Antibody data
- Antibody Data
- Antigen structure
- References [82]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
Submit
Validation data
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- Product number
- 21064-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21064-1-AP, RRID:AB_10733120
- Product name
- Synaptopodin antibody
- Antibody type
- Polyclonal
- Description
- Synaptopodin antibody (Cat. #21064-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references CDKAL1 dysfunction impairs lysine codon translation in podocytes and accelerates chronic kidney disease.
MYO1C is a urinary extracellular vesicle biomarker and mediator of podocyte injury in diabetic nephropathy.
TRIM27-controlled endothelium-derived exosomes play a central role in podocyte injury in diabetic kidney disease.
Integrating WGCNA and network pharmacology to unravel the multi-target mechanisms of Ludangshen Oral liquid against nephrotic syndrome: Involvement of TGF-β1/Smad3 and gut microbiota.
Reducing the NFAT-uPAR signal of podocyte injury exerts the effect of Danggui-Shaoyao-San in improving proteinuria in nephrotic syndrome.
Podocyte TLR4 deletion alleviates diabetic kidney disease through prohibiting PKCδ/SHP-1-dependent ER stress and relieving podocyte damage and inflammation.
Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury in Diabetic Nephropathy Rats by Inhibiting Angpltl4/Integrin β3 in the Glomerulus.
TangNaikang Formula Alleviates Podocyte Injury in Diabetic Nephropathy by Modulating the SHIP2/PI3K/AKT Pathway.
Hyperoside ameliorates lupus nephritis by suppressing AKT1-mediated PANoptosis in podocytes: integrating network pharmacology and experimental validation.
Podocyte Proteomics Revealed hUCMSC-Exosomes Ameliorate Diabetic Kidney Disease through Inhibiting Talin-1 Mediated EMT.
LARS1 lactylation inhibits autophagy by activating mTORC1 to promote podocytes injury in diabetic kidney disease.
Long noncoding RNA ENST00000458139 promotes mitochondrial dysfunction and apoptosis of podocytes in diabetic kidney disease through binding with SNRPA1.
Activation of IRF2 signaling networks facilitates podocyte pyroptosis in lupus nephritis.
Mitochondrial-Derived Signaling Mediates Differentiation of Parietal Epithelial Cells into Podocytes.
NAT10 mediates TLR2 to promote podocyte senescence in adriamycin-induced nephropathy.
Melanin-like nanoparticles slow cyst growth in ADPKD by dual inhibition of oxidative stress and CREB.
METTL10 attenuates adriamycin-induced podocyte injury by targeting cell dedifferentiation.
Fbxo11 maintains mitochondrial function and prevents podocyte injury in adriamycin-induced nephropathy by mediating the ubiquitin degradation of Fosl2.
Jinlida granules alleviate podocyte apoptosis and mitochondrial dysfunction via the AMPK/PGC‑1α pathway in diabetic nephropathy.
Safflower injection against obesity-induced mice podocyte injury by improving insulin resistance through increasing renal INSR and eNOS expression.
Antagonistic interaction between Notch3 signaling and CREB/KLF15 pathway in regulating the phenotypic alterations of glomerular parietal epithelial cells in adriamycin-induced nephropathy.
Proteogenomic characterization of non-functional pancreatic neuroendocrine tumors unravels clinically relevant subgroups.
Loss of MTX2 causes mitochondrial dysfunction, podocyte injury, nephrotic proteinuria and glomerulopathy in mice and patients.
Tanshinone IIA Promoted Autophagy and Inhibited Inflammation to Alleviate Podocyte Injury in Diabetic Nephropathy.
Overproduction of Mitochondrial Fission Proteins and Mitochondrial Fission in Podocytes of Lupus Nephritis Patients.
Effects of Inonotus obliquus on ameliorating podocyte injury in ORG mice through TNF pathway and prediction of active compounds.
Association of the podocyte phenotype with extracapillary hypercellularity in patients with diabetic kidney disease.
miR-4645-3p attenuates podocyte injury and mitochondrial dysfunction in diabetic kidney disease by targeting Cdk5.
A simple protocol to establish a conditionally immortalized mouse podocyte cell line.
Effectiveness of a novel rat model of off-target PLA2R1 knockout to renal impairment.
Quantification of urinary podocyte-derived migrasomes for the diagnosis of kidney disease.
Novel variants in CRB2 targeting the malfunction of slit diaphragm related to focal segmental glomerulosclerosis.
Cosentyx alleviates psoriasis-induced podocyte injury by inhibiting the tlr/nf-κb signaling pathway.
LncRNA evf-2 Exacerbates Podocyte Injury in Diabetic Nephropathy by Inducing Cell Cycle Re-entry and Inflammation Through Distinct Mechanisms Triggered by hnRNPU.
"Qi Nan" agarwood restores podocyte autophagy in diabetic kidney disease by targeting EGFR signaling pathway.
The influence of angiopoietin-like protein 3 on macrophages polarization and its effect on the podocyte EMT in diabetic nephropathy.
WT1(+) glomerular parietal epithelial progenitors promote renal proximal tubule regeneration after severe acute kidney injury.
Effects and mechanism of Rictor interference in podocyte injury induced by high glucose.
Klotho inhibits renal ox-LDL deposition via IGF-1R/RAC1/OLR1 signaling to ameliorate podocyte injury in diabetic kidney disease.
Acteoside protects podocyte against apoptosis through regulating AKT/GSK-3β signaling pathway in db/db mice.
mTOR/ULK1 signaling axis mediated ultrashort wave regulation of autophagy to alleviate diabetic kidney disease.
Identification of circular dorsal ruffles as signal platforms for the AKT pathway in glomerular podocytes.
Podocyte-specific deletion of ubiquitin carboxyl-terminal hydrolase L1 causes podocyte injury by inducing endoplasmic reticulum stress.
Partner, Neighbor, Housekeeper and Dimension: 3D versus 2D Glomerular Co-Cultures Reveal Drawbacks of Currently Used Cell Culture Models.
The compound heterozygous mutations of c.607G>a and c.657delC in the FAH gene are associated with renal damage with hereditary tyrosinemia type 1 (HT1).
Integrated analysis of RNA methylation regulators crosstalk and immune infiltration for predictive and personalized therapy of diabetic nephropathy.
Generation of renal tubular organoids from adult SOX9(+) kidney progenitor cells.
Inhibition of the lncRNA 585189 prevents podocyte injury and mitochondria dysfunction by promoting hnRNP A1 and SIRT1 in diabetic nephropathy.
P2X7R/AKT/mTOR signaling mediates high glucose-induced decrease in podocyte autophagy.
Activated SOX9+ renal epithelial cells promote kidney repair through secreting factors.
A glomerulus chip with spherically twisted cell-laden hollow fibers as glomerular capillary tufts.
Cdc42 upregulation under high glucose induces podocyte apoptosis and impairs β-cell insulin secretion.
Glomerular Expression of S100A8 in Lupus Nephritis: An Integrated Bioinformatics Analysis.
Synaptic proteomics reveal distinct molecular signatures of cognitive change and C9ORF72 repeat expansion in the human ALS cortex.
Novel pathogenic variants in CUBN uncouple proteinuria from renal function.
ManNAc protects against podocyte pyroptosis via inhibiting mitochondrial damage and ROS/NLRP3 signaling pathway in diabetic kidney injury model.
Inhibition of the lncRNA MIAT prevents podocyte injury and mitotic catastrophe in diabetic nephropathy.
EP300/CBP is crucial for cAMP-PKA pathway to alleviate podocyte dedifferentiation via targeting Notch3 signaling.
Experimental study on renoprotective effect of intermedin on diabetic nephropathy.
Gasdermin D Protects Mouse Podocytes Against High-Glucose-Induced Inflammation and Apoptosis via the C-Jun N-Terminal Kinase (JNK) Pathway.
Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Exacerbates Podocyte Injury and the Progression of Diabetic Kidney Disease.
Transforming growth factor-β1-induced podocyte injury is associated with increased microRNA-155 expression, enhanced inflammatory responses and MAPK pathway activation.
Cdk5-Mediated Phosphorylation of Sirt1 Contributes to Podocyte Mitochondrial Dysfunction in Diabetic Nephropathy.
Astragaloside IV alleviates puromycin aminonucleoside-induced podocyte cytoskeleton injury through the Wnt/PCP pathway.
Renal tubular Bim mediates the tubule-podocyte crosstalk via NFAT2 to induce podocyte cytoskeletal dysfunction.
Paecilomyces cicadae-fermented Radix astragali activates podocyte autophagy by attenuating PI3K/AKT/mTOR pathways to protect against diabetic nephropathy in mice.
Nestin protects podocyte from injury in lupus nephritis by mitophagy and oxidative stress.
TXNIP deficiency mitigates podocyte apoptosis via restraining the activation of mTOR or p38 MAPK signaling in diabetic nephropathy.
Plakoglobin is involved in cytoskeletal rearrangement of podocytes under the regulation of UCH-L1.
Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy.
Knockout of the neonatal Fc receptor in cultured podocytes alters IL-6 signaling and the actin cytoskeleton.
Yes-associated protein regulates podocyte cell cycle re-entry and dedifferentiation in adriamycin-induced nephropathy.
Fractalkine is Involved in Lipopolysaccharide-Induced Podocyte Injury through the Wnt/β-Catenin Pathway in an Acute Kidney Injury Mouse Model.
Weighted Gene Correlation Network Analysis (WGCNA) Detected Loss of MAGI2 Promotes Chronic Kidney Disease (CKD) by Podocyte Damage.
Genistein and Myd88 Activate Autophagy in High Glucose-Induced Renal Podocytes In Vitro.
Notch-mediated Sox9(+) cell activation contributes to kidney repair after partial nephrectomy.
Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney.
A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice.
Fyn Mediates High Glucose-Induced Actin Cytoskeleton Reorganization of Podocytes via Promoting ROCK Activation In Vitro.
Thioredoxin-interacting protein mediates NALP3 inflammasome activation in podocytes during diabetic nephropathy.
Effects of asiaticoside on levels of podocyte cytoskeletal proteins and renal slit diaphragm proteins in adriamycin-induced rat nephropathy.
Noninvasive urine-derived cell lines derived from neurological genetic patients.
Nagata H, Nagayoshi Y, Chujo T, Kaneko H, Nishiguchi K, Kakizoe Y, Ijima H, Sakakida K, Masuda T, Ohtsuki S, Wei FY, Takahashi Y, Fukuda T, Jinnouchi H, Adachi Y, Yamamura R, Matsushita K, Adachi M, Yokoi H, Nakamura K, Nakazato H, Tomizawa K
The EMBO journal 2026 May;45(9):3206-3229
The EMBO journal 2026 May;45(9):3206-3229
MYO1C is a urinary extracellular vesicle biomarker and mediator of podocyte injury in diabetic nephropathy.
Zhao Z, Yan Q, Zhou S, Liu F, Liu Y, Ren J, Pan S, Liu Z, Liu D, Liu Z, Duan J
JCI insight 2026 Mar 9;11(5)
JCI insight 2026 Mar 9;11(5)
TRIM27-controlled endothelium-derived exosomes play a central role in podocyte injury in diabetic kidney disease.
Tian Y, Liu Y, Feng X, Wu L, Song W, Zhao T, Liu J, Miao X, Ma H, Jia B, Kang L, Liu Q, Zhang W, Guo H, Yang L, Xu J, Liu S
Cell death discovery 2026 Mar 7;12(1)
Cell death discovery 2026 Mar 7;12(1)
Integrating WGCNA and network pharmacology to unravel the multi-target mechanisms of Ludangshen Oral liquid against nephrotic syndrome: Involvement of TGF-β1/Smad3 and gut microbiota.
Cheng Z, Xiang W, Chen X, Xu X, Hou W, Gao J, Zhou J
Fitoterapia 2026 Jun;191:107239
Fitoterapia 2026 Jun;191:107239
Reducing the NFAT-uPAR signal of podocyte injury exerts the effect of Danggui-Shaoyao-San in improving proteinuria in nephrotic syndrome.
Zhang X, Ding Y, Zhang C, Han W, Yu X, Wang Y, Xu F
Journal of ethnopharmacology 2026 Feb 28;357:120942
Journal of ethnopharmacology 2026 Feb 28;357:120942
Podocyte TLR4 deletion alleviates diabetic kidney disease through prohibiting PKCδ/SHP-1-dependent ER stress and relieving podocyte damage and inflammation.
Li Z, Tan D, Lin J, Zhang T, Liu B, Zhao B, Liang D, Li L, Wei X, Lv Z, Wang R, Hu M
Journal of advanced research 2026 Apr;82:845-862
Journal of advanced research 2026 Apr;82:845-862
Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury in Diabetic Nephropathy Rats by Inhibiting Angpltl4/Integrin β3 in the Glomerulus.
Liu S, Meng M, Huang C, He L, Wang P, Tang Z, Ran X, Gao H, Guo Y, He Y, Chen J, Hu H, He S, Zhao Y, Hou Z, Li L, Li W, Wang W, Wang X
Journal of diabetes research 2025;2025:6683126
Journal of diabetes research 2025;2025:6683126
TangNaikang Formula Alleviates Podocyte Injury in Diabetic Nephropathy by Modulating the SHIP2/PI3K/AKT Pathway.
Yang T, Huang Y, Li W, Qin L, Wu Y, Wu L, Liu T
Journal of diabetes research 2025;2025:6568591
Journal of diabetes research 2025;2025:6568591
Hyperoside ameliorates lupus nephritis by suppressing AKT1-mediated PANoptosis in podocytes: integrating network pharmacology and experimental validation.
Cheng L, Tang Z, Li M, Huang C
Frontiers in pharmacology 2025;16:1726254
Frontiers in pharmacology 2025;16:1726254
Podocyte Proteomics Revealed hUCMSC-Exosomes Ameliorate Diabetic Kidney Disease through Inhibiting Talin-1 Mediated EMT.
Zhang Z, Tang CM, Yu WZ, Yang XC, Yu N, Li XH, Ding WJ, Liu D, Ling MY, Song YP, Feng JC, Zou JR, Ma TM, Zhao CL, Xing YQ
Journal of proteome research 2025 Sep 5;24(9):4767-4779
Journal of proteome research 2025 Sep 5;24(9):4767-4779
LARS1 lactylation inhibits autophagy by activating mTORC1 to promote podocytes injury in diabetic kidney disease.
Fan Z, Zhang Y, Yuan L, Gao Y, Tian X, Tian J, Wan J, Li B, Wang X, Wang S, Zhang L, Wang L, Zhou P, Liu W
Cellular signalling 2025 Oct;134:111955
Cellular signalling 2025 Oct;134:111955
Long noncoding RNA ENST00000458139 promotes mitochondrial dysfunction and apoptosis of podocytes in diabetic kidney disease through binding with SNRPA1.
Yang M, Fan X, Lang Y, Hu J, Wang Q, Shen N, Zhang D, Chai S, Wang R, Lv Z
International immunopharmacology 2025 Oct 10;163:115232
International immunopharmacology 2025 Oct 10;163:115232
Activation of IRF2 signaling networks facilitates podocyte pyroptosis in lupus nephritis.
Zhang F, Xie Y, Dang RN, Yu J, Tian XX, Li LJ, Zhou QM, An XM, Chen PL, Luo YQ, Wu YS, Liu J, Zou HM
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):167990
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):167990
Mitochondrial-Derived Signaling Mediates Differentiation of Parietal Epithelial Cells into Podocytes.
Wang M, Wu W, Lu J, Lu R, Min L, Song A, Zhao B, Li Y, Xie K, Gu L
Antioxidants & redox signaling 2025 Mar;42(7-9):393-407
Antioxidants & redox signaling 2025 Mar;42(7-9):393-407
NAT10 mediates TLR2 to promote podocyte senescence in adriamycin-induced nephropathy.
Hu M, Lv L, Lei Y, Chen M, Zhou S, Liu Z
Cell death & disease 2025 Mar 19;16(1):185
Cell death & disease 2025 Mar 19;16(1):185
Melanin-like nanoparticles slow cyst growth in ADPKD by dual inhibition of oxidative stress and CREB.
Sun Y, Zou Q, Yu H, Yi X, Dou X, Yang Y, Liu Z, Yang H, Jia J, Chen Y, Sun SK, Zhang L
EMBO molecular medicine 2025 Jan;17(1):169-192
EMBO molecular medicine 2025 Jan;17(1):169-192
METTL10 attenuates adriamycin-induced podocyte injury by targeting cell dedifferentiation.
Bao J, Li Z, Yao H, Wu B, Gu L, Pan Y, Wang L
Scientific reports 2025 Jan 7;15(1):1218
Scientific reports 2025 Jan 7;15(1):1218
Fbxo11 maintains mitochondrial function and prevents podocyte injury in adriamycin-induced nephropathy by mediating the ubiquitin degradation of Fosl2.
Jin Y, Wang H, Xin Y, Zhang Y
Experimental cell research 2025 Jan 1;444(1):114345
Experimental cell research 2025 Jan 1;444(1):114345
Jinlida granules alleviate podocyte apoptosis and mitochondrial dysfunction via the AMPK/PGC‑1α pathway in diabetic nephropathy.
Sun S, Yang S, Cheng Y, Fang T, Qu J, Tian L, Zhang M, Wu S, Sun B, Chen L
International journal of molecular medicine 2025 Feb;55(2)
International journal of molecular medicine 2025 Feb;55(2)
Safflower injection against obesity-induced mice podocyte injury by improving insulin resistance through increasing renal INSR and eNOS expression.
Han Z, Wang X, Liu J, Wang R, Zhao W, Liao H
Renal failure 2025 Dec;47(1):2482888
Renal failure 2025 Dec;47(1):2482888
Antagonistic interaction between Notch3 signaling and CREB/KLF15 pathway in regulating the phenotypic alterations of glomerular parietal epithelial cells in adriamycin-induced nephropathy.
Zhu Y, Chang K, Sun K, Wang Y, Zhao Z, Chen Q, Qin Q, Liu X
Experimental cell research 2025 Aug 15;451(2):114724
Experimental cell research 2025 Aug 15;451(2):114724
Proteogenomic characterization of non-functional pancreatic neuroendocrine tumors unravels clinically relevant subgroups.
Ji S, Cao L, Gao J, Du Y, Ye Z, Lou X, Liu F, Zhang Y, Xu J, Shi X, Wang H, Li P, Li Y, Chen H, Yang Z, Gao S, Zhang W, Huang D, Ni S, Wei M, Wang F, Wang Y, Ding T, Jing D, Fan G, Gong Z, Lu R, Qin Y, Chen J, Xu X, Wang P, Zhang B, Ding L, Robles AI, Rodriguez H, Chang DK, Hruban RH, Gao D, Gao D, Jin G, Zhou H, Wu J, Yu X
Cancer cell 2025 Apr 14;43(4):776-796.e14
Cancer cell 2025 Apr 14;43(4):776-796.e14
Loss of MTX2 causes mitochondrial dysfunction, podocyte injury, nephrotic proteinuria and glomerulopathy in mice and patients.
Li T, Bao Y, Xia Y, Meng H, Zhou C, Huang L, Wang X, Lai EY, Jiang P, Mao J
International journal of biological sciences 2024;20(3):937-952
International journal of biological sciences 2024;20(3):937-952
Tanshinone IIA Promoted Autophagy and Inhibited Inflammation to Alleviate Podocyte Injury in Diabetic Nephropathy.
Li Y, Wu T, Li H, Liu M, Xu H
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:2709-2724
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:2709-2724
Overproduction of Mitochondrial Fission Proteins and Mitochondrial Fission in Podocytes of Lupus Nephritis Patients.
Wei Q, Wu X, Chen Z, Lin H, Xiong L, Wang N
Journal of inflammation research 2024;17:10807-10818
Journal of inflammation research 2024;17:10807-10818
Effects of Inonotus obliquus on ameliorating podocyte injury in ORG mice through TNF pathway and prediction of active compounds.
Han Z, Gong L, Xue Y, Wang R, Liu J, Wang X, Zhao W, Liao H, Li R
Frontiers in pharmacology 2024;15:1426917
Frontiers in pharmacology 2024;15:1426917
Association of the podocyte phenotype with extracapillary hypercellularity in patients with diabetic kidney disease.
Han W, Zheng Q, Zhang Z, Wang X, Gao L, Niu D, Wang X, Li R, Wang C
Journal of nephrology 2024 Nov;37(8):2209-2222
Journal of nephrology 2024 Nov;37(8):2209-2222
miR-4645-3p attenuates podocyte injury and mitochondrial dysfunction in diabetic kidney disease by targeting Cdk5.
Zhang Y, Xia S, Tian X, Yuan L, Gao Y, Liu D, Qi H, Wang S, Liu Z, Li Y, Zhao Z, Liu W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23668
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23668
A simple protocol to establish a conditionally immortalized mouse podocyte cell line.
Huang Y, Geng J, Wang M, Liu W, Hu H, Shi W, Li M, Huo G, Huang G, Xu A
Scientific reports 2024 May 21;14(1):11591
Scientific reports 2024 May 21;14(1):11591
Effectiveness of a novel rat model of off-target PLA2R1 knockout to renal impairment.
Huang B, Zhang Z, Sui W, Zhao L, Li Y, Feng L, Yang D, Zhou Y
Genomics 2024 Mar;116(2):110796
Genomics 2024 Mar;116(2):110796
Quantification of urinary podocyte-derived migrasomes for the diagnosis of kidney disease.
Yang R, Zhang H, Chen S, Lou K, Zhou M, Zhang M, Lu R, Zheng C, Li L, Chen Q, Liu Z, Zen K, Yuan Y, Liang H
Journal of extracellular vesicles 2024 Jun;13(6):e12460
Journal of extracellular vesicles 2024 Jun;13(6):e12460
Novel variants in CRB2 targeting the malfunction of slit diaphragm related to focal segmental glomerulosclerosis.
Yang Q, Tang D, Gan C, Bai M, Song X, Jiang W, Li Q, Chen Y, Zhang A, Wang M
Pediatric nephrology (Berlin, Germany) 2024 Jan;39(1):149-165
Pediatric nephrology (Berlin, Germany) 2024 Jan;39(1):149-165
Cosentyx alleviates psoriasis-induced podocyte injury by inhibiting the tlr/nf-κb signaling pathway.
Aixue W, Feng W, Huanhuan Z, Xixing M, Yanling L
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 2024 Feb;30(2):e13562
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 2024 Feb;30(2):e13562
LncRNA evf-2 Exacerbates Podocyte Injury in Diabetic Nephropathy by Inducing Cell Cycle Re-entry and Inflammation Through Distinct Mechanisms Triggered by hnRNPU.
Zhang C, Zhao H, Yan Y, Li Y, Lei M, Liu Y, Yang L, Zhao H, Zhou S, Pan S, Liu Z, Guo J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(47):e2406532
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(47):e2406532
"Qi Nan" agarwood restores podocyte autophagy in diabetic kidney disease by targeting EGFR signaling pathway.
Li N, Liu X, Wang H, Duan Y, Zhang Y, Zhou P, Dai H, Lan T
Chinese medicine 2024 Apr 23;19(1):63
Chinese medicine 2024 Apr 23;19(1):63
The influence of angiopoietin-like protein 3 on macrophages polarization and its effect on the podocyte EMT in diabetic nephropathy.
Ma Y, Chen Y, Xu H, Du N
Frontiers in immunology 2023;14:1228399
Frontiers in immunology 2023;14:1228399
WT1(+) glomerular parietal epithelial progenitors promote renal proximal tubule regeneration after severe acute kidney injury.
Hong X, Nie H, Deng J, Liang S, Chen L, Li J, Gong S, Wang G, Zuo W, Hou F, Zhang F
Theranostics 2023;13(4):1311-1324
Theranostics 2023;13(4):1311-1324
Effects and mechanism of Rictor interference in podocyte injury induced by high glucose.
Zeng Y, Xiong C, Chen Y, Yang C, Li Q
Experimental and therapeutic medicine 2023 Oct;26(4):473
Experimental and therapeutic medicine 2023 Oct;26(4):473
Klotho inhibits renal ox-LDL deposition via IGF-1R/RAC1/OLR1 signaling to ameliorate podocyte injury in diabetic kidney disease.
Jiang W, Gan C, Zhou X, Yang Q, Chen D, Xiao H, Dai L, Chen Y, Wang M, Yang H, Li Q
Cardiovascular diabetology 2023 Oct 27;22(1):293
Cardiovascular diabetology 2023 Oct 27;22(1):293
Acteoside protects podocyte against apoptosis through regulating AKT/GSK-3β signaling pathway in db/db mice.
Li X, Liu Z, He Z, Wang X, Li R, Wang J, Ma G, Zhang P, Ma C
BMC endocrine disorders 2023 Oct 23;23(1):230
BMC endocrine disorders 2023 Oct 23;23(1):230
mTOR/ULK1 signaling axis mediated ultrashort wave regulation of autophagy to alleviate diabetic kidney disease.
Yan Y, Yu S, Fan Y
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Nov;32(11):1265-1277
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Nov;32(11):1265-1277
Identification of circular dorsal ruffles as signal platforms for the AKT pathway in glomerular podocytes.
Hua R, Wei J, Torres M, He Y, Li Y, Sun X, Wang L, Inoki K, Yoshida S
Journal of cellular physiology 2023 May;238(5):1063-1079
Journal of cellular physiology 2023 May;238(5):1063-1079
Podocyte-specific deletion of ubiquitin carboxyl-terminal hydrolase L1 causes podocyte injury by inducing endoplasmic reticulum stress.
Hu Y, Qi C, Shi J, Tan W, Adiljan Abdurusul, Zhao Z, Xu Y, Wu H, Zhang Z
Cellular and molecular life sciences : CMLS 2023 Mar 23;80(4):106
Cellular and molecular life sciences : CMLS 2023 Mar 23;80(4):106
Partner, Neighbor, Housekeeper and Dimension: 3D versus 2D Glomerular Co-Cultures Reveal Drawbacks of Currently Used Cell Culture Models.
Rederer A, Rose V, Krüger R, Schmittutz L, Swierzy I, Fischer L, Thievessen I, Bauer J, Friedrich O, Schiffer M, Müller-Deile J
International journal of molecular sciences 2023 Jun 20;24(12)
International journal of molecular sciences 2023 Jun 20;24(12)
The compound heterozygous mutations of c.607G>a and c.657delC in the FAH gene are associated with renal damage with hereditary tyrosinemia type 1 (HT1).
Chi H, Gan C, Jiang Y, Chen D, Qiu J, Yang Q, Chen Y, Wang M, Yang H, Jiang W, Li Q
Molecular genetics & genomic medicine 2023 Jan;11(1):e2090
Molecular genetics & genomic medicine 2023 Jan;11(1):e2090
Integrated analysis of RNA methylation regulators crosstalk and immune infiltration for predictive and personalized therapy of diabetic nephropathy.
Li J, Liu D, Ren J, Li G, Zhao Z, Zhao H, Yan Q, Duan J, Liu Z
Human genomics 2023 Feb 10;17(1):6
Human genomics 2023 Feb 10;17(1):6
Generation of renal tubular organoids from adult SOX9(+) kidney progenitor cells.
Zhou D, Li D, Nie H, Duan J, Liu S, Wang Y, Zuo W
Life medicine 2023 Dec;2(6):lnad047
Life medicine 2023 Dec;2(6):lnad047
Inhibition of the lncRNA 585189 prevents podocyte injury and mitochondria dysfunction by promoting hnRNP A1 and SIRT1 in diabetic nephropathy.
Chen H, Liu Y, Zhang T, Huang T, Lang Y, Sheng Q, Liu Y, Kong Z, Gao Y, Lu S, Yang M, Li X, Wang R, Lv Z
Molecular and cellular endocrinology 2023 Dec 1;578:112065
Molecular and cellular endocrinology 2023 Dec 1;578:112065
P2X7R/AKT/mTOR signaling mediates high glucose-induced decrease in podocyte autophagy.
Qian C, Lu J, Che X, Min L, Wang M, Song A, Lu R, Gu L, Xie K
Free radical biology & medicine 2023 Aug 1;204:337-346
Free radical biology & medicine 2023 Aug 1;204:337-346
Activated SOX9+ renal epithelial cells promote kidney repair through secreting factors.
Nie H, Zhao Z, Zhou D, Li D, Wang Y, Ma Y, Liu X, Zuo W
Cell proliferation 2023 Apr;56(4):e13394
Cell proliferation 2023 Apr;56(4):e13394
A glomerulus chip with spherically twisted cell-laden hollow fibers as glomerular capillary tufts.
Dai Z, Li C, Shi Z, Li S, Luo T, Ding W
Biofabrication 2023 Apr 12;15(3)
Biofabrication 2023 Apr 12;15(3)
Cdc42 upregulation under high glucose induces podocyte apoptosis and impairs β-cell insulin secretion.
Jiang S, Xu CM, Yao S, Zhang R, Li XZ, Zhang RZ, Xie TY, Xing YQ, Zhang Q, Zhou XJ, Liao L, Dong JJ
Frontiers in endocrinology 2022;13:905703
Frontiers in endocrinology 2022;13:905703
Glomerular Expression of S100A8 in Lupus Nephritis: An Integrated Bioinformatics Analysis.
Qijiao W, Zhihan C, Makota P, Qing Y, Fei G, Zhihong W, He L
Frontiers in immunology 2022;13:843576
Frontiers in immunology 2022;13:843576
Synaptic proteomics reveal distinct molecular signatures of cognitive change and C9ORF72 repeat expansion in the human ALS cortex.
Laszlo ZI, Hindley N, Sanchez Avila A, Kline RA, Eaton SL, Lamont DJ, Smith C, Spires-Jones TL, Wishart TM, Henstridge CM
Acta neuropathologica communications 2022 Oct 29;10(1):156
Acta neuropathologica communications 2022 Oct 29;10(1):156
Novel pathogenic variants in CUBN uncouple proteinuria from renal function.
Gan C, Zhou X, Chen D, Chi H, Qiu J, You H, Chen Y, Wang M, Yang H, Jiang W, Li Q
Journal of translational medicine 2022 Oct 20;20(1):480
Journal of translational medicine 2022 Oct 20;20(1):480
ManNAc protects against podocyte pyroptosis via inhibiting mitochondrial damage and ROS/NLRP3 signaling pathway in diabetic kidney injury model.
Gao Y, Ma Y, Xie D, Jiang H
International immunopharmacology 2022 Jun;107:108711
International immunopharmacology 2022 Jun;107:108711
Inhibition of the lncRNA MIAT prevents podocyte injury and mitotic catastrophe in diabetic nephropathy.
Wang Z, Chang Y, Liu Y, Liu B, Zhen J, Li X, Lin J, Yu Q, Lv Z, Wang R
Molecular therapy. Nucleic acids 2022 Jun 14;28:136-153
Molecular therapy. Nucleic acids 2022 Jun 14;28:136-153
EP300/CBP is crucial for cAMP-PKA pathway to alleviate podocyte dedifferentiation via targeting Notch3 signaling.
Chang K, Xue R, Zhao M, Zhao Y, Yu W, Zhao Z, Liu X
Experimental cell research 2021 Oct 15;407(2):112825
Experimental cell research 2021 Oct 15;407(2):112825
Experimental study on renoprotective effect of intermedin on diabetic nephropathy.
Wang Y, Tian J, Mi Y, Ren X, Lian S, Kang J, Wang J, Zang H, Wu Z, Yang J, Qiao X, Zhou X, Wang G, Zhou Y, Li R
Molecular and cellular endocrinology 2021 May 15;528:111224
Molecular and cellular endocrinology 2021 May 15;528:111224
Gasdermin D Protects Mouse Podocytes Against High-Glucose-Induced Inflammation and Apoptosis via the C-Jun N-Terminal Kinase (JNK) Pathway.
Li H, Zhao K, Li Y
Medical science monitor : international medical journal of experimental and clinical research 2021 Mar 9;27:e928411
Medical science monitor : international medical journal of experimental and clinical research 2021 Mar 9;27:e928411
Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Exacerbates Podocyte Injury and the Progression of Diabetic Kidney Disease.
Qu H, Gong X, Liu X, Zhang R, Wang Y, Huang B, Zhang L, Zheng H, Zheng Y
Diabetes 2021 Jun;70(6):1372-1387
Diabetes 2021 Jun;70(6):1372-1387
Transforming growth factor-β1-induced podocyte injury is associated with increased microRNA-155 expression, enhanced inflammatory responses and MAPK pathway activation.
Zheng X, Zhong Q, Lin X, Gu X, Ling X, Liang Z, Qin Q, Du X
Experimental and therapeutic medicine 2021 Jun;21(6):620
Experimental and therapeutic medicine 2021 Jun;21(6):620
Cdk5-Mediated Phosphorylation of Sirt1 Contributes to Podocyte Mitochondrial Dysfunction in Diabetic Nephropathy.
Wang S, Yang Y, He X, Yang L, Wang J, Xia S, Liu D, Liu S, Yang L, Liu W, Duan H
Antioxidants & redox signaling 2021 Jan 20;34(3):171-190
Antioxidants & redox signaling 2021 Jan 20;34(3):171-190
Astragaloside IV alleviates puromycin aminonucleoside-induced podocyte cytoskeleton injury through the Wnt/PCP pathway.
Zeng Y, Zhang B, Liu X, He L, Wang T, Yu X, Kang Y, Li S
American journal of translational research 2020;12(7):3512-3521
American journal of translational research 2020;12(7):3512-3521
Renal tubular Bim mediates the tubule-podocyte crosstalk via NFAT2 to induce podocyte cytoskeletal dysfunction.
Xu C, Zhou X, Xie T, Zhou Y, Zhang Q, Jiang S, Zhang R, Liao L, Dong J
Theranostics 2020;10(15):6806-6824
Theranostics 2020;10(15):6806-6824
Paecilomyces cicadae-fermented Radix astragali activates podocyte autophagy by attenuating PI3K/AKT/mTOR pathways to protect against diabetic nephropathy in mice.
Yang F, Qu Q, Zhao C, Liu X, Yang P, Li Z, Han L, Shi X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110479
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110479
Nestin protects podocyte from injury in lupus nephritis by mitophagy and oxidative stress.
Tian Y, Guo H, Miao X, Xu J, Yang R, Zhao L, Liu J, Yang L, Gao F, Zhang W, Liu Q, Sun S, Tian Y, Li H, Huang J, Gu C, Liu S, Feng X
Cell death & disease 2020 May 5;11(5):319
Cell death & disease 2020 May 5;11(5):319
TXNIP deficiency mitigates podocyte apoptosis via restraining the activation of mTOR or p38 MAPK signaling in diabetic nephropathy.
Song S, Qiu D, Wang Y, Wei J, Wu H, Wu M, Wang S, Zhou X, Shi Y, Duan H
Experimental cell research 2020 Mar 15;388(2):111862
Experimental cell research 2020 Mar 15;388(2):111862
Plakoglobin is involved in cytoskeletal rearrangement of podocytes under the regulation of UCH-L1.
Fang Y, Li F, Qi C, Mao X, Xu Y, Zhao Z, Wu H, Zhang Z
Biochemical and biophysical research communications 2020 Aug 13;529(1):112-118
Biochemical and biophysical research communications 2020 Aug 13;529(1):112-118
Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy.
Song S, Qiu D, Shi Y, Wang S, Zhou X, Chen N, Wei J, Wu M, Wu H, Duan H
Journal of cellular physiology 2019 Sep;234(9):16485-16502
Journal of cellular physiology 2019 Sep;234(9):16485-16502
Knockout of the neonatal Fc receptor in cultured podocytes alters IL-6 signaling and the actin cytoskeleton.
Tonsawan P, Dylewski J, Lewis L, Blaine J
American journal of physiology. Cell physiology 2019 Nov 1;317(5):C1048-C1060
American journal of physiology. Cell physiology 2019 Nov 1;317(5):C1048-C1060
Yes-associated protein regulates podocyte cell cycle re-entry and dedifferentiation in adriamycin-induced nephropathy.
Xie K, Xu C, Zhang M, Wang M, Min L, Qian C, Wang Q, Ni Z, Mou S, Dai H, Pang H, Gu L
Cell death & disease 2019 Dec 4;10(12):915
Cell death & disease 2019 Dec 4;10(12):915
Fractalkine is Involved in Lipopolysaccharide-Induced Podocyte Injury through the Wnt/β-Catenin Pathway in an Acute Kidney Injury Mouse Model.
Senouthai S, Wang J, Fu D, You Y
Inflammation 2019 Aug;42(4):1287-1300
Inflammation 2019 Aug;42(4):1287-1300
Weighted Gene Correlation Network Analysis (WGCNA) Detected Loss of MAGI2 Promotes Chronic Kidney Disease (CKD) by Podocyte Damage.
Zuo Z, Shen JX, Pan Y, Pu J, Li YG, Shao XH, Wang WP
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;51(1):244-261
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;51(1):244-261
Genistein and Myd88 Activate Autophagy in High Glucose-Induced Renal Podocytes In Vitro.
Wang Y, Li Y, Zhang T, Chi Y, Liu M, Liu Y
Medical science monitor : international medical journal of experimental and clinical research 2018 Jul 12;24:4823-4831
Medical science monitor : international medical journal of experimental and clinical research 2018 Jul 12;24:4823-4831
Notch-mediated Sox9(+) cell activation contributes to kidney repair after partial nephrectomy.
Ma Q, Wang Y, Zhang T, Zuo W
Life sciences 2018 Jan 15;193:104-109
Life sciences 2018 Jan 15;193:104-109
Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney.
Menon R, Otto EA, Kokoruda A, Zhou J, Zhang Z, Yoon E, Chen YC, Troyanskaya O, Spence JR, Kretzler M, Cebrián C
Development (Cambridge, England) 2018 Aug 30;145(16)
Development (Cambridge, England) 2018 Aug 30;145(16)
A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice.
Wang L, Tao T, Su W, Yu H, Yu Y, Qin J
Lab on a chip 2017 May 16;17(10):1749-1760
Lab on a chip 2017 May 16;17(10):1749-1760
Fyn Mediates High Glucose-Induced Actin Cytoskeleton Reorganization of Podocytes via Promoting ROCK Activation In Vitro.
Lv Z, Hu M, Ren X, Fan M, Zhen J, Chen L, Lin J, Ding N, Wang Q, Wang R
Journal of diabetes research 2016;2016:5671803
Journal of diabetes research 2016;2016:5671803
Thioredoxin-interacting protein mediates NALP3 inflammasome activation in podocytes during diabetic nephropathy.
Gao P, Meng XF, Su H, He FF, Chen S, Tang H, Tian XJ, Fan D, Wang YM, Liu JS, Zhu ZH, Zhang C
Biochimica et biophysica acta 2014 Nov;1843(11):2448-60
Biochimica et biophysica acta 2014 Nov;1843(11):2448-60
Effects of asiaticoside on levels of podocyte cytoskeletal proteins and renal slit diaphragm proteins in adriamycin-induced rat nephropathy.
Wang Z, Liu J, Sun W
Life sciences 2013 Sep 3;93(8):352-8
Life sciences 2013 Sep 3;93(8):352-8
Noninvasive urine-derived cell lines derived from neurological genetic patients.
Zhang QJ, He J, Ni W, Lin X, Yao XP, Lin MT, Murong SX, Wang N, Chen WJ
Neuroreport 2013 Mar 6;24(4):161-6
Neuroreport 2013 Mar 6;24(4):161-6
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 21064-1-AP(SYNPO antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunofluorescent analysis of HepG2 cells, using SYNPO antibody 21064-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line