Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- A00339 - Provider product page
- Provider
- Boster Biological Technology
- Product name
- Anti-Cytochrome P450 3A4 CYP3A4 Antibody
- Antibody type
- Polyclonal
- Description
- Polyclonal antibody for CYTOCHROME P450 3A4/CYP3A4 detection. Host: Rabbit.Size: 100μl. Tested applications: IHC. Reactive species: Human. CYTOCHROME P450 3A4/CYP3A4 information: Molecular Weight: 57343 MW; Subcellular Localization: Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane ; Single-pass membrane protein; Tissue Specificity: Expressed in prostate and liver. According to some authors, it is not expressed in brain (PubMed:19094056). According to others, weak levels of expression are measured in some brain locations (PubMed:19359404 and PubMed:18545703). Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level).
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Vial size
- 100μl
- Concentration
- 0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
- Storage
- Store at -20°C for one year, at 4°C for one month. We suggest the antibody be aliquoted into small vials and stored frozen at -20°C upon receiving. Avoid repeated freezing and thawing.
Submitted references Involvement of NF-κB in the reversal of CYP3A down-regulation induced by sea buckthorn in BCG-induced rats.
Liu F, Wang T, Li X, Jia J, Lin Q, Xue Y
PloS one 2020;15(9):e0238810
PloS one 2020;15(9):e0238810
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Supportive validation
- Submitted by
- Boster Biological Technology (provider)
- Main image
- Experimental details
- Western blot analysis of extracts from K562 cells, using P450 3A4 antibody A00339.
- Additional image