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- Product number
- 18227-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18227-1-AP, RRID:AB_2090329
- Product name
- CYP3A4 antibody
- Antibody type
- Polyclonal
- Description
- CYP3A4 antibody (Cat. #18227-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Hepatobiliary organoids differentiated from hiPSCs relieve cholestasis-induced liver fibrosis in nonhuman primates.
Physiologically based pharmacokinetic modeling for confirming the role of CYP3A1/2 and P-glycoprotein in detoxification mechanism between glycyrrhizic acid and aconitine in rats.
A transcriptome based molecular classification scheme for cholangiocarcinoma and subtype-derived prognostic biomarker.
Microneedle array facilitates hepatic sinusoid construction in a large-scale liver-acinus-chip microsystem.
Pharmacokinetic and pharmacodynamic drug-drug interaction of Nomilin with atorvastatin in hyperlipidemic mice.
Modeling Colorectal Cancer-Induced Liver Portal Vein Microthrombus on a Hepatic Lobule Chip.
Impact of tectoridin on the pharmacokinetics of florfenicol via targeting cytochrome P450 and P-glycoprotein of rats.
Coptisine modulates the pharmacokinetics of florfenicol by targeting CYP1A2, CYP2C11 and CYP3A1 in the liver and P-gp in the jejunum of rats: a pilot study.
Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions.
A Promising Approach to Treat Psoriasis: Inhibiting Cytochrome P450 3A4 Metabolism to Enhance Desoximetasone Therapy.
Gemcitabine enhances pharmacokinetic exposure of the major components of Danggui Buxue Decoction in rat via the promotion of intestinal permeability and down-regulation of CYP3A for combination treatment of non-small cell lung cancer.
Glutaredoxin-1 alleviates acetaminophen-induced liver injury by decreasing its toxic metabolites.
Chemically induced revitalization of damaged hepatocytes for regenerative liver repair.
Hepatic ZBTB22-mediated detoxification ameliorates acetaminophen-induced liver injury by inhibiting pregnane X receptor signaling.
Development of Biomimetic Hepatic Lobule-Like Constructs on Silk-Collagen Composite Scaffolds for Liver Tissue Engineering.
Functionalized PEG-PLA nanoparticles for brain targeted delivery of ketoconazole contribute to pregnane X receptor overexpressing in drug-resistant epilepsy.
NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma.
Network Analysis of the Herb-Drug Interactions of Citrus Herbs Inspired by the "Grapefruit Juice Effect".
Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide).
Comparison of mouse and human cytochrome P450 mediated-drug metabolising activities in hepatic and extrahepatic microsomes.
The polyol pathway is an evolutionarily conserved system for sensing glucose uptake.
The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease.
Gut microbiota and host Cyp450s co-contribute to pharmacokinetic variability in mice with non-alcoholic steatohepatitis: Effects vary from drug to drug.
Panaxytriol upregulates CYP3A4 expression based on the interaction of PXR, CAR, HSP90α, and RXRα.
Kinetic Characteristics of Curcumin and Germacrone in Rat and Human Liver Microsomes: Involvement of CYP Enzymes.
Is platelet responsiveness to clopidogrel attenuated in overweight or obese patients and why? A reverse translational study in mice.
Phosphorylation-Induced Ubiquitination and Degradation of PXR through CDK2-TRIM21 Axis.
Establishment of Functional Liver Spheroids From Human Hepatocyte-Derived Liver Progenitor-Like Cells for Cell Therapy.
Curcuma zedoaria petroleum ether extract reverses the resistance of triple-negative breast cancer to docetaxel via pregnane X receptor.
Diurnal hepatic CYP3A11 contributes to chronotoxicity of the pyrrolizidine alkaloid retrorsine in mice.
Assessing CYP2C8-Mediated Pharmaceutical Excipient-Drug Interaction Potential: A Case Study of Tween 80 and Cremophor EL-35.
Modeling nonalcoholic fatty liver disease on a liver lobule chip with dual blood supply.
Effects of saikosaponin-d on CYP3A4 in HepaRG cell and protein-ligand docking study.
Assessment of long-term functional maintenance of primary human hepatocytes to predict drug-induced hepatoxicity in vitro.
A high-throughput cell-based gaussia luciferase reporter assay for measurement of CYP1A1, CYP2B6, and CYP3A4 induction.
The gut microbiota contributes to the modulation of intestinal CYP3A1 and P-gp in streptozotocin-induced type 1 diabetic rats.
Short-term standard alcohol consumption enhances platelet response to clopidogrel through inhibition of Nrf2/Ces1 pathway and induction of Cyp2c in mice.
Effect of statin treatment in obese selenium-supplemented mice lacking selenocysteine lyase.
Silybin enhances the blood concentration of brexpiprazole in rats by downregulating expression of CYP3A4 and CYP2D6.
Characterization of red ginseng-drug interaction by CYP3A activity increased in high dose administration in mice.
CYP3A4 and microRNA-122 are involved in the apoptosis of HepG2 cells induced by ILs 1-decyl-3-methylimidazolium bromide.
Differential Effects of Components in Artemisia annua Extract on the Induction of Drug-Metabolizing Enzyme Expression Mediated by Nuclear Receptors.
Generation of hepatic spheroids using human hepatocyte-derived liver progenitor-like cells for hepatotoxicity screening.
Novel hybrid three-dimensional artificial liver using human induced pluripotent stem cells and a rat decellularized liver scaffold.
Constitutive androstane receptor weakens the induction of panaxytriol on CYP3A4 by repressing the activation of pregnane X receptor.
Integrated Metabolomics and Network Pharmacology Strategy-Driven Active Traditional Chinese Medicine Ingredients Discovery for the Alleviation of Cisplatin Nephrotoxicity.
The chromatin remodeling protein BRG1 regulates APAP-induced liver injury by modulating CYP3A11 transcription in hepatocyte.
Poly(ADP-ribosyl)ated PXR is a critical regulator of acetaminophen-induced hepatotoxicity.
Alpha-ketoglutarate suppresses the NF-κB-mediated inflammatory pathway and enhances the PXR-regulated detoxification pathway.
Editor's Highlight: Pregnancy Alters Aflatoxin B1 Metabolism and Increases DNA Damage in Mouse Liver.
Suppression of carboxylesterases by imatinib mediated by the down-regulation of pregnane X receptor.
Alteration in the expression of cytochrome P450s (CYP1A1, CYP2E1, and CYP3A11) in the liver of mouse induced by microcystin-LR.
Self-renewal of hepatoblasts under chemically defined conditions by iterative growth factor and chemical screening.
Effects of tetrahydroxystilbene glucoside on mouse liver cytochrome P450 enzyme expressions.
Revival, characterization, and hepatitis B virus infection of cryopreserved human fetal hepatocytes.
Long-term maintenance of human fetal hepatocytes and prolonged susceptibility to HBV infection by co-culture with non-parenchymal cells.
Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice.
Li H, Li J, Wang T, Sun K, Huang G, Cao Y, Wu F, Xu A
International journal of biological sciences 2024;20(4):1160-1179
International journal of biological sciences 2024;20(4):1160-1179
Physiologically based pharmacokinetic modeling for confirming the role of CYP3A1/2 and P-glycoprotein in detoxification mechanism between glycyrrhizic acid and aconitine in rats.
Jin J, Xu X, Li F, Weng F, Zou B, Li Y, Zhao J, Zhang S, Yan D, Qiu F
Journal of applied toxicology : JAT 2024 Jul;44(7):978-989
Journal of applied toxicology : JAT 2024 Jul;44(7):978-989
A transcriptome based molecular classification scheme for cholangiocarcinoma and subtype-derived prognostic biomarker.
Fan Z, Zou X, Wang G, Liu Y, Jiang Y, Wang H, Zhang P, Wei F, Du X, Wang M, Sun X, Ji B, Hu X, Chen L, Zhou P, Wang D, Bai J, Xiao X, Zuo L, Xia X, Yi X, Lv G
Nature communications 2024 Jan 11;15(1):484
Nature communications 2024 Jan 11;15(1):484
Microneedle array facilitates hepatic sinusoid construction in a large-scale liver-acinus-chip microsystem.
Li S, Li C, Khan MI, Liu J, Shi Z, Gao D, Qiu B, Ding W
Microsystems & nanoengineering 2023;9:75
Microsystems & nanoengineering 2023;9:75
Pharmacokinetic and pharmacodynamic drug-drug interaction of Nomilin with atorvastatin in hyperlipidemic mice.
Ding Y, Guan H, Yan Y, Chen Y, Huang C
Heliyon 2023 Nov;9(11):e22016
Heliyon 2023 Nov;9(11):e22016
Modeling Colorectal Cancer-Induced Liver Portal Vein Microthrombus on a Hepatic Lobule Chip.
Du X, Zou R, Du K, Huang D, Miao C, Qiu B, Ding W, Li C
ACS applied materials & interfaces 2023 Nov 30;
ACS applied materials & interfaces 2023 Nov 30;
Impact of tectoridin on the pharmacokinetics of florfenicol via targeting cytochrome P450 and P-glycoprotein of rats.
Zhang M, Wang B, Li XT, Yin Q, Liang G, Li SC
Xenobiotica; the fate of foreign compounds in biological systems 2023 May;53(5):429-437
Xenobiotica; the fate of foreign compounds in biological systems 2023 May;53(5):429-437
Coptisine modulates the pharmacokinetics of florfenicol by targeting CYP1A2, CYP2C11 and CYP3A1 in the liver and P-gp in the jejunum of rats: a pilot study.
Li SC, Zhang M, Wang B, Li XT, Liang G
Xenobiotica; the fate of foreign compounds in biological systems 2023 Mar;53(3):207-214
Xenobiotica; the fate of foreign compounds in biological systems 2023 Mar;53(3):207-214
Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions.
Fan S, Yan Y, Xia Y, Zhou Z, Luo L, Zhu M, Han Y, Yao D, Zhang L, Fang M, Peng L, Yu J, Liu Y, Gao X, Guan H, Li H, Wang C, Wu X, Zhu H, Cao Y, Huang C
Nature communications 2023 Jun 8;14(1):3368
Nature communications 2023 Jun 8;14(1):3368
A Promising Approach to Treat Psoriasis: Inhibiting Cytochrome P450 3A4 Metabolism to Enhance Desoximetasone Therapy.
Guo JW, Cheng YP, Lim CJ, Liu CY, Jee SH
Pharmaceutics 2023 Jul 25;15(8)
Pharmaceutics 2023 Jul 25;15(8)
Gemcitabine enhances pharmacokinetic exposure of the major components of Danggui Buxue Decoction in rat via the promotion of intestinal permeability and down-regulation of CYP3A for combination treatment of non-small cell lung cancer.
Xu X, Sun XY, Chang M, Hu ZL, Cheng TT, Hang TJ, Song M
Pharmaceutical biology 2023 Dec;61(1):1298-1309
Pharmaceutical biology 2023 Dec;61(1):1298-1309
Glutaredoxin-1 alleviates acetaminophen-induced liver injury by decreasing its toxic metabolites.
Xu Y, Xia Y, Liu Q, Jing X, Tang Q, Zhang J, Jia Q, Zhang Z, Li J, Chen J, Xiong Y, Li Y, He J
Journal of pharmaceutical analysis 2023 Dec;13(12):1548-1561
Journal of pharmaceutical analysis 2023 Dec;13(12):1548-1561
Chemically induced revitalization of damaged hepatocytes for regenerative liver repair.
Lin P, Bai Y, Nian X, Chi J, Chen T, Zhang J, Zhang W, Zhou B, Liu Y, Zhao Y
iScience 2023 Dec 15;26(12):108532
iScience 2023 Dec 15;26(12):108532
Hepatic ZBTB22-mediated detoxification ameliorates acetaminophen-induced liver injury by inhibiting pregnane X receptor signaling.
Chen Y, Cui T, Xiao S, Li T, Zhong Y, Tang K, Guo J, Huang S, Chen J, Li J, Wang Q, Huang J, Pan H, Gao Y
iScience 2023 Apr 21;26(4):106318
iScience 2023 Apr 21;26(4):106318
Development of Biomimetic Hepatic Lobule-Like Constructs on Silk-Collagen Composite Scaffolds for Liver Tissue Engineering.
Guo L, Zhu Z, Gao C, Chen K, Lu S, Yan H, Liu W, Wang M, Ding Y, Huang L, Wang X
Frontiers in bioengineering and biotechnology 2022;10:940634
Frontiers in bioengineering and biotechnology 2022;10:940634
Functionalized PEG-PLA nanoparticles for brain targeted delivery of ketoconazole contribute to pregnane X receptor overexpressing in drug-resistant epilepsy.
Wang J, Fu J, Sun W, Yin X, Lv K, Zhang J
Epilepsy research 2022 Oct;186:107000
Epilepsy research 2022 Oct;186:107000
NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma.
Zhan Y, Zhang Z, Liu Y, Fang Y, Xie Y, Zheng Y, Li G, Liang L, Ding Y
BMC medicine 2022 Oct 19;20(1):365
BMC medicine 2022 Oct 19;20(1):365
Network Analysis of the Herb-Drug Interactions of Citrus Herbs Inspired by the "Grapefruit Juice Effect".
Lü J, Zhang D, Zhang X, Sa R, Wang X, Wu H, Lin Z, Zhang B
ACS omega 2022 Oct 11;7(40):35911-35923
ACS omega 2022 Oct 11;7(40):35911-35923
Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide).
Zeidler JD, Chini CCS, Kanamori KS, Kashyap S, Espindola-Netto JM, Thompson K, Warner G, Cabral FS, Peclat TR, Gomez LS, Lopez SA, Wandersee MK, Schoon RA, Reid K, Menzies K, Beckedorff F, Reid JM, Brachs S, Meyer RG, Meyer-Ficca ML, Chini EN
iScience 2022 Nov 18;25(11):105431
iScience 2022 Nov 18;25(11):105431
Comparison of mouse and human cytochrome P450 mediated-drug metabolising activities in hepatic and extrahepatic microsomes.
Uehara S, Murayama N, Higuchi Y, Yoneda N, Yamazaki H, Suemizu H
Xenobiotica; the fate of foreign compounds in biological systems 2022 Mar;52(3):229-239
Xenobiotica; the fate of foreign compounds in biological systems 2022 Mar;52(3):229-239
The polyol pathway is an evolutionarily conserved system for sensing glucose uptake.
Sano H, Nakamura A, Yamane M, Niwa H, Nishimura T, Araki K, Takemoto K, Ishiguro KI, Aoki H, Kato Y, Kojima M
PLoS biology 2022 Jun;20(6):e3001678
PLoS biology 2022 Jun;20(6):e3001678
The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease.
Cigliano A, Zhang S, Ribback S, Steinmann S, Sini M, Ament CE, Utpatel K, Song X, Wang J, Pilo MG, Berger F, Wang H, Tao J, Li X, Pes GM, Mancarella S, Giannelli G, Dombrowski F, Evert M, Calvisi DF, Chen X, Evert K
Journal of experimental & clinical cancer research : CR 2022 Jun 3;41(1):192
Journal of experimental & clinical cancer research : CR 2022 Jun 3;41(1):192
Gut microbiota and host Cyp450s co-contribute to pharmacokinetic variability in mice with non-alcoholic steatohepatitis: Effects vary from drug to drug.
Guo J, Xu Y, Chen LJ, Zhang SX, Liou YL, Chen XP, Tan ZR, Zhou HH, Zhang W, Chen Y
Journal of advanced research 2022 Jul;39:319-332
Journal of advanced research 2022 Jul;39:319-332
Panaxytriol upregulates CYP3A4 expression based on the interaction of PXR, CAR, HSP90α, and RXRα.
Zhang L, Yan J, Liu J, Meng C, Liu F, Xia C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul;101:154097
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul;101:154097
Kinetic Characteristics of Curcumin and Germacrone in Rat and Human Liver Microsomes: Involvement of CYP Enzymes.
Su S, Wu H, Zhou J, Yuan G, Wang H, Feng J
Molecules (Basel, Switzerland) 2022 Jul 14;27(14)
Molecules (Basel, Switzerland) 2022 Jul 14;27(14)
Is platelet responsiveness to clopidogrel attenuated in overweight or obese patients and why? A reverse translational study in mice.
Jiang LP, Ji JZ, Ge PX, Zhu T, Mi QY, Tai T, Li YF, Xie HG
British journal of pharmacology 2022 Jan;179(1):46-64
British journal of pharmacology 2022 Jan;179(1):46-64
Phosphorylation-Induced Ubiquitination and Degradation of PXR through CDK2-TRIM21 Axis.
Qin M, Xin Y, Bian Y, Yang X, Xi T, Xiong J
Cells 2022 Jan 13;11(2)
Cells 2022 Jan 13;11(2)
Establishment of Functional Liver Spheroids From Human Hepatocyte-Derived Liver Progenitor-Like Cells for Cell Therapy.
Liu WM, Zhou X, Chen CY, Lv DD, Huang WJ, Peng Y, Wu HP, Chen Y, Tang D, Guo LN, Wang XL, Zhang HD, Liu XH, Yang LQ, Yu WF, Yan HX
Frontiers in bioengineering and biotechnology 2021;9:738081
Frontiers in bioengineering and biotechnology 2021;9:738081
Curcuma zedoaria petroleum ether extract reverses the resistance of triple-negative breast cancer to docetaxel via pregnane X receptor.
Qiao EQ, Yang HJ, Yu XF, Gong LJ, Zhang XP, Chen DB
Annals of translational medicine 2021 Sep;9(17):1389
Annals of translational medicine 2021 Sep;9(17):1389
Diurnal hepatic CYP3A11 contributes to chronotoxicity of the pyrrolizidine alkaloid retrorsine in mice.
Guo L, Zhang L, Xu H, Yu P, Wang Z, Lu D, Chen M, Wu B
Xenobiotica; the fate of foreign compounds in biological systems 2021 Sep;51(9):1019-1028
Xenobiotica; the fate of foreign compounds in biological systems 2021 Sep;51(9):1019-1028
Assessing CYP2C8-Mediated Pharmaceutical Excipient-Drug Interaction Potential: A Case Study of Tween 80 and Cremophor EL-35.
Wen C, Hu H, Zhang W, Liu X, Jiang X, Wang L
Pharmaceutics 2021 Sep 17;13(9)
Pharmaceutics 2021 Sep 17;13(9)
Modeling nonalcoholic fatty liver disease on a liver lobule chip with dual blood supply.
Du K, Li S, Li C, Li P, Miao C, Luo T, Qiu B, Ding W
Acta biomaterialia 2021 Oct 15;134:228-239
Acta biomaterialia 2021 Oct 15;134:228-239
Effects of saikosaponin-d on CYP3A4 in HepaRG cell and protein-ligand docking study.
Li H, Tang Y, Wei W, Yin C, Tang F
Basic & clinical pharmacology & toxicology 2021 May;128(5):661-668
Basic & clinical pharmacology & toxicology 2021 May;128(5):661-668
Assessment of long-term functional maintenance of primary human hepatocytes to predict drug-induced hepatoxicity in vitro.
Chen Y, Tang D, Wu H, Wu Y, Yuan T, Zhang H, Jiao Y, Yu W, Yan H
Archives of toxicology 2021 Jul;95(7):2431-2442
Archives of toxicology 2021 Jul;95(7):2431-2442
A high-throughput cell-based gaussia luciferase reporter assay for measurement of CYP1A1, CYP2B6, and CYP3A4 induction.
Li H, Wang YG, Ma ZC, Yun-Hang G, Ling S, Teng-Fei C, Guang-Ping Z, Gao Y
Xenobiotica; the fate of foreign compounds in biological systems 2021 Jul;51(7):752-763
Xenobiotica; the fate of foreign compounds in biological systems 2021 Jul;51(7):752-763
The gut microbiota contributes to the modulation of intestinal CYP3A1 and P-gp in streptozotocin-induced type 1 diabetic rats.
Hu N, Liu X, Mu Q, Yu M, Wang H, Jiang Y, Chen R, Wang L
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2021 Jul 1;162:105833
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2021 Jul 1;162:105833
Short-term standard alcohol consumption enhances platelet response to clopidogrel through inhibition of Nrf2/Ces1 pathway and induction of Cyp2c in mice.
Ge PX, Jiang LP, Tai T, Zhu T, Ji JZ, Li YF, Mi QY, Xie HG
Life sciences 2021 Aug 15;279:119268
Life sciences 2021 Aug 15;279:119268
Effect of statin treatment in obese selenium-supplemented mice lacking selenocysteine lyase.
Watanabe LM, Hashimoto AC, Torres DJ, Alfulaij N, Peres R, Sultana R, Maunakea AK, Berry MJ, Seale LA
Molecular and cellular endocrinology 2021 Aug 1;533:111335
Molecular and cellular endocrinology 2021 Aug 1;533:111335
Silybin enhances the blood concentration of brexpiprazole in rats by downregulating expression of CYP3A4 and CYP2D6.
Yu C, Pan L, Wang G, Cai Z, Zhou Y, Zheng X, Chen C, Zhang X
Die Pharmazie 2020 May 1;75(5):198-200
Die Pharmazie 2020 May 1;75(5):198-200
Characterization of red ginseng-drug interaction by CYP3A activity increased in high dose administration in mice.
Kim Y, Jo JJ, Cho P, Shrestha R, Kim KM, Ki SH, Song KS, Liu KH, Song IS, Kim JH, Lee JM, Lee S
Biopharmaceutics & drug disposition 2020 Jul;41(7):295-306
Biopharmaceutics & drug disposition 2020 Jul;41(7):295-306
CYP3A4 and microRNA-122 are involved in the apoptosis of HepG2 cells induced by ILs 1-decyl-3-methylimidazolium bromide.
Li AL, Gao SS, Guo ML, Jing CQ
Journal of biochemical and molecular toxicology 2020 Jan;34(1):e22419
Journal of biochemical and molecular toxicology 2020 Jan;34(1):e22419
Differential Effects of Components in Artemisia annua Extract on the Induction of Drug-Metabolizing Enzyme Expression Mediated by Nuclear Receptors.
Zhang X, Meng R, Wang H, Xing J
Planta medica 2020 Aug;86(12):867-875
Planta medica 2020 Aug;86(12):867-875
Generation of hepatic spheroids using human hepatocyte-derived liver progenitor-like cells for hepatotoxicity screening.
Wang Z, Li W, Jing H, Ding M, Fu G, Yuan T, Huang W, Dai M, Tang D, Zeng M, Chen Y, Zhang H, Zhu X, Peng Y, Li Q, Yu WF, Yan HX, Zhai B
Theranostics 2019;9(22):6690-6705
Theranostics 2019;9(22):6690-6705
Novel hybrid three-dimensional artificial liver using human induced pluripotent stem cells and a rat decellularized liver scaffold.
Minami T, Ishii T, Yasuchika K, Fukumitsu K, Ogiso S, Miyauchi Y, Kojima H, Kawai T, Yamaoka R, Oshima Y, Kawamoto H, Kotaka M, Yasuda K, Osafune K, Uemoto S
Regenerative therapy 2019 Jun;10:127-133
Regenerative therapy 2019 Jun;10:127-133
Constitutive androstane receptor weakens the induction of panaxytriol on CYP3A4 by repressing the activation of pregnane X receptor.
Hu Q, Yao N, Wu J, Liu M, Liu F, Zhang H, Xiong Y, Xia C
Biochemical pharmacology 2019 Jan;159:32-39
Biochemical pharmacology 2019 Jan;159:32-39
Integrated Metabolomics and Network Pharmacology Strategy-Driven Active Traditional Chinese Medicine Ingredients Discovery for the Alleviation of Cisplatin Nephrotoxicity.
Xu L, Zhang Y, Zhang P, Dai X, Gao Y, Lv Y, Qin S, Xu F
Chemical research in toxicology 2019 Dec 16;32(12):2411-2421
Chemical research in toxicology 2019 Dec 16;32(12):2411-2421
The chromatin remodeling protein BRG1 regulates APAP-induced liver injury by modulating CYP3A11 transcription in hepatocyte.
Li N, Kong M, Zeng S, Xu Z, Li M, Hong W, Chu X, Sun X, Zhu M, Xu Y
Biochimica et biophysica acta. Molecular basis of disease 2018 Oct;1864(10):3487-3495
Biochimica et biophysica acta. Molecular basis of disease 2018 Oct;1864(10):3487-3495
Poly(ADP-ribosyl)ated PXR is a critical regulator of acetaminophen-induced hepatotoxicity.
Wang C, Xu W, Zhang Y, Huang D, Huang K
Cell death & disease 2018 Jul 26;9(8):819
Cell death & disease 2018 Jul 26;9(8):819
Alpha-ketoglutarate suppresses the NF-κB-mediated inflammatory pathway and enhances the PXR-regulated detoxification pathway.
He L, Li H, Huang N, Zhou X, Tian J, Li T, Wu J, Tian Y, Yin Y, Yao K
Oncotarget 2017 Nov 28;8(61):102974-102988
Oncotarget 2017 Nov 28;8(61):102974-102988
Editor's Highlight: Pregnancy Alters Aflatoxin B1 Metabolism and Increases DNA Damage in Mouse Liver.
Sriwattanapong K, Slocum SL, Chawanthayatham S, Fedeles BI, Egner PA, Groopman JD, Satayavivad J, Croy RG, Essigmann JM
Toxicological sciences : an official journal of the Society of Toxicology 2017 Nov 1;160(1):173-179
Toxicological sciences : an official journal of the Society of Toxicology 2017 Nov 1;160(1):173-179
Suppression of carboxylesterases by imatinib mediated by the down-regulation of pregnane X receptor.
Luo W, Xin Y, Zhao X, Zhang F, Liu C, Fan H, Xi T, Xiong J
British journal of pharmacology 2017 Apr;174(8):700-717
British journal of pharmacology 2017 Apr;174(8):700-717
Alteration in the expression of cytochrome P450s (CYP1A1, CYP2E1, and CYP3A11) in the liver of mouse induced by microcystin-LR.
Zhang B, Liu Y, Li X
Toxins 2015 Mar 30;7(4):1102-15
Toxins 2015 Mar 30;7(4):1102-15
Self-renewal of hepatoblasts under chemically defined conditions by iterative growth factor and chemical screening.
Lv L, Han Q, Chu Y, Zhang M, Sun L, Wei W, Jin C, Li W
Hepatology (Baltimore, Md.) 2015 Jan;61(1):337-47
Hepatology (Baltimore, Md.) 2015 Jan;61(1):337-47
Effects of tetrahydroxystilbene glucoside on mouse liver cytochrome P450 enzyme expressions.
Wang YY, Yang J, Liu H, Lin FQ, Shi JS, Zhang F
Xenobiotica; the fate of foreign compounds in biological systems 2015 Apr;45(4):279-85
Xenobiotica; the fate of foreign compounds in biological systems 2015 Apr;45(4):279-85
Revival, characterization, and hepatitis B virus infection of cryopreserved human fetal hepatocytes.
Zhou M, Huang Y, Cheng Z, Zhao F, Li J, Zhi X, Tian X, Sun W, Hu K
Journal of virological methods 2014 Oct;207:29-37
Journal of virological methods 2014 Oct;207:29-37
Long-term maintenance of human fetal hepatocytes and prolonged susceptibility to HBV infection by co-culture with non-parenchymal cells.
Zhou M, Zhao F, Li J, Cheng Z, Tian X, Zhi X, Huang Y, Hu K
Journal of virological methods 2014 Jan;195:185-93
Journal of virological methods 2014 Jan;195:185-93
Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice.
Sliva D, Loganathan J, Jiang J, Jedinak A, Lamb JG, Terry C, Baldridge LA, Adamec J, Sandusky GE, Dudhgaonkar S
PloS one 2012;7(10):e47873
PloS one 2012;7(10):e47873
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse kidney tissue were subjected to SDS PAGE followed by western blot with 18227-1-AP(CYP3A4 antibody) at dilution of 1:800
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using CYP3A4 antibody 18227-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 18227-1-AP(CYP3A4 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 18227-1-AP(CYP3A4 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
