13-5969-80

antibody from Invitrogen Antibodies
Targeting: TNFRSF14 ATAR, CD270, HVEA, HVEM, LIGHTR, TR2
Provider product page for 13-5969-80

Antibody data

Product number
13-5969-80 - Provider product page
Provider
Invitrogen Antibodies
Product name
CD270 (HVEM) Monoclonal Antibody (eBioHVEM-122), Biotin, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: The eBioHVEM-122 antibody reacts with Herpes Virus Entry Mediator (HVEM, TR2), a member of the TNF-receptor superfamily. HVEM is found on most cell types, including T cells, B cells, monocytes, neutrophils and dendritic cells. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of HVEM was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. Recent studies have shown HVEM as a unique ligand for BTLA (B and T lymphocyte attenuator). The conservation of the BTLA-HVEM interaction between mouse and human suggests that this system is an important pathway regulating lymphocyte activation and/or homeostasis in the immune response.
Conjugate
Biotin
Antibody clone number
eBioHVEM-122
Concentration
0.5 mg/mL
TNFRSF14 protein structure - 13-5969-80 shown in red.