li XR, Zhou KQ, Yin Z, Gao YL, Yang X
Neoplasma 2020 Sep;67(5):982-991
Neoplasma 2020 Sep;67(5):982-991
Discovery of N-Arylsulfonyl-Indole-2-Carboxamide Derivatives as Potent, Selective, and Orally Bioavailable Fructose-1,6-Bisphosphatase Inhibitors-Design, Synthesis, In Vivo Glucose Lowering Effects, and X-ray Crystal Complex Analysis.
Zhou J, Bie J, Wang X, Liu Q, Li R, Chen H, Hu J, Cao H, Ji W, Li Y, Liu S, Shen Z, Xu B
Journal of medicinal chemistry 2020 Sep 24;63(18):10307-10329
Journal of medicinal chemistry 2020 Sep 24;63(18):10307-10329
Hypoxia-induced GBE1 expression promotes tumor progression through metabolic reprogramming in lung adenocarcinoma.
Li L, Yang L, Fan Z, Xue W, Shen Z, Yuan Y, Sun X, Wang D, Lian J, Wang L, Zhao J, Zhang Y
Signal transduction and targeted therapy 2020 May 22;5(1):54
Signal transduction and targeted therapy 2020 May 22;5(1):54
Measurement of Organ-Specific and Acute-Phase Blood Protein Levels in Early Lyme Disease.
Zhou Y, Qin S, Sun M, Tang L, Yan X, Kim TK, Caballero J, Glusman G, Brunkow ME, Soloski MJ, Rebman AW, Scavarda C, Cooper D, Omenn GS, Moritz RL, Wormser GP, Price ND, Aucott JN, Hood L
Journal of proteome research 2020 Jan 3;19(1):346-359
Journal of proteome research 2020 Jan 3;19(1):346-359
HSF2 regulates aerobic glycolysis by suppression of FBP1 in hepatocellular carcinoma.
Yang LN, Ning ZY, Wang L, Yan X, Meng ZQ
American journal of cancer research 2019;9(8):1607-1621
American journal of cancer research 2019;9(8):1607-1621
Functional genetic variants of RUVBL1 predict overall survival of Chinese patients with epithelial ovarian cancer.
Li H, Tong X, Xu Y, Wang M, Dai H, Shi T, Sun M, Chen K, Cheng X, Wei Q
Carcinogenesis 2019 Oct 16;40(10):1209-1219
Carcinogenesis 2019 Oct 16;40(10):1209-1219
Forced overexpression of FBP1 inhibits proliferation and metastasis in cholangiocarcinoma cells via Wnt/β-catenin pathway.
Zhao W, Yang S, Chen J, Zhao J, Dong J
Life sciences 2018 Oct 1;210:224-234
Life sciences 2018 Oct 1;210:224-234
The Promoting Effect of Radiation on Glucose Metabolism in Breast Cancer Cells under the Treatment of Cobalt Chloride.
Zhao CB, Shi L, Pu HH, Zhang QY
Pathology oncology research : POR 2017 Jan;23(1):47-53
Pathology oncology research : POR 2017 Jan;23(1):47-53
Betaine supplementation in maternal diet modulates the epigenetic regulation of hepatic gluconeogenic genes in neonatal piglets.
Cai D, Jia Y, Song H, Sui S, Lu J, Jiang Z, Zhao R
PloS one 2014;9(8):e105504
PloS one 2014;9(8):e105504
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The FBP1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FBP1. This antibody recognizes human,mouse,rat antigen. The FBP1 antibody has been validated for the following applications: ELISA, WB analysis.
