Antibody data
- Antibody Data
- Antigen structure
- References [24]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
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Validation data
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- Product number
- 21064-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21064-1-AP, RRID:AB_10733120
- Product name
- Synaptopodin antibody
- Antibody type
- Polyclonal
- Description
- Synaptopodin antibody (Cat. #21064-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Experimental study on renoprotective effect of intermedin on diabetic nephropathy.
Gasdermin D Protects Mouse Podocytes Against High-Glucose-Induced Inflammation and Apoptosis via the C-Jun N-Terminal Kinase (JNK) Pathway.
Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Exacerbates Podocyte Injury and the Progression of Diabetic Kidney Disease.
Transforming growth factor-β1-induced podocyte injury is associated with increased microRNA-155 expression, enhanced inflammatory responses and MAPK pathway activation.
Cdk5-Mediated Phosphorylation of Sirt1 Contributes to Podocyte Mitochondrial Dysfunction in Diabetic Nephropathy.
Astragaloside IV alleviates puromycin aminonucleoside-induced podocyte cytoskeleton injury through the Wnt/PCP pathway.
Renal tubular Bim mediates the tubule-podocyte crosstalk via NFAT2 to induce podocyte cytoskeletal dysfunction.
Paecilomyces cicadae-fermented Radix astragali activates podocyte autophagy by attenuating PI3K/AKT/mTOR pathways to protect against diabetic nephropathy in mice.
Nestin protects podocyte from injury in lupus nephritis by mitophagy and oxidative stress.
TXNIP deficiency mitigates podocyte apoptosis via restraining the activation of mTOR or p38 MAPK signaling in diabetic nephropathy.
Plakoglobin is involved in cytoskeletal rearrangement of podocytes under the regulation of UCH-L1.
Knockout of the neonatal Fc receptor in cultured podocytes alters IL-6 signaling and the actin cytoskeleton.
Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy.
Yes-associated protein regulates podocyte cell cycle re-entry and dedifferentiation in adriamycin-induced nephropathy.
Fractalkine is Involved in Lipopolysaccharide-Induced Podocyte Injury through the Wnt/β-Catenin Pathway in an Acute Kidney Injury Mouse Model.
Weighted Gene Correlation Network Analysis (WGCNA) Detected Loss of MAGI2 Promotes Chronic Kidney Disease (CKD) by Podocyte Damage.
Genistein and Myd88 Activate Autophagy in High Glucose-Induced Renal Podocytes In Vitro.
Notch-mediated Sox9+ cell activation contributes to kidney repair after partial nephrectomy.
Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney.
A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice.
Fyn Mediates High Glucose-Induced Actin Cytoskeleton Reorganization of Podocytes via Promoting ROCK Activation In Vitro.
Thioredoxin-interacting protein mediates NALP3 inflammasome activation in podocytes during diabetic nephropathy.
Effects of asiaticoside on levels of podocyte cytoskeletal proteins and renal slit diaphragm proteins in adriamycin-induced rat nephropathy.
Noninvasive urine-derived cell lines derived from neurological genetic patients.
Wang Y, Tian J, Mi Y, Ren X, Lian S, Kang J, Wang J, Zang H, Wu Z, Yang J, Qiao X, Zhou X, Wang G, Zhou Y, Li R
Molecular and cellular endocrinology 2021 May 15;528:111224
Molecular and cellular endocrinology 2021 May 15;528:111224
Gasdermin D Protects Mouse Podocytes Against High-Glucose-Induced Inflammation and Apoptosis via the C-Jun N-Terminal Kinase (JNK) Pathway.
Li H, Zhao K, Li Y
Medical science monitor : international medical journal of experimental and clinical research 2021 Mar 9;27:e928411
Medical science monitor : international medical journal of experimental and clinical research 2021 Mar 9;27:e928411
Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Exacerbates Podocyte Injury and the Progression of Diabetic Kidney Disease.
Qu H, Gong X, Liu X, Zhang R, Wang Y, Huang B, Zhang L, Zheng H, Zheng Y
Diabetes 2021 Jun;70(6):1372-1387
Diabetes 2021 Jun;70(6):1372-1387
Transforming growth factor-β1-induced podocyte injury is associated with increased microRNA-155 expression, enhanced inflammatory responses and MAPK pathway activation.
Zheng X, Zhong Q, Lin X, Gu X, Ling X, Liang Z, Qin Q, Du X
Experimental and therapeutic medicine 2021 Jun;21(6):620
Experimental and therapeutic medicine 2021 Jun;21(6):620
Cdk5-Mediated Phosphorylation of Sirt1 Contributes to Podocyte Mitochondrial Dysfunction in Diabetic Nephropathy.
Wang S, Yang Y, He X, Yang L, Wang J, Xia S, Liu D, Liu S, Yang L, Liu W, Duan H
Antioxidants & redox signaling 2021 Jan 20;34(3):171-190
Antioxidants & redox signaling 2021 Jan 20;34(3):171-190
Astragaloside IV alleviates puromycin aminonucleoside-induced podocyte cytoskeleton injury through the Wnt/PCP pathway.
Zeng Y, Zhang B, Liu X, He L, Wang T, Yu X, Kang Y, Li S
American journal of translational research 2020;12(7):3512-3521
American journal of translational research 2020;12(7):3512-3521
Renal tubular Bim mediates the tubule-podocyte crosstalk via NFAT2 to induce podocyte cytoskeletal dysfunction.
Xu C, Zhou X, Xie T, Zhou Y, Zhang Q, Jiang S, Zhang R, Liao L, Dong J
Theranostics 2020;10(15):6806-6824
Theranostics 2020;10(15):6806-6824
Paecilomyces cicadae-fermented Radix astragali activates podocyte autophagy by attenuating PI3K/AKT/mTOR pathways to protect against diabetic nephropathy in mice.
Yang F, Qu Q, Zhao C, Liu X, Yang P, Li Z, Han L, Shi X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110479
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110479
Nestin protects podocyte from injury in lupus nephritis by mitophagy and oxidative stress.
Tian Y, Guo H, Miao X, Xu J, Yang R, Zhao L, Liu J, Yang L, Gao F, Zhang W, Liu Q, Sun S, Tian Y, Li H, Huang J, Gu C, Liu S, Feng X
Cell death & disease 2020 May 5;11(5):319
Cell death & disease 2020 May 5;11(5):319
TXNIP deficiency mitigates podocyte apoptosis via restraining the activation of mTOR or p38 MAPK signaling in diabetic nephropathy.
Song S, Qiu D, Wang Y, Wei J, Wu H, Wu M, Wang S, Zhou X, Shi Y, Duan H
Experimental cell research 2020 Mar 15;388(2):111862
Experimental cell research 2020 Mar 15;388(2):111862
Plakoglobin is involved in cytoskeletal rearrangement of podocytes under the regulation of UCH-L1.
Fang Y, Li F, Qi C, Mao X, Xu Y, Zhao Z, Wu H, Zhang Z
Biochemical and biophysical research communications 2020 Aug 13;529(1):112-118
Biochemical and biophysical research communications 2020 Aug 13;529(1):112-118
Knockout of the neonatal Fc receptor in cultured podocytes alters IL-6 signaling and the actin cytoskeleton.
Tonsawan P, Dylewski J, Lewis L, Blaine J
American journal of physiology. Cell physiology 2019 Nov 1;317(5):C1048-C1060
American journal of physiology. Cell physiology 2019 Nov 1;317(5):C1048-C1060
Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy.
Song S, Qiu D, Shi Y, Wang S, Zhou X, Chen N, Wei J, Wu M, Wu H, Duan H
Journal of cellular physiology 2019 Feb 11;
Journal of cellular physiology 2019 Feb 11;
Yes-associated protein regulates podocyte cell cycle re-entry and dedifferentiation in adriamycin-induced nephropathy.
Xie K, Xu C, Zhang M, Wang M, Min L, Qian C, Wang Q, Ni Z, Mou S, Dai H, Pang H, Gu L
Cell death & disease 2019 Dec 4;10(12):915
Cell death & disease 2019 Dec 4;10(12):915
Fractalkine is Involved in Lipopolysaccharide-Induced Podocyte Injury through the Wnt/β-Catenin Pathway in an Acute Kidney Injury Mouse Model.
Senouthai S, Wang J, Fu D, You Y
Inflammation 2019 Aug;42(4):1287-1300
Inflammation 2019 Aug;42(4):1287-1300
Weighted Gene Correlation Network Analysis (WGCNA) Detected Loss of MAGI2 Promotes Chronic Kidney Disease (CKD) by Podocyte Damage.
Zuo Z, Shen JX, Pan Y, Pu J, Li YG, Shao XH, Wang WP
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;51(1):244-261
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;51(1):244-261
Genistein and Myd88 Activate Autophagy in High Glucose-Induced Renal Podocytes In Vitro.
Wang Y, Li Y, Zhang T, Chi Y, Liu M, Liu Y
Medical science monitor : international medical journal of experimental and clinical research 2018 Jul 12;24:4823-4831
Medical science monitor : international medical journal of experimental and clinical research 2018 Jul 12;24:4823-4831
Notch-mediated Sox9+ cell activation contributes to kidney repair after partial nephrectomy.
Ma Q, Wang Y, Zhang T, Zuo W
Life sciences 2018 Jan 15;193:104-109
Life sciences 2018 Jan 15;193:104-109
Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney.
Menon R, Otto EA, Kokoruda A, Zhou J, Zhang Z, Yoon E, Chen YC, Troyanskaya O, Spence JR, Kretzler M, Cebrián C
Development (Cambridge, England) 2018 Aug 30;145(16)
Development (Cambridge, England) 2018 Aug 30;145(16)
A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice.
Wang L, Tao T, Su W, Yu H, Yu Y, Qin J
Lab on a chip 2017 May 16;17(10):1749-1760
Lab on a chip 2017 May 16;17(10):1749-1760
Fyn Mediates High Glucose-Induced Actin Cytoskeleton Reorganization of Podocytes via Promoting ROCK Activation In Vitro.
Lv Z, Hu M, Ren X, Fan M, Zhen J, Chen L, Lin J, Ding N, Wang Q, Wang R
Journal of diabetes research 2016;2016:5671803
Journal of diabetes research 2016;2016:5671803
Thioredoxin-interacting protein mediates NALP3 inflammasome activation in podocytes during diabetic nephropathy.
Gao P, Meng XF, Su H, He FF, Chen S, Tang H, Tian XJ, Fan D, Wang YM, Liu JS, Zhu ZH, Zhang C
Biochimica et biophysica acta 2014 Nov;1843(11):2448-60
Biochimica et biophysica acta 2014 Nov;1843(11):2448-60
Effects of asiaticoside on levels of podocyte cytoskeletal proteins and renal slit diaphragm proteins in adriamycin-induced rat nephropathy.
Wang Z, Liu J, Sun W
Life sciences 2013 Sep 3;93(8):352-8
Life sciences 2013 Sep 3;93(8):352-8
Noninvasive urine-derived cell lines derived from neurological genetic patients.
Zhang QJ, He J, Ni W, Lin X, Yao XP, Lin MT, Murong SX, Wang N, Chen WJ
Neuroreport 2013 Mar 6;24(4):161-6
Neuroreport 2013 Mar 6;24(4):161-6
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 21064-1-AP(SYNPO antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using SYNPO antibody 21064-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line