21064-1-AP

antibody from Proteintech Group

Targeting: SYNPO KIAA1029

Provider product page for 21064-1-AP

Western blot

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Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [52]
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Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 21064-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#21064-1-AP, RRID:AB_10733120
Product name: Synaptopodin antibody
Antibody type: Polyclonal
Description: Synaptopodin antibody (Cat. #21064-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SYNPO protein structure - 21064-1-AP shown in red.

Submitted references Loss of MTX2 causes mitochondrial dysfunction, podocyte injury, nephrotic proteinuria and glomerulopathy in mice and patients.

Li T, Bao Y, Xia Y, Meng H, Zhou C, Huang L, Wang X, Lai EY, Jiang P, Mao J
International journal of biological sciences 2024;20(3):937-952

miR-4645-3p attenuates podocyte injury and mitochondrial dysfunction in diabetic kidney disease by targeting Cdk5.

Zhang Y, Xia S, Tian X, Yuan L, Gao Y, Liu D, Qi H, Wang S, Liu Z, Li Y, Zhao Z, Liu W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23668

Effectiveness of a novel rat model of off-target PLA2R1 knockout to renal impairment.

Huang B, Zhang Z, Sui W, Zhao L, Li Y, Feng L, Yang D, Zhou Y
Genomics 2024 Mar;116(2):110796

Novel variants in CRB2 targeting the malfunction of slit diaphragm related to focal segmental glomerulosclerosis.

Yang Q, Tang D, Gan C, Bai M, Song X, Jiang W, Li Q, Chen Y, Zhang A, Wang M
Pediatric nephrology (Berlin, Germany) 2024 Jan;39(1):149-165

Cosentyx alleviates psoriasis-induced podocyte injury by inhibiting the tlr/nf-κb signaling pathway.

Aixue W, Feng W, Huanhuan Z, Xixing M, Yanling L
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 2024 Feb;30(2):e13562

"Qi Nan" agarwood restores podocyte autophagy in diabetic kidney disease by targeting EGFR signaling pathway.

Li N, Liu X, Wang H, Duan Y, Zhang Y, Zhou P, Dai H, Lan T
Chinese medicine 2024 Apr 23;19(1):63

The influence of angiopoietin-like protein 3 on macrophages polarization and its effect on the podocyte EMT in diabetic nephropathy.

Ma Y, Chen Y, Xu H, Du N
Frontiers in immunology 2023;14:1228399

WT1(+) glomerular parietal epithelial progenitors promote renal proximal tubule regeneration after severe acute kidney injury.

Hong X, Nie H, Deng J, Liang S, Chen L, Li J, Gong S, Wang G, Zuo W, Hou F, Zhang F
Theranostics 2023;13(4):1311-1324

Effects and mechanism of Rictor interference in podocyte injury induced by high glucose.

Zeng Y, Xiong C, Chen Y, Yang C, Li Q
Experimental and therapeutic medicine 2023 Oct;26(4):473

Klotho inhibits renal ox-LDL deposition via IGF-1R/RAC1/OLR1 signaling to ameliorate podocyte injury in diabetic kidney disease.

Jiang W, Gan C, Zhou X, Yang Q, Chen D, Xiao H, Dai L, Chen Y, Wang M, Yang H, Li Q
Cardiovascular diabetology 2023 Oct 27;22(1):293

Acteoside protects podocyte against apoptosis through regulating AKT/GSK-3β signaling pathway in db/db mice.

Li X, Liu Z, He Z, Wang X, Li R, Wang J, Ma G, Zhang P, Ma C
BMC endocrine disorders 2023 Oct 23;23(1):230

mTOR/ULK1 signaling axis mediated ultrashort wave regulation of autophagy to alleviate diabetic kidney disease.

Yan Y, Yu S, Fan Y
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Nov;32(11):1265-1277

Identification of circular dorsal ruffles as signal platforms for the AKT pathway in glomerular podocytes.

Hua R, Wei J, Torres M, He Y, Li Y, Sun X, Wang L, Inoki K, Yoshida S
Journal of cellular physiology 2023 May;238(5):1063-1079

Podocyte-specific deletion of ubiquitin carboxyl-terminal hydrolase L1 causes podocyte injury by inducing endoplasmic reticulum stress.

Hu Y, Qi C, Shi J, Tan W, Adiljan Abdurusul, Zhao Z, Xu Y, Wu H, Zhang Z
Cellular and molecular life sciences : CMLS 2023 Mar 23;80(4):106

Partner, Neighbor, Housekeeper and Dimension: 3D versus 2D Glomerular Co-Cultures Reveal Drawbacks of Currently Used Cell Culture Models.

Rederer A, Rose V, Krüger R, Schmittutz L, Swierzy I, Fischer L, Thievessen I, Bauer J, Friedrich O, Schiffer M, Müller-Deile J
International journal of molecular sciences 2023 Jun 20;24(12)

The compound heterozygous mutations of c.607G>a and c.657delC in the FAH gene are associated with renal damage with hereditary tyrosinemia type 1 (HT1).

Chi H, Gan C, Jiang Y, Chen D, Qiu J, Yang Q, Chen Y, Wang M, Yang H, Jiang W, Li Q
Molecular genetics & genomic medicine 2023 Jan;11(1):e2090

Integrated analysis of RNA methylation regulators crosstalk and immune infiltration for predictive and personalized therapy of diabetic nephropathy.

Li J, Liu D, Ren J, Li G, Zhao Z, Zhao H, Yan Q, Duan J, Liu Z
Human genomics 2023 Feb 10;17(1):6

Inhibition of the lncRNA 585189 prevents podocyte injury and mitochondria dysfunction by promoting hnRNP A1 and SIRT1 in diabetic nephropathy.

Chen H, Liu Y, Zhang T, Huang T, Lang Y, Sheng Q, Liu Y, Kong Z, Gao Y, Lu S, Yang M, Li X, Wang R, Lv Z
Molecular and cellular endocrinology 2023 Dec 1;578:112065

P2X7R/AKT/mTOR signaling mediates high glucose-induced decrease in podocyte autophagy.

Qian C, Lu J, Che X, Min L, Wang M, Song A, Lu R, Gu L, Xie K
Free radical biology & medicine 2023 Aug 1;204:337-346

Activated SOX9+ renal epithelial cells promote kidney repair through secreting factors.

Nie H, Zhao Z, Zhou D, Li D, Wang Y, Ma Y, Liu X, Zuo W
Cell proliferation 2023 Apr;56(4):e13394

A glomerulus chip with spherically twisted cell-laden hollow fibers as glomerular capillary tufts.

Dai Z, Li C, Shi Z, Li S, Luo T, Ding W
Biofabrication 2023 Apr 12;15(3)

Cdc42 upregulation under high glucose induces podocyte apoptosis and impairs β-cell insulin secretion.

Jiang S, Xu CM, Yao S, Zhang R, Li XZ, Zhang RZ, Xie TY, Xing YQ, Zhang Q, Zhou XJ, Liao L, Dong JJ
Frontiers in endocrinology 2022;13:905703

Glomerular Expression of S100A8 in Lupus Nephritis: An Integrated Bioinformatics Analysis.

Qijiao W, Zhihan C, Makota P, Qing Y, Fei G, Zhihong W, He L
Frontiers in immunology 2022;13:843576

Synaptic proteomics reveal distinct molecular signatures of cognitive change and C9ORF72 repeat expansion in the human ALS cortex.

Laszlo ZI, Hindley N, Sanchez Avila A, Kline RA, Eaton SL, Lamont DJ, Smith C, Spires-Jones TL, Wishart TM, Henstridge CM
Acta neuropathologica communications 2022 Oct 29;10(1):156

Novel pathogenic variants in CUBN uncouple proteinuria from renal function.

Gan C, Zhou X, Chen D, Chi H, Qiu J, You H, Chen Y, Wang M, Yang H, Jiang W, Li Q
Journal of translational medicine 2022 Oct 20;20(1):480

ManNAc protects against podocyte pyroptosis via inhibiting mitochondrial damage and ROS/NLRP3 signaling pathway in diabetic kidney injury model.

Gao Y, Ma Y, Xie D, Jiang H
International immunopharmacology 2022 Jun;107:108711

Inhibition of the lncRNA MIAT prevents podocyte injury and mitotic catastrophe in diabetic nephropathy.

Wang Z, Chang Y, Liu Y, Liu B, Zhen J, Li X, Lin J, Yu Q, Lv Z, Wang R
Molecular therapy. Nucleic acids 2022 Jun 14;28:136-153

EP300/CBP is crucial for cAMP-PKA pathway to alleviate podocyte dedifferentiation via targeting Notch3 signaling.

Chang K, Xue R, Zhao M, Zhao Y, Yu W, Zhao Z, Liu X
Experimental cell research 2021 Oct 15;407(2):112825

Experimental study on renoprotective effect of intermedin on diabetic nephropathy.

Wang Y, Tian J, Mi Y, Ren X, Lian S, Kang J, Wang J, Zang H, Wu Z, Yang J, Qiao X, Zhou X, Wang G, Zhou Y, Li R
Molecular and cellular endocrinology 2021 May 15;528:111224

Gasdermin D Protects Mouse Podocytes Against High-Glucose-Induced Inflammation and Apoptosis via the C-Jun N-Terminal Kinase (JNK) Pathway.

Li H, Zhao K, Li Y
Medical science monitor : international medical journal of experimental and clinical research 2021 Mar 9;27:e928411

Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Exacerbates Podocyte Injury and the Progression of Diabetic Kidney Disease.

Qu H, Gong X, Liu X, Zhang R, Wang Y, Huang B, Zhang L, Zheng H, Zheng Y
Diabetes 2021 Jun;70(6):1372-1387

Transforming growth factor-β1-induced podocyte injury is associated with increased microRNA-155 expression, enhanced inflammatory responses and MAPK pathway activation.

Zheng X, Zhong Q, Lin X, Gu X, Ling X, Liang Z, Qin Q, Du X
Experimental and therapeutic medicine 2021 Jun;21(6):620

Cdk5-Mediated Phosphorylation of Sirt1 Contributes to Podocyte Mitochondrial Dysfunction in Diabetic Nephropathy.

Wang S, Yang Y, He X, Yang L, Wang J, Xia S, Liu D, Liu S, Yang L, Liu W, Duan H
Antioxidants & redox signaling 2021 Jan 20;34(3):171-190

Astragaloside IV alleviates puromycin aminonucleoside-induced podocyte cytoskeleton injury through the Wnt/PCP pathway.

Zeng Y, Zhang B, Liu X, He L, Wang T, Yu X, Kang Y, Li S
American journal of translational research 2020;12(7):3512-3521

Renal tubular Bim mediates the tubule-podocyte crosstalk via NFAT2 to induce podocyte cytoskeletal dysfunction.

Xu C, Zhou X, Xie T, Zhou Y, Zhang Q, Jiang S, Zhang R, Liao L, Dong J
Theranostics 2020;10(15):6806-6824

Paecilomyces cicadae-fermented Radix astragali activates podocyte autophagy by attenuating PI3K/AKT/mTOR pathways to protect against diabetic nephropathy in mice.

Yang F, Qu Q, Zhao C, Liu X, Yang P, Li Z, Han L, Shi X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110479

Nestin protects podocyte from injury in lupus nephritis by mitophagy and oxidative stress.

Tian Y, Guo H, Miao X, Xu J, Yang R, Zhao L, Liu J, Yang L, Gao F, Zhang W, Liu Q, Sun S, Tian Y, Li H, Huang J, Gu C, Liu S, Feng X
Cell death & disease 2020 May 5;11(5):319

TXNIP deficiency mitigates podocyte apoptosis via restraining the activation of mTOR or p38 MAPK signaling in diabetic nephropathy.

Song S, Qiu D, Wang Y, Wei J, Wu H, Wu M, Wang S, Zhou X, Shi Y, Duan H
Experimental cell research 2020 Mar 15;388(2):111862

Plakoglobin is involved in cytoskeletal rearrangement of podocytes under the regulation of UCH-L1.

Fang Y, Li F, Qi C, Mao X, Xu Y, Zhao Z, Wu H, Zhang Z
Biochemical and biophysical research communications 2020 Aug 13;529(1):112-118

Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy.

Song S, Qiu D, Shi Y, Wang S, Zhou X, Chen N, Wei J, Wu M, Wu H, Duan H
Journal of cellular physiology 2019 Sep;234(9):16485-16502

Knockout of the neonatal Fc receptor in cultured podocytes alters IL-6 signaling and the actin cytoskeleton.

Tonsawan P, Dylewski J, Lewis L, Blaine J
American journal of physiology. Cell physiology 2019 Nov 1;317(5):C1048-C1060

Yes-associated protein regulates podocyte cell cycle re-entry and dedifferentiation in adriamycin-induced nephropathy.

Xie K, Xu C, Zhang M, Wang M, Min L, Qian C, Wang Q, Ni Z, Mou S, Dai H, Pang H, Gu L
Cell death & disease 2019 Dec 4;10(12):915

Fractalkine is Involved in Lipopolysaccharide-Induced Podocyte Injury through the Wnt/β-Catenin Pathway in an Acute Kidney Injury Mouse Model.

Senouthai S, Wang J, Fu D, You Y
Inflammation 2019 Aug;42(4):1287-1300

Weighted Gene Correlation Network Analysis (WGCNA) Detected Loss of MAGI2 Promotes Chronic Kidney Disease (CKD) by Podocyte Damage.

Zuo Z, Shen JX, Pan Y, Pu J, Li YG, Shao XH, Wang WP
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;51(1):244-261

Genistein and Myd88 Activate Autophagy in High Glucose-Induced Renal Podocytes In Vitro.

Wang Y, Li Y, Zhang T, Chi Y, Liu M, Liu Y
Medical science monitor : international medical journal of experimental and clinical research 2018 Jul 12;24:4823-4831

Notch-mediated Sox9(+) cell activation contributes to kidney repair after partial nephrectomy.

Ma Q, Wang Y, Zhang T, Zuo W
Life sciences 2018 Jan 15;193:104-109

Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney.

Menon R, Otto EA, Kokoruda A, Zhou J, Zhang Z, Yoon E, Chen YC, Troyanskaya O, Spence JR, Kretzler M, Cebrián C
Development (Cambridge, England) 2018 Aug 30;145(16)

A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice.

Wang L, Tao T, Su W, Yu H, Yu Y, Qin J
Lab on a chip 2017 May 16;17(10):1749-1760

Fyn Mediates High Glucose-Induced Actin Cytoskeleton Reorganization of Podocytes via Promoting ROCK Activation In Vitro.

Lv Z, Hu M, Ren X, Fan M, Zhen J, Chen L, Lin J, Ding N, Wang Q, Wang R
Journal of diabetes research 2016;2016:5671803

Thioredoxin-interacting protein mediates NALP3 inflammasome activation in podocytes during diabetic nephropathy.

Gao P, Meng XF, Su H, He FF, Chen S, Tang H, Tian XJ, Fan D, Wang YM, Liu JS, Zhu ZH, Zhang C
Biochimica et biophysica acta 2014 Nov;1843(11):2448-60

Effects of asiaticoside on levels of podocyte cytoskeletal proteins and renal slit diaphragm proteins in adriamycin-induced rat nephropathy.

Wang Z, Liu J, Sun W
Life sciences 2013 Sep 3;93(8):352-8

Noninvasive urine-derived cell lines derived from neurological genetic patients.

Zhang QJ, He J, Ni W, Lin X, Yao XP, Lin MT, Murong SX, Wang N, Chen WJ
Neuroreport 2013 Mar 6;24(4):161-6

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse brain tissue were subjected to SDS PAGE followed by western blot with 21064-1-AP(SYNPO antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using SYNPO antibody 21064-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line