Antibody data

Product number
10-7572 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-TIA-1 Antibody
Antibody type
Monoclonal
Description
TIA1 (T-cell intracellular antigen) are mRNA-binding proteins that can aggregate within granules under specific stress conditions. TIA-1 is a multi-domain ribonucleic acid (RNA) binding protein that recognizes poly-uridine tract RNA sequences to facilitate 5' splice site recognition by the U1 small nuclear ribonucleoprotein (snRNP). TIA1 mutation causes perturbed RNA splicing and cellular stress resulting in WDM (Welander distal myopathy). TIA-1 regulates developmental and stress-responsive pathways through distinct activities at the levels of alternative pre-mRNA splicing and mRNA translation by recognising uridine-rich sequences of RNAs.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
A partial length recombinant TIA-1
protein (amino acids 182-385) was u
sed as the immunogen for this antib
ody.
Isotype
IgG
Antibody clone number
ABM47E1
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
TIA1 protein structure - 10-7572 shown in red.