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- References [13]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 15647-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15647-1-AP, RRID:AB_2268006
- Product name
- PDK2 antibody
- Antibody type
- Polyclonal
- Description
- PDK2 antibody (Cat. #15647-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Mitochondrial-related genes PDK2, CHDH, and ALDH5A1 served as a diagnostic signature and correlated with immune cell infiltration in ulcerative colitis.
Monocarboxylate transporter 4 deficiency enhances high-intensity interval training-induced metabolic adaptations in skeletal muscle.
Inhibition of mitochondrial fusion via SIRT1/PDK2/PARL axis breaks mitochondrial metabolic plasticity and sensitizes cancer cells to glucose restriction therapy.
Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models.
Contribution of fatty acid oxidation to the pathogenesis of pulmonary hypertension.
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix.
Loss of miR-31-5p drives hematopoietic stem cell malignant transformation and restoration eliminates leukemia stem cells in mice.
Dichloroacetate restores colorectal cancer chemosensitivity through the p53/miR-149-3p/PDK2-mediated glucose metabolic pathway.
Thiamine mimetics sulbutiamine and benfotiamine as a nutraceutical approach to anticancer therapy.
Two dichloric compounds inhibit in vivo U87 xenograft tumor growth.
ROS/KRAS/AMPK Signaling Contributes to Gemcitabine-Induced Stem-like Cell Properties in Pancreatic Cancer.
Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells.
Retinoic acid-related orphan receptor alpha reprograms glucose metabolism in glutamine-deficient hepatoma cells.
Yang Q, Zhang P, Han L, Shi P, Zhao Z, Cui D, Hong K
Aging 2024 Feb 19;16(4):3803-3822
Aging 2024 Feb 19;16(4):3803-3822
Monocarboxylate transporter 4 deficiency enhances high-intensity interval training-induced metabolic adaptations in skeletal muscle.
Tamura Y, Jee E, Kouzaki K, Kotani T, Nakazato K
The Journal of physiology 2024 Apr;602(7):1313-1340
The Journal of physiology 2024 Apr;602(7):1313-1340
Inhibition of mitochondrial fusion via SIRT1/PDK2/PARL axis breaks mitochondrial metabolic plasticity and sensitizes cancer cells to glucose restriction therapy.
Guo Y, Luo C, Sun Y, Guo W, Zhang R, Zhang X, Ke X, Wei L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115342
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115342
Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models.
Han X, Mei Y, Mishra RK, Bi H, Jain AD, Schiltz GE, Zhao B, Sukhanova M, Wang P, Grigorescu AA, Weber PC, Piwinski JJ, Prado MA, Paulo JA, Stephens L, Anderson KE, Abrams CS, Yang J, Ji P
The Journal of clinical investigation 2023 Mar 15;133(6)
The Journal of clinical investigation 2023 Mar 15;133(6)
Contribution of fatty acid oxidation to the pathogenesis of pulmonary hypertension.
Lee MH, Sanders L, Kumar R, Hernandez-Saavedra D, Yun X, Ford JA, Perez MJ, Mickael C, Gandjeva A, Koyanagi DE, Harral JW, Irwin DC, Kassa B, Eckel RH, Shimoda LA, Graham BB, Tuder RM
American journal of physiology. Lung cellular and molecular physiology 2022 Sep 1;323(3):L355-L371
American journal of physiology. Lung cellular and molecular physiology 2022 Sep 1;323(3):L355-L371
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix.
Kay EJ, Paterson K, Riera-Domingo C, Sumpton D, Däbritz JHM, Tardito S, Boldrini C, Hernandez-Fernaud JR, Athineos D, Dhayade S, Stepanova E, Gjerga E, Neilson LJ, Lilla S, Hedley A, Koulouras G, McGregor G, Jamieson C, Johnson RM, Park M, Kirschner K, Miller C, Kamphorst JJ, Loayza-Puch F, Saez-Rodriguez J, Mazzone M, Blyth K, Zagnoni M, Zanivan S
Nature metabolism 2022 Jun;4(6):693-710
Nature metabolism 2022 Jun;4(6):693-710
Loss of miR-31-5p drives hematopoietic stem cell malignant transformation and restoration eliminates leukemia stem cells in mice.
Zhu B, Zhong W, Cao X, Pan G, Xu M, Zheng J, Chen H, Feng X, Luo C, Lu C, Xiao J, Lin W, Lai C, Li M, Du X, Yi Q, Yan D
Science translational medicine 2022 Jan 26;14(629):eabh2548
Science translational medicine 2022 Jan 26;14(629):eabh2548
Dichloroacetate restores colorectal cancer chemosensitivity through the p53/miR-149-3p/PDK2-mediated glucose metabolic pathway.
Liang Y, Hou L, Li L, Li L, Zhu L, Wang Y, Huang X, Hou Y, Zhu D, Zou H, Gu Y, Weng X, Wang Y, Li Y, Wu T, Yao M, Gross I, Gaiddon C, Luo M, Wang J, Meng X
Oncogene 2020 Jan;39(2):469-485
Oncogene 2020 Jan;39(2):469-485
Thiamine mimetics sulbutiamine and benfotiamine as a nutraceutical approach to anticancer therapy.
Jonus HC, Byrnes CC, Kim J, Valle ML, Bartlett MG, Said HM, Zastre JA
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109648
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109648
Two dichloric compounds inhibit in vivo U87 xenograft tumor growth.
Ovcharenko D, Chitjian C, Kashkin A, Fanelli A, Ovcharenko V
Cancer biology & therapy 2019;20(9):1281-1289
Cancer biology & therapy 2019;20(9):1281-1289
ROS/KRAS/AMPK Signaling Contributes to Gemcitabine-Induced Stem-like Cell Properties in Pancreatic Cancer.
Zhao H, Wu S, Li H, Duan Q, Zhang Z, Shen Q, Wang C, Yin T
Molecular therapy oncolytics 2019 Sep 27;14:299-312
Molecular therapy oncolytics 2019 Sep 27;14:299-312
Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells.
Li P, Zhang D, Shen L, Dong K, Wu M, Ou Z, Shi D
Scientific reports 2016 Mar 9;6:22831
Scientific reports 2016 Mar 9;6:22831
Retinoic acid-related orphan receptor alpha reprograms glucose metabolism in glutamine-deficient hepatoma cells.
Byun JK, Choi YK, Kang YN, Jang BK, Kang KJ, Jeon YH, Lee HW, Jeon JH, Koo SH, Jeong WI, Harris RA, Lee IK, Park KG
Hepatology (Baltimore, Md.) 2015 Mar;61(3):953-64
Hepatology (Baltimore, Md.) 2015 Mar;61(3):953-64
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human heart tissue were subjected to SDS PAGE followed by western blot with 15647-1-AP(PDK2 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 15647-1-AP(PDK2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PDK2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PDK2. This antibody recognizes human, mouse, rat antigen. The PDK2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
