318808

antibody from BioLegend
Targeting: TNFRSF14 ATAR, CD270, HVEA, HVEM, LIGHTR, TR2
Provider product page for 318808

Antibody data

Product number
318808 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#318808, RRID:AB_2565253
Product name
APC anti-human CD270 (HVEM, TR2)
Antibody type
Monoclonal
Antigen
Recombinant human HVEM protein
Description
The 122 antibody recognizes human HVEM also known as herpesvirus entry mediator A, tumor necrosis factor receptor superfamily, member 14, TNFRSF14, and tumor necrosis factor receptor like 2. HVEM, a member of the TNFR superfamily, is a type I transmembrane protein containing 2 TNF receptor domains with a predicted molecular weight of approximately 30 kD. HVEM is widely expressed in blood vessels, brain, heart, kidney, liver, lung, prostate, spleen, thymus and other organs. Resting T cells and naïve and memory B cells express high levels of HVEM as well. In humans, HVEM is not expressed in germinal center B cells. Immature dendritic cells express high levels of HVEM that is downregulated upon maturation. HVEM plays an important role in herpes simplex virus pathogenesis by enhancing entry into cells. Signaling through HVEM activates JNK1, NF-κB and AP-1 to control gene expression in response to infection or cellular stress and activate the immune response. HVEM binds to LIGHT and has also been shown to associate with several other proteins including TRAF1, TRAF2, TRAF3, TRAF5, B and T lymphocyte associated protein (BTLA), and estrogen receptor alpha.
Reactivity
Human
Host
Mouse
Conjugate
Red dye
Antibody clone number
122
Vial size
100 tests
Storage
2°C-8°C
Handling
Ambient RT
TNFRSF14 protein structure - 318808 shown in red.