12-5969-80
antibody from Invitrogen Antibodies
Targeting: TNFRSF14
ATAR, CD270, HVEA, HVEM, LIGHTR, TR2
Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Flow cytometry [2]
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Validation data
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- Product number
- 12-5969-80 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD270 (HVEM) Monoclonal Antibody (eBioHVEM-122), PE, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The eBioHVEM-122 antibody reacts with Herpes Virus Entry Mediator (HVEM, TR2), a member of the TNF-receptor superfamily. HVEM is found on most cell types, including T cells, B cells, monocytes, neutrophils and dendritic cells. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of HVEM was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. Recent studies have shown HVEM as a unique ligand for BTLA (B and T lymphocyte attenuator). The conservation of the BTLA-HVEM interaction between mouse and human suggests that this system is an important pathway regulating lymphocyte activation and/or homeostasis in the immune response.
- Conjugate
- Yellow dye
- Antibody clone number
- eBioHVEM-122
- Concentration
- 0.2 mg/mL
Submitted references Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer.
Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2.
High levels of soluble herpes virus entry mediator in sera of patients with allergic and autoimmune diseases.
Ramsay AG, Clear AJ, Fatah R, Gribben JG
Blood 2012 Aug 16;120(7):1412-21
Blood 2012 Aug 16;120(7):1412-21
Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2.
Huber S, Hoffmann R, Muskens F, Voehringer D
Blood 2010 Oct 28;116(17):3311-20
Blood 2010 Oct 28;116(17):3311-20
High levels of soluble herpes virus entry mediator in sera of patients with allergic and autoimmune diseases.
Jung HW, La SJ, Kim JY, Heo SK, Kim JY, Wang S, Kim KK, Lee KM, Cho HR, Lee HW, Kwon B, Kim BS, Kwon BS
Experimental & molecular medicine 2003 Dec 31;35(6):501-8
Experimental & molecular medicine 2003 Dec 31;35(6):501-8
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Staining of normal human peripheral blood cells with Anti-Human CD19 APC (Product # 17-0199-42) and Mouse IgG1 kappa Isotype Control PE (Product # 12-4714-81) (left) or Anti-Human CD270 (HVEM) PE (right). Cells in the lymphocyte gate were used for analysis.
- Conjugate
- Yellow dye
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Normal human peripheral blood cells were stained with CD19 Monoclonal Antibody, APC (Product # 17-0199-42) and 0.25 µg Mouse IgG1 kappa Isotype Control, PE (Product # 12-4714-82) (left) or 0.25 µg CD270 Monoclonal Antibody, PE (right). Cells in the lymphocyte gate were used for analysis.
- Conjugate
- Yellow dye