13-5969-80
antibody from Invitrogen Antibodies
Targeting: TNFRSF14
ATAR, CD270, HVEA, HVEM, LIGHTR, TR2
Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- 13-5969-80 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD270 (HVEM) Monoclonal Antibody (eBioHVEM-122), Biotin, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The eBioHVEM-122 antibody reacts with Herpes Virus Entry Mediator (HVEM, TR2), a member of the TNF-receptor superfamily. HVEM is found on most cell types, including T cells, B cells, monocytes, neutrophils and dendritic cells. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of HVEM was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. Recent studies have shown HVEM as a unique ligand for BTLA (B and T lymphocyte attenuator). The conservation of the BTLA-HVEM interaction between mouse and human suggests that this system is an important pathway regulating lymphocyte activation and/or homeostasis in the immune response.
- Conjugate
- Biotin
- Antibody clone number
- eBioHVEM-122
- Concentration
- 0.5 mg/mL
Submitted references Recipient myeloid-derived immunomodulatory cells induce PD-1 ligand-dependent donor CD4+Foxp3+ regulatory T cell proliferation and donor-recipient immune tolerance after murine nonmyeloablative bone marrow transplantation.
Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2.
High levels of soluble herpes virus entry mediator in sera of patients with allergic and autoimmune diseases.
van der Merwe M, Abdelsamed HA, Seth A, Ong T, Vogel P, Pillai AB
Journal of immunology (Baltimore, Md. : 1950) 2013 Dec 1;191(11):5764-76
Journal of immunology (Baltimore, Md. : 1950) 2013 Dec 1;191(11):5764-76
Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2.
Huber S, Hoffmann R, Muskens F, Voehringer D
Blood 2010 Oct 28;116(17):3311-20
Blood 2010 Oct 28;116(17):3311-20
High levels of soluble herpes virus entry mediator in sera of patients with allergic and autoimmune diseases.
Jung HW, La SJ, Kim JY, Heo SK, Kim JY, Wang S, Kim KK, Lee KM, Cho HR, Lee HW, Kwon B, Kim BS, Kwon BS
Experimental & molecular medicine 2003 Dec 31;35(6):501-8
Experimental & molecular medicine 2003 Dec 31;35(6):501-8
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Staining of normal human peripheral blood cells with 0.125 µg of Mouse IgG1 kappa Isotype Control Biotin (Product # 13-4714-85) (open histogram) or 0.125 µg of Anti-Human CD270 (HVEM) Biotin (filled histogram) followed by Streptavidin PE (Product # 12-4317-87). Cells in the lymphocyte gate were used for analysis.
- Conjugate
- Biotin