15647-1-AP

antibody from Proteintech Group

Targeting: PDK2 PDHK2

Provider product page for 15647-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [22]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 15647-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#15647-1-AP, RRID:AB_2268006
Product name: PDK2 antibody
Antibody type: Polyclonal
Description: PDK2 antibody (Cat. #15647-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PDK2 protein structure - 15647-1-AP shown in red.

Submitted references Mitochondria-targeting iridium(III) complex enhances anticancer activity via PDK inhibition and energy metabolism disruption.

Xu S, Xu N, Fang H, Zhu Z, Su Y, Su Z
Journal of inorganic biochemistry 2026 Jul;280:113317

Identification and Experimental Validation of Oxidative Stress-Related Biomarkers in Ulcerative Colitis Using Machine Learning.

Duan S, Yi Q, Qiu M, Zhu Z, Zhang Z, Gao Y, Zhang D
Journal of inflammation research 2025;18:11415-11435

Multi-dimensional data-driven computational drug repurposing strategy for screening novel neuroprotective agents in ischemic stroke.

Meng Q, Liu Q, Mi Y, Xu L, Wang F, Mu D, Liu Y, Yang Y, Huang Y, He D, Hou Y
Theranostics 2025;15(15):7653-7676

Mitophagy mitigates mitochondrial fatty acid β-oxidation deficient cardiomyopathy.

Sun N, Barta H, Chaudhuri S, Chen K, Jin J, Luo H, Yang M, Krigman J, Zhang R, Sanghvi S, Sekine S, Sanders H, Kolonay D, Patel M, Baskin K, Singh H, Zhang P, Xin G, Finkel T
Nature communications 2025 Jul 1;16(1):5465

Lycorine hydrochloride interferes with energy metabolism to inhibit chemoresistant glioblastoma multiforme cell growth through suppressing PDK3.

Dong Q, Niu W, Mu M, Ye C, Wu P, Hu S, Niu C
Molecular and cellular biochemistry 2025 Jan;480(1):355-369

PANAXADIOL SAPONIN ALLEVIATES LPS-INDUCED CARDIOMYOPATHY SIMILAR TO DEXAMETHASONE VIA IMPROVING MITOCHONDRIAL QUALITY CONTROL.

Yang Z, Gao Y, Li D, Zhao L, Du Y
Shock (Augusta, Ga.) 2025 Feb 1;63(2):282-291

Glioma angiogenesis phosphoproteome landscape and biomarker sets identified with phenome-centered multiomics toward 3P medical approaches.

Gong X, Guo T, Li C, Li Z, Li X, Yang L, Li N, Zhan X
The EPMA journal 2025 Dec;16(4):831-856

G protein pathway suppressor 2 suppresses aerobic glycolysis through RACK1-mediated HIF-1α degradation in breast cancer.

Si Y, Ou H, Jin X, Gu M, Sheng S, Peng W, Yang D, Zhan X, Zhang L, Yu Q, Liu X, Liu Y
Free radical biology & medicine 2024 Sep;222:478-492

NOTCH1 mitochondria localization during heart development promotes mitochondrial metabolism and the endothelial-to-mesenchymal transition in mice.

Wang J, Zhao R, Xu S, Zhou XY, Cai K, Chen YL, Zhou ZY, Sun X, Shi Y, Wang F, Gui YH, Tao H, Zhao JY
Nature communications 2024 Nov 16;15(1):9945

Mitochondrial-related genes PDK2, CHDH, and ALDH5A1 served as a diagnostic signature and correlated with immune cell infiltration in ulcerative colitis.

Yang Q, Zhang P, Han L, Shi P, Zhao Z, Cui D, Hong K
Aging 2024 Feb 19;16(4):3803-3822

Monocarboxylate transporter 4 deficiency enhances high-intensity interval training-induced metabolic adaptations in skeletal muscle.

Tamura Y, Jee E, Kouzaki K, Kotani T, Nakazato K
The Journal of physiology 2024 Apr;602(7):1313-1340

Inhibition of mitochondrial fusion via SIRT1/PDK2/PARL axis breaks mitochondrial metabolic plasticity and sensitizes cancer cells to glucose restriction therapy.

Guo Y, Luo C, Sun Y, Guo W, Zhang R, Zhang X, Ke X, Wei L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115342

Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models.

Han X, Mei Y, Mishra RK, Bi H, Jain AD, Schiltz GE, Zhao B, Sukhanova M, Wang P, Grigorescu AA, Weber PC, Piwinski JJ, Prado MA, Paulo JA, Stephens L, Anderson KE, Abrams CS, Yang J, Ji P
The Journal of clinical investigation 2023 Mar 15;133(6)

Contribution of fatty acid oxidation to the pathogenesis of pulmonary hypertension.

Lee MH, Sanders L, Kumar R, Hernandez-Saavedra D, Yun X, Ford JA, Perez MJ, Mickael C, Gandjeva A, Koyanagi DE, Harral JW, Irwin DC, Kassa B, Eckel RH, Shimoda LA, Graham BB, Tuder RM
American journal of physiology. Lung cellular and molecular physiology 2022 Sep 1;323(3):L355-L371

Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix.

Kay EJ, Paterson K, Riera-Domingo C, Sumpton D, Däbritz JHM, Tardito S, Boldrini C, Hernandez-Fernaud JR, Athineos D, Dhayade S, Stepanova E, Gjerga E, Neilson LJ, Lilla S, Hedley A, Koulouras G, McGregor G, Jamieson C, Johnson RM, Park M, Kirschner K, Miller C, Kamphorst JJ, Loayza-Puch F, Saez-Rodriguez J, Mazzone M, Blyth K, Zagnoni M, Zanivan S
Nature metabolism 2022 Jun;4(6):693-710

Loss of miR-31-5p drives hematopoietic stem cell malignant transformation and restoration eliminates leukemia stem cells in mice.

Zhu B, Zhong W, Cao X, Pan G, Xu M, Zheng J, Chen H, Feng X, Luo C, Lu C, Xiao J, Lin W, Lai C, Li M, Du X, Yi Q, Yan D
Science translational medicine 2022 Jan 26;14(629):eabh2548

Dichloroacetate restores colorectal cancer chemosensitivity through the p53/miR-149-3p/PDK2-mediated glucose metabolic pathway.

Liang Y, Hou L, Li L, Li L, Zhu L, Wang Y, Huang X, Hou Y, Zhu D, Zou H, Gu Y, Weng X, Wang Y, Li Y, Wu T, Yao M, Gross I, Gaiddon C, Luo M, Wang J, Meng X
Oncogene 2020 Jan;39(2):469-485

Thiamine mimetics sulbutiamine and benfotiamine as a nutraceutical approach to anticancer therapy.

Jonus HC, Byrnes CC, Kim J, Valle ML, Bartlett MG, Said HM, Zastre JA
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109648

Two dichloric compounds inhibit in vivo U87 xenograft tumor growth.

Ovcharenko D, Chitjian C, Kashkin A, Fanelli A, Ovcharenko V
Cancer biology & therapy 2019;20(9):1281-1289

ROS/KRAS/AMPK Signaling Contributes to Gemcitabine-Induced Stem-like Cell Properties in Pancreatic Cancer.

Zhao H, Wu S, Li H, Duan Q, Zhang Z, Shen Q, Wang C, Yin T
Molecular therapy oncolytics 2019 Sep 27;14:299-312

Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells.

Li P, Zhang D, Shen L, Dong K, Wu M, Ou Z, Shi D
Scientific reports 2016 Mar 9;6:22831

Retinoic acid-related orphan receptor alpha reprograms glucose metabolism in glutamine-deficient hepatoma cells.

Byun JK, Choi YK, Kang YN, Jang BK, Kang KJ, Jeon YH, Lee HW, Jeon JH, Koo SH, Jeong WI, Harris RA, Lee IK, Park KG
Hepatology (Baltimore, Md.) 2015 Mar;61(3):953-64

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human heart tissue were subjected to SDS PAGE followed by western blot with 15647-1-AP(PDK2 antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human brain using 15647-1-AP(PDK2 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The PDK2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PDK2. This antibody recognizes human, mouse, rat antigen. The PDK2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 15647-1-AP.pdf

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